徐宏喜

徐宏喜教授，现为上海中医药大学教授、博士生导师、上海中医药大学中药学院院长。上海市首批特聘专家。1994年获得日本富山医科药科大学国立和汉药研究所药学博士学位。并于新加坡国立大学化学系及加拿大Dalhousie大学微生物学系进行博士後研究工作。曾先后受聘于香港中文大学中药研究中心科学主任、香港和记黄埔(中国)有限公司副总经理兼高级医药顾问，上海和黄药业有限公司董事兼研究开发总监。2001至2010年,担任香港赛马会中药研究院副总裁兼中药研究室主任。徐教授至今已发表SCI论文200多篇，总引用次数超过5500次，H指数为40，入选2014年中国高被引用学者榜。拥有1项PCT专利以及6项美国专利。 ADSFAEQWER353423413434

人物介绍

徐教授的主要社会兼职包括：中华中医药学会中药实验药理学分会主任委员、世界中医药协会联合会中药分析专业委员会副会长、世中联中药鉴定专业委员会副会长、全国中医药高等教育学会中药教育研究会第三届理事会副理事长、国际现代化中医药学术会议联席主席、上海市侨界知识分子联谊会第八届理事会常务理事、上海市药学会中药专业委员会主任委员、国际国内十余种学术刊物的编委、现代化中医药国际协会创会董事等职。先后应邀前往美国、日本、新加坡、韩国、巴西、加拿大、奥地利、印度等国家以及台湾、香港、澳门等地做学术报告。 ADSFAEQWER353423413434

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研究方向和领域 ADFASDFAF23RQ23R

主要研究领域包括中药活性成分及药效评价研究，中药新药开发以及中药质量控制分析方法研究等。重点进行病毒、肿瘤、耐药菌及糖尿病等重大疾病的中药防治与药效评价研究，阐明中药药效物质基础及作用机制，研发具有自主知识产权的创新药物。

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(1)  抗病毒及抗耐药菌中药药理机制研究
从事中药及其活性成分抗病毒及抗耐药菌药理作用机制研究。已建立抗病毒（HSV和EV71）筛选平台及基于MgrA靶标蛋白荧光探针的高通量筛选体系，致力于阐明中药抗病毒和抗金黄色葡萄球菌耐药菌活性物质基础，揭示其药效作用机制，发现活性强、毒性小、选择性高的先导化合物。 ADSFAEQWER353423413434
(2)  抗肿瘤中药药理作用机制研究
从事中药及其活性成分抗肿瘤药理作用机制研究。已建立分子、细胞及动物水平的抗肿瘤药物筛选及药效评价模型，重点开展肝癌、前列腺癌及胰腺癌的体内外药效筛选和药效评价，致力于从中草药和天然产物中寻找抗肿瘤先导化合物，阐明其诱导肿瘤细胞凋亡、调节自噬、抑制转移及防止复发等药效作用机制。近年来重点开展中国产藤黄属植物中具有抗肿瘤活性的PPAPs类和Xanthones类成分的鉴定及其作用机制研究。

主要SCI研究论文（IF》3） ADSFAEQWER353423413434

1.        Y. Z. Lao, G. Wan, Z. Y. Liu, X. Y. Wang,P. Ruan, W. Xu, D. Q. Xu, W. D. Xie, Y. Zhang, H.X.Xu, N. H. Xu, The natural compound oblongifolin C inhibitsautophagic flux and enhances antitumor efficacy of nutrient deprivation, Autophagy, 10(5): 1-14 (2014). (IF=11.753)

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2.        G. Wan, W. D. Xie, Z. Y. Liu, W. Xu, Y. Z. Lao, N. Huang, K. Cui, M. J. Liao, J. He, Y. Y. Jiang, Burton B Yang, H. X. Xu, N. H. Xu, Y. Zhang, Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway, Autophagy, 10(1):70-79 (2014). (IF=11.753)

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3.        G. Lin, J. Y. Wang, N. Li, M. Li, H. Gao, Y. Ji, F. Zhang, H. L. Wang, Y. Zhou, Y. Ye, H. X. Xu, J. Zheng, Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum, Journal of Hepatology, 54(4), 666-673 (2011). (IF=11.336) ADFASDFAF23RQ23R

4.        M.H.Feng, B.Q.Tang, N.Z.Wang, H.H.Xu, X.F.Jiang, Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids, Angewandte Chemie (International ed. in English), doi: 10.1002/anie.201508340. [Epub ahead of print] (2015). (IF=11.261) ADFASDFAF23RQ23R

