罗敏敏

罗敏敏博士1973年出生于中国江西，1995年毕业于北京大学，2000年获美国宾夕法尼亚大学神经科学博士。现为北京脑科学与类脑研究中心资深研究员、联合主任，同时担任北京生命科学研究所资深研究员、清华大学教授。        自2004年以来，罗敏敏博士主要致力探索感觉信号及奖惩信号处理的神经机制及相关环路与人类精神疾病的关系研究。在过去的十几年中，罗敏敏博士领导的研究

罗敏敏

生理和行为机制的研究上取得了一系列国际同行公认的创新性成果：发现了中缝背核五羟色胺神经元编码奖赏并提出此类神经元编码环境有益性的理论，发现了内侧缰核、脚间核、下丘脑侧核及中脑多巴胺系统在奖惩行为中的作用，同时在对一些人类重要精神疾病的遗传

学研究、药物靶点的确认、和小分子化学药物的寻找等方面取得了初步成绩，在精神疾病的治疗和药物开发上具有可观的应用前景。以通讯作者发表包括Science （3篇）、Cell（1篇）、Neuron（11篇）、Nature Methods（2篇）、Journal of Neuroscience（8篇）、PNAS （2篇）等一流期刊发表论文70多篇，总被引5000多次。

Minmin Luo, Ph.D. Investigator, NIBS, Beijing, China 

Phone：010-80726688 

Fax： 010-80723342

E-mail：luominmin@nibs.ac.cn

2000 美国宾夕法尼亚大学神经学博士
Ph. D. Neuroscience, 2000, University of Pennsylvania, USA

1997 美国宾夕法尼亚大学 计算机科学硕士
M.S. Computer Science, 1997，University of Pennsylvania, USA

1995 北京大学心理学学士
B.S. Psychology，1995，Peking University, China

2013-present 北京生命科学研究所资深研究员 Investigator, National Institute of Biological Sciences, Beijing, China 

2010-2013 北京生命科学研究所高级研究员 Associate Investigator in the National Institute of Biological Sciences, Beijing, China 

2005-2010 北京生命科学研究所研究员 Assistant Investigator in the National Institute of Biological Sciences, Beijing, China Recipient of HFSP Young Investigators Award (2006-2009) and NSFC Young Investigator Award (2006-2009) 

2004 -2005 中科院神经科学研究所研究员 Investigator in the Institute of Neuroscience of Chinese Academy of Sciences 

2000-2004 杜克大学神经生物学系博士后 Postdoctoral Fellow with Lawrence C. Katz in HHMI and the Department of Neurobiology, Duke University, USA Recipient of

本实验室目前主要研究两个相关的神经生物学问题：

 奖赏与惩罚驱使动物接近或逃避、产生快乐与痛苦、并指导学习与记忆形成。奖赏与惩罚关乎动物的生死与种系繁衍、并在人类的日常生活中影响情绪与情感。小鼠与人有类似的神经环路，并对奖赏与惩罚有相似的行为反应。我们实验室以转基因小鼠为模型，研究哺乳动物处理奖赏与惩罚的神经环路机制，特别是中缝背核及内侧缰核两个脑区及相连的神经环路的作用。我们运用电生理和光学成像，从清醒小鼠中记录特定类型神经元的在奖赏与惩罚相关行为中的反应特点。继而运用光遗传学及化学遗传学手段，检测激活、抑制、损毁相关神经元对于行为的影响。我们也利用全细胞膜片钳和光学成像等手段，探索不同药物及细胞信号转导途径在奖赏与惩罚行为中的作用及分子细胞机制。脑内处理奖赏与惩罚的神经环路异常导致多种人类精神疾病，包括抑郁、精神分裂、药物成瘾等。因此，我们的工作不仅有助于理解与奖赏与惩罚相关行为的神经生物学基础，亦可具有临床意义。

