张智

 张　智　教授、博士生导师，1979年7月生，安徽医科大学学术副校长、基础医学院院长，中国科学技术大学讲席教授。国家高层次海外引进人才（2012年），国家杰出青年基金获得者（2020年），国家重点基础研究发展计划（973计划）首席科学家（2014年），科技创新2030（中国脑计划）首席科学家（2021年），国家重点研发计划首席科学家；兼任中科院脑功能与脑疾病重点实验室主任、安徽省神经科学学会理事长等。2001年毕业于安徽大学并获生物化学学士学位，2008年获中国科学技术大学神经生物学博士学位，2008-2012年在美国德克萨斯大学MD Anderson cancer center麻醉与疼痛医学系从事博士后工作，2012年11月起任中国科学技术大学生命科学学院教授，主要从事疼痛与情绪以及不同感觉系统相互作用的分子和神经环路研究，致力于临床的转化和应用。兼任安徽省神经科学学会理事长、中科院脑功能与脑疾病重点实验室副主任。

1.疼痛与情绪（抑郁和焦虑等）相互作用的神经机制

2.大脑与外周组织/器官相互作用的神经机制

3.调控疼痛和情绪神经环路的物理刺激方式（声、光、电和磁刺激）

      1.   2021.12-2026.12 感知觉与情绪相互作用的神经环路机制，科技创新2030—重大项目，3500万，主持；

2.   2023.08-2026.08 基于针灸治疗胃系症候的临床评价研究及其现代生物学机制，安徽省科技厅专项项目，1940万，主持；

3.   2021.01-2025.12 感觉与行为的神经环路机制，基金委杰出青年科学基金，400万，主持；

4.   2023.01-2025.12 神经-内分泌-免疫环路调控慢性疼痛的机制研究，基金委专项项目，250万，主持；

5.   2014.01-2019.12 表观遗传调控的中央杏仁核GABA神经环路与慢性神经痛，科技部973计划，462万，主持；

6.    2018.01-2019.12 基于精准靶向神经环路的非药物治疗难治性抑郁症的基础与临床研究，基金委重大研究计划集成项目，200万，主持；

7.   2019.12-2021.12 衰老进程中小胶质细胞调控的神经可塑性与老年疼痛，基金委重大研究计划培育项目，60万，主持；

8.   2014.01-2016.12 表观遗传学调控的中央杏仁核GABA神经环路参与慢性疼痛并发的抑郁症，基金委重大研究计划培育项目，70万，主持；

9.    2019.01-2022.12 MeCP2调控的神经环路适应性与慢性疼痛遗传，基金委面上项目，56万，主持。

 2024年

1. Xia Zhu1; Ji-Ye Huang1; Wan-Ying Dong1; Hao-Di Tang1; Si Xu, Qielan Wu; Huimin Zhang; Ping-Kai Cheng; Yuxin Jin; Meng-Yu Zhu; Wan Zhao; Yu Mao; Haitao Wang; Yan Zhang; Hao Wang; Wenjuan Tao*; Yanghua Tian*; Li Bai*; Zhi Zhang*; Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen. Nature Neuroscience, 2024, 27(3): 471-483.

2. Danyang Chen1; Qianqian Lou1; Xiang-Jie Song1; Fang Kang; An Liu; Changjian Zheng; Yanhua Li; Di Wang; Sen Qun; Zhi Zhang*; Peng Cao*; Yan Jin*; Microglia govern the extinction of acute stress-induced anxiety-[like] behaviors in male mice, Nature Communications, 2024, 15(1): 449.

2023年

1. Wan-Ying Dong1; Xia Zhu1; Hao-Di Tang1; Ji-Ye Huang1; Meng-Yu Zhu; Ping-Kai Cheng; Hao Wang; Xi-Yang Wang; Haitao Wang; Yu Mao; Wan Zhao; Yan Zhang; Wen-Juan Tao*; Zhi Zhang*; Brain regulation of gastric dysfunction induced by stress, Nature Metabolism, 2023, 5(9): 1494-1505. 

2022年

1. Wenjie Zhou1; Chonghuan Ye1; Haitao Wang1; Yu Mao1; Weijia Zhang; An Liu; Chen-Ling Yang; Tianming Li; Lauren Hayashi; Wan Zhao; Lin Chen; Yuanyuan Liu*; Wenjuan Tao*; Zhi Zhang*; Sound induces analgesia via corticothalamic circuits, Science, 2022, 377, 198–204.

2. Hao-Di Tang1; Wan-Ying Dong1; Rui Hu1; Ji-Ye Huang; Zhao-Huan Huang; Wei Xiong; Tian Xue; Ji Liu*; Jun-Ma Yu*; Xia Zhu*; Zhi Zhang*; A neural circuit for the suppression of feeding under persistent pain, Nature Metabolism, 2022, 4(12): 1746-1755.

2021年

1. Peng Cao1; An Liu1; Changmao Chen1; Qinghong Shan; Xia Zhu; Chunhui Jia; Xiaoqi Peng; Mingjun Zhang; Zahra Farzinpour; Wenjie Zhou; Haitao Wang; Jiang-Ning Zhou; Xiaoyuan Song; Liecheng Wang; Wenjuan Tao; Changjian Zheng; Yan Zhang; Yu-Qiang Ding; Yan Jin*; Lin Xu*; Zhi Zhang*; Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines, Neuron, 2021, 109(16):2573-2589.e9.

