周虎

周虎博士、副教授，2005年毕业于清华大学生物科学与技术系，获理学博士学位。2005年起在美国加利福尼亚州Sanford-Burnham医学研究所从事博士后研究。目前任厦门大学药学院副教授。主要从事细胞信号传导，核受体，以及抗肿瘤药物的研究。论文发表在Science，Cancer Cell，Cancer Research，the Journal of Biological Chemistry，FASEB J，Oncogene等国际前沿期刊。研究成果获得过2004年度教育部中国高校十大科技进展。

• 2001-2005 清华大学，生物学，理学博士
• 1998-2001 徐州医学院，生物化学与分子生物学，理学硕士
• 1992-1996 安徽大学，生物化学，理学学士

• 以细胞信号传导和核受体为研究对象，探寻肿瘤及其他疾病发生发展过程中的分子变化方式、程序和机制。
• 研究一些疾病之间的相互关联方式和转化机制，如炎症与肿瘤，并且寻找有效的治疗靶点和方法。
• 寻找新的核受体调节配体分子和细胞信号传导调控分子，研发新的靶点药物。

1. Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK, Zeng JZ. Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells. FASEB J. 2011, 25(1):192-205.
2. Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010, 17(6):560-573. (co-first authors)
3. Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK, Zeng JZ. Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma. Cancer Res. 2010, 70(6):2285-2295.
4. Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, Zeng JZ, Zhang XK. A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations. J Biol Chem. 2009, 284(27):18503-18514.
5. Su Y, Zhang L, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J. 2007, 21(3):682-690.
6. Pei DS, Fu Y, Sun YF, Hu SQ, Zhou H, Lu L, Zhao HR. Cys74 and Cys163 are necessary for IL-18 to elicit IFN-gamma production from peripheral blood lymphoid mononuclear cells. Mol Immunol. 2005, 42(11):1367-1373.
7. Zhang L X, Zhou H, Su Y, Sun Z H, Zhang H W, Zhang L, Zhang Y, Ning Y H, Chen Y G, Meng A M. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science. 2004, 306(5693):114-117. (co-first authors)
8. Zhou H, Lu L, Pei D S, Zhao H R. Murine interleukin-18 cDNA cloning and its expression in murine H22 hepatocarcinoma cell. Immunological Journal. 2002, 18(3). In Chinese.
9. Zhou H, Zhao H R, Pei D S, Lu L, Hu S Q. Expression and purification of murine interleukin 18 in Escherichia coli and its antitumor effects. Chinese Journal of Biotechnology. 2001, 17(5):548-552. In Chinese.
10. Chen Y, Li Y K, Bao S L, Zhou H. The property of Glycoproteins separated and purified from Baitouweng. Chinese Journal of Biochemical Pharmaceutics. 1997, 18(4):180-183. In Chinese.

电话：0592-2182552 ADSFAEQWER353423413434

E-mail：huzhou@xmu.edu.cn

• Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK, Zeng JZ. Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells. FASEB J. 2011, 25(1):192-205.
• Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010, 17(6):560-573.
• Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK, Zeng JZ. Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma. Cancer Res. 2010, 70(6):2285-2295.
• Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, Zeng JZ, Zhang XK. A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations. J Biol Chem. 2009, 284(27):18503-18514.
• Su Y, Zhang L, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J. 2007, 21(3):682-690.
• Pei DS, Fu Y, Sun YF, Hu SQ, Zhou H, Lu L, Zhao HR. Cys74 and Cys163 are necessary for IL-18 to elicit IFN-gamma production from peripheral blood lymphoid mononuclear cells. Mol Immunol. 2005, 42(11):1367-1373.
• Zhang LX, Zhou H, Su Y, Sun ZH, Zhang HW, Zhang L, Zhang Y, Ning YH, Chen YG, Meng AM. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science. 2004, 306(5693):114-117.
• Zhou H, Lu L, Pei DS, Zhao HR. Murine interleukin-18 cDNA cloning and its expression in murine H22 hepatocarcinoma cell. Immunological Journal. 2002, 18(3).
• Zhou H, Zhao HR, Pei DS, Lu L, Hu SQ. Expression and purification of murine interleukin 18 in Escherichia coli and its antitumor effects. Chinese Journal of Biotechnology. 2001, 17(5):548-552.
• Chen Y, Li YK, Bao SL, Zhou H. The property of Glycoproteins separated and purified from Baitouweng. Chinese Journal of Biochemical Pharmaceutics. 1997, 18(4):180-183.
• Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev. 2006;58(4):760-772.
• Chen L, Wang ZG, Aleshin A, Chen F, Chen J, Jiang F, Alkan S, Zhang XK, Xu H. Sulfasalazine inhibits the growth of colorectal cancer cell lines via suppression of nuclear factor-κB and induction of apoptosis. Cancer Biol Ther. 2007;6(2):237-243.
• 韩玉华, 周虎, 张晓坤. 核受体RXRα在肿瘤发生发展中的作用研究进展. 中国药理学通报. 2011;27(1):1-4.
• 吴昊, 周虎, 曾锦章. Nur77与β-连环蛋白在结肠癌中的相互作用研究. 中国科学:生命科学. 2010;40(10):945-952.