徐宏喜

人物介绍

徐宏喜 博士

徐宏喜

徐宏喜教授，现为上海中医药大学教授、博士生导师、上海中医药大学中药学院院长。国家中组部“千人计划”特聘教授，上海市首批特聘专家。1994年获得日本富山医科药科大学国立和汉药研究所药学博士学位。并于新加坡国立大学化学系及加拿大Dalhousie大学微生物学系进行博士後研究工作。曾先后受聘于香港中文大学中药研究中心科学主任、香港和记黄埔(中国)有限公司副总经理兼高级医药顾问，上海和黄药业有限公司董事兼研究开发总监。2001至2010年,担任香港赛马会中药研究院副总裁兼中药研究室主任。徐教授至今已发表SCI论文200多篇，总引用次数超过5500次，H指数为40，入选2014年中国高被引用学者榜。拥有1项PCT专利以及6项美国专利。

人物介绍

徐教授的主要社会兼职包括：中华中医药学会中药实验药理学分会主任委员、世界中医药协会联合会中药分析专业委员会副会长、世中联中药鉴定专业委员会副会长、全国中医药高等教育学会中药教育研究会第三届理事会副理事长、国际现代化中医药学术会议联席主席、上海市侨界知识分子联谊会第八届理事会常务理事、上海市药学会中药专业委员会主任委员、国际国内十余种学术刊物的编委、现代化中医药国际协会创会董事等职。先后应邀前往美国、日本、新加坡、韩国、巴西、加拿大、奥地利、印度等国家以及台湾、香港、澳门等地做学术报告。

研究方向和领域

主要研究领域包括中药活性成分及药效评价研究，中药新药开发以及中药质量控制分析方法研究等。重点进行病毒、肿瘤、耐药菌及糖尿病等重大疾病的中药防治与药效评价研究，阐明中药药效物质基础及作用机制，研发具有自主知识产权的创新药物。

(1)  抗病毒及抗耐药菌中药药理机制研究
从事中药及其活性成分抗病毒及抗耐药菌药理作用机制研究。已建立抗病毒（HSV和EV71）筛选平台及基于MgrA靶标蛋白荧光探针的高通量筛选体系，致力于阐明中药抗病毒和抗金黄色葡萄球菌耐药菌活性物质基础，揭示其药效作用机制，发现活性强、毒性小、选择性高的先导化合物。
(2)  抗肿瘤中药药理作用机制研究
从事中药及其活性成分抗肿瘤药理作用机制研究。已建立分子、细胞及动物水平的抗肿瘤药物筛选及药效评价模型，重点开展肝癌、前列腺癌及胰腺癌的体内外药效筛选和药效评价，致力于从中草药和天然产物中寻找抗肿瘤先导化合物，阐明其诱导肿瘤细胞凋亡、调节自噬、抑制转移及防止复发等药效作用机制。近年来重点开展中国产藤黄属植物中具有抗肿瘤活性的PPAPs类和Xanthones类成分的鉴定及其作用机制研究。

主要SCI研究论文（IF》3）

1.        Y. Z. Lao, G. Wan, Z. Y. Liu, X. Y. Wang,P. Ruan, W. Xu, D. Q. Xu, W. D. Xie, Y. Zhang, H.X.Xu*, N. H. Xu, The natural compound oblongifolin C inhibitsautophagic flux and enhances antitumor efficacy of nutrient deprivation, Autophagy, 10(5): 1-14 (2014). (IF=11.753)

2.        G. Wan, W. D. Xie, Z. Y. Liu, W. Xu, Y. Z. Lao, N. Huang, K. Cui, M. J. Liao, J. He, Y. Y. Jiang, Burton B Yang, H. X. Xu, N. H. Xu, Y. Zhang, Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway, Autophagy, 10(1):70-79 (2014). (IF=11.753)

3.        G. Lin, J. Y. Wang, N. Li, M. Li, H. Gao, Y. Ji, F. Zhang, H. L. Wang, Y. Zhou, Y. Ye, H. X. Xu, J. Zheng, Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum, Journal of Hepatology, 54(4), 666-673 (2011). (IF=11.336)

4.        M.H.Feng, B.Q.Tang, N.Z.Wang, H.H.Xu, X.F.Jiang*, Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids, Angewandte Chemie (International ed. in English), doi: 10.1002/anie.201508340. [Epub ahead of print] (2015). (IF=11.261)

