高晓明

高晓明，男，1962年出生，博士，教授，博士生导师。现任苏州大学基础医学与生物科学学院院长、感染与免疫实验室副主任、苏州大学特聘教授。

ADFASDFAF23RQ23R

1979-1984年就读于北京医科大学（本科）；1984-1987年在卫生部长春生物制品研究所任实习研究员；1987-1989年在英国Wellcome研究所攻读博士学位；1990-1993年在英国牛津大学分子医学研究所从事博士后研究；1994-1998年任英国帝国理工医学院Wellcome Senior Fellow；1997-2010年任北京大学医学部免疫学系教授、博士生导师、系主任；2010年至今任苏州大学生物医学研究院教授、博士生导师、PI，同时兼任苏州大学基础医学与生物科学学院教授、博士生导师、院长。 ADSFAEQWER353423413434

• 糖免疫生物学
• 免疫调节与免疫耐受的分子与细胞机制
• 自身免疫病的发病机制及免疫治疗
• 抗感染免疫应答的分子与细胞机制

独自撰写长学制免疫学教材两部：

ADSFAEQWER353423413434

• 《免疫学教程》，2006年，高等教育出版社，北京大学长学制本科生教材
• 《医学免疫学基础》，2001年，北京大学医学出版社，“十一五”规划教材，面向21世纪课程教材，北京市高等教育精品教材

主编或共同主编教材五部： ADFASDFAF23RQ23R

• “十一五”规划教材《医学免疫学》第二版（主编），2010年，高等教育出版社
• “十一五”规划教材《医学免疫学》（主编），2006年，高等教育出版社
• “十一五”规划教材《医学免疫学》（主编），2004年，北京大学医学出版社
• “十一五”规划教材《医学免疫学》第二版（副主编），2009年，人民卫生出版社
• “十一五”规划教材《医学免疫学》（副主编），2005年，人民卫生出版社

