张智

2001年毕业于安徽大学并获生物化学学士学位，2008年获中国科学技术大学神经生物学博士学位，2008-2012年在美国德克萨斯大学MD Anderson cancer center麻醉与疼痛医学系从事博士后工作，2012年11月起任中国科学技术大学生命科学学院教授，主要从事疼痛与情绪以及不同感觉系统相互作用的分子和神经环路研究，致力于临床的转化和应用。兼任安徽省神经科学学会理事长、中科院脑功能与脑疾病重点实验室副主任。 ADFASDFAF23RQ23R

• 疼痛与情绪（抑郁和焦虑等）相互作用的神经机制
• 大脑与外周组织/器官相互作用的神经机制
• 调控疼痛和情绪神经环路的物理刺激方式（声、光、电和磁刺激）

2024年

1. Xia Zhu¹; Ji-Ye Huang¹; Wan-Ying Dong¹; Hao-Di Tang¹; Si Xu, Qielan Wu; Huimin Zhang; Ping-Kai Cheng; Yuxin Jin; Meng-Yu Zhu; Wan Zhao; Yu Mao; Haitao Wang; Yan Zhang; Hao Wang; Wenjuan Tao*; Yanghua Tian*; Li Bai*; Zhi Zhang*; Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen. Nature Neuroscience, 2024, 27(3): 471-483. ADFASDFAF23RQ23R

2. Danyang Chen¹; Qianqian Lou¹; Xiang-Jie Song¹; Fang Kang; An Liu; Changjian Zheng; Yanhua Li; Di Wang; Sen Qun; Zhi Zhang*; Peng Cao*; Yan Jin*; Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice, Nature Communications, 2024, 15(1): 449.

2023年

1. Wan-Ying Dong¹; Xia Zhu¹; Hao-Di Tang¹; Ji-Ye Huang¹; Meng-Yu Zhu; Ping-Kai Cheng; Hao Wang; Xi-Yang Wang; Haitao Wang; Yu Mao; Wan Zhao; Yan Zhang; Wen-Juan Tao*; Zhi Zhang*; Brain regulation of gastric dysfunction induced by stress, Nature Metabolism, 2023, 5(9): 1494-1505. ADSFAEQWER353423413434

2022年

1. Wenjie Zhou¹; Chonghuan Ye¹; Haitao Wang¹; Yu Mao¹; Weijia Zhang; An Liu; Chen-Ling Yang; Tianming Li; Lauren Hayashi; Wan Zhao; Lin Chen; Yuanyuan Liu*; Wenjuan Tao*; Zhi Zhang*; Sound induces analgesia via corticothalamic circuits, Science, 2022, 377, 198–204.

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2. Hao-Di Tang¹; Wan-Ying Dong¹; Rui Hu¹; Ji-Ye Huang; Zhao-Huan Huang; Wei Xiong; Tian Xue; Ji Liu*; Jun-Ma Yu*; Xia Zhu*; Zhi Zhang*; A neural circuit for the suppression of feeding under persistent pain, Nature Metabolism, 2022, 4(12): 1746-1755. ADSFAEQWER353423413434

2021年

1. Peng Cao¹; An Liu¹; Changmao Chen¹; Qinghong Shan; Xia Zhu; Chunhui Jia; Xiaoqi Peng; Mingjun Zhang; Zahra Farzinpour; Wenjie Zhou; Haitao Wang; Jiang-Ning Zhou; Xiaoyuan Song; Liecheng Wang; Wenjuan Tao; Changjian Zheng; Yan Zhang; Yu-Qiang Ding; Yan Jin*; Lin Xu*; Zhi Zhang*; Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines, Neuron, 2021, 109(16):2573-2589.e9.

2. Xia Zhu¹; Hao-Di Tang¹; Wan-Ying Dong¹; Fang Kang¹; An Liu; Yu Mao; Wen Xie; Xulai Zhang; Peng Cao; Wenjie Zhou; Haitao Wang; Zahra Farzinpou; Wenjuan Tao; Xiaoyuan Song; Yan Zhang; Tian Xue; Yan Jin*; Juan Li*; Zhi Zhang*; Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states, Nature Neuroscience, 2021, 24(4): 542-553. ADFASDFAF23RQ23R

2020年

1. Wenjuan Tao¹; Changmao Chen¹; Yuping Wang¹; Wenjie Zhou; Yan Jin; Yu Mao; Haitao Wang; Likui Wang; Wen Xie; Xulai Zhang; Jie Li; Juan Li; Xiangyao Li; Zhen-Quan Tang; Chenghua Zhou; Zhizhong Z. Pang*; Zhi Zhang*; MeCP2 mediates transgenerational transmission of chronic pain, Progress in Neurobiology, 2020, 189:101790. ADSFAEQWER353423413434

2. Yan Jin¹; Qian Meng¹; Lisheng Mei; Wenjie Zhou; Xia Zhu; Yu Mao; Wen Xie; Xulai Zhang; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Xiangyao Li; Zhi Zhang*; A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain, PAIN, 2020, 161(2): 416-428.

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3. Weiwei Yin¹; Lisheng Mei¹; Tingting Sun; Yuping Wang; Jie Li; Changmao Chen; Zahra Farzinpour; Yu Mao; Wenjuan Tao; Juan Li; Wen Xie; Zhi Zhang*; A central amygdala–ventrolateral periaqueductal gray matter pathway for pain in a mouse model of depression-like behavior, Anesthesiology, 2020, Jan 27. ADFASDFAF23RQ23R

2019年

1. Wenjie Zhou¹; Yan Jin¹; Qian Meng¹; Xia Zhu¹; Tongjian Bai; Yanghua Tian; Yu Mao; Likui Wang; Wen Xie; Hui Zhong; Na Zhang; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Ben-Sheng Qiu; Jiang-Ning Zhou; Xiangyao Li; Han Xu; Kai Wang; Xiaochu Zhang; Yong Liu; Gal Richter-Levin; Lin Xu; Zhi Zhang*; A neural circuit for comorbid depressive symptoms in chronic pain, Nature Neuroscience, 2019, 22(10): 1649-1658.