5.        H. L. Zhao, Y. Sui, C. F. Qiao, K. Y. Yip, R. K. K. Leung, S. K. W. Tsui, H. M. Lee, H. K. T. Wong, X. Zhu, J. J. Siu, L. He, J. Guan, L. Z. Liu, H. X. Xu, P. C. Y. Tong, J. C. N. Chan, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression, Diabetes, 61(4), 933-943 (2012). (IF=8.095)

6.        X. W. Yang, X. Deng, X. Liu, C. Y. Wu, X. N. Li, B. Wu, H. R. Luo, Y. Li, H. X. Xu, Q. S. Zhao, G. Xu, Hypercohin A, a new polycyclic polyprenylated acylphloroglucinols possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens, Chemical Communications, 48: 5998-6000 (2012). (IF=6.834)

7.        Y. Liao, X. Liu, J. Yang, Y.Z. Lao, X.W.Yang, X.N.Li, J.J.Zhang, Z.J.Ding, H.X.Xu* and G. Xu*,Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile, Organic Letters, 17 (5), 1172–1175(2015). (IF=6.364)

8.        Q. B. Han, T. F. Tso, S. Cheung, Tai, J. Z. Song, C. F. Qiao, H. D. Sun, and H. X. Xu*, Maoecrystal Z, a Cytotoxic Diterpene from Isodon eriocalyx with an Unique Skeleton, Organic Letters, 8 (21), 4727-4730 ( 2006). (IF=6.364)

9.        Z.J.Ding, Y.Z.Lao, H.Zhang, W.W.Fu, L.L.Zhu, H.S.Tan, H.X.Xu*, Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer,Oncotarget, in press.(2015). (IF=6.359)

10.    X.H.Pang,J.Y.Song,Y.J.Zhu,H.X.Xu,L.F.Huang,S.L.Chen, Applying plant DNA barcodes for Rosaceae species identification,Cladistics,27(2), 165-170(2011). (IF=6.217)

11.    K.K. Shen, J.L.Xie, H. Wang, H.Zhang, M.Y.Yu, F.F. Lu, H.S. Tan,H.X.Xu*, Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells, Molecular Cancer Therapeutics, 14(7):1738-1749. (2015). (IF=5.683)

12.    T. W. D. Chan, P. P. H. But, S. W. Cheng, I. M. Y. Kwok, F. W. Lau, H. X. Xu, Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS, Analytical Chemistry, 72(6), 1281-1287 (2000). (IF=5.636)

13.    X.Y. Wang, Y. Z. Lao, N.H. Xu, Z.C. Xu, M. Wu, H. Wang, X. Li, H.S. Tan, M.H. Sun, H. X. Xu*, Oblongifolin C inhibits metastesis by up-regulating keratin 18 and tubulins, Scientific Reports, 5:10293-10305. (2015). (IF=5.578)

14.    W. L. Ting Kan, C. Yin, H. X. Xu*, G. Xu, K. K.W. To, C. H. Cho, J. A. Rudd, G.Lin, Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1 cell cycle arrest and apoptosis, International Journalof Cancer, 132(3): 707-716 (2013). (IF=5.085)

15.    C.Feng,L.Y.Zhou,T.Yu,G.Xu,H.L.Tian,J.J.Xu,H.X.Xu*,K.Q.Luo, A new anticancer compound, Oblongifolin C,inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation, International Journalof Cancer,131(6):1445-1454 (2012). (IF=5.085)

16.    Z.C.Xi, M.Yao, Y.Li, C.L.Xie, J. Holst, T. Liu, S.F.Cai, Y.Z.Lao, H.S.Tan, H.X. Xu* and Q.H. Dong*, Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells viastabilization of FBXW7 and subsequent c-MYC degradation, Cell Death & Disease, under revised. (2015). (IF=5.014)

17.    Y.Lu, S.F.Cai, J.Nie, Y.Y. Li, G.C.Shi, J.M.Hao, W.W.Fu, H.S.Tan, S.L.Chen, B. Li*, H.X.Xu* ,The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma, Biochemical Pharmacology, S0006-2952(15)00713-3. doi: 10.1016/j.bcp.2015.11.004. [Epub ahead of print] . (2015). (IF=5.009)

18.    D.H.He, L.S.Ding, H.X.Xu*, X.X.Lei, H.P.Xiao, Y.Zhou,Gymnothelignans A-O: Conformation and Absolute Configuration Analyses of Lignans Bearing Tetrahydrofuran from Gymnotheca chinensis,Journal of Organic Chemistry, 77(19): 8435-8443 (2012). (IF=4.721)