1. Hong, C., X. Qiu, Y. Li, Q. Huang, Z. Zhong, Y. Zhang, X. Liu, L. Sun, P. Lv, and X. M. Gao. Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease. J Immunol. 2010. 185:4561-4569.
2. Dai H, ZG Li, Y Zhang, P Lv, XM Gao: Elevated levels of serum Abs against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus. 2009. Lupus 18(12): 1087-90
3. Bo H, XQ Wei, HL Dong, Y Zhang, P Lv, XM Gao: Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against systemic lupus erythematosus. Scan J Immunol. 2009, 69(2): 119-29.
4. Zhao JC, QR Huang, W Wang, Y Zhang, P Lv, XM Gao: Identification and characterization of helper T cell epitopes in the nucleocapsid protein of SARS-CoV. J Virology 2007, 81(11): 6079-88.
5. Zhao J, W Wang, WL Wang, Z Zhao1, Y Zhang, P Lv, F Ren, XM Gao: Comparison of IgG responses against the spike and nucleocapsid proteins of SARS-coronavirus in patients with severe acute respiratory syndrome. Clin. Vaccine Virology 2007, 14(7): 839-846.
6. Yang P, B Li, P Lv, Y Zhang, XM Gao: Interaction between autoreactive T cells and antigen presenting cells. Cell Res 2007, 17: 556-564.
7. Zhao JC, W Wang, RJ Jia, ZH Yuan, ZD Zhao, XJ Xu, P Lv, Y Zhang, XM Gao: A study on antigenicity and receptor-binding ability of fragment 450-650 of the spike protein of SARS-corona virus. Virology 2007, 359: 362-370.
8. Lu Y, W Xu, Z Ye, P Lv and XM Gao: Regulatory activity of activated murine peripheral CD4+CD25- T cells: A possible mechanism of feedback regulation on adaptive immunity. Scandinavian J Immunol. 2006, 64: 501-506.
9. Li ZG, R Mu, ZP Dai, XM Gao: T cell vaccination in systemic lupus erythematosus with autologous activated T cells. Lupus 2005，14: 884-889.
10. Zhao JC, W Wang, GF Wang, ZH Yuan, RJ Jia, X Xu, FR Ren, ZD Zhao, XM Gao: Development and evaluation of an enzyme-linked immunosorbent assay for detection of antibodies against the spike protein of SARS-coronavirus. J Clin Virol. 2005, 33(1): 12-18.
11. Han SH., B. Li, YT. Chen and XM Gao: Isolation and functional analysis of autoreactive T cells from BXSB mice with murine lupus. J. Autoimmunity 2002. 19(1-2): 45-54.
12. Zhao Y., ZP Dai, P Lu & XM Gao：Phenotype and functional analysis of human T lymphocytes in early second and third trimester to fetuses. Clin. Exp. Immunol. 2002. 129(2): 302-8.
13. Chilvers MM., P. Wordsworth, A. Stubbs and XM. Gao: T cell receptor usage by homocysteine-specific human CTL. J. Immunol., 1998, 160: 3737-42.
14. Gao, XM., MM. Chilvers and P. Wordsworth: A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis. In Proceedings of the 10th International Congress of Immunology, 1998，Vol. 2：785-92.
15. Gao, XM. and A. McMichael: Collagen-specific CTL do not cause arthritis in B10 mice. Clin. Exp. Immunol., 1996, 103: 89 - 93.
16. Gao, XM., J. Bell, C. Quinn and A. McMichael: Expression and function of HLA-B27 in lipid-linked form: implications for CTL-induced apoptosis. Eur. J. Immunol., 1993, 23: 653-8.
17. Hill, AVS., J. Elvin, AC. Willis, CEM. Allsopp, XM. Gao, M. Takiguchi, BM. Greenwood, ARM. Townsend, A McMichael and HC. Whittle: Molecular analysis of an HLA-disease association: HLA-B53 and resistance to severe malaria. Nature, 1992, 360: 434-9.
18. Gao, XM., JP. Tite, M. Lipscombe, S. Rowland-Jones and A. McMichael: Recombinant Salmonella typhimurium invading non-phagocytic cells are resistant to recognition by antigen-specific cytotoxic T lymphocytes. Infect. & Immunity, 1992, 60(9): 3780-90.
19. Gao, XM., FY. Liew, K. Bottomly, A. Meager and JP. Tite: Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology, 1991, 72: 256-60.
20. Gao, XM., B. Zheng, FY. Liew, S. Brett and JP. Tite: Priming of influenza virus specific CTL in vivo by short synthetic peptides. J. Immunol., 1991, 147(10): 3268 - 73.
21. Gao, XM., and J. Rhodes: Chemical events in immune induction: pre-formation of Schiff-bases on accessory cells inhibits antigen-dependent T-cell activation. J. Immunol., 1990, 144 (8): 2883-90.
22. Gao, XM., FY. Liew and JP. Tite: A dominant Th epitope in influenza nucleoprotein: analysis of the fine specificity and functional repertoire of T-cells recognising a single determinant. J. Immunol., 1990, 144 (7): 2730-7.
23. Gao, XM., FY. Liew and J. P. Tite: Identification and characterisation of Th epitopes in nucleoprotein of influenza A virus. J. Immunol., 1989, 143 (9): 3007-14.
24. Gao, XM., JA. Schmidt and F. Y. Liew: Suppressive substance produced by T-cells from mice chronically infected with Trypanosoma cruzi, III Genetic restriction and further characterisation. J. Immunol., 1988, 141(3): 989-95.

