丁小燕

丁小燕，女，1949年4月生，研究员。1985年在细胞生物学研究所庄孝僡实验室获硕士学位，随后在该实验室工作至今。1991年赴德国Tuebingen马普发育所P. Hausen实验室进修并建立长期合作关系。目前与美国新奥尔良杜兰大学陈一平教授、海德堡H. Steinbeisser教授有合作项目。完成中科院九五重点项目、自然科学基金项目等多项任务。 ADFASDFAF23RQ23R

目前的研究方向为转录调控因子T-box基因家族在两栖类胚胎体轴建立中的作用、两栖类胚胎肌肉分化主控基因myf-5的表达调控研究以及胚胎干细胞向神经和肌肉分化中的基因调控。 ADSFAEQWER353423413434

肌肉分化主控基因myf-5在脊椎动物胚胎发育中的表达调控

肌肉是脊椎动物胚胎发育过程中最早形成的器官。Myf-5基因在肌肉发生过程中的动态表达图式和功能分析表明myf-5与早期肌肉前体细胞的决定密切相关。本实验室克隆了非洲爪蟾（Xenopus Laevis）Xmyf-5的基因组5'上游序列，利用转基因技术及分子生物学操作对其中的调控元件进行了研究。

ADFASDFAF23RQ23R

胚胎发育中重要新基因的克隆与功能分析

T-box基因家族是近十年来发现的在胚胎早期发育和遗传性疾病中起多方面重要作用的一类调控因子。本实验室从克隆新的Tbx基因入手，对该基因家族在胚胎早期发育中的功能进行了分析。已经发现了一个Tbx家族成员对胚胎中细胞命运的决定有重要作用。 ADFASDFAF23RQ23R

胚胎干细胞定向分化的分子机制

胚胎干细胞是具有全能性的一类特殊细胞。胚胎干细胞在体外可诱导形成神经或是肌肉，对其中的基因调控规律研究可解释胚胎发育中的现象。胚胎干细胞定向分化的分子机制为干细胞的应用提供理论基础。 ADSFAEQWER353423413434

• Ying Chen, Gu Fa Lin, Ruiying Hu, Yuguang Chen, Xiaoyan Ding. Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos. BBRC, 2003, 310:121-127.
• Xin Geng, Lei Xiao, Qinghua Tao, Ruiying Hu, Ralph AW Rupp, Xiaoyan Ding. The Xenopus noggin promoter drives roof-plate specific transcription. NeuroReport, 2003, accepted, in press.
• Xin Geng, Lei Xiao, Gu Fa Lin, Ruiying Hu, Jin Hu Wang, Ralph AW Rupp, Xiaoyan Ding. Lef/Tcf-dependent Wnt/b-catenin Signaling during Xenopus Axis Specification. FEBS Letters, 2003, 547:1-6.
• Gu Fa Lin, Xin Geng, Ying Chen, Bin Qu, Fubin Wang, Ruiying Hu, Xiaoyan Ding. A T-box binding site mediates the dorsal activation of Myf5 in Xenopus gastrula embryos. Developmental Dynamics, 2003, 226:51-58.
• Jing Yang, Wenyan Mei, Andreas Otto, Lei Xiao, Qinghua Tao, Xin Geng, Ralph A.W. Rupp, Xiaoyan Ding. Repression through a distal TCF-3 binding site restricts Xenopus myf-5 expression in gastrula mesoderm. Mechanism of Development, 2002, 115:79-89.
• Wenyan Mei, Jing Yang, Qinghua Tao, Xin Geng, Ralph A.W. Rupp, Xiaoyan Ding. An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis. FEBS Letters, 2001, 505(1):47-52.
• MEI WenYan, YANG Jing, Tao Qing Hua, DING Xiao Yan. The regulation of Xmyf-5, a muscle determinant, expression in Xenopus laevis. Acta Biochemica et Biophysica Sinica, 1999, 31(5):583-586.
• HUANG Yong, Xiao Yan DING. Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo. Cell Research, 1999, 9:71-76.
• MEI Wen Yan, DING Xiao Yan. Tissue specific differentiation of dorsal mesoderm in Xenopus mid-gastrula embryos. Acta Biologiae Experimentalis Sinica, 1999, 32(2):127-133.
• TAO Qing Hua, Jing YANG, WenYan MEI, Xin GENG, Xiao Yan DING. Cloning and analysing of 5'flanking region of Xenopus organizer gene noggin. Cell Research, 1999, 9:209-216.
• TAO Qing Hua, DING Xiaoyan. Analysis for the dorsalization potency of the animal blastomeres of the 16 cell stage Xenopus embryo. Chinese Science Bulletin, 1999, 44(6):538-540.
• Xiaoyan Ding, Peter Hausen, Herbert Steinbeisser. Pre-MBT patterning of early gene regulation in Xenopus: the role of the cortical rotation and mesoderm induction. Mechanism of Development, 1998, 70:15-24.
• Xiong Hao, DING Xiaoyan. The acquisition of developmental capacity of 16 cell stage animal blastomeres in Xenopus embryo. Acta Biologiae Experimentalis Sinica, 1998, 31(1):69-77.