Reward and punishment motivate animal behaviors, produce the feelings of pleasure and disappointment, and guide learning and memory formation. They are a matter of life and death for an individual as well as the species, and affect mood and emotion in our daily life. Mice share with humanskey features of reward- and punishment-related behaviors and theunderlying neural pathways. Using genetically modified mice as the model system, my laboratory studies how neural circuits organize behavioral responses to reward and punishment. At present we focus on the dorsal raphe nucleus and the medial habenula, as well as their interconnected brain areas. Using electrophysiological and optical approaches, we record the activity patterns of genetically identified neuron types from behaving mice. We also combine optogenetics and chemogenetics to examine how stimulation, inhibition, or lesion of specific neurons affects animal behaviors. Finally, we carry out whole-cell patch recordings from brain slices to study the effects of drugs and cellular signal transduction pathways. The dysfunctions of reward and punishment processing are associated with several devastating psychiatric disorders, such as depression, schizophrenia, and drug addiction. Thus, our study not only help understand the neurobiological basis of some fundamental animal behaviors but also may facilitate clinical efforts toward the cure of mental diseases.

 主持和参与的重大科研项目

起始年份     项目类别      项目来源     项目编号      扮演角色

2008          863计划          科技部      2008AA022312       主持

2008          863计划          科技部      2008AA022902       主持

2010          973计划          科技部      2010CB833902       主持

2012          973计划          科技部      2012CB837700       主持

2012         China MOST        科技部      2012CB837701       参与

2012         China MOST        科技部      2012YQ03026005     参与

2013      国家科技重大专项     科技部      2013ZX09509102     参与

2013         China MOST        科技部      2013ZX0950910      参与

2015         China MOST        科技部      2015BAI08B02       参与

2015        重大研究计划   国家自然科学基金  91432114         主持

1.  2018年入选“臻溪生命学者”；

2.  2016年入选The 16th Wu Jieping-Paul Janssen Medical & Pharmaceutical Award (吴阶平-保罗×杨森医学药学奖), the International Exchange and CooperationCenter of the Ministry of Health,China;

3.  国家杰出青年科学基金 (2006-2009) ;

4.  2015年入选“北京学者”人才培养计划；

5.  Human FrontierScience Program Young Investigator Grants (2006-2008);

6.  2011年中国青年科技奖;

7.  2009年首届张香桐青年神经科学家奖;

8.  2016年入选第二批国家“万人计划”领军人才;

9.  2011年药明康德生命化学研究奖二等奖;

10.2011年入选“北京市海外高层次人才”（海聚人才工程，北京市特聘专家);

11.  2002年Burroughs Wellcome Fund Career Award in the BiomedicalSciences;

12.  2013年入选国家人社部“百千万人才工程”及“有突出贡献中青年专家”；

13.  2014年入选国家科技部“创新人才推进计划中青年科技创新领军人才”；

14.  1994-2013国家杰出青年基金20周年巡礼资助人介绍（生命科学领域共20人）；

15.  中国神经科学学会常务理事、副理事长；

16.  美国Society forNeuroscience Program Committee Theme Chair

17.  Neuron EditorialBoard Member

18.  Journal ofNeurophysiology Board Member

19.  Frontier in NeuralCircuit Board Member and Guest Associate Editor

20.  2007科技导报中国十大科技进展之一

 Research Articles

1.    Lin R*CA,Liang J*, Wang R, Yan T, Zhou Y, Liu Y, Feng Q, Li A, Gong H, Luo MCA (2020) Theraphe dopamine system controls the expression of incentive memory. Neurondoi 10.1016/j.neuron.2020.02.009.

2.    Lu L*, Wang R, Luo MCA (2020) Anoptical brain-to-brain interface supports rapid information transmission forprecise locomotion control. Science China Life Sciences doi 10.10.0.7/s11427-020-1675-x.

3.    Lu L*, Ren Y*, Yu T, LiuZ, Wang S, Tan L, Zeng J, Feng Q, Lin R, Liu Y, Guo Q, Luo MCA (2020) Control of locomotor speed,arousal, and hippocampal theta rhythms by the nucleus incertus. NatureCommunications doi 10.1038/s41467-019-14116-y.

