高晓明
高晓明教授 男，博士，教授，博士生导师。1962年出生，现任苏州大学基础医学与生物科学学院院长、感染与免疫实验室副主任、苏州大学特聘教授。
简历:
1979-1984北京医科大学本科
1984-1987卫生部长春生物制品研究所实习研究员
1987-1989英国 Wellcome 研究所博士
1990-1993英国 牛津大学分子医学研究所博士后研究员
1994-1998英国 帝国理工医学院Wellcome Senior Fellow
1997-2010北京大学 医学部 免疫学系教授，博导，系主任
2010-今 苏州大学生物医学研究院教授，博导，PI
2010-今 苏州大学基础医学与生物科学学院 教授，博导，院长
1、 糖免疫生物学
2、 免疫调节与免疫耐受的分子与细胞机制
3、 自身免疫病的发病机制及免疫治疗
4、 抗感染免疫应答的分子与细胞机制。
独自撰写长学制免疫学教材两部
《免疫学教程》，2006年，高等教育出版社出版，北京大学长学制本科生教材
《医学免疫学基础》，2001年，北京大学医学出版社，“十一五”规划教材，面向21世纪课程教材，北京市高等教育精品教材
主编或共同主编教材五部
“十一五”规划教材《医学免疫学》第二版（主编），2010年，高等教育出版社
“十一五”规划教材《医学免疫学》（主编），2006年，高等教育出版社
“十一五”规划教材《医学免疫学》（主编），2004年，北京大学医学出版社
“十一五”规划教材《医学免疫学》第二版（副主编），2009年，人卫出版社
“十一五”规划教材《医学免疫学》（副主编），2005年，人民卫生出版社
1 Hong, C., X. Qiu, Y. Li, Q. Huang, Z. Zhong, Y. Zhang, X. Liu, L. Sun, P. Lv, and X. M. Gao. Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease. J Immunol. 2010. 185:4561-4569.
2 Dai H, ZG Li, Y Zhang, P Lv, XM Gao: Elevated levels of serum Abs against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus. 2009. Lupus 18(12): 1087-90
3 Bo H, XQ Wei, HL Dong, Y Zhang, P Lv, XM Gao: Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against systemic lupus erythematosus. Scan J Immunol. 2009, 69(2): 119-29.
4 Zhao JC, QR Huang, W Wang, Y Zhang, P Lv, XM Gao: Identification and characterization of helper T cell epitopes in the nucleocapsid protein of SARS-CoV. J Virology 2007, 81(11): 6079-88.
5 Zhao J, W Wang, WL Wang, Z Zhao1, Y Zhang, P Lv, F Ren, XM Gao: Comparison of IgG responses against the spike and nucleocapsid proteins of SARS-coronavirus in patients with severe acute respiratory syndrome. Clin. Vaccine Virology 2007, 14(7): 839-846.
6 Yang P, B Li, P Lv, Y Zhang, XM Gao: Interaction between autoreactive T cells and antigen presenting cells. Cell Res 2007, 17: 556-564.
7 Zhao JC, W Wang, RJ Jia, ZH Yuan, ZD Zhao, XJ Xu, P Lv, Y Zhang, XM Gao: A study on antigenicity and receptor-binding ability of fragment 450-650 of the spike protein of SARS-corona virus. Virology 2007, 359: 362-370.
8 Lu Y, W Xu, Z Ye, P Lv and XM Gao: Regulatory activity of activated murine peripheral CD4+CD25- T cells: A possible mechanism of feedback regulation on adaptive immunity. Scandinavian J Immunol. 2006, 64: 501-506.
9 Li ZG, R Mu, ZP Dai, XM Gao: T cell vaccination in systemic lupus erythematosus with autologous activated T cells. Lupus 2005，14: 884-889.
10 Zhao JC, W Wang, GF Wang, ZH Yuan, RJ Jia, X Xu, FR Ren, ZD Zhao, XM Gao: Development and evaluation of an enzyme-linked immunosorbent assay for detection of antibodies against the spike protein of SARS-coronavirus. J Clin Virol. 2005, 33(1): 12-18.
11 Han SH., B. Li, YT. Chen and XM Gao: Isolation and functional analysis of autoreactive T cells from BXSB mice with murine lupus. J. Autoimmunity 2002. 19(1-2): 45-54.
12 Zhao Y., ZP Dai, P Lu & XM Gao：Phenotype and functional analysis of human T lymphocytes in early second and third trimester to fetuses. Clin. Exp. Immunol. 2002. 129(2): 302-8.
13 Chilvers MM., P. Wordsworth, A. Stubbs and XM. Gao: T cell receptor usage by homocysteine-specific human CTL. J. Immunol., 1998, 160: 3737-42.
