黄俊

黄俊 ADFASDFAF23RQ23R

浙江大学生命科学研究院 ADSFAEQWER353423413434

黄俊 教授，研究员，博士生导师

Email：huangjuntc@hotmail.com ADFASDFAF23RQ23R

• 1997.9-2001.7：南开大学生命科学学院微生物学 学士
• 2001.9-2006.7：北京大学生命科学学院细胞生物学 博士
• 2006.10-2009.6：美国耶鲁大学 (Yale University) 医学院博士后
• 2009.7-2009.12：美国安德尔森癌症研究中心 (MD Anderson Cancer Center) 博士后
• 2010.1-至今：浙江大学生命科学研究院教授，研究员，博士生导师

• 2005：教育部提名国家自然科学一等奖 (第六完成人)
• 2006：第八届谈家桢基金九源奖学金一等奖

本实验室主要研究癌症发生的分子机制。维持基因组的稳定对于细胞存活并抑制肿瘤的发生起着重要作用。为此，细胞建立了整套的分子信号传导通路如DNA Checkpoint和DNA Repair并通过它们之间的相互协调来保持基因组的稳定。然而，DNA损伤的检验点(DNA checkpoint) 如何同DNA修复(DNA repair)，特别是同源重组 (Homologous Recombination)修复之间进行协调还不清楚。因此，深入研究这些信号通路不仅能够促进我们了解肿瘤的发生机制，而且对于进一步的药物治疗都具有重要的意义。

The research interest of our laboratory is to understand the molecular mechanisms underlying genomic instability and tumorigenesis. Maintenance of genome stability is central to cell survival, and dysregulation of which contributes to tumorigenesis. To this end, the cell has evolved numerous signaling pathways, which via their concerted action, promotes genetic integrity through DNA repair and cell cycle checkpoint activation. An emerging concept in the rapidly expanding field of DNA damage checkpoint/repair is of continuous cross-talks between cell cycle checkpoint control and DNA repair. However, how DNA damage checkpoint pathways communicate with DNA repair processes, especially the error-free homologous recombination repair pathway remains elusive. Therefore, understanding how these processes work together will not only increase our knowledge about tumorigenesis in general but may also lead to clinical interventions for cancer treatment.

1. Michael S.Y. Huen, Jun Huang, Junjie Chen. Regulation of chromatin architecture by a PWWP domain-containing DNA damage responsive factor EXPAND1. Mol Cell. 37(6):854-64. 【PDF】
2. Jun Huang, Zihua Gong, Ghosal G and Junjie Chen. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 1435(3):384-93. 【PDF】 (Comment in: Mol Cell. 2009 Aug 1435(3):258-9.) 【PDF】
3. Lin Feng, Jun Huang and Junjie Chen. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 2009 Mar 1523(6):719-28. 【PDF】
4. Jun Huang, Michael S. Y. Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover, Xiaochun Yu and Junjie Chen. RAD18 transmits DNA damage signaling to elicit homologous recombination repair. Nat Cell Biol. 2009 May11(5):592-603.
5. Michael S. Y. Huen, Jun Huang, Jingsong Yuan, Masahiro Yamamoto, Shizuo Akira, Carolyn Ashley, Wei Xiao, and Junjie Chen. Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly. Mol Cell Biol. 2008 19:6104-12. 【PDF】
6. Zheng Fu, Liviu Malureanu, Jun Huang, Wei Wang, Hao Li, Jan M. van Deursen, Donald J. Tindall1, and Junjie Chen. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008, 9:1076-82. 【PDF】
7. Jun Huang and Junjie Chen. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene. 2008, 27:4056-64. 【PDF】
8. Hongtae Kim, Jun Huang, and Junjie Chen. CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response. Nature Structural & Molecular Biology. 2007, 14: 710-15 (co-first authors). 【PDF】
9. Jun Huang, Ting Liu, Danying Chen, Zhonghe Zhai, and Hong-Bing Shu. SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 2005, 24: 4018-28 (co-first authors). 【PDF】
10. Jun Huang, Lin Teng, Lixia Li, Ting Liu, Lianyun Li, Danying Chen, Zhonghe Zhai, and Hong-Bing Shu. ZNF216 Is an A20-like and IkappB Kinase gamma-Interacting Inhibitor of NF-kappaB Activation. J Biol Chem. 2004, 279: 16847-53. 【PDF】

• Huen MSY, Huang J, Chen J. Regulation of chromatin architecture by a PWWP domain-containing DNA damage responsive factor EXPAND1. Mol Cell. 2010;37(6):854-864.
• Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009;35(3):384-393.
• Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 2009;23(6):719-728.
• Huang J, Huen MSY, Kim H, et al. RAD18 transmits DNA damage signaling to elicit homologous recombination repair. Nat Cell Biol. 2009;11(5):592-603.
• Huen MSY, Huang J, Yuan J, et al. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol. 2008;28(19):6104-6112.
• Fu Z, Malureanu L, Huang J, et al. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008;10(9):1076-1082.
• Huang J, Chen J. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene. 2008;27(29):4056-4064.
• Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response. Nat Struct Mol Biol. 2007;14(8):710-715.
• Huang J, Liu T, Chen D, Zhai Z, Shu HB. SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 2005;24(23):4018-4028.
• Huang J, Teng L, Li L, et al. ZNF216 is an A20-like and IKK gamma-interacting inhibitor of NF-kappaB activation. J Biol Chem. 2004;279(16):16847-16853.
• Scully R, Panday A, Elango R, Willis NA. DNA double-strand break repair-pathway choice in somatic mammalian cells. Nat Rev Mol Cell Biol. 2019;20(11):698-714.
• Ceccaldi R, Rondinelli B, D'Andrea AD. Repair pathway choices and consequences at the double-strand break. Trends Cell Biol. 2016;26(1):52-64.
• 李红, 王晓明. 同源重组修复与肿瘤发生的研究进展. 遗传. 2018;40(10):826-839.
• 张三丰, 李小明. DNA损伤检验点信号通路在肿瘤治疗中的潜在靶点. 中国科学: 生命科学. 2020;50(12):1403-1415.