4.    Huang L, Xi Y, Peng Y,Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KFCA, Ren CCA(2019) A visual circuit related to habenulaunderlies the antidepressive effects of light therapy. Neuron102, 128-142. e8

5.    Sun Q, Li X, Ren M, Zhao M, Zhong Q, Ren Y, Luo P,Ni H, Zhang X, Zhang C, Yuan J, Li A, LuoM, Gong H, Luo QCA (2019) A whole-brain map of long-rangeinputs to GABAergic interneurons in the mouse medialprefrontal cortex. Nature Neurosci doi 10.1038/s41593-019-0429-9.

6.    Li Y,Liu Z, Guo Q, Luo M (2019) Long-term Fiber Photometry for Neuroscience Studies NeuroscienceBulletin 35, 425-433.

7.    Ren J, Isakova A,Friedmann D, Zeng J, Grutzner S, Pun A, Zhao GQ, Kolluru SS, Wang R, Lin R, LiP, Li A, Raymond JL, Luo Q, Luo M,Quake SR, Luo L (2019) Serotonin Neurons inthe Dorsal and Medial Raphe Nuclei: from Single-Cell Transcriptomes toWhole-Brain Projections. Elife; 8: e49424.

8.    ZhaoY, Liu C, Liu Z, Luo W, Li L, Cai X, Liang D, Su Y, Ding H, Wang Q, Yin L, GuanJ, Luo M, Sheng XCA (2019)Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics inFreely Moving Animals. IEEETransactions on Electron Devices 66(1): 785-792, doi:10.1109/TED.2018.2882397.

9.    Lin R*, Wang R*, Yuan J*,Feng Q, Zhou Y, Zeng S, Ren M, Jiang S, Ni H, Zhou C, Gong HCA,Luo MCA (2018) Cell type- andprojection-specific brain-wide reconstruction of single neurons. NatureMethods 15: 1033–1036, doi:10.1038/s41592-018-0184-y.

10.  Wei C*, Han X*,Weng D, Feng Q, Qi X, Li JCA,Luo MCA (2018) Response dynamics of midbrain dopamineneurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA. CellDiscovery 4(1): 60, doi:10.1038/s41421-018-0060-z.

11.  Jing M, Zhang P, Wang G, Jiang H, Mesik L, Feng J, Zeng J, Wang S,Looby J, Guagliardo NA, Langma LW, Lu J, Zuo Y, Talmage DA, Role LW, BarrettPQ, Zhang LI, Luo M, Song Y,Zhu J, Li YCA (2018) A genetically-encoded fluorescent acetylcholineindicator A genetically encoded fluorescent acetylcholine indicator for invitro and in vivo studies. Nature Biotechnology 36(8): 726-737,doi:10.1038/nbt.4184

12.  Ding H, Lu L, Shi Z, Wang D, Li L, Li X, Ren Y, Liu C, Cheng D, KimH, Giebink NC, Wang X, Yin L, Zhao L, LuoM, Sheng XCA (2018) Microscale optoelectronicinfrared-to-visible upconversion devices and their use as injectable lightsources. PNAS 115(26): 6632-6637, doi:10.1073/pnas.1802064115.

13.  Cai D, Yue Y, Su X, Liu M, Wang Y, You L, Xie F, Deng F, Chen F, Luo M, Yuan KCA(2018) Distinct Anatomical Connectivity Patterns Differentiate Subdivisions ofthe Nonlemniscal Auditory Thalamus in Mice. Cerebral Cortex doi:10.1093/cercor/bhy115.

14.  Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi Z, Tang N,Shao F, Luo MCA (2018) A hybridization chain-reaction-based method for amplifyingimmunosignals. Nature Methods 15(4): 275-278, doi:10.1038/nmeth.4611.

15.  Li Y, Zeng J, Zhang J, Yue C, Zhong W, Liu Z, Feng Q, Luo MCA (2018) Hypothalamic Circuits for Predation and Evasion Neuron97: 911–924, doi:10.1016/j.neuron.2018.01.005. Featured with Cover and VideoAbstract.