14 Gao, XM., MM. Chilvers and P. Wordsworth: A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis. In Proceedings of the 10th International Congress of Immunology, 1998，Vol. 2：785-92.
15 Gao, XM. and A. McMichael: Collagen-specific CTL do not cause arthritis in B10 mice. Clin. Exp. Immunol., 1996, 103: 89 - 93.
16 Gao, XM., J. Bell, C. Quinn and A. McMichael: Expression and function of HLA-B27 in lipid-linked form: implications for CTL-induced apoptosis. Eur. J. Immunol., 1993, 23: 653-8.
17 Hill, AVS., J. Elvin, AC. Willis, CEM. Allsopp, XM. Gao, M. Takiguchi, BM. Greenwood, ARM. Townsend, A McMichael and HC. Whittle: Molecular analysis of an HLA-disease association: HLA-B53 and resistance to severe malaria. Nature, 1992, 360: 434-9.
18 Gao, XM., JP. Tite, M. Lipscombe, S. Rowland-Jones and A. McMichael: Recombinant Salmonella typhimurium invading non-phagocytic cells are resistant to recognition by antigen-specific cytotoxic T lymphocytes. Infect. & Immunity, 1992, 60(9): 3780-90.
19 Gao, XM., FY. Liew, K. Bottomly, A. Meager and JP. Tite: Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology, 1991, 72: 256-60.
20 Gao, XM., B. Zheng, FY. Liew, S. Brett and JP. Tite: Priming of influenza virus specific CTL in vivo by short synthetic peptides. J. Immunol., 1991, 147(10): 3268 - 73.
<, SPAN style="mso-list: Ignore">21 Gao, XM., and J. Rhodes: Chemical events in immune induction: pre-formation of Schiff-bases on accessory cells inhibits antigen-dependent T-cell activation. J. Immunol., 1990, 144 (8): 2883-90.
22 Gao, XM., FY. Liew and JP. Tite: A dominant Th epitope in influenza nucleoprotein: analysis of the fine specificity and functional repertoire of T-cells recognising a single determinant. J. Immunol., 1990, 144 (7): 2730-7.
23 Gao, XM., FY. Liew and J. P. Tite: Identification and characterisation of Th epitopes in nucleoprotein of influenza A virus. J. Immunol., 1989, 143 (9): 3007-14.
24 Gao, XM., JA. Schmidt and F. Y. Liew: Suppressive substance produced by T-cells from mice chronically infected with Trypanosoma cruzi, III Genetic restriction and further characterisation. J. Immunol., 1988, 141(3): 989-95.
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| 高晓明 |
1984-1987卫生部长春生物制品研究所实习研究员
1987-1989英国 Wellcome 研究所博士
1990-1993英国 牛津大学分子医学研究所博士后研究员
1994-1998英国 帝国理工医学院Wellcome Senior Fellow
1997-2010北京大学 医学部 免疫学系教授，博导，系主任
2010-今 苏州大学生物医学研究院教授，博导，PI
2010-今 苏州大学基础医学与生物科学学院 教授，博导，院长
主要研究方向：
1、 糖免疫生物学
2、 免疫调节与免疫耐受的分子与细胞机制
3、 自身免疫病的发病机制及免疫治疗
4、 抗感染免疫应答的分子与细胞机制。
教学专著:
独自撰写长学制免疫学教材两部
《免疫学教程》，2006年，高等教育出版社出版，北京大学长学制本科生教材
《医学免疫学基础》，2001年，北京大学医学出版社，“十一五”规划教材，面向21世纪课程教材，北京市高等教育精品教材
主编或共同主编教材五部
“十一五”规划教材《医学免疫学》第二版（主编），2010年，高等教育出版社
“十一五”规划教材《医学免疫学》（主编），2006年，高等教育出版社
“十一五”规划教材《医学免疫学》（主编），2004年，北京大学医学出版社
“十一五”规划教材《医学免疫学》第二版（副主编），2009年，人卫出版社
“十一五”规划教材《医学免疫学》（副主编），2005年，人民卫生出版社
代表性论文目录:
1 Hong, C., X. Qiu, Y. Li, Q. Huang, Z. Zhong, Y. Zhang, X. Liu, L. Sun, P. Lv, and X. M. Gao. Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease. J Immunol. 2010. 185:4561-4569.
2 Dai H, ZG Li, Y Zhang, P Lv, XM Gao: Elevated levels of serum Abs against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus. 2009. Lupus 18(12): 1087-90
3 Bo H, XQ Wei, HL Dong, Y Zhang, P Lv, XM Gao: Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against systemic lupus erythematosus. Scan J Immunol. 2009, 69(2): 119-29.
4 Zhao JC, QR Huang, W Wang, Y Zhang, P Lv, XM Gao: Identification and characterization of helper T cell epitopes in the nucleocapsid protein of SARS-CoV. J Virology 2007, 81(11): 6079-88.