19.    H. Y. Qin, J. C. Y. Wu, X. D. Tong, J. J. Y. Sung, H. X. Xu, Z. X. Bian,Systematicreview of  animal models of post-infectious/post-inflammatory irritable bowel syndrome. Journal of Gastroenterology, 46(2), 164-174(2011). (IF=4.523)

20.    Z. X. Bian, Z. Li, Z. X. Huang, M. Zhang, H. L. Chen, H. X. Xu, J. J. Y. Sung, Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients, Journal of Gastroenterology, 44(7), 666-674 (2009). (IF=4.523)

21.    Y. Zhou, N. Li, F. F. K. Choi, C. F. Qiao, J. Z. Song, S. L. Li, X. Liu, Z. W. Cai, P. P. Fu, G. Lin*, H. X. Xu*, A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry, Analytica Chimica Acta, 681(1-2), 33-40 (2010). (IF=4.513)

22.    Y. Zhou, Stephanie Lee, Franky F. K. Choi, G. Xu, X. Liu, J. Z. Song, S. L. Li, C. F. Qiao, H. X. Xu*, Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Analytica Chimica Acta, 678(1), 96-107 (2010). (IF=4.513)

23.    Y. Zhou, X. Liu, J. Yang, Q. B. Han, J. Z. Song, S. L. Li, L. S. Ding, H. X. Xu*, Analysis of caged xanthones from the resin of Garcinia hanburyi using ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Analytica Chimica Acta, 629, 104-118 (2008). (IF=4.513)

24.    L. Z. Liu, S. C. K. Cheung, L. L. Lan, S. K. S. Ho, H. X. Xu, J. C. N. Chan, P. C. Y. Tong, Berberine modulates insulin signaling transduction in insulin-resistant cells, Molecular and Cellular Endocrinology, 317 (1-2), 148-153 (2010). (IF=4.405)

25.    M.S. Liu, L.Tao, S. L. Chow, R. Wu, H. Zhang, Y.F.Yang, D.J.Yang, Z.X.Bian, A.P.Lu, Q.B.Han, H.H.Xu*,Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: finding anti-enterovirus 71 agents from Anemarrhena asphodeloides.,Journal of Chromatography A, 1368：116-124 (2014). (IF=4.169)

26.    S. L. Li,H. Shen, L. Y. Zhu, J. Xu, X. B. Jia, H. M. Zhang ,H. X. Xu*, G. Lin, H. Cai, B. C. Cai, S. L. Chen, Ultra-high-performance liquid chromatography-quadrupole/time of flight massspectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng, Journal of Chromatography A, 1231: 31-45 (2012). (IF=4.169)

27.    Y. Zhou, J. Z. Song, Franky F. K. Choi, H. F. Wu, C. F. Qiao, L. S. Ding, S. L. Gesang, H. X. Xu*, An experimental design approach using response surface techniques to obtain optimal liquid chromatography and mass spectrometry conditions to determine the alkaloids in Meconopsi species, Journal of Chromatography A, 1216 (42), 7013-7023 (2009). (IF=4.169)

28.    J. Z. Song, C. F. Qiao, S. L.  Li, Y. Zhou, M. T. Hsieh, H. X. Xu*, Rapid optimization of dual-mode gradient high performance liquid chromatographic separation of Radix et Rhizoma Salviae Miltiorrhizae by Response Surface Methodology, Journal of Chromatography A, 1216 (42), 7007-7012 (2009). (IF=4.169)

29.    Y. Zhou, G. Xu, F. F. K. Choi, L. S. Ding, Q. B. Han, J. Z. Song, C. F. Qiao, Q. S. Zhao, H. X. Xu*, Qualitative and quantitative analysis of diterpenoids in Salvia species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 1216 (24), 4847-4858 (2009). (IF=4.169)

30.    C. Y. Li, H. X. Xu, Q. B. Han, T. S. Wu, Quality assessment Radix Codonopsis by quantitative nuclear magnetic resonance, Journal of Chromatography A, 1216(11), 2124-2129 (2009). (IF=4.169)

31.    Y. Zhou, Q. B. Han, J. Z. Song, H. X. Xu*, Characterization of polyprenylated xanthones in Garcinia xipshuanbannaensis using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 1206 (2), 131-139 (2008). (IF=4.169)

32.    Q. B. Han, J. Z. Song, C. F. Qiao, L. Wong, and H. X. Xu*, Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography, Journal of Chromatography A, 1127(1-2), 298-301 (2006). (IF=4.169)

