张永清

张永清，男，博士，研究员，博士生导师。现任中国科学院遗传与发育生物学研究所遗传与发育生物学研究所副所长。联系电话：86-10-64807393，E-mail：yqzhang@genetics.ac.cn。

1985年获武汉华中农业大学学士学位，1991年获北京农业大学（现中国农业大学）博士学位。1992－1993在中国科学院微生物研究所作博士后。1994年在荷兰Wageningen大学作访问学者。1995-1997年在英国剑桥大学作博士后。1998-2003年先后在美国尤他大学和Vanderbilt大学作博士后和访问学者。

先后获得美国FRAXA Research Foundation（2001-2002）和Vanderbilt大学Kennedy Center for Research on Human Development（2003）的研究奖。2004年中国科学院“百人计划”入选者，2005年国家杰出青年科学基金获得者。

张永清研究员的主要研究方向：利用传统的模式动物果蝇进行神经生物学的基础应用研究。由于果蝇的神经系统在分子和细胞水平上与哺乳动物的非常相似，这一研究将有助于我们对人类大脑结构和功能的认识。

主要研究内容包括：

• 以果蝇为材料，用分子、细胞、遗传、发育和神经生物学为主要实验检测手段研究神经系统的结构和功能。
• 以果蝇为模式动物研究人类重要神经疾病包括智力低下的分子遗传机制，从而为这类疾病的预防和治疗提供理论依据，同时为神经系统的正常发育和功能提供新的见解。

1. Zhihua Liu, Yan Huang, Yi Zhang, Di Chen, and Yong Q. Zhang. Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. Journal of Neuroscience, accepted.
2. Aiyu Yao, Shan Jin, Xinhai Li, Zhihua Liu, Xuehua Ma, Jing Tang, and Yong Q. Zhang. Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. Human Molecular Genetics, doi:10.1093/hmg/ddq431, 2010.
3. Haiying Zhang, Ling Tian, Stephen Tobe, Ying Xiong, Songyan Wang, Xinda Lin, Yanan Liu, William Bendena, Sheng Li, and Yong Q Zhang. Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene. Biochemical and Biophysical Research Communications, 401: 182-187, 2010.
4. Zhiwei Liu, Yan Chen, Dan Wang, Songyan Wang, Yong Q. Zhang. Distinct pre- and postsynaptic dismantling processes of Drosophila neuromuscular junctions during metamorphosis. Journal of Neuroscience, 30: 11624-11634, 2010. Commented on in Faculty of 1000 at http://f1000.com/5488963.
5. Dan Wang, Lijun Zhang, Guoli Zhao, Gudrun Wahlström, Tapio I. Heino, Jiong Chen, and Yong Q. Zhang. Drosophila twinfilin is required for cell migration and synaptic endocytosis. Journal of Cell Science, 123: 1546-1556, 2010.
6. Shan Jin, Luyuan Pan, Zhihua Liu, Qifu Wang, Zhiheng Xu, and Yong Q. Zhang. Drosophila tubulin chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development, 136: 1571-1581, 2009.
7. Simon P. Reeve, Xinda Lin (co-first author), Bahar H. Sahin, Fangfang Jiang, Aiyu Yao, Zhihua Liu, Hui Zhi, Kendal Broadie, Wei Li, Angela Giangrande, Bassem A. Hassan, Yong Q. Zhang. Mutational analysis establishes a critical role for the N terminus of Fragile X mental retardation protein FMRP. Journal of Neuroscience, 28(12):3221-3226, 2008.
8. Feng Gu, Hai-Yin Zhang, Shao-Yi Hu, Shang-Zhi Huang, Xu Ma, Yong Q. Zhang. Erectile dysfunction in Fragile X patients. Asian J Androl, 8: 483-487, 2006.
9. Yong Q. Zhang and Kendal Broadie. Fathoming fragile X in fruit flies. Trends in Genetics, 21(1): 37-45, 2005.
10. Yong Q. Zhang, David Friedman, Zhe Wang, Elvin Woodruff III, Luyuan Pan, Janis O’Donnell and Kendal Broadie. Protein Expression Profiling of the Drosophila Fragile X Mutant Brain Reveals Upregulation of Monoamine Synthesis. Molecular and Cellular Proteomics, 4(3): 278-290, 2005.
11. Luyuan Pan, Yong Q. Zhang, Elvin Woodruff and Kendal Broadie. The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Current Biology, 14: 1863-1870, 2004.
12. Yong Q. Zhang, Heinrich J. G. Matthies, Joel Mancuso, Hillary K. Andrews, Elvin Woodruff, III, David Friedman and Kendal Broadie. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Developmental Biology, 270(2): 290-307, 2004.
13. Hillary Andrews, Yong Zhang, Nick Trotta and Kendal Broadie. Drosophila Sec10 is required for hormone secretion but not general exocytosis or neurotransmission. Traffic, 3(12): 906-921, 2002.
14. Yong Zhang, Christopher Rodesch and Kendal Broadie. A living synaptic vesicle marker: synaptotagmin-GFP. Genesis, 34: 142-145, 2002.
15. Yong Zhang, Adina M. Bailey, Heinrich J. G. Matthies, Robert B. Renden, Mark A. Smith, Sean D. Speese, Gerald M. Rubin and Kendal Broadie. Drosophila fragile X related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell, 107: 591-603, 2001.
16. Yong Zhang, David Featherstone, Warren Davis, Emma Rushton and Kendal Broadie. Drosophila D-Titin is required for myoblast fusion and skeletal muscle striation. Journal of Cell Science, 113: 3101-3115, 2000.
17. Yong Zhang, John Roote, Saverio Brogna, Andrew W. Davis, Daniel A. Barbash, David Nash and Michael Ashburner. stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster. Genetics, 153 (2): 891-903, 1999.

• Zhang Y, Bailey AM, Matthies HJG, et al. Drosophila fragile X related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell, 2001, 107(5): 591-603.
• Yao A, Jin S, Li X, et al. Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. Human Molecular Genetics, 2010, doi:10.1093/hmg/ddq431.
• Liu Z, Huang Y, Zhang Y, et al. Drosophila acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. Journal of Neuroscience, (accepted).
• Zhang YQ, Broadie K. Fathoming fragile X in fruit flies. Trends in Genetics, 2005, 21(1): 37-45.
• Zarnescu DC, Jin P, Betschinger J, et al. Fragile X protein functions with Lgl and the PAR complex in flies and mice. Developmental Cell, 2005, 8(1): 43-52.
• Zhang YQ, Matthies HJG, Mancuso J, et al. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Developmental Biology, 2004, 270(2): 290-307.
• 潘鲁原, 张永清, Broadie K. 果蝇脆性X基因负调控神经元发育和突触分化. Current Biology, 2004, 14: 1863-1870.
• 张永清, 陈炯, 王丹, 等. 果蝇twinfilin在细胞迁移和突触内吞中的作用. Journal of Cell Science, 2010, 123: 1546-1556.