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庄小威

生平与学术经历编辑本段

庄小威，博士。美国哈佛大学物理学教授、化学及化学生物学教授。 ADSFAEQWER353423413434

1987年，15岁的庄小威考入中国科学技术大学少年班，1991年赴美留学，1997年在加州大学伯克利分校获得物理学博士学位。之后在斯坦福大学师从诺贝尔物理学奖得主朱棣文教授进行博士后研究。34岁成为哈佛大学两个系的双聘教授。在本科及博士学习阶段，庄小威一直研究物理专业；1997年后，她在斯坦福大学师从朱棣文进行博士后研究时，才接触化学、生物学科，做跟踪分子行为的实验。

ADSFAEQWER353423413434

科研成就编辑本段

2001年，庄小威被聘为哈佛大学助理教授。她的物理根底启发她将带荧光的分子标记物附在病毒上，当用激光照射时，标记物发射出特殊的彩色光。用这种方法，借助显微镜，她详实跟踪了单个病毒的行为，也跟踪了诸如蛋白质和核糖核酸（RNA）片断这样的单个分子行为。她拍摄到单个流感病毒的连续影像，这是世界上首次记录到病毒的各阶段过程。

ADFASDFAF23RQ23R

2006年初，庄小威晋升为哈佛正教授。她在哈佛大学建立了以自己名字命名的单分子生物物理实验室，带领21名博士、博士后研究流感病毒、艾滋病病毒、SARS等病毒侵入宿主细胞的过程。 ADSFAEQWER353423413434

教育经历编辑本段

1987-1991：就读于中国科学技术大学物理系
1991-1996：留学美国，在加州大学伯克利分校取得物理系博士学位
1997-2001：在斯坦福大学做博士后研究

工作经历编辑本段

09/2005-：哈佛大学医学院研究院
01/2006-：哈佛大学物理系教授、化学与化学生物学系教授
07/2005-12/2005：哈佛大学物理系教授、化学与化学生物学系副教授
08/2001-06/2005：哈佛大学物理系教授、化学与化学生物学系助理教授

主要奖项与荣誉编辑本段

年份	奖项
2008	HHMI Collaborative Innovation Award
2008	Coblentz Award
2006	Pure Chemistry Award
2005	Camille Dreyfus Teacher-Scholar Award
2004	Alfred P. Sloan Research Fellowship
2004	Technology Review Worlds Top 100 Young Innovators Award
2003	MacArthur Fellowship
2003	Packard Fellowship for Science and Engineering
2003	CAREER award, National Science Foundation
2003	Searle Scholar
2003	Beckman Young Investigator Award
2002	Young Investigator Award, Office of Naval Research
2000	Individual National Research Service Award, National Institute of Health
1997	Chodorow Postdoctoral Fellowship, Stanford University
1993	Victor F. Lenzen Memorial Scholarship, University of California
1992	George C. and Helen N. Pardee Scholarship, University of California
1991	Bernice Teuteberg Memorial Scholarship, University of California

