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伍龙军

Long-Jun Wu, Ph.D.

TitleInstructor in Pediatrics
InstitutionChildren's Hospital Boston
DepartmentPediatrics
AddressChildrens Hospital
Enders 1309
300 Longwood Ave 
Boston, MA 02115
Phone617/919-2672
Email
Awards and Honors
1999Guanghua Education Scholarship, Taiwan Guanghua Foundation
2001IET Scholarship, IET Education Foundation of China
2002IBRO Travel Fellowship, International Brain Research Organization
2002Qiushi Graduate Student Scholarship, Qiushi Science & Technology Foundation of Hong Kong
2005 - 2008Medical Research Postdoctoral Fellowship, The Fragile X Research Foundation of Canada
2006 - 2009CIHR Postdoctoral Fellowship Award, Canadian Institutes of Health Research
2007Best Poster Award, 1st place, The 2nd International Conference of Neurons and Brain Disease
2007CaBP07 Travel Award, The 14th Congress of Calcium Binding Proteins in Health and Disease
2007Hubert van Tol Fellowship Award, NeuroScience Canada
2009 - 2011Lefler Postdoctoral Fellowship, The Edward R. and Anne G. Lefler Center, Harvard Medical School
2011 - 2015NCRP Scientist Development Grant Award, American Heart Association
Publications
List All  |  Timeline
  1. Toyoda H, Li XY, Wu LJ, Zhao MG, Descalzi G, Chen T, Koga K, Zhuo M. Interplay of amygdala and cingulate plasticity in emotional fear. Neural Plast. 2011; 2011:813749.
    View in: PubMed
  2. Zhuo M, Wu G, Wu LJ. Neuronal and microglial mechanisms of neuropathic pain. Mol Brain. 2011; 4:31.
    View in: PubMed
  3. Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, Xu H, Shang Y, Endoh K, Iwamoto T, Mamiya N, Okano E, Hasegawa S, Mercaldo V, Zhang Y, Maeda R, Ohta M, Josselyn SA, Zhuo M, Kida S. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011 Jun 15; 31(24):8786-802.
    View in: PubMed
  4. Kim SS, Wang H, Li XY, Chen T, Mercaldo V, Descalzi G, Wu LJ, Zhuo M. Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice. Mol Brain. 2011; 4:6.
    View in: PubMed
  5. Wang H, Xu H, Wu LJ, Kim SS, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Sci Transl Med. 2011 Jan 12; 3(65):65ra3.
    View in: PubMed
  6. Cao X, Mercaldo V, Li P, Wu LJ, Zhuo M. Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex. Mol Pain. 2010; 6:52.
    View in: PubMed
  7. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010 Sep; 62(3):381-404.
    View in: PubMed
  8. Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28; 65(2):165-77.
    View in: PubMed
  9. Wu LJ, Mellström B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M. DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory. Mol Brain. 2010; 3:3.
    View in: PubMed
  10. Cao XY, Xu H, Wu LJ, Li XY, Chen T, Zhuo M. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury. Mol Pain. 2009; 5:73.
    View in: PubMed
  11. Wu LJ, Li X, Chen T, Ren M, Zhuo M. Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Mol Brain. 2009; 2:32.
    View in: PubMed
  12. Wu LJ, Zhuo M. Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics. 2009 Oct; 6(4):693-702.
    View in: PubMed
  13. Toyoda H, Zhao MG, Ulzhöfer B, Wu LJ, Xu H, Seeburg PH, Sprengel R, Kuner R, Zhuo M. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain. 2009; 5:46.
    View in: PubMed
  14. Wu LJ, Wang YT, Zhuo M. Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus. Mol Brain. 2009; 2(1):17.
    View in: PubMed
  15. Wu LJ, Kim SS, Li X, Zhang F, Zhuo M. Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex. Mol Brain. 2009; 2(1):9.
    View in: PubMed
  16. Fukushima H, Maeda R, Suzuki R, Suzuki A, Nomoto M, Toyoda H, Wu LJ, Xu H, Zhao MG, Ueda K, Kitamoto A, Mamiya N, Yoshida T, Homma S, Masushige S, Zhuo M, Kida S. Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J Neurosci. 2008 Oct 1; 28(40):9910-9.