• Hong, C., et al. Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease. J Immunol. 2010;185:4561-4569.
• Dai H, et al. Elevated levels of serum Abs against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus. Lupus. 2009;18(12):1087-1090.
• Bo H, et al. Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: a potential target for immunotherapy against systemic lupus erythematosus. Scand J Immunol. 2009;69(2):119-129.
• Zhao JC, et al. Identification and characterization of helper T cell epitopes in the nucleocapsid protein of SARS-CoV. J Virol. 2007;81(11):6079-6088.
• Zhao J, et al. Comparison of IgG responses against the spike and nucleocapsid proteins of SARS-coronavirus in patients with severe acute respiratory syndrome. Clin Vaccine Immunol. 2007;14(7):839-846.
• Yang P, et al. Interaction between autoreactive T cells and antigen presenting cells. Cell Res. 2007;17:556-564.
• Zhao JC, et al. A study on antigenicity and receptor-binding ability of fragment 450-650 of the spike protein of SARS-corona virus. Virology. 2007;359:362-370.
• Lu Y, et al. Regulatory activity of activated murine peripheral CD4+CD25- T cells: A possible mechanism of feedback regulation on adaptive immunity. Scand J Immunol. 2006;64:501-506.
• Li ZG, et al. T cell vaccination in systemic lupus erythematosus with autologous activated T cells. Lupus. 2005;14:884-889.
• Zhao JC, et al. Development and evaluation of an enzyme-linked immunosorbent assay for detection of antibodies against the spike protein of SARS-coronavirus. J Clin Virol. 2005;33(1):12-18.
• Han SH, et al. Isolation and functional analysis of autoreactive T cells from BXSB mice with murine lupus. J Autoimmun. 2002;19(1-2):45-54.
• Zhao Y, et al. Phenotype and functional analysis of human T lymphocytes in early second and third trimester to fetuses. Clin Exp Immunol. 2002;129(2):302-308.
• Chilvers MM, et al. T cell receptor usage by homocysteine-specific human CTL. J Immunol. 1998;160:3737-3742.
• Gao XM, et al. A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis. Proc 10th Int Congr Immunol. 1998;2:785-792.
• Gao XM, McMichael A. Collagen-specific CTL do not cause arthritis in B10 mice. Clin Exp Immunol. 1996;103:89-93.
• Gao XM, et al. Expression and function of HLA-B27 in lipid-linked form: implications for CTL-induced apoptosis. Eur J Immunol. 1993;23:653-658.
• Hill AVS, et al. Molecular analysis of an HLA-disease association: HLA-B53 and resistance to severe malaria. Nature. 1992;360:434-439.
• Gao XM, et al. Recombinant Salmonella typhimurium invading non-phagocytic cells are resistant to recognition by antigen-specific cytotoxic T lymphocytes. Infect Immun. 1992;60(9):3780-3790.
• Gao XM, et al. Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells. Immunology. 1991;72:256-260.
• Gao XM, et al. Priming of influenza virus specific CTL in vivo by short synthetic peptides. J Immunol. 1991;147(10):3268-3273.
• Gao XM, Rhodes J. Chemical events in immune induction: pre-formation of Schiff-bases on accessory cells inhibits antigen-dependent T-cell activation. J Immunol. 1990;144(8):2883-2890.
• Gao XM, et al. A dominant Th epitope in influenza nucleoprotein: analysis of the fine specificity and functional repertoire of T-cells recognising a single determinant. J Immunol. 1990;144(7):2730-2737.
• Gao XM, et al. Identification and characterisation of Th epitopes in nucleoprotein of influenza A virus. J Immunol. 1989;143(9):3007-3014.
• Gao XM, et al. Suppressive substance produced by T-cells from mice chronically infected with Trypanosoma cruzi, III Genetic restriction and further characterisation. J Immunol. 1988;141(3):989-995.
• Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 9th ed. Philadelphia: Elsevier; 2017.
• Murphy K, Weaver C. Janeway's Immunobiology. 9th ed. New York: Garland Science; 2016.
• 曹雪涛. 医学免疫学. 第4版. 北京: 人民卫生出版社; 2018.
• 龚非力. 医学免疫学. 第3版. 北京: 科学出版社; 2012.