梅林

梅林，美国乔治亚健康科技大学教授，博导。1982年江西医学院毕业，1985年在军事医学科学院神经药理硕士，1989年在美国亚利桑那大学药理毒理博士，1989-1994年在约翰霍普金斯大学医学院博士后。1994 –1999 年弗吉尼亚大学医学院助理教授，1999 - 2004年阿拉巴马大学伯明翰分校助理教授，副教授（终身教职）。2004年至今，乔治亚健康科学大学医学院神经内科系终身教授，同时是乔治亚科学联盟（Georgia Research Alliance）神经科学杰出学者，2009年起任美国乔治亚健康科学大学分子医学与遗传学研究所所长。

1994年以来，从事发育神经生物学的研究，在神经突触形成和可塑性的研究，尤其是在神经肌肉接头形成和神经调节素与精神分裂症的机制等领域颇有建树，是该领域的国际领军人物，研究成果有助于对神经肌肉疾病、脊髓损伤、癫痫、精神疾病的治疗和诊断。发表原创性研究论文100余篇，申请或获得四项发明专利。同时任美国国立卫生研究院和自然科学基金评审专家，Molecular Brain, PLoS ONE，Journal of Neuroscience 等6家专业杂志的主编、副主编、或编委。创建中科院上海神经科学研究所的主要发起人之一，曾担任国家自然科学基金第一届海外评委，中科院神经所，江西医学院，南方医科大学，徐州医科大学客座教授。在北京大学，香港科技大学，中科院上海神经科学研究所和南方医科大学主持或讲授本科或研究生课程。

2004年获国家自然基金委杰出青年基金B类，2005年受聘为国家教育部“长江学者奖励计划讲座教授”。2008年获美国NARSAD（National Alliance for Research on Schizophrenia and Depression）杰出科学家奖和美国Mathilde Solowey奖(Foundation for Advanced Education in the Sciences)。2011年入选中央组织部“千人计划”。

Research Articles:

• Y.Z. Huang, S.S. Won, D.W. Ali, Q. Wang, M. Tanowitz, Q.S. Du, W.C. Xiong, K.A. Pelkey, M.W. Salter, and Lin Mei. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26:443-455, 2000
• Z.G. Luo, Q. Wang, J.Z. Zhou, J. Wang, Z. Luo, M. Liu, X. He, A. Wynshaw-Boris, W.C. Xiong, B. Lu, Lin Mei. Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1. Neuron 35:489-505, 2002.
• R.-S. Woo, X.M. Li, Y. Tao, E. Carpenter-Hyland, Y.Z. Huang, J. Weber, H. Neiswender, X.P. Dong, J. Wu, M. Gassmann, C. Lai, W.-C. Xiong, T.-M. Gao, L. Mei. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007.
• X.-M. Li, X.-P. Dong, S.W. Luo, B. Zhang, D.H. Lee, A.K.L. Ting, H. Neiswender, C.H. Kim, E. Carpenter-Hyland, T.M. Gao, W.C. Xiong, L. Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nature Neurosci. 11:262-268, 2008.
• S. Luo, B. Zhang, X.-p. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C.A. Chiu, W.C. Xiong, L. Mei. HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008.
• B. Zhang, S. Luo, Q. Wang, T. Suzuki, W.C. Xiong, Lin Mei. LRP4 serves as a co-receptor of agrin. Neuron 60:285-297, 2008.
• Y. Tao, P. Dai, Y. Liu, S. Marchetto, W.C. Xiong, J.-P. Borg, L. Mei. Erbin regulates NRG1 signaling and myelination. Proc. Nat. Acad. Sci. USA 106:9477-9482, 2009.
• L. Wen1, Y.S. Lu1, X. Zhu1, X.M. Li, R.-S. Woo, Y.-J. Chen, D.-M. Yin, C. Lai, A. Vazdarjanova, W.C. Xiong, and L. Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Nat. Acad. Sci. USA 107:1211-1216, 2010.
• Y.J. Chen, M. Zhang, D.M. Yin, L. Wen, A. Ting, P. Wang, Y.S. Lu, X.H. Zhu, S.J. Li, C.Y. Wu, X.M. Wang, C. Lai, W.C. Xiong, L. Mei, T.M. Gao. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc. Nat. Acad. Sci. USA 107: 21818-21823, 2010.
• Ting, Y. Chen, L. Wen, D.M. Yin, C. Shen, Y. Tao, X. Liu, W.C. Xiong, L. Mei. Neuregulin 1 promotes excitatory synapse development specifically in GABAergic interneurons. J. Neurosci. 31:15-25, 2011.
• X.H. Liu, R. Bates, D.M. Yin, C.Y. Shen, F. Wang, S. Nan, S.A. Kirov, Y. Luo, J.-Z. Wang, W.C. Xiong, and L. Mei. Specific regulation of NRG1 isoform expression by neuronal activity. J. Neurosci. 31:8491-8501, 2011.
• B. Zhang, J.S. Tzartos, M. Belimezi, S. Ragheb, B. Bealmear, R.A. Lewis, W.C. Xiong, R.P. Lisak, S.J. Tzartos, Lin Mei. Autoantibodies to LRP4 in double seronegative myasthenia gravis patients. Archive Neurol. 69:445-451, 2012.
• G.H. Tan1, Y.Y. Liu1, X.L. Hu1, D.M. Yin, L. Mei and Z.Q. Xiong. Neuregulin1 represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons. Nature Neurosci. 15:258-266, 2012.
• Y. Zong, B. Zhang, S. Gu, K. Lee, J. Zhou, G. Yao, D. Figueiredo, K. Perry, L. Mei and Rongsheng Jin. Structural basis of neuron-specific regulation of postsynaptic differentiation. Genes & Development. 26:247-258, 2012.
• H.T. Wu, Y.S. Lu, C.Y. Shen, W.C. Xiong, L. Mei. Distinct Roles of Muscle and motoneuron LRP4 in Neuromuscular Junction Formation. Neuron. 75(1):94-107, 2012.
• H.T. Wu, Yisheng Lu, A. Barik, A. Joseph, M.M. Taketo, W.C. Xiong, L. Mei. beta-Catenin gain-of-function in muscles impairs neuromuscular junction formation. Development, in press.

