周俭民
周俭民 博士简介：
周俭民 博士，高级研究员；
研究经历:
2004- ,中国北京生命科学研究所工作，高级研究员
2002- , 堪萨斯州立大学植物病理系，副教授
1997-2002，堪萨斯州立大学植物病理系，助理教授
1994-1997，普渡大学，博士后，研究助理
1989-1994，普渡大学，博士生，研究助理
1987-1989，中国科学院遗传研究所，研究助理
1984-1987，中国科学院遗传研究所，硕士生，研究助理
研究概述 :
周俭民博士实验室主要从事植物与微生物间相互作用机理的研究。植物可以感受病原菌的入侵，并且启动防卫反应成功地抵御病原菌的感染。同样，病原菌能够感受植物寄主来激活毒性机制感染寄主，引发病害。在漫长的历史长河中，植物和病原微生物协同进化，抗性机制和毒性机制互相制约。
当前的研究主要集中于拟南芥和假单孢杆菌间互作的模式体系。假单孢杆菌包括至少50个不同的pathovar，每个pathovar都有一个特定感染的寄主范围。像其他的很多革兰氏阴性细菌一样，假单孢杆菌通过细菌三型分泌系统将许多效应蛋白直接分泌到寄主细胞。每种病原菌携带一套不同的效应因子, 这些效应因子决定了它们的寄主范围。编码三型分泌系统及其效应因子的基因受未知的寄主信号激活而表达。在寄主细胞里，这些效应蛋白协同作用而促进病原菌的寄生。
实验室主要基于下述方面的研究来阐释植物病理学中的一些基本问题。植物是怎样感受病原菌并激活先天免疫反应的？病原菌是怎样感受寄主并激活其毒性机制的？病原菌寄主范围的决定因素是什么？寄主的免疫机制和病原菌毒性机制是如何相互作用的？
近期发表研究论文：
1. Fangming Xiao, S. Mark Goodwin, Yanmei Xiao, Zhaoyu Sun, Douglas Baker, Xiaoyan Tang, Matthew A. Jenks, and Jian-Min Zhou (2004) Arabidopsis CYP86A2 represses Pseudomonas syringae type III genes and is required for cuticle development. EMBO J., in press.
2. Thara K. Venkatappa, Alexander R. Seilaniantz, Youping Deng, Yinghua Dong, Yinong Yang, Xiaoyan Tang, and Jian-Min Zhou (2004) Tobacco Genes Induced by the Bacterial Effector Protein AvrPto. MPMI, in press.
3. Ping He, Satya Chintamanani, Zhongying Chen, Lihuang Zhu, Barbara N. Kunkel, James R. Alfano, Xiaoyan Tang, and Jian-Min Zhou (2004). Activation of a COI1-dependent pathway in Arabidopsis by Pseudomonas syringae type III effectors and coronatine. The Plant Journal, 37, 589-602.
4. Li Kang, Jianxiong Li, Tiehan Zhao, Fangming Xiao, Xiaoyan Tang, Roger Thilmony, ShengYang He, and Jian-Min Zhou (2003). Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence. PNAS, 100, 3519-3524.
5. Jian-Min Zhou and Xiaoyan Tang (2002). Plant disease resistance genes in gene-for-gene resistance and general resistance. In: Andrew J. Wood ed. Biochemical and Molecular Responses of Plants to the Environment, Biochemical & Molecular Responses of Plants to the Environment. Research Signpost, Trivandrum India. pp127. ISBN: 81-7736-167-8.
6. Ping He, Bernd Friebe, Bikram Gill, and Jian-Min Zhou (2003). Allopolyploidy alters gene expression in the highly stable hexaploid wheat. Plant Molecular Biology, 52, 401-414.
7. Thara Venkatappa, John Fellers, and Jian-Min Zhou (2003). In planta induced genes of Puccinia triticina. Molecular Plant Pathology, 4, 51-56.
