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庄小威

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庄小威,博士。美国哈佛大学物理学教授、化学及化学生物学教授。

1987年15岁考入中国科学技术大学少年班,1991年赴美留学,1997年在加州大学伯克利分校获得物理学博士学位,之后在斯坦福大学师从诺贝 尔物理学奖得主朱棣文教授进行博士后研究,34岁成为哈佛大学两个系的双聘教授。在本科及博士学习阶段,庄小威一直是研究物理专业,1997年之后,她在 斯坦福大学师从诺贝尔物理学奖得主朱棣文进行博士后研究时,才接触化学、生物学科,做跟踪分子行为的实验。

2001年,庄小威被聘为哈佛大学助理教授。她的物理根底启发她将带荧光的分子标记物附在病毒上,当用激光照射时,标记物发射出特殊的彩色光。用这 种方法,借助显微镜,她详实跟踪了单个病毒的行为,也跟踪了诸如蛋白质和核糖核酸(RNA)片断这样的单个分子行为。她拍摄到单个流感病毒的连续影像,这 是世界上首次记录到病毒的各阶段过程。

2006年初,庄小威晋升为哈佛正教授,34岁的正教授。她在哈佛大学建立了以自己名字命名的单分子生物物理实验室,带领21名博士、博士后研究流感病毒、艾滋病病毒、SARS等病毒侵入宿主细胞的过程。

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教育经历

1987-1991 就读于中国科技大学物理系

1991-1996 留学美国,在加州大学伯克利分校取得物理系博士学位。

1997-2001 在斯坦福大学做博士后研究。

工作经历

09/2005- 哈佛大学医学院研究院

01/2006- 哈佛大学物理系教授、化学与化学生物学系教授。

07/2005-12/2005 哈佛大学物理系教授、化学与化学生物学系副教授。

08/2001-06/2005 哈佛大学物理系教授、化学与化学生物学系助理教授。

奖励:

2008 HHMI collaborative Innovation Award

2008 Coblentz Award

2006 Pure Chemistry Award

2005 Camille Dreyfus Teacher-Scholar Award

2004 Alfred P. Sloan Research Fellowship

2004 Technology Review Worlds Top 100 Young Innovators Award

2003 MacArthur Fellowship

2003 Packard Fellowship for Science and Engineering

2003 CAREER award, National Science Foundation

2003 Searle Scholar

2003 Beckman Young Investigator Award

2002 Young Investigator Award, Office of Naval Research

2000 Individual National Research Service Award, National Institute of Health

1997 Chodorow Postdoctoral Fellowship, Stanford University,

1993 Victor F. Lenzen Memorial Scholarship, University of California

1992 George C. and Helen N. Pardee Scholarship, University of California

1991 Bernice Teuteberg Memorial Scholarship, University of California

代表论文:

1. B. Huang, M. Bates, X. Zhuang. Super-resolution fluorescence microscopy. Annu. Rev.Biochem. (in press)

2. E. Abbondanzieri, X. Zhuang. Concealed enzyme coordination. Nature 457, 392-393(2009).

3. H. M. van der Schaar, M. J. Rust, C. Chen, H. van der Ende-Metselaar, J. Wilschut, X.Zhuang*, J. M. Smit*. Dissecting the Cell Entry Pathway of Single Dengue Virus Particles in Living Cells. PLoS Pathogen 4, e1000244 (in press)

4. S. Liu, E. Abbondanzieri, J. W. Rausch, S. F. J. Le Grice, X. Zhuang. Slide into action:dynamic shuttling of HIV reverse transcriptase on nucleic acid substrate. Science 322,1092-1097 (2008).

5. B. Huang, S. Jones, B. Brandenburg, X. Zhuang. Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution. Nat. Meth. 5,1047 - 1052 (2008).

6. M. Bates, B. Huang, X. Zhuang. Super-resolution microscopy by nanoscale localization of photo-switchable fluorescent probes. Curr. Opin. Chem. Biol. 208, 1-10 (2008)

7. C. Chen, X. Zhuang. Epsin1 is a cargo specific adaptor for the clathrin-mediated endocytosis of influenza virus. Proc. Natl. Acad. Sci. USA 105, 11790-11795 (2008)

8. J. Zheng, X. Zhuang. Luminescent and Raman active silver nanoparticles with polycrystalline structure. J. Am. Chem. Soc. 130, 10472-10473 (2008)

9. E. Abbondanzieri, G. Bokinsky, J. W. Rausch, J. X. Zhang, S. F. J. Le Grice, X. Zhuang.Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature 453, 184-189 (2008).