5 Zhao J, W Wang, WL Wang, Z Zhao1, Y Zhang, P Lv, F Ren, XM Gao: Comparison of IgG responses against the spike and nucleocapsid proteins of SARS-coronavirus in patients with severe acute respiratory syndrome. Clin. Vaccine Virology 2007, 14(7): 839-846.
6 Yang P, B Li, P Lv, Y Zhang, XM Gao: Interaction between autoreactive T cells and antigen presenting cells. Cell Res 2007, 17: 556-564.
7 Zhao JC, W Wang, RJ Jia, ZH Yuan, ZD Zhao, XJ Xu, P Lv, Y Zhang, XM Gao: A study on antigenicity and receptor-binding ability of fragment 450-650 of the spike protein of SARS-corona virus. Virology 2007, 359: 362-370.
8 Lu Y, W Xu, Z Ye, P Lv and XM Gao: Regulatory activity of activated murine peripheral CD4+CD25- T cells: A possible mechanism of feedback regulation on adaptive immunity. Scandinavian J Immunol. 2006, 64: 501-506.
9 Li ZG, R Mu, ZP Dai, XM Gao: T cell vaccination in systemic lupus erythematosus with autologous activated T cells. Lupus 2005，14: 884-889.
10 Zhao JC, W Wang, GF Wang, ZH Yuan, RJ Jia, X Xu, FR Ren, ZD Zhao, XM Gao: Development and evaluation of an enzyme-linked immunosorbent assay for detection of antibodies against the spike protein of SARS-coronavirus. J Clin Virol. 2005, 33(1): 12-18.
11 Han SH., B. Li, YT. Chen and XM Gao: Isolation and functional analysis of autoreactive T cells from BXSB mice with murine lupus. J. Autoimmunity 2002. 19(1-2): 45-54.
12 Zhao Y., ZP Dai, P Lu & XM Gao：Phenotype and functional analysis of human T lymphocytes in early second and third trimester to fetuses. Clin. Exp. Immunol. 2002. 129(2): 302-8.
13 Chilvers MM., P. Wordsworth, A. Stubbs and XM. Gao: T cell receptor usage by homocysteine-specific human CTL. J. Immunol., 1998, 160: 3737-42.
14 Gao, XM., MM. Chilvers and P. Wordsworth: A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis. In Proceedings of the 10th International Congress of Immunology, 1998，Vol. 2：785-92.
15 Gao, XM. and A. McMichael: Collagen-specific CTL do not cause arthritis in B10 mice. Clin. Exp. Immunol., 1996, 103: 89 - 93.
16 Gao, XM., J. Bell, C. Quinn and A. McMichael: Expression and function of HLA-B27 in lipid-linked form: implications for CTL-induced apoptosis. Eur. J. Immunol., 1993, 23: 653-8.
17 Hill, AVS., J. Elvin, AC. Willis, CEM. Allsopp, XM. Gao, M. Takiguchi, BM. Greenwood, ARM. Townsend, A McMichael and HC. Whittle: Molecular analysis of an HLA-disease association: HLA-B53 and resistance to severe malaria. Nature, 1992, 360: 434-9.
18 Gao, XM., JP. Tite, M. Lipscombe, S. Rowland-Jones and A. McMichael: Recombinant Salmonella typhimurium invading non-phagocytic cells are resistant to recognition by antigen-specific cytotoxic T lymphocytes. Infect. & Immunity, 1992, 60(9): 3780-90.
19 Gao, XM., FY. Liew, K. Bottomly, A. Meager and JP. Tite: Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology, 1991, 72: 256-60.
20 Gao, XM., B. Zheng, FY. Liew, S. Brett and JP. Tite: Priming of influenza virus specific CTL in vivo by short synthetic peptides. J. Immunol., 1991, 147(10): 3268 - 73.
<, SPAN style="mso-list: Ignore">21 Gao, XM., and J. Rhodes: Chemical events in immune induction: pre-formation of Schiff-bases on accessory cells inhibits antigen-dependent T-cell activation. J. Immunol., 1990, 144 (8): 2883-90.
22 Gao, XM., FY. Liew and JP. Tite: A dominant Th epitope in influenza nucleoprotein: analysis of the fine specificity and functional repertoire of T-cells recognising a single determinant. J. Immunol., 1990, 144 (7): 2730-7.
23 Gao, XM., FY. Liew and J. P. Tite: Identification and characterisation of Th epitopes in nucleoprotein of influenza A virus. J. Immunol., 1989, 143 (9): 3007-14.
24 Gao, XM., JA. Schmidt and F. Y. Liew: Suppressive substance produced by T-cells from mice chronically infected with Trypanosoma cruzi, III Genetic restriction and further characterisation. J. Immunol., 1988, 141(3): 989-95.
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