16.  Ables JL, Görlich Antolin-Fontes B, Wang C, Lipford S, Riad MH, Ren J, Hu F, LuoM, Kenny PJ, Heintz N, Ibañez-Tallon ICA (2017) A Retrograde inhibition by a specificsubset of interpeduncular a5 nicotinicneurons regulates nicotine preference. PNAS114(49): 13012-13017, doi:10.1073/pnas.1717506114.

17.  Qi Z, Guo Q, Liu Q, Chen M, Gong H, Zeng S,Luo Q, Luo M, Fu LCA(2017) GRIN lens based high speed confocal system for deep brain calciumimaging. International Conference on Photonics and Imaging in Biology andMedicine doi:10.1364/PIBM.2017.T1A.4.

18.  Zhong W, Li Y, Feng Q, Luo MCA (2017) Learning and Stress Shape theReward Response Patterns of Serotonin Neurons. J Neurosci 37: 8863-8875.

19.  Luo J., Feng Q, Wei LCA, Luo MCA (2017)Optogenetic activation of dorsal raphe neurons rescues the autistic-like socialdeficits in Shank3 knockout mice. Cell Res 27(7): 950-953,doi:10.1038/cr.2017.52.

20.  Zhao Z, Wang L, Gao W, Hu F, Zhang J, RenY, Lin R, Feng Q, Cheng, M, Ju D, Chi Q, Wang D, Song S, Luo M, Zhan CCA (2017) A centralcatecholaminergic circuit controls blood glucose levels during stress Neuron95(1): 138-152, doi:10.1016/j.neuron.2017.05.031.

21.  Wang D, Li Y, Feng Q, Guo Q, Zhou J, Luo MCA (2017)Learning shapes the aversion and reward responses of lateral habenula neurons. eLife6:e23045.

22.  Huang L, Yuan T, Tan M, Xi Y, Hu Y, Tao Q,Zhao Z, Zheng J, Han Y, Xu F, Luo M,Sollars PJ, Pu M, Pickard GE, So K-FCA, Ren CCA (2017) Aretinoraphe projection regulates serotonergic activity and looming-evokeddefensive behavior Nature Comms 8: 14908, doi:10.1038/ncomms14908.

23.  Ren JCA, Zhang M, Li T, Zhang J,Lin R, Chen S, Luo M, Dong MCA(2016) Quantitative proteomics of sleep-deprived mouse brains reveals globalchanges in mitochondrial proteins. PLoS ONE 11 doi:10.1371/journal.pone.0163500.

24.  ZhangJ, Tan L, Ren Y, Liang J, Lin R, Feng Q, Zhou J, Hu F, Ren J, Wei C, Yu T,Zhuang Y, Bettler B, WangF, Luo MCA (2016) Presynaptic excitation viaGABAB receptors in habenula cholinergic neurons regulates fear memoryexpression. Cell 166: 716–728, doi:10.1016/j.cell.2016.06.026.

25.  Hu R, Zhang J, Luo M, Hu JCA (2016) Response patterns of GABAergicneurons in the anterior piriform cortex of awake mice. Cerebral Cortex doi:10.1093/cercox/bhw175.

26.  Glajch K, Kelver D, Hegeman D, Cui Q,Xenias H, Augustine E, Hernandez V, Verma N, Huang T, Luo M, Justice N, Chan SCA (2016) Npas1+ pallidalneurons target striatal projection neurons. J Neurosci 36(20):5472-5488.

27.  Li Y, Zhong W, Wang D, Feng Q, Liu Z, ZhouJ, Jia C, Hu F, Zeng J, Guo Q, Fu L, LuoMCA (2016) Serotonin neurons in the dorsal raphe nucleusencode reward signals. Nature Comms 7: 10503,doi:10.1038/ncomms10503.

28.  Soria-Gómez E, Busquets-Garcia A, Hu F,Mehidi A, Cannich A, Roux L, Louit I, Alonso L, Wiesner T, Georges F, VerrierD, Vincent P, Ferreira G, Luo M,Marsicano GCA (2015) Habenular CB1 receptors control the expressionof aversive memories. Neuron 88: 306-13,doi:10.1016/j.neuron.2015.08.035.