5.        H. L. Zhao, Y. Sui, C. F. Qiao, K. Y. Yip, R. K. K. Leung, S. K. W. Tsui, H. M. Lee, H. K. T. Wong, X. Zhu, J. J. Siu, L. He, J. Guan, L. Z. Liu, H. X. Xu, P. C. Y. Tong, J. C. N. Chan, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression, Diabetes, 61(4), 933-943 (2012). (IF=8.095)

6.        X. W. Yang, X. Deng, X. Liu, C. Y. Wu, X. N. Li, B. Wu, H. R. Luo, Y. Li, H. X. Xu, Q. S. Zhao, G. Xu, Hypercohin A, a new polycyclic polyprenylated acylphloroglucinols possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens, Chemical Communications, 48: 5998-6000 (2012). (IF=6.834) ADSFAEQWER353423413434

7.        Y. Liao, X. Liu, J. Yang, Y.Z. Lao, X.W.Yang, X.N.Li, J.J.Zhang, Z.J.Ding, H.X.Xu and G. Xu,Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile, Organic Letters, 17 (5), 1172–1175(2015). (IF=6.364) ADFASDFAF23RQ23R

8.        Q. B. Han, T. F. Tso, S. Cheung, Tai, J. Z. Song, C. F. Qiao, H. D. Sun, and H. X. Xu, Maoecrystal Z, a Cytotoxic Diterpene from Isodon eriocalyx with an Unique Skeleton, Organic Letters, 8 (21), 4727-4730 ( 2006). (IF=6.364)

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9.        Z.J.Ding, Y.Z.Lao, H.Zhang, W.W.Fu, L.L.Zhu, H.S.Tan, H.X.Xu, Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer,Oncotarget, in press.(2015). (IF=6.359) ADSFAEQWER353423413434

10.    X.H.Pang,J.Y.Song,Y.J.Zhu,H.X.Xu,L.F.Huang,S.L.Chen, Applying plant DNA barcodes for Rosaceae species identification,Cladistics,27(2), 165-170(2011). (IF=6.217)

11.    K.K. Shen, J.L.Xie, H. Wang, H.Zhang, M.Y.Yu, F.F. Lu, H.S. Tan,H.X.Xu, Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells, Molecular Cancer Therapeutics, 14(7):1738-1749. (2015). (IF=5.683) ADFASDFAF23RQ23R

12.    T. W. D. Chan, P. P. H. But, S. W. Cheng, I. M. Y. Kwok, F. W. Lau, H. X. Xu, Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS, Analytical Chemistry, 72(6), 1281-1287 (2000). (IF=5.636) ADFASDFAF23RQ23R

13.    X.Y. Wang, Y. Z. Lao, N.H. Xu, Z.C. Xu, M. Wu, H. Wang, X. Li, H.S. Tan, M.H. Sun, H. X. Xu, Oblongifolin C inhibits metastesis by up-regulating keratin 18 and tubulins, Scientific Reports, 5:10293-10305. (2015). (IF=5.578)

14.    W. L. Ting Kan, C. Yin, H. X. Xu, G. Xu, K. K.W. To, C. H. Cho, J. A. Rudd, G.Lin, Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1 cell cycle arrest and apoptosis, International Journalof Cancer, 132(3): 707-716 (2013). (IF=5.085) ADFASDFAF23RQ23R

15.    C.Feng,L.Y.Zhou,T.Yu,G.Xu,H.L.Tian,J.J.Xu,H.X.Xu,K.Q.Luo, A new anticancer compound, Oblongifolin C,inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation, International Journalof Cancer,131(6):1445-1454 (2012). (IF=5.085) ADSFAEQWER353423413434

16.    Z.C.Xi, M.Yao, Y.Li, C.L.Xie, J. Holst, T. Liu, S.F.Cai, Y.Z.Lao, H.S.Tan, H.X. Xu and Q.H. Dong, Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells viastabilization of FBXW7 and subsequent c-MYC degradation, Cell Death & Disease, under revised. (2015). (IF=5.014)

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17.    Y.Lu, S.F.Cai, J.Nie, Y.Y. Li, G.C.Shi, J.M.Hao, W.W.Fu, H.S.Tan, S.L.Chen, B. Li, H.X.Xu ,The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma, Biochemical Pharmacology, S0006-2952(15)00713-3. doi: 10.1016/j.bcp.2015.11.004. [Epub ahead of print] . (2015). (IF=5.009) ADFASDFAF23RQ23R