10. B. Huang, W. Wang, M. Bates, X. Zhuang. Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy. Science 319, 810-813 (2008).

11. M. Bates, B. Huang, G. Dempsey, X. Zhuang. Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science 317, 1749-1753 (2007).

12. S. Liu, G. Bokinsky, N. G. Walter, X. Zhuang. Dissecting the multi-step reaction pathway of an RNA enzyme by single-molecule kinetic fingerprinting. Proc. Natl. Acad. Sci. USA 104, 12634-12639 (2007).

13. M. D. Stone, M. Mihalusova, C. M. O’Connor, R. Prathapam, K. Collins, X. Zhuang.Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein.Nature 446, 458-461 (2007).

14. B. Brandenburg, L. Y. Lee, M. Lakadamyali, M. J. Rust, X. Zhuang*, and J. M. Hogle*.Imaging poliovirus entry in live cells. PLoS Biol. 5, 1543-1555 (2007).

15. B. Brandenburg, X. Zhuang. Virus trafficking – learning from single-virus tracking. Nat.Rev. Microbiol. 5, 197-208 (2007).

16. Y. Zhou, X. Zhuang. Kinetic analysis of sequential multi-step reactions. J. Phys. Chem. B,111, 13600-13610, 2007 (2007).

17. H. M. van der Shaar, M. J. Rust, B. Waarts, H. van der Ende Metselaar, R. J. Kuhn, J.Wilschut, X. Zhuang, J. M. Smit. Characterization of the early events in Dengue virus cell entry by biochemical assays and single-virus tracking. J. Virol., 81, 12019-12028 (2007).

18. C. K. Payne, S. Jones, C. Chen, X. Zhuang. Internalization and trafficking of cell surface proteoglycans and proteoglycan binding ligands. Traffic 8, 389-401 (2007).

19. Y. Zhou and X. Zhuang. Robust reconstruction of the rate constant distribution using the phase function method. Biophys. J. 91, 4045-4053 (2006).

20. M. J. Rust, M. Bates, X. Zhuang. Sub-diffraction-limit imaging by stochastic reconstruction optical microscopy (STORM). Nat. Meth. 3, 793-795 (2006).

21. G. Bokinsky, L. G. Nivon, S. Liu, G. Chai., M. Hong, K. M. Weeks, X. Zhuang. Two distinct binding mode of a protein cofactor with its target RNA. J. Mol. Biol. 361, 771-784 (2006).

22. M. Lakadamyali, M. J. Rust, X. Zhuang. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124, 997-1009(2006).

23. X. Zhuang. Single-molecule RNA Science. Annu. Rev. Biophys. Biomol. Struct. 34,399-414 (2005)

24. G. Bokinsky, X. Zhuang. Single-molecule RNA folding. Acct. Chem. Res. 38, 566-573(2005).

25. M. Bates, T. R. Blosser, X. Zhuang. Short-range spectroscopic ruler based on a singlemolecule optical switch. Phys. Rev. Lett. 94, 108101 (2005).

26. X. Zhuang. Unraveling DNA condensation by optical tweezers. Science 305, 188-190(2004).

27. M. Lakadamyali, M. J. Rust, X. Zhuang. Endocytosis of influenza viruses. Micro. Infect. 6,929-936 (2004).

28. M. J. Rust, M. Lakadamyali, F. Zhang, X. Zhuang. Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat. Struct. Mol. Biol. 11, 567-573(2004).

29. F. Patolsky, G. Zheng, O. Hayden, M. Lakadamyali, X. Zhuang*, C. M. Lieber*. Electrical detection of single viruses. Proc. Natl. Acad. Sci. USA 101, 14017-14022 (2004).

30. H. P. Babcock, C. Chen, X. Zhuang. Using single particle-tracking to study nuclear trafficking of viral genes. Biophys. J. 87, 2749-2758 (2004).

31. D. Rueda, G. Bokinsky, M. M. Rhodes, M. J. Rust, X. Zhuang*, N. G. Walter*. Singlemolecule enzymology of RNA: Essential functional groups impact catalysis from adistance. Proc. Natl. Acad. Sci. USA 101, 10066-10071 (2004).

32. M. Lakadamyali, M. J. Rust, H P. Babcock, X. Zhuang. Visualizing infection of individual influenza viruses. Proc. Natl. Acad. Sci. USA 100, 9280-9285 (2003).

33. G. Bokinsky, D. Rueda, V. K. Misra, A. Gordus, M. M. Rhodes, H. P. Babcock, N. G.Walter*, X. Zhuang*. Single-molecule transition-state analysis of RNA folding. Proc. Natl.Acad. Sci. USA 100, 9302-9307(2003).

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