戴尅戎
戴尅戎头衔：中国工程院院士，首届上海市发明家，‘97香港杰出中国访问学人、上海市医学荣誉奖、何梁何利基金科学与技术奖、上海市科技功臣等荣誉称号获得者。
研究方向：
戴尅戎教授通过医工结合有特色地发展了骨科学学科。在国际上首先将形状记忆合金用于医学领域，发明多种内固定和人工关节制品，用于人体内部，从而推动了形状记忆合金的医学应用。在关节外科特别是人工关节方面作出创造性贡献，发展出多种具首创性的人工关节和骨折内固定装置，设计出计算机辅助个体化人工关节并实现产业化。在国内医院中首先建立骨科生物力学研究室，开展步态分析和骨结构、内固定等方面的生物力学研究。先后获国家发明二等奖、国家科技进步二、三等奖、国家教委、卫生部、上海市科技进步一、二、三等奖等28项奖励，获得授权及申请专利11项。主要成果
戴尅戎院士是在国内外均有很大影响的骨科专家，长期致力于骨科临床和基础研究，特别重视医学与工程科学、生物科学的交叉研究。最早在国内系统开展骨科生物力学和力学生物学研究，对不同力学环境下骨的生物学与力学性能变化进行了系统研究，包括内植物对骨的应力遮挡效应、力学环境与骨关节炎、骨质疏松症的相关性、力学环境对骨移植的影响等。在国际上首先将形状记忆合金制品用于人体内部，研制成功形状记忆加压骑缝钉，用于骨折内固定，已在全国340多家医院3千余例骨折病人中应用。以后相继发明形状记忆双杯髋假体、形状记忆锯齿臂环抱内固定器，并在国际上首先开发成功兼具机械和生物学固定作用的骨粒骨水泥，广泛用于人工关节固定和肿瘤切除后的骨缺损修复。又与上海交通大学长期合作，在国内最早将CAD/CAM、敏捷制造和快速原形技术用于定制型人工关节，创造性提出优先区定制概念并取得国家专利。目前计算机辅助定制型人工髋、膝、肩、骨盆、长骨已在全国许多医院推广应用。继而建立了上海交大-二医大医学内植物工程联合研究所并任联合所长，形成了生产实体，为医工结合的深层次发展和科研成果产业化走出新路。
戴尅戎院士在骨质疏松症的研究方面注重对骨结构的分析，创立了对骨小梁微构筑方式的定量评定方法并应用于临床病人的诊断。对骨质疏松性骨折发生机理和骨折愈合方式进行了系列研究，为临床上老年骨折的治疗提供了指导意见。近年来又开展了干细胞移植和基因治疗促进骨软骨再生的系列研究，在成体干细胞的诱导分化研究、细胞载体复合体系的建立等方面取得了有自主知识产权的成果。
戴尅戎教授由于其学术成就，在海内外具有很高知名度。特别是近几年，他相继进入多个知名国际学术组织的领导机构，担任世界华裔骨科学会会长、亚洲太平洋人工关节学会会长和知名度极高的国际内固定学会(AO/ASIF)理事。是美国密西西比大学医学院客座教授和2本国际学术刊物及美国医学会杂志(JAMA) 中文版的编委。是香港科学研究资助委员会和香港大学海外科学技术评审委员，并被授予97年香港杰出中国访问学人。2000年他当选为美国骨科学会通信会员，该学会已有一百多年历史，现在世界各地有通信会员43人，戴教授为该会唯一的中国会员。2002年经法国外交部与卫生部批准，被授予法国地中海大学荣誉博士，是获得该殊荣的唯一亚洲人。2004年获何梁何利基金科学与技术奖。
近期主要论文
1. Li H, Dai K, Tang T, Zhang X, Yan M, Lou J. Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2. Biochem Biophys Res Commun. 2007 May 18;356(4):836-42.
2. Tang TT, Lu B, Yue B, Xie XH, Xie YZ, Dai KR, Lu JX, Lou JR. Treatment of osteonecrosis of the femoral head with hBMP-2-gene-modified tissue-engineered bone in goats. J Bone Joint Surg Br. 2007 Jan;89(1):127-9.
3. Xie Y, Hardouin P, Zhu Z, Tang T, Dai K, Lu J. Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold. Tissue Eng. 2006 Dec;12(12):3535-43.
4. Sun H, Wu C, Dai K, Chang J, Tang T. Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics. Biomaterials. 2006 Nov;27(33):5651-7.
