齐瀛川

上海科技大学 研究员 ADFASDFAF23RQ23R

所在院所：生命科学与技术学院

教育经历： ADSFAEQWER353423413434

1994/09—1998/06，北京大学，学士
1998/09—2003/05，美国路易维尔大学医学院，博士

ADFASDFAF23RQ23R

博士后及工作经历：

2004/03—2009/06，美国加州大学圣地亚哥分校，霍华德休斯医学研究所，博士后
2009/07—2011/06，美国加州大学圣地亚哥分校，神经科学系，助理项目科学家

该研究组的研究兴趣是神经细胞的发育和神经回路的建立。建立恰当的突触连接是神经系统发育的必要步骤。在发育中，在已有的突触连接的基础上时常发生大量的新突触形成和旧突触拆除——突触重塑。我们以线虫中的一类运动神经元作模式，用分子遗传学的手段来探究突触重塑的机理。另一个方向是研究脊髓尾段发出的副交感神经回路的建立。这个回路调节着人体重要的生理器官。问题包括节前神经元的产生分化、轴突的导向、回路的成熟与活动机制。我们将以小鼠和鸡胚为实验模式，从建立遗传分子标记入手，从遗传学、细胞学、生理学、行为学的水平上对这些问题进行探究。 ADSFAEQWER353423413434

• MYRF: A unique transmembrane transcription factor- from proteolytic self-processing to its multifaceted roles in animal development. Qi Y.B. et al. Bioessays (2024)
• Essential Function of Membrane-Bound Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans Development. Xu Z. et al. Elife (2023)
• The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling. Xia SL. et al. Elife (2021)
• Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. Huang H. et al. J Neurosci (2018)
• Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Meng et al. Developmental Cell (2017)
• Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans. Jin Y, Qi YB. Curr Opin Neurobiol (2018)

• Qi Y.B. et al. MYRF: A unique transmembrane transcription factor- from proteolytic self-processing to its multifaceted roles in animal development. Bioessays, 2024.
• Xu Z. et al. Essential Function of Membrane-Bound Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans Development. Elife, 2023.
• Xia SL. et al. The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling. Elife, 2021.
• Huang H. et al. Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. J Neurosci, 2018.
• Meng et al. Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Developmental Cell, 2017.
• Jin Y, Qi YB. Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans. Curr Opin Neurobiol, 2018.
• Broughton S, et al. MYRF: a membrane-bound transcription factor involved in myelination and beyond. Trends in Cell Biology, 2020.
• Kim H, et al. The role of MYRF in oligodendrocyte differentiation and CNS myelination. Glia, 2019.
• 陈平, 等. 线虫突触重塑的分子机制研究进展. 遗传, 2020.
• 王磊, 等. 副交感神经发育的分子调控. 中国科学: 生命科学, 2021.