赵经纬

赵经纬博士于2014年5月从英国剑桥大学回到浙江大学，现任浙江大学基础医学系神经科学研究中心教授、PI、博士生导师。研究兴趣是研究髓鞘损伤的神经生物学机制，探索促进少突胶质细胞前体细胞修复受损髓鞘的新策略。共发表SCI原著论文20篇，合计影响因子为102，H index为15。目前发表的论文被引用超过900次。发表的论文4次被选为封面图片，4篇论文配发编者按，2篇论文被Faculty 1000评为必读论文，其中1篇发表于2012年Cell Stem Cell的论文被Science杂志以研究亮点配发专文述评，并被国际专业学会评为“2012年关于多发性硬化症的最佳基础科学论文”。该论文首次揭示了年轻的血液能够显著增强老年神经胶质细胞前体细胞的髓鞘修复能力。与同事一起进一步证明了年轻的巨噬细胞特异性极化可以增强髓鞘修复能力（Nature Neuroscience, 2013）。上述论文被国际同行广泛认可，分别被他引超过180次和220次。是中国神经科学学会胶质细胞分会委员、浙江省神经科学学会理事、浙江省解剖学会理事。在2016年3月在广州举行的“中英神经胶质细胞俱乐部2016年年会”上担任中方执行主席。

• 1997-2000: 第四军医大学梁銶琚脑研究中心和中科院上海生理研究所联合培养，医学博士学位
• 1992-1995: 第四军医大学梁銶琚脑研究中心,医学硕士学位
• 1986-1992: 第四军医大学六年制医疗系，医学学士学位
• 2014-至今：浙江大学医学院基础医学系，教授，博导，神经科学研究所PI
• 2004-2014：英国剑桥大学脑修复中心、MRC-Wellcome Trust剑桥干细胞研究所、MRC再生医学中心先后任Research Associate、Senior Research Fellow。
• 2000-2004: 复旦大学副教授，硕士生导师，复旦大学神经生物学研究所。
• 1995-1997: 第四军医大学梁銶琚脑研究中心，历任助教、讲师。

• 2006年: 国家教育部2006年自然科学一等奖，获奖人：杨雄里，杜久林，韩明虎，赵经纬，张道启，《抑制性神经递质GABA和甘氨酸在视网膜信号处理中的作用》
• 2006年: 上海市2006年自然科学一等奖，获奖人：杨雄里，杜久林，韩明虎，赵经纬，张道启。
• 2002年: 上海市政府科技启明星称号

• 2015-2017: 课题负责人, 国家自然科学基金面上项目, 25万元
• 2001-2004: 课题负责人, 国家自然科学基金面上项目，20万元
• 2002-2004: 课题负责人, 上海市科技启明星研究基金，12万元
• 2002-2004: 课题负责人,英国联合利华国际研究与发展基金会，15万元。
• 2000-2005: 国家973计划项目《脑功能与脑重大疾病的基础研究》的研究骨干之一，项目经费1200万元