5. Zhu ZA, Dai KR, Wang Y, Sun YH, Shi DW, Tang J, Hao YQ, Yan MN. Total hip arthroplasty for Crowe type-IV development dysplasia of hip in adults. Chinese Journal of Surgery. 2006 Oct 15;44(20):1403-6.
6. Xie YZ, Zhu ZA, Tang TT, Dai KR, Lu JX, Pierre H. Using perfusion bioreactor for mesenchymal stem cell proliferation in large tricalcium phosphate scaffold. Chinese Medical Journal. 2006 Jun 20;86(23):1633-7.
7. Xia S, Dai K, Tang T. Expression of nerve growth factor and its receptor during osteoinduction of recombined human bone morphogenetic protein 2. Chinese Journal of Reparative and Reconstructive Surgery. 2006 Apr;20(4):454-8.
8. Shengli Xia, kerong Dai, Tingting Tang. Synergistic effect of nerve growth factor on ectopic bone formation induced by recombinant human bone morphogenetic protein-2. Journal of Shanghai Jiaotong University (Medical Science). 2006 Mar 25; 26(3):273-277.
9. Zhang X, Yu C, Xushi, Zhang C, Tang T, Dai K. Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo. Biochem Biophys Res Commun. 2006 Mar 3;341(1):202-8.
10. Zhang Pu, Gan Yao-kai, Li Hua, Hao Yong-qiang, Wang You, Sun Yue-hua, Zhu Zhen-an, Dai Ke-rong. The primary report of clinical application of enriched bone marrow stem cells combining with β-tricalcium phosphate in spine fusion. J Clin Orthop. 2006 Feb 26;9(1):1-4
11. Yan Mengning, Tang tingting, Dai Ke-rong, et al. Effects of Impaction on tissue engineered bone modified by BMP-2 Gene. Chinese Journal of Reparative and Reconstructive Surgery. 2006 Feb 15; 20(2):98-101.
12. Wendong Xue, Kerong Dai, Tingting Tang. Computer-aided measurement of medullary cavity of proximal femur. Chinese Journal of Clinical Rehabilitation. 2006 Feb 10; 10(5):176-178.
13. Jianxi Lu, Tingting Tang, Huifeng Ding, Kerong Dai. Micro-particles of bioceramics could cause cell and tissue damage. J Biomed (Chinese). 2006 Feb;23(1):85-9.
14. Bing Yue, Yanfei Chen, Tingting Tang, Bing Lu, Chaofeng Yu, Jueren Lou, Kerong Dai. Study on the differentiation of marrow mesenchymal stem cells of the rats mediated by bone morphogenetic protein. Chinese J Reparative and Reconstructive Surgery. 2006 Jan 18; 20(1):53-57.
15. Ma Ruyu, Xue Wendong, Dai Kerong, Wang Chengtao. A method for automatic selection of optimal standard hip stems. J Biomed Eng. 2005 Dec;22(6):1256-8.
16. Yue B, Lu B, Dai KR, Zhang XL, Yu CF, Lou JR, Tang TT. BMP2 gene therapy on the repair of bone defects of aged rats. Calcif Tissue Int. 2005 Dec;77(6):395-403.
17. Dong Jiandong, Wang you, Zhu zhenan, Gu dongyun, Xue wendong, Dai Kerong. Computerized three-dimentional reconstruction and morphologic measurement of adult acetabulum bone structure. Chin J Surg. 2005 Dec 15;43(24):1583-6.
18. Xu XL, Lou J, Tang T, Ng KW, Zhang J, Yu C, Dai K. Evaluation of different scaffolds for BMP-2 genetic orthopedic tissue engineering. J Biomed Mater Res B Appl Biomater. 2005 Nov;75(2):289-303.
19. Zhang Junhui, Chen Yongqiang, Tang Tingting, Lou Jueren，Hao Yongqiang, Yu Chaofeng, Dai Kerong. Hyaluronic acid mixed with BMP-2 gene transfected bone marrow derived mesenchymal stem cells for repair of diaphyseal defects in rabbits. Chin J Orthop. 2005 Oct 25; 25(10):608-612.
20. Zhou Xinshe, Dai Kerong, Tang Tingting, Jia qingwei, Yan mengning. Preliminary observation of Biological characters of chondrocytes in articular loose body. Chinese J Reparative and Reconstructive Surgery. 2005 Sep;19(9):751-4.
21. Zhang Pu, Li Hua, Sun Yuehua, Wang You, Zhu Zhenan, Dai Kerong. A case of anterior combining with posterior approaches for treating of lower lumbar tuberculous spondylitis associated with systemic lupus erythematosus. Journal of Clinical Orthopaedics. 2005 Aug 25; 8(4):313-315.
