吴缅

吴缅，教授，博士生导师，中科院百人计划引进人才。1982年本科毕业于南京师范大学生物系，1984年获美国哥伦比亚大学生物化学硕士，1988年获哥伦比亚大学分子生物学博士，1988-1990年美国哈佛大学细胞发育系的博士后。1991-1998新加坡大学及新加坡中央医院神经内科任助理教授及高级研究员。2000年至今，中国科技大学生命科学学院教授。

在SCI杂志上共发表了论文50多篇，被国际同行引用超过800次。Journal of Molecular and Cell Biology副主编，Acta Biochimica et Biophysica Sinica编委，科学通报编委。

• p53与肿瘤代谢
• 非编码RNA与肿瘤
• iPS分子调控机制

• 中科院先导专项子课题：“非编码RNA及线粒体代谢调控体细胞重编程”（XDA01020104）,2011.01-2015.12
• 国家自然科学基金委员会重点项目：“p53家族蛋白调控细胞代谢的机制研究”（31030046）,2011.01-2014.12
• 科技部重大研究计划：“干细胞编程与重编程中表观遗传密码识别和解读的分子机制和结构基础”（2011CB966302），2011.01-2015.12
• 科技部重大研究计划：“非编码RNA相关蛋白质调控肿瘤细胞程序性死亡以及治疗抗性的功能研究”（2010CB912804），2010.01-2014.12

1. Peng Jiang, Wenjing Du, Xingwu Wang, Anthony Mancuso, Xiang Gao, Mian Wu and Xiaolu Yang. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. 2011 Mar, 13(3):310–316
2. Guoxing Wang, Xiang Gao, Yun Huang, Zhan Yao, Qinghua Shi and Mian Wu. NPM/B23 inhibits Eg5-mediated microtubules depolymerization via inactivating its ATPase activity. J Biol Chem. 2010 Jun 18;285(25):19060-7.
3. Zhan Yao, Shanshan Duan, Dezhi Hou, Wenyu Wang, Guoxing Wang, Yajing Liu, Longping Wen and Mian Wu. B23 acts as a nucleolar stress sensor and promotes cell survival via its dynamic interaction with hnRNPU and hnRNPA1. Oncogene, 2010 Mar 25;29(12):1821-34.
4. Lin Miao, Zhiyin Song, Lei Jin, Y M Zhu, LP Wen and Mian Wu. ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene, 2010 Feb 4;29(5):711-22.
5. Wenjing Du, Peng Jiang, Nan Li, Yide Mei, Xingwu Wang, Longping Wen, Xiaolu Yang and Mian Wu. Suppression of p53 activity by Siva1. Cell Death & Differ 2009 Nov;16(11):1493-1504. (Featured article)
6. Shanshan Duan, Zhan Yao, Youming Zhu, Guoxing Wang, Dezhi Hou, Longping Wen and Mian Wu. The Pirh2-Keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis. Cell Death & Differ 2009 Jun;16(6):826-37
7. Shanshan Duan, Zhan Yao, Dezhi Hou, Zhengsheng Wu, Wei-guo Zhu and Mian Wu. Phosphorylation of Pirh2 by Calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J, 2007 Jul 11;26(13):3062-74.
8. Zhan Yao, Shanshan Duan, Dezhi Hou, Klaus Heese and Mian Wu. Death effector domain DEDa, a self-cleaved product of Caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and up-regulates procaspase-8 expression via a p53-dependent mechanism. EMBO J, 2007 Feb 21;26(4):1068-80
9. Jiang P, Du W, Heese K, Wu M. The Bad Guy Cooperates with Good Cop p53: Bad Is Transcriptionally Up-Regulated by p53 and Forms a Bad/p53 Complex at the Mitochondria To Induce Apoptosis. Mol Cell Biol. 2006 Dec;26(23):9071-9082

合肥微尺度物质科学国家实验室（筹）及中国科技大学生命科学学院，安徽，合肥，230027。电话：0551-3606264；传真：0551-3606264；电子邮件：wumian@ustc.edu.cn

• P. Jiang, W. Du, X. Wang, et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology, 2011, 13(3): 310-316.
• S. Duan, Z. Yao, D. Hou, et al. Phosphorylation of Pirh2 by Calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO Journal, 2007, 26(13): 3062-3074.
• Jiang P, Du W, Heese K, Wu M. The Bad Guy Cooperates with Good Cop p53: Bad Is Transcriptionally Up-Regulated by p53 and Forms a Bad/p53 Complex at the Mitochondria To Induce Apoptosis. Molecular and Cellular Biology, 2006, 26(23): 9071-9082.
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature, 2000, 408(6810): 307-310.
• Esteller M. Non-coding RNAs in human disease. Nature Reviews Genetics, 2011, 12(12): 861-874.
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006, 126(4): 663-676.
• Wu M, et al. 中国科学技术大学吴缅课题组相关研究. 中国科学: 生命科学, 2012, 42(10): 789-795.