2. Xia Zhu1; Hao-Di Tang1; Wan-Ying Dong1; Fang Kang1; An Liu; Yu Mao; Wen Xie; Xulai Zhang; Peng Cao; Wenjie Zhou; Haitao Wang; Zahra Farzinpou; Wenjuan Tao; Xiaoyuan Song; Yan Zhang; Tian Xue; Yan Jin*; Juan Li*; Zhi Zhang*; Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states, Nature Neuroscience, 2021, 24(4): 542-553.

2020年

1. Wenjuan Tao1; Changmao Chenb1; Yuping Wang1; Wenjie Zhou; Yan Jin; Yu Mao; Haitao Wang; Likui Wang; Wen Xie; Xulai Zhangd; Jie Li; Juan Li; Xiangyao Lie; Zhen-Quan Tang; Chenghua Zhoug; Zhizhong Z. Pang*; Zhi Zhang*; MeCP2 mediates transgenerational transmission of chronic pain,Progress in Neurobiology, 2020, 189:101790.

2. Yan Jin1; Qian Meng1; Lisheng Mei; Wenjie Zhou; Xia Zhu; Yu Mao; Wen Xie; Xulai Zhang; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Xiangyao Li; Zhi Zhang*; A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain, PAIN, 2020, 161(2): 416-428.

3.  Weiwei Yin1; Lisheng Mei1; Tingting Sun; Yuping Wang; Jie Li; Changmao Chen; Zahra Farzinpour; Yu Mao; Wenjuan Tao; Juan Li; Wen Xie; Zhi Zhang*; A central amygdala–ventrolateral periaqueductal gray matter pathway for pain in a mouse model of depression-like behavior, Anesthesiology, 2020, Jan 27.

2019年

1. Wenjie Zhou1; Yan Jin1; Qian Meng1; Xia Zhu1; Tongjian Bai; Yanghua Tian; Yu Mao; Likui Wang; Wen Xie; Hui Zhong; Na Zhang; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Ben-Sheng Qiu; Jiang-Ning Zhou; Xiangyao Li; Han Xu; Kai Wang; Xiaochu Zhang; Yong Liu; Gal Richter-Levin; Lin Xu; Zhi Zhang*; A neural circuit for comorbid depressive symptoms in chronic pain, Nature Neuroscience, 2019, 22(10): 1649-1658.

2. Tingting Sun1; Zihua Song1; Yanghua Tian1; Wenbo Tian; Chunyan Zhu; Gongjun Ji; Yudan Luo; Shi Chen; Likui Wang; Yu Mao; Wen Xie; Hui Zhong; Fei Zhao; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Jiang-Ning Zhou; Kai Wang*; Zhi Zhang*; Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior, PNAS, 2019, 116(9): 3799-3804.

3. Xia Zhu1; Wenjie Zhou1; Yan Jin; Haodi Tang; Peng Cao; Yu Mao; Wen Xie; Xulai Zhang; Fei Zhao; Min-Hua Luo; Haitao Wang; Jie Li; Wenjuan Tao; Zahra Farzinpour; Likui Wang; Xiangyao Li; Juan Li; Zheng-Quan Tang; Chenghua Zhou; Zhizhong Z. Pan*; Zhi Zhang*; A central amygdala input to the parafascicular nucleus controls comorbid pain in depression, Cell Reports, 2019, 29(12): 3847-3858.

4.  Haitao Wang1; Jiahui Chen1; Xiaotong Xu; Wen-Jian Sun; Xi Chen; Fei Zhao; Min-Hua Luo; Chunhua Liu; Yiping Guo; Wen Xie; Hui Zhong; Tongjian Bai; Yanghua Tian; Yu Mao; Chonghuan Ye; Wenjuan Tao; Jie Li; Zahra Farzinpour; Juan Li; Jiang-Ning Zhou; Kai Wang; Jufang He; Lin Chen*; Zhi Zhang*; Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior, PLoS Biology, 2019, 17(8): e3000417.

2008-2018年

1. Zhi Zhang; Wenjuan Tao; Yuan-Yuan Hou; Wei Wang; Paul J. Kenny; Zhizhong Z. Pan*; MeCP2 repression of G9a in regulation of pain and morphine reward, Journal of Neuroscience, 2014, 34(27): 9076-9087.

2. Zhi Zhang; You-Qing Cai; Fang Zou; Bihua Bie; Zhizhong Z. Pan*; Epigenetic suppression of GAD65 expression mediates persistent pain, Nature Medicine, 2011, 17(11): 1448-1455. Highlighted by Nature Reviews Drug Discovery (2011 Nov 18;10(12):900).

3. Zhi Zhang; Zhizhong Z. Pan*; Synaptic mechanism for functional synergism between delta- and mu-opioid receptors, Journal of Neuroscience, 2010, 30(13): 4735-4745. Highlighted by Nature Reviews Neuroscience (2010 May 12; 11:374-375).

4. Zhi Zhang; Neng Gong; Wei Wang; Lin Xu; Tian-Le Xu*; Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval, Cerebral Cortex, 2008, 18(10): 2391-2401.

招生招聘：

实验室招聘神经生物学（电生理)和分子生物学等相关背景的博士后(有表观遗传学背景者优先)和实验员，待遇从优。同时欢迎本科实习生和报考研究生。

联系方式：zhizhang@ustc.edu.cn

联系电话：0551-63602715