    View in: PubMed
  17. Zhang XH, Wu LJ, Gong B, Ren M, Li BM, Zhuo M. Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. Mol Brain. 2008; 1(1):9.
    View in: PubMed
  18. Wu LJ, Steenland HW, Kim SS, Isiegas C, Abel T, Kaang BK, Zhuo M. Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Mol Pain. 2008; 4:40.
    View in: PubMed
  19. Wang H, Wu LJ, Kim SS, Lee FJ, Gong B, Toyoda H, Ren M, Shang YZ, Xu H, Liu F, Zhao MG, Zhuo M. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron. 2008 Aug 28; 59(4):634-47.
    View in: PubMed
  20. Xu H, Wu LJ, Wang H, Zhang X, Vadakkan KI, Kim SS, Steenland HW, Zhuo M. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci. 2008 Jul 16; 28(29):7445-53.
    View in: PubMed
  21. Ko SW, Wu LJ, Shum F, Quan J, Zhuo M. Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance. Mol Brain. 2008; 1(1):2.
    View in: PubMed
  22. Hines RM, Wu L, Hines DJ, Steenland H, Mansour S, Dahlhaus R, Singaraja RR, Cao X, Sammler E, Hormuzdi SG, Zhuo M, El-Husseini A. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci. 2008 Jun 11; 28(24):6055-67.
    View in: PubMed
  23. Isiegas C, McDonough C, Huang T, Havekes R, Fabian S, Wu LJ, Xu H, Zhao MG, Kim JI, Lee YS, Lee HR, Ko HG, Lee N, Choi SL, Lee JS, Son H, Zhuo M, Kaang BK, Abel T. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci. 2008 Jun 11; 28(24):6220-30.
    View in: PubMed
  24. Wang H, Wu LJ, Zhang F, Zhuo M. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23; 28(17):4385-97.
    View in: PubMed
  25. Zhang F, Vadakkan KI, Kim SS, Wu LJ, Shang Y, Zhuo M. Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Mol Pain. 2008; 4:15.
    View in: PubMed
  26. Wu LJ, Kim SS, Zhuo M. Molecular targets of anxiety: from membrane to nucleus. Neurochem Res. 2008 Oct; 33(10):1925-32.
    View in: PubMed
  27. Wu LJ, Zhang XH, Fukushima H, Zhang F, Wang H, Toyoda H, Li BM, Kida S, Zhuo M. Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. Eur J Neurosci. 2008 Apr; 27(8):1923-32.
    View in: PubMed
  28. Wu LJ, Zhuo M. Resting microglial motility is independent of synaptic plasticity in mammalian brain. J Neurophysiol. 2008 Apr; 99(4):2026-32.
    View in: PubMed
  29. Wu LJ, Ren M, Wang H, Kim SS, Cao X, Zhuo M. Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. PLoS One. 2008; 3(1):e1407.
    View in: PubMed
  30. Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, Wei Y, Wang Y, Blumenthal R, Machado-Vieira R, Yuan P, Chen G, Zhuo M, Manji HK. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. J Neurosci. 2008 Jan 2; 28(1):68-79.
    View in: PubMed
  31. Toyoda H, Zhao MG, Xu H, Wu LJ, Ren M, Zhuo M. Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain. 2007; 3:36.
    View in: PubMed
  32. Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci. 2007 Oct 10; 27(41):11139-48.
    View in: PubMed
  33. Wu LJ, Vadakkan KI, Zhuo M. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia. 2007 Jun; 55(8):810-21.
    View in: PubMed
  34. Toyoda H, Wu LJ, Zhao MG, Xu H, Jia Z, Zhuo M. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol. 2007 May; 211(2):336-43.
    View in: PubMed
  35. Wu LJ, Xu H, Ren M, Cao X, Zhuo M. Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Mol Pain. 2007; 3:11.
    View in: PubMed
  36. Shum FW, Wu LJ, Zhao MG, Toyoda H, Xu H, Ren M, Pinaud R, Ko SW, Lee YS, Kaang BK, Zhuo M. Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem. 2007 Apr; 14(4):304-12.
    View in: PubMed
  37. Toyoda H, Wu LJ, Zhao MG, Xu H, Zhuo M. Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. Dev Neurobiol. 2007 Mar; 67(4):498-509.