• Chen Y, Lin GF, Hu R, et al. Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos. Biochemical and Biophysical Research Communications, 2003, 310(1):121-127.
• Geng X, Xiao L, Tao Q, et al. The Xenopus noggin promoter drives roof-plate specific transcription. NeuroReport, 2003, 14(16): 2163-2166.
• Geng X, Xiao L, Lin GF, et al. Lef/Tcf-dependent Wnt/β-catenin signaling during Xenopus axis specification. FEBS Letters, 2003, 547(1-3):1-6.
• Lin GF, Geng X, Chen Y, et al. A T-box binding site mediates the dorsal activation of Myf5 in Xenopus gastrula embryos. Developmental Dynamics, 2003, 226(1):51-58.
• Yang J, Mei W, Otto A, et al. Repression through a distal TCF-3 binding site restricts Xenopus myf-5 expression in gastrula mesoderm. Mechanism of Development, 2002, 115(1-2):79-89.
• Mei W, Yang J, Tao Q, et al. An interferon regulatory factor-like binding element restricts Xmyf-5 expression in the posterior somites during Xenopus myogenesis. FEBS Letters, 2001, 505(1):47-52.
• MEI WY, YANG J, TAO QH, et al. The regulation of Xmyf-5, a muscle determinant, expression in Xenopus laevis. Acta Biochimica et Biophysica Sinica, 1999, 31(5):583-586.
• HUANG Y, DING XY. Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo. Cell Research, 1999, 9(1):71-76.
• MEI WY, DING XY. Tissue specific differentiation of dorsal mesoderm in Xenopus mid-gastrula embryos. Acta Biologiae Experimentalis Sinica, 1999, 32(2):127-133.
• TAO QH, YANG J, MEI WY, et al. Cloning and analysing of 5'flanking region of Xenopus organizer gene noggin. Cell Research, 1999, 9(3):209-216.
• TAO QH, DING XY. Analysis for the dorsalization potency of the animal blastomeres of the 16 cell stage Xenopus embryo. Chinese Science Bulletin, 1999, 44(6):538-540.
• Ding X, Hausen P, Steinbeisser H. Pre-MBT patterning of early gene regulation in Xenopus: the role of the cortical rotation and mesoderm induction. Mechanism of Development, 1998, 70(1-2):15-24.
• Xiong H, DING XY. The acquisition of developmental capacity of 16 cell stage animal blastomeres in Xenopus embryo. Acta Biologiae Experimentalis Sinica, 1998, 31(1):69-77.
• Showell C, Binder O, Conlon FL. T-box genes in early embryogenesis. Developmental Dynamics, 2004, 229(1):201-218.
• Pownall ME, Gustafsson MK, Emerson CP Jr. Myogenic regulatory factors and the specification of muscle progenitors in vertebrate embryos. Annual Review of Cell and Developmental Biology, 2002, 18:747-783.
• 吴晓东, 翟中和. 非洲爪蟾胚胎发育中肌肉分化主控基因的调控. 细胞生物学杂志, 2005, 27(3):245-250.
• 陈志, 丁小燕. T-box基因与胚胎体轴形成. 发育与生殖生物学学报, 2006, 15(2):113-118.