牟阳灵

牟阳灵（1974-2019），1996年本科毕业于华中科技大学生物技术专业，1997年至1999年在清华大学赵南明教授实验室学习并获得硕士学位，2001至2006年在美国加州大学伯克利分校美国科学院院士蒲慕明教授实验室学习并获得博士学位，随后在蒲慕明教授实验室做博士后。她在蒲慕明教授实验室主要从事突触可塑性的分子与细胞机制研究。2007年起至今在加州索克生物研究所美国科学院院士Fred H. Gage教授实验室任助理研究员，主要从事神经元再生和神经干细胞方面的研究。在Nature、Cell、Neuron、Nat. Neurosci.、Cell Stem Cell、J. Neurosci.、PLoS ONE等国际著名刊物上发表10多篇文章，拥有1项中国专利。华中科技大学同济医学院基础医学院生理学系教授、博士生导师、系主任。 ADFASDFAF23RQ23R

综合电生理、光遗传学、荧光成像技术、转基因与动物行为学等多学科手段研究情绪影响海马学习记忆的神经基础，重点探索调控成年动物脑内新生神经元精确整合的神经环路，新生神经元在处理学习和记忆信息过程中编码机制及其功能。

1. Mu Y, Zhao C and Gage FH (2011). Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci 31, 4113-23.
2. Mu Y and Poo M (2006). Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system. Neuron 50, 115-25.
3. Lien CC, Mu Y, Vargas-Caballero M and Poo M (2006). Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci 9, 372-80 (equally contributed).
4. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, and Goldstein LS (2012). Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482, 216-20.
5. Mu Y and Gage FH (2011). Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener 6, 85 (corresponding author).
6. Brennand K, Jou J, Gelboin-Burkhart C, Tran N, Simone A, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J and Gage FH (2011). Modeling schizophrenia using hiPSC-derived neurons. Nature 473, 221-5.
7. Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH and Muotri AR (2010). A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-39.
8. Mu Y, Lee SW and Gage FH (2010). Signaling in adult neurogenesis. Curr Opin Neurobiol 20, 416-23.
9. Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV and Gage FH (2009). L1 Retrotransposition in Human Neural Progenitor Cells. Nature 460, 1127-31.
10. Li Y, Mu Y and Gage FH (2009). Development of neural circuits in the adult hippocampus. Curr Top Dev Biol 87, 149-74 (equally contributed).
11. Marchetto MC, Muotri AR, Mu Y, Smith AM, Ceza GG and Gage FH (2008). Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3, 649-57.

牟阳灵在突触可塑性、成年神经发生及神经干细胞领域做出了重要贡献。她与蒲慕明合作揭示了脉冲时序依赖可塑性（STDP）在视觉经验依赖性可塑性中的作用，为理解发育中视觉系统的突触修饰机制提供了关键证据。在Fred Gage实验室，她系统研究了成年海马神经发生的分子信号通路及环路整合机制，特别是多巴胺能调制对新生齿状回颗粒细胞成熟过程中皮层输入的影响。她还参与了利用诱导多能干细胞（iPSC）模拟阿尔茨海默病、精神分裂症和Rett综合征的研究，推动了神经精神疾病的体外模型建立。这些研究为认知功能障碍相关疾病（如阿尔茨海默病）的机制解析和潜在干预靶点提供了理论依据。

• Mu Y, Zhao C, Gage FH. Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci. 2011;31(11):4113-4123.
• Mu Y, Poo M. Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system. Neuron. 2006;50(1):115-125.
• Lien CC, Mu Y, Vargas-Caballero M, Poo M. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci. 2006;9(3):372-380.
• Israel MA, Yuan SH, Bardy C, et al. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012;482(7384):216-220.
• Mu Y, Gage FH. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener. 2011;6:85.
• Brennand K, Jou J, Gelboin-Burkhart C, et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011;473(7346):221-225.
• Marchetto MC, Carromeu C, Acab A, et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010;143(4):527-539.
• Mu Y, Lee SW, Gage FH. Signaling in adult neurogenesis. Curr Opin Neurobiol. 2010;20(4):416-423.
• Coufal NG, Garcia-Perez JL, Peng GE, et al. L1 retrotransposition in human neural progenitor cells. Nature. 2009;460(7259):1127-1131.
• Li Y, Mu Y, Gage FH. Development of neural circuits in the adult hippocampus. Curr Top Dev Biol. 2009;87:149-174.
• Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008;3(6):649-657.
• 仇子龙, 郭爱克. 神经干细胞与成年神经发生研究进展. 生物化学与生物物理进展. 2010;37(9):928-934.
• 张玉秋, 赵志奇. 海马神经发生与学习记忆. 生理科学进展. 2008;39(4):303-307.
• Deng W, Aimone JB, Gage FH. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci. 2010;11(5):339-350.
• Ming GL, Song H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron. 2011;70(4):687-702.