8. Fangming Xiao, Ming Lu, Tiehan Zhao, Xiaoyan Tang, and Jian-Min Zhou (2003). Pto mutants differentially activate Prf-dependent, AvrPto-independent resistance and gene-for-gene resistance. Plant Physiology, 131, 1239-1249.
9. Jianxiong Li, Libo Shan, Jian-Min Zhou, and Xiaoyan Tang (2002). Overexpression of Pto induces a salicylate-independent cell death but inhibits necrotic lesions caused by salicylate deficiency in tomato plants. MPMI, 15, 654-661.
10. Fang-Ming Xiao, Xiaoyan Tang, and Jian-Min Zhou (2001). Expression of 35S::Pto globally activates defense gene expression in tomato plants. Plant Physiology, 126, 1637-1645.
11. Ping He, Randall F. Warren, Libo Shan, Tiehan Zhao, Lihuang Zhu, Xiaoyan Tang, and Jian-Min Zhou (2001). Overexpression of Pti5 potentiates pathogen-induced defense gene expression in tomato. MPMI 14, 1453-1457.
12. Ming Lu, Xiaoyan Tang, and Jian-Min Zhou. (2001) Arabidopsis NHO1 is required for general resistance against Pseudomonas bacteria. Plant Cell, 13, 437-447.
13. Libo Shan, Venkatappa Thara, Gregory Martin, Jian-Min Zhou, and Xiaoyan Tang (2000). The Pseudomonas AvrPto protein is differentially recognized by tomato and tobacco and is
localized to the plant plasma membrane. Plant Cell, 12, 2323-2338.
14. Libo Shan, Ping He, Jian-Min Zhou, and Xiaoyan Tang (2000). A cluster of mutations disrupt the avirulence but not the virulence function of AvrPto. MPMI 13, 592-598.
15. Yong-Qiang Gu, Caimei Yang, Venkatappa Thara, Jian-Min Zhou, and Gregory Martin (2000). Pti4 is induced by ethylene and salicylic acid, and its product is phosphorylated by the Pto kinase. Plant Cell 12, 771-785.
周俭民 博士，高级研究员；
研究经历:
2004- ,中国北京生命科学研究所工作，高级研究员
2002- , 堪萨斯州立大学植物病理系，副教授
1997-2002，堪萨斯州立大学植物病理系，助理教授
1994-1997，普渡大学，博士后，研究助理
1989-1994，普渡大学，博士生，研究助理
1987-1989，中国科学院遗传研究所，研究助理
1984-1987，中国科学院遗传研究所，硕士生，研究助理
研究概述 :
周俭民博士实验室主要从事植物与微生物间相互作用机理的研究。植物可以感受病原菌的入侵，并且启动防卫反应成功地抵御病原菌的感染。同样，病原菌能够感受植物寄主来激活毒性机制感染寄主，引发病害。在漫长的历史长河中，植物和病原微生物协同进化，抗性机制和毒性机制互相制约。
当前的研究主要集中于拟南芥和假单孢杆菌间互作的模式体系。假单孢杆菌包括至少50个不同的pathovar，每个pathovar都有一个特定感染的寄主范围。像其他的很多革兰氏阴性细菌一样，假单孢杆菌通过细菌三型分泌系统将许多效应蛋白直接分泌到寄主细胞。每种病原菌携带一套不同的效应因子, 这些效应因子决定了它们的寄主范围。编码三型分泌系统及其效应因子的基因受未知的寄主信号激活而表达。在寄主细胞里，这些效应蛋白协同作用而促进病原菌的寄生。
实验室主要基于下述方面的研究来阐释植物病理学中的一些基本问题。植物是怎样感受病原菌并激活先天免疫反应的？病原菌是怎样感受寄主并激活其毒性机制的？病原菌寄主范围的决定因素是什么？寄主的免疫机制和病原菌毒性机制是如何相互作用的？
近期发表研究论文：
1. Fangming Xiao, S. Mark Goodwin, Yanmei Xiao, Zhaoyu Sun, Douglas Baker, Xiaoyan Tang, Matthew A. Jenks, and Jian-Min Zhou (2004) Arabidopsis CYP86A2 represses Pseudomonas syringae type III genes and is required for cuticle development. EMBO J., in press.
