冯新华

冯新华博士，浙江大学生命科学研究院教授、首席研究员、博士生导师、院长。办公地点：医学院科研楼A313。电话：0571-88981336。传真：0571-88981337。Email: lsi@zju.edu.cn (公务); xhfeng@zju.edu.cn (个人)。实验室网站：http://lsi.zju.edu.cn/yjdw_detail.aspx?ID=9。 ADFASDFAF23RQ23R

• 1983年：武汉大学生物学学士学位
• 1986年：中国科学院遗传研究所遗传学硕士
• 1992年：美国马里兰大学（University of Maryland-College Park）植物生物学博士
• 1993-1997年：美国加州大学旧金山分校（UCSF）生化/细胞生物学博士后

• 1997-1999年：加州大学旧金山分校组织细胞学系研究助理教授
• 1999-2003年：美国贝勒医学院（BCM）外科学系、分子与细胞生物学系助理教授
• 2003-2007年：美国贝勒医学院分子与细胞生物学系、外科学系副教授（tenured）
• 2007年至今：美国贝勒医学院分子与细胞生物学系、外科学系、分子生理与生物物理学系教授（tenured），Duncan癌症中心研究员、STaR干细胞与再生医学中心研究员、炎症生物学中心研究员
• 2008年至今：美国德州农工医学中心（Texas A&M Health Science Center）兼职教授（Adjunct Professor）
• 2009年至今：浙江大学生命科学研究院（兼职）教授、首席研究员、院长

• 2002年：Research Excellence Award, The W. M. Keck Foundation Distinguished Young Scholars in Biomedical Research
• 2003年：Scholar Award, Leukemia & Lymphoma Society
• 2003年：Research Scholar Award, American Cancer Society
• 2004年：国家自然科学基金委员会海外青年学者合作研究基金（杰青B类）
• 2006年：贝勒医学院Michael E. DeBakey Excellence in Research Award
• 2007年：贝勒医学院MCB Award of Excellence in Research
• 2008年：长江学者讲座教授
• 2006年至今：Editorial Board member, Journal of Biological Chemistry (JBC)
• 2008年至今：Associate Editor, BMC Developmental Biology
• 2010年至今：Editorial Board member, Journal of Genetics and Genomics
• 2010年至今：Editorial Board member, Cell Research
• 2010年至今：Editorial Board member, BMC Bioscience Journal
• 2006-2007年：President, 美洲华人生物科学学会SCBA-Texas Chapter
• 2011-2012年：Treasurer-elect, 美洲华人生物科学学会(SCBA)

分子信号传导、蛋白质修饰及其在癌症或其他相关疾病发生和发育过程中的功能。主要研究目标是阐明蛋白质修饰、信号传导通路和基因转录之间的潜在机制和相互作用，以及它们在细胞增殖、组织分化和人类疾病发病机制中的作用。

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1. Feng XH and Derynck R (1997) A kinase subdomain of TGF-β type I receptor determines TGF-β intracellular signaling specificity. EMBO J. 16: 3912-3923.
2. Zhang Y, Feng XH and Derynck R. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β induced transcription. Nature. 394: 909-913.
3. Feng XH, Zhang Y, Wu RY, and Derynck R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 12: 2153-2163.
4. Derynck R, Zhang Y, and Feng XH. (1998) Smads: transcriptional activators of TGF-β responses. Cell. 95: 737-740.
5. Lin X, Liang M, and Feng XH. (2000). Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J. Biol. Chem. 275: 36818-36822.
6. Feng XH, Lin X, and Derynck R. (2000) Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 19: 5178-5193.
7. Feng XH, Liang YY, Liang M, Zhai W, and Lin X. (2002). Direct interaction of oncogenic c-Myc with tumor suppressors Smad2 and Smad3 to inhibit TGF-β-mediated induction of the CDK inhibitor p15INK4B. Mol. Cell. 9: 133-143.
8. Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, and Feng XH. (2003). Activation of TGF-β signaling by SUMO modification of tumor suppressor Smad4/DPC4. J. Biol. Chem., 278:18714-18719.
9. Lin X, Sun B, Liang M, Liang YY, Gast A, Hildebrand J, Brunicardi FC, Melchior F, and Feng XH. (2003). Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol. Cell, 11: 1389-1396.
10. Lin X, Liang YY, Sun B, Liang M, Brunicardi FC, and Feng XH. (2003). Smad6 recruits transcription corepressor CtBP to repress BMP-induced transcription. Mol. Cell. Biol., 23: 9081-9093.
11. Liang M, Liang YY, Wrighton KH, Ungermannova D, Wang X, Brunicardi FC, Liu X, Feng XH, and Lin X. (2004). Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2. Mol. Cell. Biol., 24: 7524-7537.
12. Feng XH and Derynck R. (2005) Specificity and versatility of TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol., 12: 659-693. (review article)
13. Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, and Feng XH. (2006). PPM1A functions a Smad phosphatase to terminate TGF-β signaling. Cell, 125: 915-928.
14. Wrighton KH, Willis D, Long J, Liu F, Lin X, and Feng XH. (2006). Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-β signaling. J. Biol. Chem., 281: 38365–38375.
15. Dai F, Chang C, Lin X, Dai P, Mei L, and Feng XH. (2007). Erbin inhibits TGFβ signaling through a novel Smad-interacting domain. Mol. Cell. Biol., 27: 6183-6194.
16. Wang D, Long J, Dai F, Liang M, Feng XH, and Lin X. (2008). Bcl6 represses Smad signaling in TGFβ resistance. Cancer Research, 68: 783-789.
17. Wrighton KH, Lin X, and Feng XH. (2008). Critical regulation of TGFβ signaling by HSP90. Proc. Natl. Acad. Sci. USA, 105: 9244-9249.
18. Wrighton KH, Dai F, and Feng XH. (2008). A new kid on the TGFβ block: TAZ controls Smad nucleocytoplasmic shuttling. Dev. Cell, 15: 8-10. (preview)
19. Wrighton KH, and Feng XH. (2008). To TGFβ or not to TGFβ: fine-tuning of Smad signaling via post-translational modifications. Cell. Signal. 20: 1579-1591.
20. Li C, Liang YY, Feng XH, Tsai SY, Tsai MJ, O'Malley BW. (2008). Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol. Cell. 31: 835-49.
21. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. (2008). Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 29: 44-56.
22. Wrighton KH, Lin X, and Feng XH. (2009). Phospho-control of TGF-β superfamily signaling. Cell Research. 19: 8–20. (review)
23. Wrighton KH, Lin X, Yu P, and Feng XH. (2009). TGF-β stimulates Smad1 phosphorylation independently of BMP receptors. J. Biol. Chem. 284:9755-9763.
24. Dai F, Lin X, Chang C, and Feng XH. (2009). Nuclear export of Smad2 and Smad3 by RanBP3 facilitate termination of TGF-β signaling. Dev. Cell, 16:345-357.
25. Martinez GJ, Zhang Z, Chung Y, Reynolds JM, Lin X, Jetten AM, Feng XH, and Dong C. (2009). SMAD3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J. Biol. Chem. 284: 35283-35286.