代表论文编辑本段

B. Huang, M. Bates, X. Zhuang. Super-resolution fluorescence microscopy. Annu. Rev.Biochem. (in press)
E. Abbondanzieri, X. Zhuang. Concealed enzyme coordination. Nature 457, 392-393(2009).
H. M. van der Schaar, M. J. Rust, C. Chen, H. van der Ende-Metselaar, J. Wilschut, X. Zhuang, J. M. Smit. Dissecting the Cell Entry Pathway of Single Dengue Virus Particles in Living Cells. PLoS Pathogen 4, e1000244 (in press)
S. Liu, E. Abbondanzieri, J. W. Rausch, S. F. J. Le Grice, X. Zhuang. Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrate. Science 322, 1092-1097 (2008).
B. Huang, S. Jones, B. Brandenburg, X. Zhuang. Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution. Nat. Meth. 5, 1047-1052 (2008).
M. Bates, B. Huang, X. Zhuang. Super-resolution microscopy by nanoscale localization of photo-switchable fluorescent probes. Curr. Opin. Chem. Biol. 208, 1-10 (2008)
C. Chen, X. Zhuang. Epsin1 is a cargo specific adaptor for the clathrin-mediated endocytosis of influenza virus. Proc. Natl. Acad. Sci. USA 105, 11790-11795 (2008)
J. Zheng, X. Zhuang. Luminescent and Raman active silver nanoparticles with polycrystalline structure. J. Am. Chem. Soc. 130, 10472-10473 (2008)
E. Abbondanzieri, G. Bokinsky, J. W. Rausch, J. X. Zhang, S. F. J. Le Grice, X. Zhuang. Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature 453, 184-189 (2008).
B. Huang, W. Wang, M. Bates, X. Zhuang. Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy. Science 319, 810-813 (2008).
M. Bates, B. Huang, G. Dempsey, X. Zhuang. Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science 317, 1749-1753 (2007).
S. Liu, G. Bokinsky, N. G. Walter, X. Zhuang. Dissecting the multi-step reaction pathway of an RNA enzyme by single-molecule kinetic fingerprinting. Proc. Natl. Acad. Sci. USA 104, 12634-12639 (2007).
M. D. Stone, M. Mihalusova, C. M. O'Connor, R. Prathapam, K. Collins, X. Zhuang. Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein. Nature 446, 458-461 (2007).
B. Brandenburg, L. Y. Lee, M. Lakadamyali, M. J. Rust, X. Zhuang, J. M. Hogle. Imaging poliovirus entry in live cells. PLoS Biol. 5, 1543-1555 (2007).
B. Brandenburg, X. Zhuang. Virus trafficking – learning from single-virus tracking. Nat. Rev. Microbiol. 5, 197-208 (2007).
Y. Zhou, X. Zhuang. Kinetic analysis of sequential multi-step reactions. J. Phys. Chem. B, 111, 13600-13610, 2007 (2007).
H. M. van der Shaar, M. J. Rust, B. Waarts, H. van der Ende Metselaar, R. J. Kuhn, J. Wilschut, X. Zhuang, J. M. Smit. Characterization of the early events in Dengue virus cell entry by biochemical assays and single-virus tracking. J. Virol., 81, 12019-12028 (2007).
C. K. Payne, S. Jones, C. Chen, X. Zhuang. Internalization and trafficking of cell surface proteoglycans and proteoglycan binding ligands. Traffic 8, 389-401 (2007).
Y. Zhou, X. Zhuang. Robust reconstruction of the rate constant distribution using the phase function method. Biophys. J. 91, 4045-4053 (2006).
M. J. Rust, M. Bates, X. Zhuang. Sub-diffraction-limit imaging by stochastic reconstruction optical microscopy (STORM). Nat. Meth. 3, 793-795 (2006).
G. Bokinsky, L. G. Nivon, S. Liu, G. Chai., M. Hong, K. M. Weeks, X. Zhuang. Two distinct binding mode of a protein cofactor with its target RNA. J. Mol. Biol. 361, 771-784 (2006).
M. Lakadamyali, M. J. Rust, X. Zhuang. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124, 997-1009(2006).
X. Zhuang. Single-molecule RNA Science. Annu. Rev. Biophys. Biomol. Struct. 34, 399-414 (2005)
G. Bokinsky, X. Zhuang. Single-molecule RNA folding. Acct. Chem. Res. 38, 566-573(2005).
M. Bates, T. R. Blosser, X. Zhuang. Short-range spectroscopic ruler based on a single-molecule optical switch. Phys. Rev. Lett. 94, 108101 (2005).
X. Zhuang. Unraveling DNA condensation by optical tweezers. Science 305, 188-190(2004).
M. Lakadamyali, M. J. Rust, X. Zhuang. Endocytosis of influenza viruses. Micro. Infect. 6, 929-936 (2004).
M. J. Rust, M. Lakadamyali, F. Zhang, X. Zhuang. Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat. Struct. Mol. Biol. 11, 567-573(2004).
F. Patolsky, G. Zheng, O. Hayden, M. Lakadamyali, X. Zhuang, C. M. Lieber. Electrical detection of single viruses. Proc. Natl. Acad. Sci. USA 101, 14017-14022 (2004).
H. P. Babcock, C. Chen, X. Zhuang. Using single particle-tracking to study nuclear trafficking of viral genes. Biophys. J. 87, 2749-2758 (2004).
D. Rueda, G. Bokinsky, M. M. Rhodes, M. J. Rust, X. Zhuang, N. G. Walter. Single-molecule enzymology of RNA: Essential functional groups impact catalysis from a distance. Proc. Natl. Acad. Sci. USA 101, 10066-10071 (2004).
M. Lakadamyali, M. J. Rust, H P. Babcock, X. Zhuang. Visualizing infection of individual influenza viruses. Proc. Natl. Acad. Sci. USA 100, 9280-9285 (2003).
G. Bokinsky, D. Rueda, V. K. Misra, A. Gordus, M. M. Rhodes, H. P. Babcock, N. G. Walter, X. Zhuang. Single-molecule transition-state analysis of RNA folding. Proc. Natl. Acad. Sci. USA 100, 9302-9307(2003).

参考资料编辑本段

Rust, M. J., Bates, M., & Zhuang, X. (2006). Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nature Methods, 3(10), 793-796.
Huang, B., Wang, W., Bates, M., & Zhuang, X. (2008). Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy. Science, 319(5864), 810-813.
Lakadamyali, M., Rust, M. J., & Zhuang, X. (2006). Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell, 124(5), 997-1009.
Liu, S., Abbondanzieri, E. A., Rausch, J. W., Le Grice, S. F. J., & Zhuang, X. (2008). Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrate. Science, 322(5904), 1092-1097.
Zhuang, X. (2005). Single-molecule RNA science. Annual Review of Biophysics and Biomolecular Structure, 34, 399-414.
庄小威. (2006). 单分子生物物理与超分辨率成像. 生物物理学报, 22(3), 163-170.
Bates, M., Huang, B., & Zhuang, X. (2008). Super-resolution microscopy by nanoscale localization of photo-switchable fluorescent probes. Current Opinion in Chemical Biology, 12(5), 505-514.
黄波, 庄小威. (2009). 随机光学重建显微术（STORM）的发展与应用. 中国科学G辑, 39(1), 1-10.