Reviews:

• W.C. Xiong and Lin Mei: An Unconventional Role of Neurotransmission in Synapse Formation. Neuron 46:521-523, 2005.
• B. Zhang, W.C. Xiong, L. Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev. Cell 16:325-327, 2009.
• L. Mei and W.C. Xiong. Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008.
• H. Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010.

• Huang YZ, Won SS, Ali DW, et al. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 2000;26(2):443-455.
• Luo ZG, Wang Q, Zhou JZ, et al. Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron. 2002;35(3):489-505.
• Woo RS, Li XM, Tao Y, et al. Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 2007;54(4):599-610.
• Li XM, Dong XP, Luo SW, et al. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nat Neurosci. 2008;11(3):262-268.
• Luo S, Zhang B, Dong XP, et al. HSP90β regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron. 2008;60(1):97-110.
• Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, Mei L. LRP4 serves as a co-receptor of agrin. Neuron. 2008;60(2):285-297.
• Tao Y, Dai P, Liu Y, et al. Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci USA. 2009;106(23):9477-9482.
• Wen L, Lu YS, Zhu X, et al. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci USA. 2010;107(3):1211-1216.
• Chen YJ, Zhang M, Yin DM, et al. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci USA. 2010;107(50):21818-21823.
• Ting AK, Chen Y, Wen L, et al. Neuregulin 1 promotes excitatory synapse development specifically in GABAergic interneurons. J Neurosci. 2011;31(1):15-25.
• Liu XH, Bates R, Yin DM, et al. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci. 2011;31(23):8491-8501.
• Zhang B, Tzartos JS, Belimezi M, et al. Autoantibodies to LRP4 in double seronegative myasthenia gravis patients. Arch Neurol. 2012;69(4):445-451.
• Tan GH, Liu YY, Hu XL, et al. Neuregulin 1 represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons. Nat Neurosci. 2012;15(2):258-266.
• Zong Y, Zhang B, Gu S, et al. Structural basis of neuron-specific regulation of postsynaptic differentiation. Genes Dev. 2012;26(3):247-258.
• Wu HT, Lu YS, Shen CY, Xiong WC, Mei L. Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron. 2012;75(1):94-107.
• Wu HT, Lu Y, Barik A, et al. beta-Catenin gain-of-function in muscles impairs neuromuscular junction formation. Development. 2012;139(13):2392-2401.
• Mei L, Xiong WC. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci. 2008;9(6):437-452.
• Fishbach GD. Preview: Neuregulin-1 and GABA release. Neuron. 2007;54(4):495-497.
• Role LW, Talmage DA. News and View: Neuregulin-1 and GABA release. Nature. 2007;448:263.
• Xiong WC, Mei L. An unconventional role of neurotransmission in synapse formation. Neuron. 2005;46(4):521-523.