18.    D.H.He, L.S.Ding, H.X.Xu, X.X.Lei, H.P.Xiao, Y.Zhou,Gymnothelignans A-O: Conformation and Absolute Configuration Analyses of Lignans Bearing Tetrahydrofuran from Gymnotheca chinensis,Journal of Organic Chemistry, 77(19): 8435-8443 (2012). (IF=4.721) ADSFAEQWER353423413434

19.    H. Y. Qin, J. C. Y. Wu, X. D. Tong, J. J. Y. Sung, H. X. Xu, Z. X. Bian,Systematicreview of  animal models of post-infectious/post-inflammatory irritable bowel syndrome. Journal of Gastroenterology, 46(2), 164-174(2011). (IF=4.523) ADSFAEQWER353423413434

20.    Z. X. Bian, Z. Li, Z. X. Huang, M. Zhang, H. L. Chen, H. X. Xu, J. J. Y. Sung, Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients, Journal of Gastroenterology, 44(7), 666-674 (2009). (IF=4.523)

21.    Y. Zhou, N. Li, F. F. K. Choi, C. F. Qiao, J. Z. Song, S. L. Li, X. Liu, Z. W. Cai, P. P. Fu, G. Lin, H. X. Xu, A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry, Analytica Chimica Acta, 681(1-2), 33-40 (2010). (IF=4.513)

22.    Y. Zhou, Stephanie Lee, Franky F. K. Choi, G. Xu, X. Liu, J. Z. Song, S. L. Li, C. F. Qiao, H. X. Xu, Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Analytica Chimica Acta, 678(1), 96-107 (2010). (IF=4.513) ADSFAEQWER353423413434

23.    Y. Zhou, X. Liu, J. Yang, Q. B. Han, J. Z. Song, S. L. Li, L. S. Ding, H. X. Xu, Analysis of caged xanthones from the resin of Garcinia hanburyi using ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Analytica Chimica Acta, 629, 104-118 (2008). (IF=4.513) ADFASDFAF23RQ23R

24.    L. Z. Liu, S. C. K. Cheung, L. L. Lan, S. K. S. Ho, H. X. Xu, J. C. N. Chan, P. C. Y. Tong, Berberine modulates insulin signaling transduction in insulin-resistant cells, Molecular and Cellular Endocrinology, 317 (1-2), 148-153 (2010). (IF=4.405)

25.    M.S. Liu, L.Tao, S. L. Chow, R. Wu, H. Zhang, Y.F.Yang, D.J.Yang, Z.X.Bian, A.P.Lu, Q.B.Han, H.H.Xu,Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: finding anti-enterovirus 71 agents from Anemarrhena asphodeloides.,Journal of Chromatography A, 1368：116-124 (2014). (IF=4.169)

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26.    S. L. Li,H. Shen, L. Y. Zhu, J. Xu, X. B. Jia, H. M. Zhang ,H. X. Xu, G. Lin, H. Cai, B. C. Cai, S. L. Chen, Ultra-high-performance liquid chromatography-quadrupole/time of flight massspectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng, Journal of Chromatography A, 1231: 31-45 (2012). (IF=4.169)

27.    Y. Zhou, J. Z. Song, Franky F. K. Choi, H. F. Wu, C. F. Qiao, L. S. Ding, S. L. Gesang, H. X. Xu, An experimental design approach using response surface techniques to obtain optimal liquid chromatography and mass spectrometry conditions to determine the alkaloids in Meconopsi species, Journal of Chromatography A, 1216 (42), 7013-7023 (2009). (IF=4.169)

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28.    J. Z. Song, C. F. Qiao, S. L.  Li, Y. Zhou, M. T. Hsieh, H. X. Xu, Rapid optimization of dual-mode gradient high performance liquid chromatographic separation of Radix et Rhizoma Salviae Miltiorrhizae by Response Surface Methodology, Journal of Chromatography A, 1216 (42), 7007-7012 (2009). (IF=4.169) ADFASDFAF23RQ23R

29.    Y. Zhou, G. Xu, F. F. K. Choi, L. S. Ding, Q. B. Han, J. Z. Song, C. F. Qiao, Q. S. Zhao, H. X. Xu, Qualitative and quantitative analysis of diterpenoids in Salvia species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 1216 (24), 4847-4858 (2009). (IF=4.169) ADSFAEQWER353423413434