33.    S. B. Chen, H. P. Liu, R. T. Yian, D. J. Yang, S. L. Chen, H. X. Xu, A. S. C. Chan, and P. S. Xie, High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. Journal of ChromatographyA, 1121(1), 114-119 (2006). (IF=4.169)

34.    Y. Xie, Z. H. Jiang, H. Zhou, H. X. Xu, and L. Liu, Simultaneous determination of six Aconitum alkaloids in proprietary Chinese medicines by high-performance liquid chromatography, Journal of ChromatographyA, 1093 (1-2), 195-203 (2005). (IF=4.169)

35.    J. Z. Song, H. X. Xu, S. J. Tian, and P. P. H. But, Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis, Journal of ChromatographyA, 857, 303-311(1999). (IF=4.169)

36.    X. J. Zhang, Z. Li, W. M. Leung, L. Liu, H. X. Xu, Z. X. Bian, The Analgesic Effect of Paeoniflorin on Neonatal Maternal Separation-Induced Visceral Hyperalgesia in Rats, Journal of Pain, 9 (6), 497-505 (2008). (IF=4.01)

37.    X. J. Zhang, F. F.K.Choi, Y. Zhou, F. P. Leung, S. Tan, S. H. Lin, H. X. Xu, W. Jia, J. J.Y.Sung, Z. W. Cai, Z. X. Bian, Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics: A pilot study, FEBS Journal, 279(13): 2322-2338 (2012). (IF=4.001)

38.    Y. W. Zhang, P. P. H. But, V. E. C. Ooi, H. X. Xu, G. D. Delaney, S. H. S. Lee, S. F. Lee,  Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin–carbohydrate complex from Prunella vulgaris, Antiviral Research, 75 (3), 242-249 (2007). (IF=3.938)

39.    H. X. Xu, S. H. S. Lee, S. F. Lee, R. L. White, J. Blay, Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris, Antiviral Research, 44(1), 43-54 (1999). (IF=3.938)

40.    Kurokawa, H. Ochiai, K. Nagasaka, H. X. Xu, S. Kadota, T. Namba, and K. Shiraki, Antiviral traditional medicines against herpes simplex virus, poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV infection in mice, Antiviral Research, 22, 175-188 (1993). (IF=3.938)

41.    W. M. Fu, J. F. Zhang, H. Wang, Z.C. Xi, W.M. Wang, P. Zhuang, X. Zhu, S.C. Chen, T. M. Chan, K. S. Leung, G. Lu, H. X. Xu*, H. F. Kung, Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma, Journal of Proteomics, 75(15): 4833-4843 (2012). (IF=3.888)

42.    Q. B. Han, H. X. Xu*, Caged Garcinia Xanthones: Development Since 1937, Current Medicinal Chemistry, 16 (28), 3775-3796 (2009). Review(IF=3.853)

43.    W.W.Fu, M.Wu, L.L.Zhu, Y.Z. Lao, L.P.Wang, H.S.Tan, Q.H. Yuan, H.X.Xu*.Prenylated benzoylphloroglucinols and biphenyl derivatives from the leaves of Garcinia multiflora Champ, RSC Advances, 5, 78259-78267 (2015). (IF=3.84)

44.    Y.J.Wang, H.Zhang, Q.Z. Zhang, Y.J. Liang, L.Ma, H.S.Tan, Y.Z.Lao*, H.X. Xu*and Z.G.Li*,  Genetically encoded fluorescence screening probe for MgrA, a global regulator in Staphylococcus aureus, RSC Advances, 5, 87216-87220 (2015). (IF=3.84)

45.    G.Y.He, S.X.Zhang, L.Xu, Y.L.Xia, P.Wang, S.Y.Li, L.L.Zhu, H.X.Xu, G.B.Ge and  L.Yang, C-8 Mannich base derivatives of baicalein display improved glucuronidation stability: exploring the mechanism by experimentation and theoretical calculations, RSC Advances, DOI: 10.1039/C5RA20213B (2015). (IF=3.84) 2015-10-14

46.    X. Wang, Y. C. Chen, Q. B. Han, C. Y. Chan, H. Wang, Z. Liu, C. H. K. Cheng, D. T. Yew, M. C. M. Lin, M. L. He, H. X. Xu*, J. J. Y. Sung, H. F. Kung, Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma, Proteomics, 9(2), 242-253 (2009). (IF=3.807)