29.  Guo Q*, Zhou J*, Feng Q,Lin R, Gong H, Luo Q, Zeng S, Luo MCA,Fu LCA (2015) Multi-channel fiber photometry for population neuronalactivity recording. Biomedical Optics Express 6: 3919-3931, doi:10.1364/BOE.6.003919.

30.  Guo Q, Wang D, He X, Feng Q, Lin R, Xu F,Fu L, Luo MCA(2015) Whole-brain mapping of inputs to projection neurons and cholinergicinterneurons in the dorsal striatum. PLoS ONE doi:10.1371/journal.pone.0123381.

31.  Wang D, He X, Zhao Z, Feng Q, Lin R, Sun Y,Ding T, Xu FCA, Luo MCA,Zhan CCA  (2015) Whole-brainmapping of the direct inputs and axonal projections of pro-opiomelanocortin(POMC) and agouti-related peptide (AgRP) neurons. Front. Neuroanat. doi:10.3389/fnana.2015.00040.

32.  Gao L, Jiang Y, Mu L, Liu Y, Wang F, WangP, Zhang A, Tang N, Chen T, Luo M,Yu L, Gao S, Chen LCA (2015) Efficient Generation of Mice withConsistent Transgene Expression by FEEST. Scientific reports 5: 16284.

33.  Zhou J, Jia C, Feng Q, Bao J, Luo MCA (2015)Prospective coding of dorsal raphe reward signals by the orbitofrontal cortex. JNeurosci 35: 2717-2730.

34. Liu Z*,Zhou J*, Li Y, Hu F, Wang D, Lu Y, Ma M, Feng Q, Zhang J,Zeng J, Bao, Kim J, Chen Z, Mestikawy SE,Luo MCA (2014) Dorsal raphe neurons signal reward through 5-HT and glutamate.Neuron81: 1360–1374. (F1000 recommendation)

35. Han Y, Shi Y-F, Xi W, Zhou R, Tan Z-B, Wang H, Li X-M,Chen Z, Feng G, LuoM, Huang Z-L, Duan SCA,Yu Y-QCA (2014) Selective Activation of Cholinergic BasalForebrain Neurons Induces Immediate Sleep-wake Transitions. Current Biology 24: 693–698.

36. Wang S, Tan Y, Zhang J, Luo MCA (2013) Pharmacogenetic activation of midbrain dopamineneurons induces hyperactivity. Neurosci Bulletin 29: 517-524.

37.  Zhan CCA, ZhouJ, Feng Q, Zhang J, Lin S, Bao J, Wu P,Luo MCA (2013) Acute and long-term suppression of feedingbehavior by POMC neurons in the brainstem and hypothalamus, respectively. JNeurosci 33: 3624–3632. (F1000recommendation)

38. Hu F, Ren J, Zhang J, Zhong W, Luo MCA (2012) Atrialnatriuretic peptide blocks synaptic transmission by activatingPhosphodiesterase 2A andeliminating basal PKA activity in presynaptic terminals. PNAS 109: 17681–17686. (F1000recommendation)

39. Ma M, Luo MCA (2012) Optogenetic activation of basalforebrain cholinergic neurons modulates neuronal excitability and sensoryresponses in the main olfactory bulb. JNeurosci 32: 10105-10116.(TWIJ feature article).

40.  Gong R*, Ding C*, HuJ*, Lu Y, Liu F, Mann E, Xu F, Cohen MB and Luo MCA (2011)Role for the membrane receptor guanylyl cyclase-C in attention deficiency andhyperactive behavior. Science 333: 1642-1646.

41.  Zhao S, Ting JT, Atallah HE, Qiu L, Tan J,Gloss B, Augustine GJ, Deisseroth K, LuoM,  Graybiel AM, Feng GCA (2011) Cell type–specificchannelrhodopsin-2 transgenic mice for optogenetic dissection of neuralcircuitry function. Nature Methods 8: 745-752.

42.  Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S,Feng G, Luo MCA(2011) Habenula "cholinergic" neurons co-release glutamate andacetylcholine and activate postsynaptic neurons via distinct transmissionmodes. Neuron 69: 445-452. (Cover; F1000 recommendation)

43.  Zhan C, Luo MCA (2010) Diverse patterns of odorrepresentation by neurons in the anterior piriform cortex of awake mice. JNeurosci 30: 16662–16672.