30.    C. Y. Li, H. X. Xu, Q. B. Han, T. S. Wu, Quality assessment Radix Codonopsis by quantitative nuclear magnetic resonance, Journal of Chromatography A, 1216(11), 2124-2129 (2009). (IF=4.169)

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31.    Y. Zhou, Q. B. Han, J. Z. Song, H. X. Xu, Characterization of polyprenylated xanthones in Garcinia xipshuanbannaensis using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 1206 (2), 131-139 (2008). (IF=4.169) ADSFAEQWER353423413434

32.    Q. B. Han, J. Z. Song, C. F. Qiao, L. Wong, and H. X. Xu, Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography, Journal of Chromatography A, 1127(1-2), 298-301 (2006). (IF=4.169) ADSFAEQWER353423413434

33.    S. B. Chen, H. P. Liu, R. T. Yian, D. J. Yang, S. L. Chen, H. X. Xu, A. S. C. Chan, and P. S. Xie, High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. Journal of ChromatographyA, 1121(1), 114-119 (2006). (IF=4.169) ADFASDFAF23RQ23R

34.    Y. Xie, Z. H. Jiang, H. Zhou, H. X. Xu, and L. Liu, Simultaneous determination of six Aconitum alkaloids in proprietary Chinese medicines by high-performance liquid chromatography, Journal of ChromatographyA, 1093 (1-2), 195-203 (2005). (IF=4.169)

35.    J. Z. Song, H. X. Xu, S. J. Tian, and P. P. H. But, Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis, Journal of ChromatographyA, 857, 303-311(1999). (IF=4.169)

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36.    X. J. Zhang, Z. Li, W. M. Leung, L. Liu, H. X. Xu, Z. X. Bian, The Analgesic Effect of Paeoniflorin on Neonatal Maternal Separation-Induced Visceral Hyperalgesia in Rats, Journal of Pain, 9 (6), 497-505 (2008). (IF=4.01)

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37.    X. J. Zhang, F. F.K.Choi, Y. Zhou, F. P. Leung, S. Tan, S. H. Lin, H. X. Xu, W. Jia, J. J.Y.Sung, Z. W. Cai, Z. X. Bian, Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics: A pilot study, FEBS Journal, 279(13): 2322-2338 (2012). (IF=4.001)

38.    Y. W. Zhang, P. P. H. But, V. E. C. Ooi, H. X. Xu, G. D. Delaney, S. H. S. Lee, S. F. Lee,  Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin–carbohydrate complex from Prunella vulgaris, Antiviral Research, 75 (3), 242-249 (2007). (IF=3.938)

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39.    H. X. Xu, S. H. S. Lee, S. F. Lee, R. L. White, J. Blay, Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris, Antiviral Research, 44(1), 43-54 (1999). (IF=3.938) ADFASDFAF23RQ23R

40.    Kurokawa, H. Ochiai, K. Nagasaka, H. X. Xu, S. Kadota, T. Namba, and K. Shiraki, Antiviral traditional medicines against herpes simplex virus, poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV infection in mice, Antiviral Research, 22, 175-188 (1993). (IF=3.938)

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41.    W. M. Fu, J. F. Zhang, H. Wang, Z.C. Xi, W.M. Wang, P. Zhuang, X. Zhu, S.C. Chen, T. M. Chan, K. S. Leung, G. Lu, H. X. Xu, H. F. Kung, Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma, Journal of Proteomics, 75(15): 4833-4843 (2012). (IF=3.888)

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42.    Q. B. Han, H. X. Xu, Caged Garcinia Xanthones: Development Since 1937, Current Medicinal Chemistry, 16 (28), 3775-3796 (2009). Review(IF=3.853)

43.    W.W.Fu, M.Wu, L.L.Zhu, Y.Z. Lao, L.P.Wang, H.S.Tan, Q.H. Yuan, H.X.Xu.Prenylated benzoylphloroglucinols and biphenyl derivatives from the leaves of Garcinia multiflora Champ, RSC Advances, 5, 78259-78267 (2015). (IF=3.84)

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44.    Y.J.Wang, H.Zhang, Q.Z. Zhang, Y.J. Liang, L.Ma, H.S.Tan, Y.Z.Lao, H.X. Xuand Z.G.Li,  Genetically encoded fluorescence screening probe for MgrA, a global regulator in Staphylococcus aureus, RSC Advances, 5, 87216-87220 (2015). (IF=3.84) ADSFAEQWER353423413434