2. Thara K. Venkatappa, Alexander R. Seilaniantz, Youping Deng, Yinghua Dong, Yinong Yang, Xiaoyan Tang, and Jian-Min Zhou (2004) Tobacco Genes Induced by the Bacterial Effector Protein AvrPto. MPMI, in press.
3. Ping He, Satya Chintamanani, Zhongying Chen, Lihuang Zhu, Barbara N. Kunkel, James R. Alfano, Xiaoyan Tang, and Jian-Min Zhou (2004). Activation of a COI1-dependent pathway in Arabidopsis by Pseudomonas syringae type III effectors and coronatine. The Plant Journal, 37, 589-602.
4. Li Kang, Jianxiong Li, Tiehan Zhao, Fangming Xiao, Xiaoyan Tang, Roger Thilmony, ShengYang He, and Jian-Min Zhou (2003). Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence. PNAS, 100, 3519-3524.
5. Jian-Min Zhou and Xiaoyan Tang (2002). Plant disease resistance genes in gene-for-gene resistance and general resistance. In: Andrew J. Wood ed. Biochemical and Molecular Responses of Plants to the Environment, Biochemical & Molecular Responses of Plants to the Environment. Research Signpost, Trivandrum India. pp127. ISBN: 81-7736-167-8.
6. Ping He, Bernd Friebe, Bikram Gill, and Jian-Min Zhou (2003). Allopolyploidy alters gene expression in the highly stable hexaploid wheat. Plant Molecular Biology, 52, 401-414.
7. Thara Venkatappa, John Fellers, and Jian-Min Zhou (2003). In planta induced genes of Puccinia triticina. Molecular Plant Pathology, 4, 51-56.
8. Fangming Xiao, Ming Lu, Tiehan Zhao, Xiaoyan Tang, and Jian-Min Zhou (2003). Pto mutants differentially activate Prf-dependent, AvrPto-independent resistance and gene-for-gene resistance. Plant Physiology, 131, 1239-1249.
9. Jianxiong Li, Libo Shan, Jian-Min Zhou, and Xiaoyan Tang (2002). Overexpression of Pto induces a salicylate-independent cell death but inhibits necrotic lesions caused by salicylate deficiency in tomato plants. MPMI, 15, 654-661.
10. Fang-Ming Xiao, Xiaoyan Tang, and Jian-Min Zhou (2001). Expression of 35S::Pto globally activates defense gene expression in tomato plants. Plant Physiology, 126, 1637-1645.
11. Ping He, Randall F. Warren, Libo Shan, Tiehan Zhao, Lihuang Zhu, Xiaoyan Tang, and Jian-Min Zhou (2001). Overexpression of Pti5 potentiates pathogen-induced defense gene expression in tomato. MPMI 14, 1453-1457.
12. Ming Lu, Xiaoyan Tang, and Jian-Min Zhou. (2001) Arabidopsis NHO1 is required for general resistance against Pseudomonas bacteria. Plant Cell, 13, 437-447.
13. Libo Shan, Venkatappa Thara, Gregory Martin, Jian-Min Zhou, and Xiaoyan Tang (2000). The Pseudomonas AvrPto protein is differentially recognized by tomato and tobacco and is
localized to the plant plasma membrane. Plant Cell, 12, 2323-2338.
14. Libo Shan, Ping He, Jian-Min Zhou, and Xiaoyan Tang (2000). A cluster of mutations disrupt the avirulence but not the virulence function of AvrPto. MPMI 13, 592-598.
15. Yong-Qiang Gu, Caimei Yang, Venkatappa Thara, Jian-Min Zhou, and Gregory Martin (2000). Pti4 is induced by ethylene and salicylic acid, and its product is phosphorylated by the Pto kinase. Plant Cell 12, 771-785.
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