詹仁知

詹仁知教授，1985年毕业于东南大学医学院，1993年获上海交通大学临床硕士学位，2000年获日本新泻大学医学博士学位。1998年至2001年任日本新泻大学医学院助理教授，2001年至2009年8月在美国杜克大学医学中心，在苔藓纤维发芽发现者及颞叶癫痫苔藓纤维发芽假说提出者Nadler JV教授的实验室从事博士后研究。2009年9月起受聘为山东大学医学院教授、博士生导师。 ADSFAEQWER353423413434

1993年，硕士期间工作分获中华医学会上海分会施思明医学奖及第一届全国中青年麻醉学会议论文二等奖。在日本新泻大学期间，率先证明线粒体在脑缺血预处理诱导的保护中起关键作用，独立主持完成日本文部科学省课题一项。在杜克大学期间，主要从事中间神经元与神经系统疾病及癫痫导致的海马齿状回突触重组研究，率先发现匹罗卡品诱导的大鼠颞叶癫痫模型中γ-氨基丁酸（GABA）能紧张性抑制作用的增强。

• 中间神经元爆发性放电机制及其与神经可塑性和记忆形成的关系
• 胞周投射型GABA能中间神经元在癫痫发生和扩散中的作用
• 麻醉药作用的细胞及分子机制

主要研究方法包括神经系统疾病动物模型制作、多种模式的脑片膜片钳记录、生物素负荷显示所记录细胞形态后的多重免疫染色、对电压门控性和配体门控性离子通道的RNA干扰技术等。 ADSFAEQWER353423413434

脑组织中的神经细胞分为兴奋性主细胞和中间神经元。中间神经元合成释放GABA，占神经元总数的10-20%。根据轴突投射域分为四型：

Parvalbumin和胆囊收缩素阳性篮状细胞均属胞周投射型，但作用不同。 ADFASDFAF23RQ23R

1. Zhan R-Z, Cameron MC, Evenson DA, Nadler JV. Activation of T-type calcium current underlies burst firing in hilar ectopic granule cells of epileptic brain. J Neurosci (in submission).
2. Zhan R-Z, Timofeeva O, Nadler JV. Electrophysiological properties of hilar ectopic granule cells generated after status epilepticus in the rat. J Neurophysiol (in submission).
3. Zhan R-Z, Nadler JV. Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. J Neurophysiol 2009;102(2):670-681.
4. Nadler JV and Zhan R-Z. Properties of dentate granule cells and their relevance to seizures. In: Schwartzkroin PA, ed, Encyclopedia of Basic Epilepsy Research, Vol 1. Oxford, Academic, 2009;472-476.
5. Zhan R-Z, Nadler JV, Schwartz-Bloom RD. Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. J Cereb Blood Flow Metab 2007;27(8):1444-1452.
6. Zhan R-Z, Nadler JV, Schwartz-Bloom RD. Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia. J Cereb Blood Flow Metab 2006;26(1):112-124.
7. Zhan R-Z, Fujihara H, Baba H, Yamakura T, Shimoji K. Ischemic preconditioning is capable of inducing mitochondrial tolerance in the rat brain. Anesthesiology 2002;97(4):896-901. (通讯作者)
8. Zhan R-Z, Wu C, Fujihara H, Taga K, Qi S, Naito M, Shimoji K. Both caspase-dependent and caspase-independent pathways may be involved in hippocampal CA1 neuronal death because of loss of cytochrome c from mitochondria in a rat forebrain ischemia model. J Cereb Blood Flow Metab 2001;21(5):529-540. (通讯作者)
9. Zhan R-Z, Qi S, Wu C, Fujihara H, Taga K, Shimoji K. Intravenous anesthetics differentially reduce neurotransmission damage caused by oxygen-glucose deprivation in rat hippocampal slices in correlation with N-methyl-D-aspartate receptor inhibition. Crit Care Med 2001;29(4):808-813.

山东省济南市文化西路44号 ADFASDFAF23RQ23R
山东大学医学院生理学研究所
邮编：250012
电子邮箱：zhan0001@sdu.edu.cn
电话：15066152368 ADFASDFAF23RQ23R

• Zhan R-Z, Nadler JV. Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. J Neurophysiol. 2009;102(2):670-681.
• Zhan R-Z, Nadler JV, Schwartz-Bloom RD. Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. J Cereb Blood Flow Metab. 2007;27(8):1444-1452.
• Zhan R-Z, Fujihara H, Baba H, Yamakura T, Shimoji K. Ischemic preconditioning is capable of inducing mitochondrial tolerance in the rat brain. Anesthesiology. 2002;97(4):896-901.
• Nadler JV, Zhan R-Z. Properties of dentate granule cells and their relevance to seizures. In: Schwartzkroin PA, ed. Encyclopedia of Basic Epilepsy Research. Vol 1. Oxford: Academic Press; 2009:472-476.
• Zhan R-Z, Wu C, Fujihara H, Taga K, Qi S, Naito M, Shimoji K. Both caspase-dependent and caspase-independent pathways may be involved in hippocampal CA1 neuronal death because of loss of cytochrome c from mitochondria in a rat forebrain ischemia model. J Cereb Blood Flow Metab. 2001;21(5):529-540.
• Zhan R-Z, Qi S, Wu C, Fujihara H, Taga K, Shimoji K. Intravenous anesthetics differentially reduce neurotransmission damage caused by oxygen-glucose deprivation in rat hippocampal slices in correlation with N-methyl-D-aspartate receptor inhibition. Crit Care Med. 2001;29(4):808-813.
• Freund TF, Katona I. Perisomatic inhibition. Neuron. 2007;56(1):33-42.
• Klausberger T, Somogyi P. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science. 2008;321(5885):53-57.
• de Lanerolle NC, Kim JH, Williamson A, et al. A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive neuronal subpopulations. Acta Neuropathol. 2012;123(4):513-528.
• 陈明, 张旭. GABA能中间神经元在癫痫中的作用研究进展. 生理科学进展. 2015;46(3):201-206.