47.    H. Zhang, D. D. Zhang, Y. Z. Lao, W. W. Fu, S. Liang, Q. H. Yuan, L. Yang, and H.X.Xu*, Cytotoxic and Anti-inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta, Journal of Natural Products, 77:1700-1707 (2014). (IF=3.798)

48.    H. Zhang, L. Tao, W. W. Fu, S. Liang, Y. F. Yang, Q. H. Yuan, D. J. Yang, A. P. Lu, H.X.Xu*, Prenylated benzoylphloroglucinols and xanthones from the leaves of Garcinia oblongifolia with antienteroviral activity, Journal of Natural Products,77:1037-1046(2014). (IF=3.798)

49.    C. Feng, S. X. Huang, X. M. Gao,H.X.Xu*, Kathy Luo, Characterization of proapoptotic compounds from the bard of Garcinia oblongifolia, Journal of Natural Products. 77:1111-1116 (2014). (IF=3.798)

50.    Z. X. Xia, D. D. Zhang, S. Liang, Y. Z. Lao, H. Zhang, H. S. Tan, S. L. Chen, X. H. Wang, H.X.Xu*.Bioassay-Guided Isolation of Prenylated Xanthones and Polycyclic Acylphloroglucinols from the Leaves of Garcinia nujiangensis，Journal of Natural Products. 75(8):1459-1464 (2012). (IF=3.798)

51.    X. Liu, T. Yu, X. M. Gao, Y. Zhou, C. F. Qiao, Y. Peng, S. L. Chen, Kathy Q. Luo, H. X. Xu*, Apoptosis effects of Polyprenylated Benzoylphloroglucinol Derivatives from the Twigs of Garcinia multiflora, Journal of Natural Product, 73(8),1355-1359 (2010). (IF=3.798)

52.    G. Xu, W. L. T. Kan, Y. Zhou, J. Z. Song, Q. B. Han, C. F. Qiao, C. H. Cho, J. A. Rudd, G. Lin, H. X. Xu*, Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa, Journal of Natural Product, 73(2), 104-108 (2010). (IF=3.798)

53.    S. X. Huang, C. Feng, Y. Zhou, G. Xu, Q. B. Han, C. F. Qiao, D. C. Chang, K. Q. Luo, H. X. Xu*, Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia, Journal of Natural Product, 72 (1), 130-135 (2009). (IF=3.798)

54.    R. W. Jiang, J. R. Zhou, P. M. Hon, S. L. Li, Y. Zhou, L. L. I, W. C. Ye, H. X. Xu, P. C. Shaw, P. P. But, Lignans from Dysosma versipellis with Inhibitory Effects on Prostate Cancer Cell Lines, Journal of Natural Product, 70 (2), 283-286 (2007). (IF=3.798)

55.    R. W. Jiang, P. M. Hon, Y. Zhou, Y. M. Chan, Y. T. Xu, H. X. Xu, H. Greger, P. C. Shaw, P. P. H. But, Alkaloids and Chemical Diversity of Stemona tuberose, Journal of Natural Product, 69(5), 749-754 (2006). (IF=3.798)

56.    H. Dong, S. X. Chen, R. M. Kini, H. X. Xu, Effects of Tannins from Geum japonicum on the Catalytic Activity of Thrombin and Factor Xa of Blood Coagulation Cascade,Journal of Natural Product, 61(11), 1356-1360 (1998). (IF=3.798)

57.    H. Dong, S. X. Chen, H. X. Xu, S, Kadota, and T. Namba, A new antiplatelet Diarylheptanoid from Alpinia blepharocalyx, Journal of Natural Product, 61 (1), 142-144 (1998). (IF=3.798)

58.    H. X. Xu, F. Q. Zeng, M. Wan, K. Y. Sim, Anti-HIV triterpene acids from Geum japonicum, Journal of Natural Product, 59 (7), 643-645 (1996). (IF=3.798)

59.    L. T. Yi, Y.C. Li, Y. Pan, J. M. Li, Q. Xu, S. F. Mo, C. F. Mo, F. X. Xu, H. X. Xu, X. B. Lu, L. D. Kong, H. F. Kung, Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 15; 32(2), 510-519 (2008). (IF=3.689)

60.    W.M. Fu, L.P. Tang, X. Zhu, Y.F. Lu, Y.L. Zhang, W.Y. Lee, H. Wang, Y. Yu, W.C. Liang, C.H. Ko, H.X.Xu, H.F. Kung, J.F. Zhang.MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells,Apoptosis, 20(1):75-82. (2015). (IF=3.685)

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