1. Julia M Ruckh, Jing-Wei Zhao, Jennifer L Shadrach, et al. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell, 2012, 10: 96-103. (共同第一作者, IF 22.27; with Editor's note; highlighted by Faculty 1000; highlighted by Science; 被评为“2012年度发表的关于多发性硬化症研究的最佳论文”) 他引约180次。
2. Jing-Wei Zhao, Sean C Dyson, Christina Kriegel, et al. Modelling of a nanotherapeutic "stroma" to deliver LIF, or XAV939, for promotion of human fetal dopaminergic cells in treatment of Parkinson's disease. Disease Models & Mechanisms, 2014, 7(10):1193-203. (共同第一作者, IF 4.97, with Editor's note, 杂志封面图片)。
3. Jing-Wei Zhao, Ruma-Raha Chowdhury, James W Fawcett, et al. Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. European Journal of Neuroscience, 2010, 29: 1853-69. (共同通讯作者, highlighted in “news and views” by Nature Neuroscience, IF 3.18) 他引约50次。
4. Veronique E Miron, Amanda Boyd, Jing-Wei Zhao, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nature Neuroscience, 2013, 16(9):1211-18. (IF 16.10) 他引约220次。
5. Jing-Wei Zhao, Jiu-Lin Du, Ji-Shuo Li, et al. Expression of GABA transporters on bullfrog retinal Müller cells. Glia, 2000, 31 (2): 104-117. (杂志封面图片, IF 6.03) 他引约30次。
6. Jing-Wei Zhao, Xiong-Li Yang. Glutamate transporter EAAC1 is expressed on Müller cells of lower vertebrate retinas. Journal of Neuroscience Research, 2001, 66(1):89-95. (IF 2.97) 他引约20次。
7. Hong-Ping Xu*, Jing-Wei Zhao*, Xiong-Li Yang. Cholinergic and dopaminergic amacrine cells differentially express calcium channel subunits in the rat retina. Neuroscience, 2003, 118:763-768. (共同通讯作者, IF 3.34) 他引30次。
8. Miao Tian, Ling Chen, Jun-Xia Xie, et al. Expression patterns of inwardly rectifying potassium channel subunits in rat retina. Neuroscience Letters, 2003, 345:9-12. (通讯作者, IF 2.03) 他引16次。
9. Michael Fricker, Jonas J Neher, Jing-Wei Zhao, et al. MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. Journal of Neuroscience, 2012, 32(8):2657–2666. (IF 6.34) 他引约60次。
10. Jonas J Neher, Neniskyte U, Jing-Wei Zhao, et al. Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. Journal of Immunology, 2011, 186: 4973-4983. (IF 4.92) 他引约100次。
11. Fael Al-Mayhani TM, Siolian L Ball, Jing-Wei Zhao, et al. An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. Journal of Neuroscience Methods, 2009, 176(2): 192-99. (IF 2.11) 他引约80次。
12. Wei-Li Kuan, Jing-Wei Zhao, Roger A Barker. The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease... Psychopharmacology, 2008, 197(2): 279-93. (IF 4.70) 他引30次。
13. Jian Liu, Jing-Wei Zhao, Jiu-Lin Du, et al. Functional GABA(B) receptors are expressed at the cone photoreceptor terminals in bullfrog retina. Neuroscience, 2005, 132(1):103-13. (IF 3.34)
14. Li-Ya Xu, Jing-Wei Zhao, Xiong-Li Yang. GLAST expression on bullfrog Muller cells is regulated by dark/light. Neuroreport, 2004, 15(16): 2451-4. (杂志封面图片)。
15. Ling Chen, Yong-Cun Yu, Jing-Wei Zhao, et al. Inwardly rectifying potassium channels in rat retinal ganglion cells. European Journal of Neuroscience, 2004, 20(4): 956-64. (IF 3.18) 他引约30次。
16. Li-Hui Cao, Yong-Chun Yu, Jing-Wei Zhao, et al. Expression of natriuretic peptides in rat Muller cells. Neuroscience Letters, 2004, 365(3): 176-9. (IF 2.03) 他引约20次。
17. Miao Tian, Jing-Wei Zhao, Xiong-Li Yang, et al. Differential expression of voltage-gated potassium channel subunits on cholinergic and dopaminergic amacrine cells in rat retina. Neuroreport, 2003, 14:1763-1766. (杂志封面图片)
18. Hong-Ping Xu, Jing-Wei Zhao, Xiong-Li Yang. Expression of voltage-dependent calcium channel subunits in the rat retina. Neuroscience Letters, 2002, 329: 297-300. (IF 2.03) 他引约50次。
19. Ilias Kazanis, Natalia Gorenkova, Jing-Wei Zhao, et al. The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to areas of damage to their niche. Experimental Neurology, 2013, 248:387-397. (IF 4.70)。
20. Ruma Raha-Chowdhury, Animesh A Raha, Serhiy Forostyak, Jing-Wei Zhao, et al. Expression and cellular localization of hepcidin mRNA and protein in normal rat brain. BMC Neuroscience, 2015, 16(1):24. (IF 2.65).

