张智

主要研究兴趣:

1.慢性疼痛相关的情绪疾病

2.慢性疼痛产生的表观遗传学机制

3.药物成瘾

代表性论文：

1.Zhang Z, Pan ZZ. Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception.Molecular Pharmacology, 2012 Mar;81(3):375-83.

2.Bie B, Wang Y, Cai YQ, Zhang Z, Hou YY, Pan ZZ. Upregulation of Nerve Growth Factor in Central Amygdala Increases Sensitivity to Opioid Reward.Neuropsychopharmacology. 2012 Aug 8. doi: 10.1038/npp.2012.144. [Epub ahead of print]

3.Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ. Epigenetic suppression of GAD65 expression mediates persistent pain.Nature Medicine. 2011 Oct 9;17(11):1448-55. Highlighted by:Harrison C, Analgesia: Unravelling epigenetic mechanisms of chronic pain. Nature Reviews Drug Discovery. 2011 Nov 18;10(12):900.

4.Zhang Z, Pan ZZ. Synaptic mechanism for functional synergism between delta- and mu-opioid receptors.Journal of Neuroscience,2010 Mar 31;30(13):4735-45.　 Highlighted by: Kingwell K. Pain:Moreish analgesics dealt a blow, Nature Reviews Neuroscience, 2010 May 12; 11:374-375.

5.Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. Nerve growth factor-regulated emergence of functional delta-opioid receptors.Journal of Neuroscience 2010 Apr 21;30(16):5617-28.

6.Metzele R, Alt C, Bai X, Yan Y, Zhang Z, Pan Z, Coleman M, Vykoukal J, Song YH, Alt E.Human adipose tissue-derived stem cells exhibit proliferation potential and spontaneous rhythmic contraction after fusion with neonatal rat cardiomyocytes.FASEB J. 2011 Mar;25(3):830-9.

7.Zhang Z, Gong N, Wang W, Xu L, Xu TL.Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval.Cerebral Cortex. 2008 Oct;18(10):2391-401.

招生招聘：

实验室招聘神经生物学（电生理)和分子生物学等相关背景的博士后(有表观遗传学背景者优先)和实验员，待遇从优。同时欢迎本科实习生和报考研究生。

联系方式：zhizhang@ustc.edu.cn

联系电话：63602715