22. Xiaoliang Xu, Kerong Dai, Tingting Tang, Mengan Yan, Zhenan Zhu, Zhaofeng Yu, Min Xu, Jiaoren Lou. An immunological study on adenovirus mediated human bone morphogenetic protein 2 gene therapy. Chinese J reparative and Reconstructive Surgery. 2005 Aug 15;19(8):635-638.
23. Bi Shu-xiong, Dai Ke-rong, Tang ting-ting. An experimental investigation on the immune tolerance of bone xenograft induced by the combined addition of Interleukin (IL-4) and (IL-10). Orthop J Chin. 2005 Aug 5;13(15):1174-1178.
24. Dai KR, Xu XL, Tang TT, Zhu ZA, Yu CF, Lou JR, Zhang XL. Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone. Calcif Tissue Int. 2005 Jul;77(1):55-61.
25. Lu Bin, Tang Tingting, Yue Bing, Dai Kerong, Lou Jueren. Biomechanical study on the repair of femoral head necrosis in goat with the BMP-2 gene transfected autologons bone marrow derived mesenchymal stem cells. Journal of Medical Biomechanics. 2005 Jun 30; 20(2):71-75.
26. Tang Liuding, Zhu Jianmin, Li Bingzhe, Dai kerong. Study of biomechanical properties on the interface between femora and bioactive ceramics coatings prosthesis during the initial implant stage. Journal of Medical Biomechanics. 2005 Jun 30;20(2):76-80.
27. Lu Hua, Tingting Tang, Kerong Dai. The Effect of Culture in Vitro on the Biological Behavior of Human Bone Marrow Mesenchymal. Journal of Clinical Orthopaedics. 2005 Jun 28;8(3):264-267.
28. Yan MN, Tang TT, Zhu ZA, Zhou XS, Jia QW, Yu CF, Lou JR, Dai KR. Effects of bone morphogenetic protein-2 gene therapy on the bone-implant interface: an experimental study with dogs. Natl Med J China. 2005 Jun 15; 85 (22):1521-1525.
29. Haifeng Li, Tingting Tang, Kerong Dai, Shimin Zhang, Guangrong Yu. The influence of freeze-dried cancellous bone on mesenchymal stem cells´ osteogenic potential. Orthop J Chin. 2005 Jun 5;13(11):850-852.
30. Kerong Dai, Zhenan Zhu, Yuehua Sun, You Wang, Mengning Yan, Chengzhu Wang. Computer aided design of individualized hemipelvic prosthesis and its clinical application. Chin J Orthop. 2005 May 25; 25(5):258-262.
31. Lin YP, Wang CT, Dai KR. Reverse engineering in CAD model reconstruction of customized artificial joint. Med Eng Phys. 2005 Mar;27(2):189-93.
32. Huiwu Li, Kerong Dai, Tingting Tang, Zhaofeng Yu, Mengning Yan, Xu Li, Jueren Lou. Ectopic bone formation of hBMP-2 gene transfected human adipose tissue-derived stromal cells. Chin J Exp Surg. 2005 May 8;22(5):588-591.
33. Tingting Tang, Bin Lu, Bin Yue, Jueren Lou, Kerong Dai. Repair of bone injury and osteonecrosis with BMP2 gene therapy and stem cell transplantation. Journal of Tissue Engineering and Reconstructive Surgery. 2005 Feb 28;1(1):34-38.
34. Mengning Yan, Kerong Dai, Qingwei Jia, Hongbin Li, Xiaoqing Wang. Isolation and analysis of wear particles from severe osteolytic tissue around acetabular implant. Journal of Clinical Orthopaedics. 2005 Feb 25; 8(1):70-74.
35. Tang TT, Xu XL, Dai KR, Yu CF, Yue B, Lou JR. Ectopic bone formation of human bone morphogenetic protein-2 gene transfected goat bone marrow-derived mesenchymal stem cells in nude mice. Chin J Traumatol. 2005 Feb;8(1):3-7.
36. Shuxiong Bi, Kerong Dai, Tingting Tang. Comparative investigation on the immunoreaction of frozen-dried bone xenograft rejection with bone allograft rejection. Orthop J Chin. 2005 Jan 5,13(1):51-54.
37. Yongqiang Hao, Kerong Dai. Ultrastructure observation of experimental osteoporotic fracture healing. Chin J Orthop. 2004 Nov 25;24(11):670-673.