• Ruckh JM, Zhao JW, Shadrach JL, et al. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell. 2012;10(1):96-103.
• Zhao JW, Dyson SC, Kriegel C, et al. Modelling of a nanotherapeutic 'stroma' to deliver LIF, or XAV939, for promotion of human fetal dopaminergic cells in treatment of Parkinson's disease. Dis Model Mech. 2014;7(10):1193-1203.
• Zhao JW, Raha-Chowdhury R, Fawcett JW, Watts C. Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. Eur J Neurosci. 2010;29(9):1853-1869.
• Miron VE, Boyd A, Zhao JW, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 2013;16(9):1211-1218.
• Zhao JW, Du JL, Li JS, Yang XL. Expression of GABA transporters on bullfrog retinal Müller cells. Glia. 2000;31(2):104-117.
• Zhao JW, Yang XL. Glutamate transporter EAAC1 is expressed on Müller cells of lower vertebrate retinas. J Neurosci Res. 2001;66(1):89-95.
• Xu HP, Zhao JW, Yang XL. Cholinergic and dopaminergic amacrine cells differentially express calcium channel subunits in the rat retina. Neuroscience. 2003;118(3):763-768.
• Tian M, Chen L, Xie JX, et al. Expression patterns of inwardly rectifying potassium channel subunits in rat retina. Neurosci Lett. 2003;345(1):9-12.
• Fricker M, Neher JJ, Zhao JW, et al. MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. J Neurosci. 2012;32(8):2657-2666.
• Neher JJ, Neniskyte U, Zhao JW, et al. Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol. 2011;186(9):4973-4983.
• Al-Mayhani TMF, Ball SL, Zhao JW, et al. An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. J Neurosci Methods. 2009;176(2):192-199.
• Kuan WL, Zhao JW, Barker RA. The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease... Psychopharmacology. 2008;197(2):279-293.
• Liu J, Zhao JW, Du JL, Yang XL. Functional GABA(B) receptors are expressed at the cone photoreceptor terminals in bullfrog retina. Neuroscience. 2005;132(1):103-113.
• Xu LY, Zhao JW, Yang XL. GLAST expression on bullfrog Muller cells is regulated by dark/light. Neuroreport. 2004;15(16):2451-2454.
• Chen L, Yu YC, Zhao JW, Yang XL. Inwardly rectifying potassium channels in rat retinal ganglion cells. Eur J Neurosci. 2004;20(4):956-964.
• Cao LH, Yu YC, Zhao JW, Yang XL. Expression of natriuretic peptides in rat Muller cells. Neurosci Lett. 2004;365(3):176-179.
• Tian M, Zhao JW, Yang XL, Xie JX. Differential expression of voltage-gated potassium channel subunits on cholinergic and dopaminergic amacrine cells in rat retina. Neuroreport. 2003;14(13):1763-1766.
• Xu HP, Zhao JW, Yang XL. Expression of voltage-dependent calcium channel subunits in the rat retina. Neurosci Lett. 2002;329(3):297-300.
• Kazanis I, Gorenkova N, Zhao JW, et al. The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to areas of damage to their niche. Exp Neurol. 2013;248:387-397.
• Raha-Chowdhury R, Raha AA, Forostyak S, et al. Expression and cellular localization of hepcidin mRNA and protein in normal rat brain. BMC Neurosci. 2015;16(1):24.
• Franklin RJM, ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci. 2008;9(11):839-855.
• Nave KA, Werner HB. Myelination of the nervous system: mechanisms and functions. Annu Rev Cell Dev Biol. 2014;30:503-533.
• 陈忠, 赵经纬. 髓鞘修复与多发性硬化治疗新策略. 中国科学: 生命科学. 2016;46(4):390-398.
• 杨雄里, 赵经纬. 视网膜神经递质和调质系统的研究进展. 生理科学进展. 2005;36(1):1-6.