    View in: PubMed
  38. Wu LJ, Xu H, Ren M, Zhuo M. Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Dev Neurobiol. 2007 Feb 1; 67(2):146-57.
    View in: PubMed
  39. Wu LJ, Ko SW, Toyoda H, Zhao MG, Xu H, Vadakkan KI, Ren M, Knifed E, Shum F, Quan J, Zhang XH, Zhuo M. Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS One. 2007; 2(1):e167.
    View in: PubMed
  40. Wu LJ, Ko SW, Zhuo M. Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortex. Curr Pharm Des. 2007; 13(15):1597-605.
    View in: PubMed
  41. Steenland HW, Ko SW, Wu LJ, Zhuo M. Hot receptors in the brain. Mol Pain. 2006; 2:34.
    View in: PubMed
  42. Zeng H, Gragerov A, Hohmann JG, Pavlova MN, Schimpf BA, Xu H, Wu LJ, Toyoda H, Zhao MG, Rohde AD, Gragerova G, Onrust R, Bergmann JE, Zhuo M, Gaitanaris GA. Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Mol Cell Biol. 2006 Dec; 26(24):9352-63.
    View in: PubMed
  43. Blaeser F, Sanders MJ, Truong N, Ko S, Wu LJ, Wozniak DF, Fanselow MS, Zhuo M, Chatila TA. Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol. 2006 Dec; 26(23):9105-15.
    View in: PubMed
  44. Xu H, Wu LJ, Zhao MG, Toyoda H, Vadakkan KI, Jia Y, Pinaud R, Zhuo M. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain. 2006; 2:29.
    View in: PubMed
  45. Zhao MG, Ko SW, Wu LJ, Toyoda H, Xu H, Quan J, Li J, Jia Y, Ren M, Xu ZC, Zhuo M. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain. J Neurosci. 2006 Aug 30; 26(35):8923-30.
    View in: PubMed
  46. Ko SW, Jia Y, Xu H, Yim SJ, Jang DH, Lee YS, Zhao MG, Toyoda H, Wu LJ, Chatila T, Kaang BK, Zhuo M. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci. 2006 Apr; 23(8):2158-68.
    View in: PubMed
  47. Wei F, Vadakkan KI, Toyoda H, Wu LJ, Zhao MG, Xu H, Shum FW, Jia YH, Zhuo M. Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice. J Neurosci. 2006 Jan 18; 26(3):851-61.
    View in: PubMed
  48. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci. 2005 Nov 30; 25(48):11107-16.
    View in: PubMed
  49. Wu LJ, Xu H, Ko SW, Yoshimura M, Zhuo M. Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P. Mol Pain. 2005; 1:34.
    View in: PubMed
  50. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005 Sep 15; 47(6):859-72.
    View in: PubMed
  51. Zhao MG, Toyoda H, Ko SW, Ding HK, Wu LJ, Zhuo M. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci. 2005 Aug 10; 25(32):7385-92.
    View in: PubMed
  52. Liauw J, Wu LJ, Zhuo M. Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex. J Neurophysiol. 2005 Jul; 94(1):878-82.
    View in: PubMed
  53. Wu LJ, Zhao MG, Toyoda H, Ko SW, Zhuo M. Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. J Neurophysiol. 2005 Sep; 94(3):1805-13.
    View in: PubMed
  54. Gao J, Wu LJ, Xu L, Xu TL. Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons. Brain Res. 2004 Aug 13; 1017(1-2):197-207.
    View in: PubMed
  55. Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem. 2004 Oct 15; 279(42):43716-24.
    View in: PubMed
  56. Li Y, Wu LJ, Legendre P, Xu TL. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. J Biol Chem. 2003 Oct 3; 278(40):38637-45.
    View in: PubMed
  57. Li YF, Wu LJ, Li Y, Xu L, Xu TL. Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons. J Physiol. 2003 Oct 1; 552(Pt 1):73-87.
    View in: PubMed
  58. Wu LJ, Li Y, Xu TL. Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. Neuroreport. 2002 May 24; 13(7):977-81.
    View in: PubMed
  59. Wu LJ, Lu Y, Xu TL. A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. J Neurosci Methods. 2001 Jul 30; 108(2):199-206.
    View in: PubMed

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