陈晓科

实验室的长期目标是理解感觉信息和生理状态如何整合以驱动决策和行为。目前聚焦于内感受（interoception），即对身体生理状态的感觉，包括饥饿、饱腹、应激时血压和心率升高、不同类型疼痛的辨别。结合基于遗传学的脑环路操控、在体电生理和光学记录技术，解析内感受的编码逻辑。

与骆利群实验室合作，正在开发一种新颖的实验策略，可可视化并操控全脑神经活动。结合该平台与光遗传学、在体双光子成像，将系统性解析内感受的神经环路。 ADFASDFAF23RQ23R

• 内感受的神经环路基础
• 感觉信息与生理状态的整合
• 全脑神经活动可视化技术

Chen X, Gabitto M, Peng Y, Ryba NJ, Zuker CS. A gustotopic map of taste qualities in mammalian brain. Science. 2011; 333(6047):1262-1266. (Research Article)

Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Trankner D, Ryba NJ, Zuker CS. The cells and logic for mammalian sour taste detection. Nature. 2006; 442(7105):934-938. ADSFAEQWER353423413434

Chen XK, Wang LC, Zhou Y, Zhen LH, Zhou Z. “Kiss-and-run” glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes. J Neurosci. 2005; 25(40):9236-9243.

ADFASDFAF23RQ23R

Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z. Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC. Nat Neurosci. 2005;8(9):1160-1168. ADFASDFAF23RQ23R

• Chen X, Gabitto M, Peng Y, Ryba NJ, Zuker CS. A gustotopic map of taste qualities in mammalian brain. Science. 2011;333(6047):1262-1266.
• Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Trankner D, Ryba NJ, Zuker CS. The cells and logic for mammalian sour taste detection. Nature. 2006;442(7105):934-938.
• Chen XK, Wang LC, Zhou Y, Zhen LH, Zhou Z. "Kiss-and-run" glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes. J Neurosci. 2005;25(40):9236-9243.
• Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z. Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC. Nat Neurosci. 2005;8(9):1160-1168.
• Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655-666.
• Quigley KS, Kanoski S, Grill WM, Barrett LF, Blessing WW, Chapman HA, et al. The neurobiology of interoception and its influence on health and disease. Neuron. 2021;109(20):3271-3288.
• 戴维·林登. 内感受的神经基础. 生理科学进展. 2018;49(3):161-168.
• 张旭, 段树民. 疼痛与内感受的神经机制. 中国科学:生命科学. 2020;50(10):1065-1074.