陈永龙

陈永龙，博士，中国科学院广州生物医药与健康研究院研究员。研究方向包括胰腺发育的分子机制及胚胎干细胞的定向诱导分化。

• 1982-1989，西北师范大学学士，硕士
• 1995-1999，德国埃森大学博士

• 1989-1995，西北师范大学助教，讲师
• 1999-2001，德国哥廷根大学博士后
• 2002-2007，德国哥廷根大学研究组长

• 胰腺发育的分子机制
• 胚胎干细胞的定向诱导分化

• Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., Chen,Y. 2014. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development 141: 707-714.
• Zhang, T., Guo, X., Chen,Y. 2013. Retinoic acid-activated Ndrg1a represses Wnt/β-catenin signaling to allow Xenopus pancreas, oesophagus, stomach, and duodenum specification. PLoS One 8, e65058.
• Zhao, H., Han, D., Dawid, I.B., Pieler, T., and Chen,Y. 2012. Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos. Proc. Natl. Acad. Sci. U S A. 109，8594-8599.
• Lei, Y., Guo, X., Liu, Y., Cao, Y., Deng, Y., Chen, X., Cheng, C.H., Dawid, I.B., Chen,Y., Zhao, H. 2012. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc. Natl. Acad. Sci. U S A. 109，17484-17489.
• Li, L., Wen, L., Gong, Y., Mei, G., Jinsong Liu, J., Chen,Y. and Peng, T. 2012. Xenopus as a Model System for the Study of GOLPH2/GP73 Function: Xenopus golph2 Is Required for Pronephros Development. PLoS One 7, e38939.
• Han, D., Wen, L., and Chen,Y. 2012. Molecular Cloning of phd1 and Comparative Analysis of phd1, 2, and3 Expression in Xenopus laevis. The Scientific World Journal 2012:689287.
• Li, X., Han, D., Kam, R. K. T., Guo, X., Chen, M., Yang, Y., Zhao, H., and Chen,Y. 2010. Developmental expression of sideroflexin genes in Xenopus embryos. Developmental Dynamics 239, 2742–2747.
• Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D., Chen,Y. 2010. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Developmental Dynamics 239, 2198-2207.

以上研究表明，陈永龙团队在胰腺发育和基因编辑技术领域取得了多项重要成果，为理解器官发育和疾病模型构建提供了基础。

• Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., Chen, Y. (2014). Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development, 141, 707-714.
• Zhang, T., Guo, X., Chen, Y. (2013). Retinoic acid-activated Ndrg1a represses Wnt/β-catenin signaling to allow Xenopus pancreas, oesophagus, stomach, and duodenum specification. PLoS One, 8, e65058.
• Zhao, H., Han, D., Dawid, I.B., Pieler, T., & Chen, Y. (2012). Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos. Proceedings of the National Academy of Sciences, 109, 8594-8599.
• Lei, Y., Guo, X., Liu, Y., Cao, Y., Deng, Y., Chen, X., Cheng, C.H., Dawid, I.B., Chen, Y., & Zhao, H. (2012). Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proceedings of the National Academy of Sciences, 109, 17484-17489.
• Li, L., Wen, L., Gong, Y., Mei, G., Liu, J., Chen, Y., & Peng, T. (2012). Xenopus as a Model System for the Study of GOLPH2/GP73 Function: Xenopus golph2 Is Required for Pronephros Development. PLoS One, 7, e38939.
• Han, D., Wen, L., & Chen, Y. (2012). Molecular Cloning of phd1 and Comparative Analysis of phd1, 2, and 3 Expression in Xenopus laevis. The Scientific World Journal, 2012, 689287.
• Li, X., Han, D., Kam, R.K.T., Guo, X., Chen, M., Yang, Y., Zhao, H., & Chen, Y. (2010). Developmental expression of sideroflexin genes in Xenopus embryos. Developmental Dynamics, 239, 2742–2747.
• Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D., & Chen, Y. (2010). Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Developmental Dynamics, 239, 2198-2207.
• Zorn, A.M., & Wells, J.M. (2009). Vertebrate endoderm development and organ formation. Annual Review of Cell and Developmental Biology, 25, 221-251.
• Spagnoli, F.M., & Brivanlou, A.H. (2008). The Gata5 target, TGIF2, defines the pancreatic region by modulating the activity of the TGFβ signaling pathway. Developmental Cell, 14, 592-604.
• 韩东, 陈永龙. (2012). 非洲爪蟾胰腺发育的分子机制研究进展. 遗传, 34(4), 413-422.
• 赵华, 陈永龙. (2013). 非洲爪蟾作为模式生物在发育生物学中的应用. 中国科学: 生命科学, 43(6), 471-480.