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2. Tingting Sun¹; Zihua Song¹; Yanghua Tian¹; Wenbo Tian; Chunyan Zhu; Gongjun Ji; Yudan Luo; Shi Chen; Likui Wang; Yu Mao; Wen Xie; Hui Zhong; Fei Zhao; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Jiang-Ning Zhou; Kai Wang*; Zhi Zhang*; Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior, PNAS, 2019, 116(9): 3799-3804. ADFASDFAF23RQ23R

3. Xia Zhu¹; Wenjie Zhou¹; Yan Jin; Haodi Tang; Peng Cao; Yu Mao; Wen Xie; Xulai Zhang; Fei Zhao; Min-Hua Luo; Haitao Wang; Jie Li; Wenjuan Tao; Zahra Farzinpour; Likui Wang; Xiangyao Li; Juan Li; Zheng-Quan Tang; Chenghua Zhou; Zhizhong Z. Pan*; Zhi Zhang*; A central amygdala input to the parafascicular nucleus controls comorbid pain in depression, Cell Reports, 2019, 29(12): 3847-3858.

4. Haitao Wang¹; Jiahui Chen¹; Xiaotong Xu; Wen-Jian Sun; Xi Chen; Fei Zhao; Min-Hua Luo; Chunhua Liu; Yiping Guo; Wen Xie; Hui Zhong; Tongjian Bai; Yanghua Tian; Yu Mao; Chonghuan Ye; Wenjuan Tao; Jie Li; Zahra Farzinpour; Juan Li; Jiang-Ning Zhou; Kai Wang; Jufang He; Lin Chen*; Zhi Zhang*; Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior, PLoS Biology, 2019, 17(8): e3000417.

2008-2018年

1. Zhi Zhang; Wenjuan Tao; Yuan-Yuan Hou; Wei Wang; Paul J. Kenny; Zhizhong Z. Pan*; MeCP2 repression of G9a in regulation of pain and morphine reward, Journal of Neuroscience, 2014, 34(27): 9076-9087.

2. Zhi Zhang; You-Qing Cai; Fang Zou; Bihua Bie; Zhizhong Z. Pan*; Epigenetic suppression of GAD65 expression mediates persistent pain, Nature Medicine, 2011, 17(11): 1448-1455. Highlighted by Nature Reviews Drug Discovery (2011 Nov 18;10(12):900). ADSFAEQWER353423413434

3. Zhi Zhang; Zhizhong Z. Pan*; Synaptic mechanism for functional synergism between delta- and mu-opioid receptors, Journal of Neuroscience, 2010, 30(13): 4735-4745. Highlighted by Nature Reviews Neuroscience (2010 May 12; 11:374-375).

4. Zhi Zhang; Neng Gong; Wei Wang; Lin Xu; Tian-Le Xu*; Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval, Cerebral Cortex, 2008, 18(10): 2391-2401. ADFASDFAF23RQ23R

实验室招聘神经生物学（电生理）和分子生物学等相关背景的博士后（有表观遗传学背景者优先）和实验员，待遇从优。同时欢迎本科实习生和报考研究生。 ADFASDFAF23RQ23R

联系方式：zhizhang@ustc.edu.cn 联系电话：0551-63602715

• Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ. Epigenetic suppression of GAD65 expression mediates persistent pain. Nature Medicine. 2011;17(11):1448-1455.
• Zhang Z, Tao W, Hou YY, Wang W, Kenny PJ, Pan ZZ. MeCP2 repression of G9a in regulation of pain and morphine reward. Journal of Neuroscience. 2014;34(27):9076-9087.
• Zhang Z, Gong N, Wang W, Xu L, Xu TL. Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval. Cerebral Cortex. 2008;18(10):2391-2401.
• Zhou W, Ye C, Wang H, Mao Y, Zhang W, Liu A, et al. Sound induces analgesia via corticothalamic circuits. Science. 2022;377:198-204.
• Zhu X, Tang HD, Dong WY, Kang F, Liu A, Mao Y, et al. Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience. 2021;24(4):542-553.
• Dong WY, Zhu X, Tang HD, Huang JY, Zhu MY, Cheng PK, et al. Brain regulation of gastric dysfunction induced by stress. Nature Metabolism. 2023;5(9):1494-1505.
• Zhu X, Huang JY, Dong WY, Tang HD, Xu S, Wu Q, et al. Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen. Nature Neuroscience. 2024;27(3):471-483.
• Cao P, Liu A, Chen C, Shan Q, Zhu X, Jia C, et al. Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron. 2021;109(16):2573-2589.e9.
• Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nature Neuroscience. 2019;22(10):1649-1658.
• Tao W, Chen C, Wang Y, Zhou W, Jin Y, Mao Y, et al. MeCP2 mediates transgenerational transmission of chronic pain. Progress in Neurobiology. 2020;189:101790.
• 张智, 徐天乐. D-丝氨酸在海马长时程抑制和空间记忆提取中的作用. 中国科学C辑:生命科学. 2008;38(10):928-938.
• 张智, 潘志中. 疼痛和情绪相互作用的神经环路机制. 中国疼痛医学杂志. 2020;26(1):1-5.