38. Dongyun Gu, Kerong Dai, Xin Hu, Ye Jin. Morphological Analysis of Acetabulum Bony Curved Surface. J Biomed Eng. 2004 Oct 1;21(5):721-726.
39. Ruyu Ma, Ying Tie, Wendong Xue, Kerong Dai, Chengtao Wang. Construction of 3-D Finite element models of human pelvis based on spiral computer tomography images. J Med biomech. 2004 Sep 25;19(3):180-183.
40. Li Wang, Kerong Dai, Tingting Tang. Absorbable high-strength poly-L-lactide screws in internal fixation of femoral condylar osteotomy in rabbits. Chin J Orthop Trauma. 2004 Sep 15;6(9):1034-1041.
41. Junhui Zhang, Yongqiang Chen, Tingting Tang, Jueren Lou, Yongqiang Hao, Chaofeng Yu, Kerong Dai. In vitro and in vivo osteogenetic effects of hyaluronic acid mixed with BMP-2 gene transfected bone marrow derived mesenchymal stem cells. Chin J Exp Surg. 2004 Sep 8;21(7):845-847.
42. Xinshe Zhou, Kerong Dai, Tingting Tang, Danning Hu. In vitro isolation and cultivation of human chondrocytes from weight-loading cartilage. J Clin Orthop. 2004 Jun 26;7(2)209-212.
43. Wendong Xue, Oskar Schmid, Kerong Dai. Thermoplastic marking measurement for three-dimensional foot motion analysis. Chin Clin Rehab. 2004 May 15;5(15):2758-2759.
44. Qinwei Jia, Tingting Tang, Kerong Dai. CFPEEK composite materials for hip prosthesis: fabrication and wear. Orthop Biomech Mater Clin Study. 2004 Apr 15;1(2):1-4.
45. Sun Yuehua, Gong Weihua, Zhu zhenan, Chen Yongqiang, Dai Kerong. Treatment of distal tibial fractures using minimally invasive percutaneous plate osteosynthesis. J Clin Orthop. 2004 Mar 26;7(1):9-11.
46. Wenqiang Zhang, Kerong Dai, Chengtao Wang. The present state and development of navigation System for Orthopedic Surgery. J Med Biomech. 2004 Mar 1;19(1):51-55.
47. Gu dongyun, Dai Kerong, Wang you, Hu xin, Xi juntong. Morphologic features of the acetabulum bone joint area. J Biomed Eng . 2003 Dec 1;20(4):618-621.
48. Qingwei Jia, Junying Sun, Kang Sun, Yuji Wang, Kerong Dai. CFPEEK composite materials for hip prosthesis: Fabrication, Wear and Biological Fixation. Orthop J Chin. 2003 Sep 25;11(18):1279-1281.
49. Xiaoliang Xu, Kerong Dai, Tingting Tang. The role of smads and related transcription factors in the signal transduction of bone morphogenetic protein inducing bone formation. Chin J Reparative Reconstructive Surg. 2003 Sep 10;17(5):359-62.
50. Xiaoliang Xu, Kerong Dai, Tingting Tang, Chaofeng Yu, Jueren Lou. β-galactosidase expression in osteoblasts in vivo and in vitro. Chin J Exp Surg. 2003 Sep 8;20(9):829-830.
51. Tang tingting, Xu xiaoliang, Dai kerong, Yu chaofeng, Zhu liulong，Lou Jueren. Ectopic bone formation of hBMP-2 gene transfected goat bone marrow-derived mesenchymal stem cells. Chin J Orthop. 2003 Aug 25,23(8):489-492.
52. Congqin Nin, Yu Zhou, Congchun Huang, Yajun Gu, Dechao Li, Kerong Dai. In vivo bioactivity of Ti/HA biocomposites fabricated by powder metallurgy methods. Journal of inorganic materials. 2003 Jul 1;18(4):879-884.
53. Kerong Dai, Xiaoliang Xu, Tingting Tang, Zhu Zhenan, Yu Chaofeng, Xu Min, Zhu Liulong, Hao Yongqiang, Lou Jueren. BMP-2 gene modified tissue-engineered bone repairing segmental tibial bone defects in goats. Natl Med J China. 2003 Aug 10;83(15):1345-9.
54. Zhou Jian, Dai Kerong, Tang tingting. Calcium phosphate ceramics hybrided with mesenchymal stem cells for repairing cancellous bone defects in rabbits. J Clin Orthop . 2003 Jun 26;6(2):97-102.
专著与综述
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