陈晓科
Xiaoke Chen
Principal Investigator
xkchen@stanford.edu
Office: 385 Serra Mall, Room 122E
Phone: (650) 723-4892
Email: xkchen@stanford.edu
Our long-term goal is to understand how sensory information and physiological state integrate to drive decisions and behaviors. We are now focusing on interoception, which is the sense of the physiological condition of the body. This includes our abilities to feel hungry or satiated, to sense heightened blood pressure and heart rate during stress, and to discriminate different types of pain. In our lab, we combine genetics-based brain circuit manipulation with in vivo electrophysiological and optical recording of neuronal ensembles to dissect the coding logic underlying interoception.
Selected Publications:
Chen X, Gabitto M, Peng Y, Ryba NJ, Zuker CS.
A gustotopic map of taste qualities in mammalian brain.
Science. 2011; 333(6047):1262-1266. (Research Article)
Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Trankner D, Ryba NJ, Zuker CS.
The cells and logic for mammalian sour taste detection.
Nature. 2006; 442(7105):934-938.
Chen XK, Wang LC, Zhou Y, Zhen LH, Zhou Z.
“Kiss-and-run” glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes
J Neurosci. 2005; 25(40):9236-9243
Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z.
Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC.
Nat Neurosci. 2005;8(9):1160-1168.
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