45.    G.Y.He, S.X.Zhang, L.Xu, Y.L.Xia, P.Wang, S.Y.Li, L.L.Zhu, H.X.Xu, G.B.Ge and  L.Yang, C-8 Mannich base derivatives of baicalein display improved glucuronidation stability: exploring the mechanism by experimentation and theoretical calculations, RSC Advances, DOI: 10.1039/C5RA20213B (2015). (IF=3.84) 2015-10-14

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46.    X. Wang, Y. C. Chen, Q. B. Han, C. Y. Chan, H. Wang, Z. Liu, C. H. K. Cheng, D. T. Yew, M. C. M. Lin, M. L. He, H. X. Xu, J. J. Y. Sung, H. F. Kung, Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma, Proteomics, 9(2), 242-253 (2009). (IF=3.807) ADFASDFAF23RQ23R

47.    H. Zhang, D. D. Zhang, Y. Z. Lao, W. W. Fu, S. Liang, Q. H. Yuan, L. Yang, and H.X.Xu, Cytotoxic and Anti-inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta, Journal of Natural Products, 77:1700-1707 (2014). (IF=3.798) ADSFAEQWER353423413434

48.    H. Zhang, L. Tao, W. W. Fu, S. Liang, Y. F. Yang, Q. H. Yuan, D. J. Yang, A. P. Lu, H.X.Xu, Prenylated benzoylphloroglucinols and xanthones from the leaves of Garcinia oblongifolia with antienteroviral activity, Journal of Natural Products,77:1037-1046(2014). (IF=3.798) ADSFAEQWER353423413434

49.    C. Feng, S. X. Huang, X. M. Gao,H.X.Xu, Kathy Luo, Characterization of proapoptotic compounds from the bard of Garcinia oblongifolia, Journal of Natural Products. 77:1111-1116 (2014). (IF=3.798)

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50.    Z. X. Xia, D. D. Zhang, S. Liang, Y. Z. Lao, H. Zhang, H. S. Tan, S. L. Chen, X. H. Wang, H.X.Xu.Bioassay-Guided Isolation of Prenylated Xanthones and Polycyclic Acylphloroglucinols from the Leaves of Garcinia nujiangensis，Journal of Natural Products. 75(8):1459-1464 (2012). (IF=3.798) ADFASDFAF23RQ23R

51.    X. Liu, T. Yu, X. M. Gao, Y. Zhou, C. F. Qiao, Y. Peng, S. L. Chen, Kathy Q. Luo, H. X. Xu, Apoptosis effects of Polyprenylated Benzoylphloroglucinol Derivatives from the Twigs of Garcinia multiflora, Journal of Natural Product, 73(8),1355-1359 (2010). (IF=3.798) ADFASDFAF23RQ23R

52.    G. Xu, W. L. T. Kan, Y. Zhou, J. Z. Song, Q. B. Han, C. F. Qiao, C. H. Cho, J. A. Rudd, G. Lin, H. X. Xu, Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa, Journal of Natural Product, 73(2), 104-108 (2010). (IF=3.798)

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53.    S. X. Huang, C. Feng, Y. Zhou, G. Xu, Q. B. Han, C. F. Qiao, D. C. Chang, K. Q. Luo, H. X. Xu, Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia, Journal of Natural Product, 72 (1), 130-135 (2009). (IF=3.798) ADSFAEQWER353423413434

54.    R. W. Jiang, J. R. Zhou, P. M. Hon, S. L. Li, Y. Zhou, L. L. I, W. C. Ye, H. X. Xu, P. C. Shaw, P. P. But, Lignans from Dysosma versipellis with Inhibitory Effects on Prostate Cancer Cell Lines, Journal of Natural Product, 70 (2), 283-286 (2007). (IF=3.798)

55.    R. W. Jiang, P. M. Hon, Y. Zhou, Y. M. Chan, Y. T. Xu, H. X. Xu, H. Greger, P. C. Shaw, P. P. H. But, Alkaloids and Chemical Diversity of Stemona tuberose, Journal of Natural Product, 69(5), 749-754 (2006). (IF=3.798) ADSFAEQWER353423413434

56.    H. Dong, S. X. Chen, R. M. Kini, H. X. Xu, Effects of Tannins from Geum japonicum on the Catalytic Activity of Thrombin and Factor Xa of Blood Coagulation Cascade,Journal of Natural Product, 61(11), 1356-1360 (1998). (IF=3.798)

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