• Feng XH, Derynck R. A kinase subdomain of TGF-β type I receptor determines TGF-β intracellular signaling specificity. EMBO J. 1997;16(13):3912-3923.
• Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β induced transcription. Nature. 1998;394(6696):909-913.
• Feng XH, Zhang Y, Wu RY, Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 1998;12(14):2153-2163.
• Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-β responses. Cell. 1998;95(6):737-740.
• Lin X, Liang M, Feng XH. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J Biol Chem. 2000;275(47):36818-36822.
• Feng XH, Lin X, Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 2000;19(19):5178-5193.
• Feng XH, Liang YY, Liang M, Zhai W, Lin X. Direct interaction of oncogenic c-Myc with tumor suppressors Smad2 and Smad3 to inhibit TGF-β-mediated induction of the CDK inhibitor p15INK4B. Mol Cell. 2002;9(1):133-143.
• Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, Feng XH. Activation of TGF-β signaling by SUMO modification of tumor suppressor Smad4/DPC4. J Biol Chem. 2003;278(21):18714-18719.
• Lin X, Sun B, Liang M, et al. Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell. 2003;11(6):1389-1396.
• Lin X, Liang YY, Sun B, Liang M, Brunicardi FC, Feng XH. Smad6 recruits transcription corepressor CtBP to repress BMP-induced transcription. Mol Cell Biol. 2003;23(24):9081-9093.
• Liang M, Liang YY, Wrighton KH, et al. Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2. Mol Cell Biol. 2004;24(17):7524-7537.
• Feng XH, Derynck R. Specificity and versatility of TGF-β signaling through Smads. Annu Rev Cell Dev Biol. 2005;21:659-693.
• Lin X, Duan X, Liang YY, et al. PPM1A functions as a Smad phosphatase to terminate TGF-β signaling. Cell. 2006;125(5):915-928.
• Wrighton KH, Willis D, Long J, Liu F, Lin X, Feng XH. Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-β signaling. J Biol Chem. 2006;281(50):38365-38375.
• Dai F, Chang C, Lin X, Dai P, Mei L, Feng XH. Erbin inhibits TGFβ signaling through a novel Smad-interacting domain. Mol Cell Biol. 2007;27(17):6183-6194.
• Wang D, Long J, Dai F, Liang M, Feng XH, Lin X. Bcl6 represses Smad signaling in TGFβ resistance. Cancer Res. 2008;68(3):783-789.
• Wrighton KH, Lin X, Feng XH. Critical regulation of TGFβ signaling by HSP90. Proc Natl Acad Sci U S A. 2008;105(27):9244-9249.
• Wrighton KH, Dai F, Feng XH. A new kid on the TGFβ block: TAZ controls Smad nucleocytoplasmic shuttling. Dev Cell. 2008;15(1):8-10.
• Wrighton KH, Feng XH. To TGFβ or not to TGFβ: fine-tuning of Smad signaling via post-translational modifications. Cell Signal. 2008;20(9):1579-1591.
• Li C, Liang YY, Feng XH, Tsai SY, Tsai MJ, O'Malley BW. Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell. 2008;31(6):835-849.
• Yang XO, Nurieva R, Martinez GJ, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008;29(1):44-56.
• Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-β superfamily signaling. Cell Res. 2009;19(1):8-20.
• Wrighton KH, Lin X, Yu P, Feng XH. TGF-β stimulates Smad1 phosphorylation independently of BMP receptors. J Biol Chem. 2009;284(14):9755-9763.
• Dai F, Lin X, Chang C, Feng XH. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-β signaling. Dev Cell. 2009;16(3):345-357.
• Martinez GJ, Zhang Z, Chung Y, et al. SMAD3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem. 2009;284(51):35283-35286.
• Massagué J. TGFβ signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616-630.
• Xu P, Lin X, Feng XH. Posttranslational regulation of Smads. Cold Spring Harb Perspect Biol. 2016;8(12):a022087.
• Moustakas A, Heldin CH. The regulation of TGFβ signal transduction. Development. 2009;136(22):3699-3714.
• 张彦, 冯新华. TGF-β信号转导与Smad蛋白功能研究进展. 中国科学: 生命科学. 2010;40(5):387-396.