李载平

李载平 (1925.08.17－)，中国工程院院士，研究员，博士生导师，分子生物学家。1947年毕业于北京大学化学系，1960年上海生物化学研究所研究生毕业。曾任国家生物工程顾问委员会副主任、联合国基因工程生物技术中心(ICGEB)评审组成员、中国遗传学会副理事长、国家863生物技术和国家973人口与健康专家组成员。现已招收培养博士生8名，硕士生21名。

ADFASDFAF23RQ23R

• 肝癌相关基因发现与功能
• 基因功能及其调控
  • 基因功能的蛋白质科学
  • 基因功能的表观遗传调控

分子生物学和基因工程。

• 肝癌新功能基因fup1的功能相关基因，酵母双杂交、FUP1的功能结构域分析、RNAi的抑制。
• 肝癌相关新基因的功能分析。
• 肿瘤新生血管抑制新基因的检定。
• 基因工程药物。

获奖：十五年来获得的系统成果有“酵母丙氨酸转移核糖核酸的人工合成”、“氨基酰－tRNA合成酶及其与相关tRNA的相互作用”、“雄激素对大鼠PSBP基因转录的调控”和“蛋白酶抑制剂的结构与功能”等，共获得各类奖二十九项。 ADFASDFAF23RQ23R

专利：2001年至2005年期间，共有20项发明专利获得授权，31项发明专利正在受理之中。 ADSFAEQWER353423413434

论著：在第四届时段（2001－2005）共发表论文22篇；专著一本（《核糖核酸与核糖核酸组》）。2001年3月在《SCIENCE》上发表的论文“An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats”是我国微观生物学领域在《SCIENCE》上发表的第一个国内独立完成的工作。 ADSFAEQWER353423413434

2005年学术讲座：

ADFASDFAF23RQ23R

• Dr. Du Yanzhi (Shanghai Jiaotong University) Microarray Platform in IHS and Its Applications (2005.12.09.)
• Dr. Guoping Fan (Department of Human Genetics, UCLA, USA) Epigenetic Mechanisms in Neural Development and Stem Cell Differentiation (2005.12.06.)
• Dr. Xin-Hua Lin (Associate Professor; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center University of Saarland) “Patterning the animal body: how do growth factor morphogens work?” (05.11.29)
• Prof. Jorn Walter (University of Saarland, Germany) “Mechanism of Epigenetic Reprogramming in Mammals” (05.11.22.)
• Prof. Bo-liang Li (SLMB) Human acyl-CoA: cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma (2005.11.10.)
• SLMB Annual Lectures: (2005.11.02.)
• Prof. Ding-gan Liu Identification and preliminary functional studies of proteins specifically interacting with C/EBPbeta 3'UTR RNA
• Mr. Fei-long Meng Aging profile of a dimorphic fungus: candida albicans
• Mr. Zhen-hua Xie Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect regulation by DNMT3L
• Mr Zhong-hua Hu Targeted disruption of NDST-1 gene caused multiple abnormalities in mice
• Mr. Xue-ming Mao The CaSwi/Snf complex is required for filaments and virulence in Candida albicans.
• Mr. Tai-chang Yuan Lipid microdomain and regulation of insulin-stimulated glucose transporter translocation
• Mr. Jia Chen Expression regulation and role of human ACAT1 gene
• Ms. Jie Qiu Cloning, identification and function analysis of genes related to hepatocellular carcinoma.
• Dr. Yi-ping Li (Forsyth Institute, Harvard School of Dental Medicine, USA) “Osteoclast and Bone Disease” (05.07.22.)
• Prof. Alex M Kopylov (Moscow State University, Russia) “Application of Small RNA Technology to Study Human Gene Function” (05.07.26)
• Dr. Chenxin Gong (Department of Parasitology, The Rockefeller University) “Telomere Protection in Human and Trypanosome” (05.07.18.)
• Dr. Chenxin Gong (State Institute for Basic Research in Developmental Disabilities, New York and the Graduate Center of the City University of New York) “Deregulation of O-GlcNAcylation of tau protein: A new mechanism of neurodegeneration” (05.07.15)

1. Liang Liang, Mujun Zhao, Zhenhua Xu, Yokoyama K. Kazunari, Tsaiping Li. Molecular cloning and characterization of CIDE-3, a novel member of cell death-inducing DFF45-like effector family. Biochem J. 2003 Feb 15;370:195-203.
2. Zhenhua Xu, Mujun Zhao, Tsaiping Li. p73beta inhibits transcriptional activities of enhancer I and X promoter in hepatitis B virus more efficiently than p73alpha. World J Gastroenterol. 2002 Dec;8(6):1094-7.
3. Wei Pan, Qiang Zhang, Quansheng Xi, Renbao Gan, Tsaiping Li. FUP1, a Gene Associated with Hepatocellular Carcinoma, Stimulates NIH3T3 Cell Proliferation and Tumor Formation in Nude Mice. Biochemical and Biophysical Research Communications, 2001;286(5):1033-1038.
4. Li Xin, Ren Xu, Qiang Zhang, Tsaiping Li, Renbao Gan. Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis. Biochemical and Biophysical Research Communications, 2000;277(1):186-190.
5. Liao Cheng, Zhao Mujun, Song Hai, Kiyoshi Uchida, Kazunari K. Yokoyama, Li Tsaiping. Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma. Hepatology. 2000;32(4):721-727.

• Liang L, Zhao M, Xu Z, et al. Molecular cloning and characterization of CIDE-3, a novel member of cell death-inducing DFF45-like effector family. Biochem J, 2003, 370: 195-203.
• Xu Z, Zhao M, Li T. p73beta inhibits transcriptional activities of enhancer I and X promoter in hepatitis B virus more efficiently than p73alpha. World J Gastroenterol, 2002, 8(6): 1094-1097.
• Pan W, Zhang Q, Xi Q, et al. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. Biochem Biophys Res Commun, 2001, 286(5): 1033-1038.
• Li X, Xu R, Zhang Q, et al. Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis. Biochem Biophys Res Commun, 2000, 277(1): 186-190.
• Liao C, Zhao M, Song H, et al. Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma. Hepatology, 2000, 32(4): 721-727.
• Li ZP. Hepatitis B virus adr subtype genome cloning and sequencing. Sci Sin B, 1985, 28(9): 954-964.
• Wang Y, Li ZP. A novel enhancer element ENII in hepatitis B virus genome. Chin Sci Bull, 1990, 35(15): 1175-1178.
• Li ZP. Advances in gene engineering hepatitis B vaccine. Prog Biochem Biophys, 1993, 20(2): 82-86.
• Pan W, Li ZP. FUP1: a new gene related to hepatocellular carcinoma. GenBank Accession No. AF276753, 2001.