生物百科 >>所属分类 >> 神经科学家   

梅林

标签: 暂无标签

顶[0] 发表评论(0) 编辑词条
      梅林,美国乔治亚健康科技大学教授,博导。1982年江西医学毕业,1985年在军医学神经药士,1989年在美国亚利桑那大学药理毒理博士,1989-1994年在约翰霍普金斯大学医学院博士后。1994 –1999 年弗吉尼亚学医学院助理授,1999 - 2004年阿拉巴马伯明翰分校助理授,副终身教职2004年至今,乔亚健康科学学医学院神经内科终身授,同亚科学联盟(Georgia Research Alliance)神经杰出者,2009年起任美国乔亚健康科学学分子医学与遗传学研究所所长。
      1994年以来育神生物在神经形成和可塑性的究,尤其是在神肌肉接形成和神经调节精神分裂症的机制等有建,是该领域的国际领军人物,究成果有助于肌肉疾病、脊髓损伤癫痫、精神疾病的治诊断表原100余篇,申请四项发利。同任美国国究院和自然科基金评审专家,Molecular Brain, PLoS ONEJournal of Neuroscience 6家专业杂志的主、副主、或委。建中科院上海神学研究所的主要起人之一,曾担任家自然科基金第一海外委,中科院神经所,江西医学,南方医科大,徐州科大学客座教授。在北京大,香港科技大,中科院上海神学研究所和南方科大主持或授本科或究生程。
      2004年获国家自然基金委杰出年基金B2005年受聘为国育部奖励计划讲2008年获美国NARSADNational Alliance for Research on Schizophrenia and Depression)杰出科学奖和美国Mathilde Solowey(Foundation for Advanced Education in the Sciences)2011年入选千人计划
 
 
代表性论文:
Research Articles:
1.      Y.Z. Huang, S.S. Won, D.W. Ali, Q. Wang, M. Tanowitz, Q.S. Du, W.C. Xiong, K.A. Pelkey, M.W. Salter, and Lin Mei. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26:443-455, 2000
2.      Z.G. Luo,* Q. Wang,* J.Z. Zhou, J. Wang, Z. Luo, M. Liu, X. He, A. Wynshaw-Boris, W.C. Xiong, B. Lu, Lin Mei. Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1. Neuron 35:489-505, 2002. (highlighted in Neurobiology Paper Alert, Curr. Opinion Neurobiol. 12:463-470, 2002).
3.      R.-S. Woo,* X.M. Li,* Y. Tao, E. Carpenter-Hyland, Y.Z. Huang, J. Weber, H. Neiswender, X.P. Dong, J. Wu, M. Gassmann, C. Lai, W.-C. Xiong, T.-M. Gao,* L. Mei.* Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007 (high-lighted in Preview by G. Fischbach, Neuron 54:495-497, 2007; in News and View by L.W. Role and D.A. Talmage Nature 448:263, 2007 and in Nature Review Neurosci., 8:492, 2007).
4.      X.-M. Li,* X.-P. Dong,* S.W. Luo, B. Zhang, D.H. Lee, A.K.L. Ting, H. Neiswender, C.H. Kim, E. Carpenter-Hyland, T.M. Gao, W.C. Xiong, L. Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nature Neurosci. 11:262-268, 2008. (highlighted in News & Views by Fu et al., Nature Neurosci. 11:244, 2008).
5.      S. Luo, B. Zhang, X.-p. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C.A. Chiu, W.C. Xiong, L. Mei. HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008
6.      B. Zhang, S. Luo, Q. Wang, T. Suzuki, W.C. Xiong, Lin Mei. LRP4 serves as a co-receptor of agrin. Neuron 60:285-297, 2008 (highlighted in Nature 455:1153, 2008 and in Nature Review Neurosci., December, 2008)
7.      Y. Tao, P. Dai, Y. Liu, S. Marchetto, W.C. Xiong, J.-P. Borg, L. Mei. Erbin regulates NRG1 signaling and myelination. Proc. Nat. Acad. Sci. USA 106:9477-9482, 2009 (highlighted at Faculty of 1000, 2009)
8.      L. Wen1, Y.S. Lu1, X. Zhu1, X.M. Li, R.-S. Woo, Y.-J. Chen, D.-M. Yin, C. Lai, A. Vazdarjanova, W.C. Xiong, and L. Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Nat. Acad. Sci. USA 107:1211-1216, 2010
9.      Y.J. Chen, M. Zhang, D.M. Yin, L. Wen, A. Ting, P. Wang, Y.S. Lu, X.H. Zhu, S.J. Li, C.Y. Wu, X.M. Wang, C. Lai, W.C. Xiong, L. Mei*, T.M. Gao*. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc. Nat. Acad. Sci. USA 107: 21818-21823, 2010 (*, co-correspondence).
10.  Ting, Y. Chen, L. Wen, D.M. Yin, C. Shen, Y. Tao, X. Liu, W.C. Xiong, L. Mei. Neuregulin 1 promotes excitatory synapse development specifically in GABAergic interneurons. J. Neurosci. 31:15-25, 2011.
11.  X.H. Liu, R. Bates, D.M. Yin, C.Y. Shen, F. Wang, S. Nan, S.A. Kirov, Y. Luo, J.-Z. Wang, W.C. Xiong, and L. Mei. Specific regulation of NRG1 isoform expression by neuronal activity. J. Neurosci. 31:8491-8501, 2011
12.  B. Zhang, J.S. Tzartos, M. Belimezi, S. Ragheb, B. Bealmear, R.A. Lewis, W.C. Xiong, R.P. Lisak, S.J. Tzartos, Lin Mei. Autoantibodies to LRP4 in double seronegative myasthenia gravis patients. Archive Neurol. 69:445-451, 2012
13.  G.H. Tan1, Y.Y. Liu1, X.L. Hu1, D.M. Yin, L. Mei* and Z.Q. Xiong*. Neuregulin1 represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons. Nature Neurosci. 15:258-266, 2012 (1, co-first; *, co-correspondent)
14.  Y. Zong, B. Zhang, S. Gu, K. Lee, J. Zhou, G. Yao, D. Figueiredo, K. Perry, L. Mei* and Rongsheng Jin*. Structural basis of neuron-specific regulation of postsynaptic differentiation. Genes & Development. 26:247-258, 2012 (Cover) (*, co-correspondence).
15.  H.T. Wu, Y.S. Lu, C.Y. Shen, W.C. Xiong, L. Mei. Distinct Roles of Muscle and motoneuron LRP4 in Neuromuscular Junction Formation. Neuron. 75(1):94-107, 2012
16.  H.T. Wu*, Yisheng Lu*, A. Barik, A. Joseph, M.M. Taketo, W.C. Xiong, L. Mei. beta-Catenin gain-of-function in muscles impairs neuromuscular junction formation. Development, in press. (*, equal contribution)
 
Reviews:
1.      W.C. Xiong and Lin Mei: An Unconventional Role of Neurotransmission in Synapse Formation. Neuron 46:521-523, 2005
2.      B. Zhang, W.C. Xiong, L. Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev. Cell 16:325-327, 2009
3.      L. Mei and W.C. Xiong. Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008
4.      H. Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010

附件列表


→如果您认为本词条还有待完善,请 编辑词条

上一篇周志敏 下一篇蒋如朗

词条内容仅供参考,如果您需要解决具体问题
(尤其在法律、医学等领域),建议您咨询相关领域专业人士。
0

收藏到:  

词条信息

admin
admin
超级管理员
词条创建者 发短消息   

相关词条