44.  Han J, LuoMCA (2010) Loss of CO2 sensing by the olfactorysystem of CNGA3 knockout mice. Curr Zoology 56: 793−799.

45.  Gao L, Hu J, Zhong C, Luo MCA (2010) Integration of CO2 andodorant signals in the mouse olfactory bulb. Neuroscience 170: 881–892.

46.  Tan J, Savigner A, Ma M, and Luo MCA (2010) Odorinformation processing by the olfactory bulb analyzed in gene-targeted mice. Neuron65: 912-926. (Video abstract)

47.  Sun L, Wan H, Hu J, Han J, Matsunami H, andLuo MCA (2009)Guanylyl cyclase-D in the olfactory CO2 neurons is activated bybicarbonate. PNAS 106: 2041-2046.

48.  Qin C, LuoMCA (2009)Neurochemical phenotypes of the afferent and efferent projections of the mousemedial habenula. Neuroscience 161: 827-37

49.  Fan S, LuoMCA (2009) The organization of feedback projections in apathway important for processing pheromonal signals. Neuroscience 161: 489-500

50.  Yan Z, Tan J, Qin C, Lu Y, Ding C, and Luo MCA (2008)Precise circuitry links bilaterally symmetric olfactory maps. Neuron58: 613–624. (Featured with a preview)

51.  Bian X, Yanagawa Y, Chen WR, and Luo MCA (2008)Cortical-like functional organization of the pheromone-processing circuits inthe medial amygdala. J Neurophysiol 99: 77-86.

52.  LuoMCA(2008) The Necklace Olfactory System in Mammals. J Neurogenetics 22: 229-238.

53.  Hu J*, Zhong C*, DingC, Chi Q, Walz A, Mombaerts P, Matsunami H, and Luo MCA (2007) Detection of near-atmosphericconcentrations of CO2 by an olfactory subsystem. Science 317: 953-957.

54.  Grosmaitre X, Santarelli LC, Tan J, Luo M, and Ma MCA (2007) Dual functions of mammalianolfactory sensory neurons as odor detectors and mechanical sensors. Nature Neurosci 10: 348-354.

Invited Review

55. Liu Z, Lin R, LuoMCA (2020) RewardContributions to Serotonergic Functions. AnnualReview of Neuroscience. In press.

56.  Lin R, Yan T, Luo MCA (2019) The two faces of PVN CRF neurons. Nature Neuroscience doi:10.1038/s41593-019-0363-x.

57.  Luo F, Wei Y, Wang Z, Luo M,Hu J (2019) Genetically encoded neural activity indicators. BrainScience Advances 4, 1-15.

58.  Luo F, Wei Y, Wang Z, Luo M, Hu JCA (2018) Genetically encoded neuralactivity indicators. Brain Science Advances 4(1): 1-15.

59.  LinRCA, Li Y, Luo M(2018) A Neural Circuit Driving Maternal Behaviors Neuron 98: 7-8, doi:10.1016/j.neuron.2018.03.025.

60.  LuoMCA, Li Y, Zhong W (2016) Do dorsalraphe 5-HT neurons encode “beneficialness”? Neurobiology of Learning andMemory doi:10.1016/j.nlm.2016.08.008.

61.  LuoMCA,Zhou, J, Liu Z (2015) Reward processing by the dorsal raphe nucleus: 5-HT andbeyond. Learning Memory 22: 452-460. doi:10.1101/lm.037317.114. 

62.  LuoMCA (2011) Long-range intracortical excitationshapes olfactory processing. Neuron 72: 1-3. 

63.  LuoMCA, SunL, and Hu J (2009) Neural detection of gases—carbon dioxide, oxygen—invertebrates and invertebrates. Curr Opinion Neurobiol 19: 354-361.

64.  Luo, MCA andKatz LC (2004) Encoding pheromones by the mammalian vomeronasal system. CurrOpinion Neurobiol 14: 428-34.