何士刚

何士刚，上海交通大学生命科学技术学院和自然科学研究院特聘教授、博导，国家杰出青年基金获得者，中国科学院百人计划获得者，兼任中国神经科学学会秘书长、常务理事，《生物物理学报》执行主编。1995年在澳大利亚国立大学获得神经科学博士学位。

1994至1997年在哈佛医学院/霍华德·休斯医学研究院任研究员。1997至1999年在昆士兰大学生理学系视觉、触觉和听觉研究中心任高级研究员。1999至2004年在中国科学院上海生命科学研究院神经科学研究所任研究员。2005年至2011年任中国科学院生物物理研究所研究员。

其实验室以视网膜为模型，结合形态学、电生理学、免疫细胞化学和分子生物学等方法，研究神经细胞形态和功能的相关性，神经细胞树突的发育和环路的形成调控机制以及视网膜中的信号处理，特别是运动方向计算的机制。

• Sun, L., Han, X. and He, S. (2011) Direction-Selective Circuitry in Rat Retina Develops Independently of GABAergic, Cholinergic and Action Potential Activity. The Public Library of Science 6:e19477. equal contribution.
• Ren, L., Liang, H., Diao, L. and He, S. (2010) Changing dendritic field size of mouse retinal ganglion cells in early postnatal development. Developmental Neurobiology 70:397-407. equal contribution.
• Yu, X., Xu, X., He, S. and He, J. (2009) Change detection by thalamic reticular neurons. Nature Neuroscience 12:1165-1170. Co-corresponding author.
• Chen, M., Weng, S., Deng, Q., Xu, Z. and He, S. (2009) Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina. Journal of Physiology (London) 587:819-828. equal contribution.
• He, S. (2008) Alpha cells take off first. Neuron 59:352-253. (preview)
• Sun, W., Deng, Q., Levick, W.R. and He, S. (2006) ON direction-selective ganglion cells in the mouse retina. Journal of Physiology (London) 576:197-202. equal contribution.
• Deng, Q., Wang, L., Dong, W. and He, S. (2006) Lateral components in the cone terminals of the rabbit retina: Horizontal cell origin and glutamate receptor expression. Journal of Comparative Neurology 496:698-795.
• Huang, H., Li, H. and He, S. (2005) Identification of connexin 50 and 57 on A-type horizontal cells in the rabbit retina. Cell Research 15:207-211.
• Weng, S., Sun, W. and He, S. (2005) Identification of ON-OFF direction selective retinal ganglion cells in the mouse. Journal of Physiology (London) 562: 899-913.
• Diao, L., Sun, W., Deng, Q. and He, S. (2004) Development of the mouse retina: Emerging morphological diversity of the ganglion cells. Journal of Neurobiology 61:236-249.
• Dong, W., Sun, W., Zhang, Y., Chen, X. and He, S. (2004) Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina. Journal of Physiology (London) 556:11-17.
• Li, H., Gaughwin, P.M., Li, N. and He, S. (2004) Localization of dopamine D1-receptor to A-type horizontal cells in the rabbit retina by single cell RT-PCR. Neuroscience Letters 355:146-148.
• He, S., Dong, W., Deng, Q., Weng, S. and Sun, W. (2003) Seeing more clearly: Recent advances in understanding the retinal circuitry. Science 302:408-411. (invited review).
• Sun, W, Li, N. and He, S. (2002) Large scale morphological survey of rat retinal ganglion cells. Visual Neuroscience 19:483-493.

何士刚教授在视网膜神经环路的研究中做出了系统性的贡献，特别是在方向选择性神经元的发育与功能、树突重塑以及信号处理机制方面。其工作揭示了神经活动独立于GABA能和胆碱能系统发育方向选择性环路，以及小鼠视网膜神经节细胞在发展过程中树突野大小的变化规律。此外，他还与合作者阐明了丘脑网状神经元在变化检测中的作用，为理解大脑感知机制提供了重要线索。

对视网膜信号处理的深入理解有助于开发人工视觉假体及治疗视网膜相关疾病。何士刚教授的研究成果为神经科学和视光学领域的基础研究与应用转化奠定了坚实基础。

• Sun, L., Han, X. and He, S. (2011) Direction-Selective Circuitry in Rat Retina Develops Independently of GABAergic, Cholinergic and Action Potential Activity. PLoS ONE 6:e19477.
• Ren, L., Liang, H., Diao, L. and He, S. (2010) Changing dendritic field size of mouse retinal ganglion cells in early postnatal development. Developmental Neurobiology 70:397-407.
• Yu, X., Xu, X., He, S. and He, J. (2009) Change detection by thalamic reticular neurons. Nature Neuroscience 12:1165-1170.
• Chen, M., Weng, S., Deng, Q., Xu, Z. and He, S. (2009) Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina. Journal of Physiology (London) 587:819-828.
• He, S. (2008) Alpha cells take off first. Neuron 59:352-253.
• Sun, W., Deng, Q., Levick, W.R. and He, S. (2006) ON direction-selective ganglion cells in the mouse retina. Journal of Physiology (London) 576:197-202.
• Deng, Q., Wang, L., Dong, W. and He, S. (2006) Lateral components in the cone terminals of the rabbit retina: Horizontal cell origin and glutamate receptor expression. Journal of Comparative Neurology 496:698-795.
• Huang, H., Li, H. and He, S. (2005) Identification of connexin 50 and 57 on A-type horizontal cells in the rabbit retina. Cell Research 15:207-211.
• Weng, S., Sun, W. and He, S. (2005) Identification of ON-OFF direction selective retinal ganglion cells in the mouse. Journal of Physiology (London) 562:899-913.
• Diao, L., Sun, W., Deng, Q. and He, S. (2004) Development of the mouse retina: Emerging morphological diversity of the ganglion cells. Journal of Neurobiology 61:236-249.
• Dong, W., Sun, W., Zhang, Y., Chen, X. and He, S. (2004) Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina. Journal of Physiology (London) 556:11-17.
• Li, H., Gaughwin, P.M., Li, N. and He, S. (2004) Localization of dopamine D1-receptor to A-type horizontal cells in the rabbit retina by single cell RT-PCR. Neuroscience Letters 355:146-148.
• He, S., Dong, W., Deng, Q., Weng, S. and Sun, W. (2003) Seeing more clearly: Recent advances in understanding the retinal circuitry. Science 302:408-411.
• Sun, W., Li, N. and He, S. (2002) Large scale morphological survey of rat retinal ganglion cells. Visual Neuroscience 19:483-493.
• 李武, 何士刚. (2010) 视网膜神经节细胞方向选择性机制的研究进展. 生命科学 22(6): 534-540.
• Wang, L., He, S. (2018) Retinal circuits for direction selectivity. Neuroscience Bulletin 34(5): 753-764.
• Barlow, H.B., Levick, W.R. (1965) The mechanism of directionally selective units in rabbit's retina. Journal of Physiology 178(3): 477-504.
• Demb, J.B., Singer, J.H. (2015) Functional circuitry of the retina. Annual Review of Vision Science 1: 263-289.