肖瑞平

肖瑞平教授的研究方向主要集中在G蛋白偶联受体（GPCR）及其信号转导网络，尤其是心脏β肾上腺素受体（β-AR）亚型功能选择性信号转导及重大心血管疾病相关GPCR新药物靶点的基础研究。自80年代末开始，她系统地研究了心肌细胞β-AR不同亚型的信号转导机制及其生理学、病理学意义，取得了一系列重要成果，迄今已在国际一流学术刊物上发表论文100余篇，引用近5000次。她的这些研究工作得到了国际同行的广泛认同。她经常为Science STKE、Circulation、Circulation Research、Trends in Pharmacological Sciences等国际一流学术刊物撰写特邀综述或评论。肖瑞平教授兼具医学和分子生物学背景，长期从事心血管疾病药物靶点研究。2003年至今任北京大学分子医学研究所所长，于2010年全职回国。 ADFASDFAF23RQ23R

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• Chen KH, Guo XM, Ma DL, et al. Dysregulation of A Novel Hyperplasia Suppressor Gene Triggers Vascular Proliferative Disorders. NATURE CELL BIOLOGY, 6:872-883, 2004.
• Zhu WZ, Zheng M, Lefkowitz RJ, et al. Dual modulation of cardiac cell survival and cell death by β2-adrenergic signaling in adult mouse heart cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98: 1607-1612, 2001.
• Zhu WZ, Wang SQ, Chakir K, et al. Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/Calmodulin Kinase II. JOURNAL OF CLINICAL INVESTIGATION, 111:617-625, 2003.
• Xiao RP, Cheng H, Lederer WJ, et al. Dual regulation of Ca2+/calmodulin-dependent Kinase II activity by membrane voltage and by calcium influx. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 91: 9659-9663, 1994.

• Cao CM, Zhang Y, Weislede N, et al. MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation. 2010;121:2565-2574.
• Chen KH, Guo XM, Ma DL, et al. Dysregulation of A Novel Hyperplasia Suppressor Gene Triggers Vascular Proliferative Disorders. Nature Cell Biology. 2004;6:872-883.
• Zhu WZ, Zheng M, Lefkowitz RJ, et al. Dual modulation of cardiac cell survival and cell death by β2-adrenergic signaling in adult mouse heart cells. PNAS. 2001;98:1607-1612.
• Zhu WZ, Wang SQ, Chakir K, et al. Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/Calmodulin Kinase II. J Clin Invest. 2003;111:617-625.
• Xiao RP, Cheng H, Lederer WJ, et al. Dual regulation of Ca2+/calmodulin-dependent Kinase II activity by membrane voltage and by calcium influx. PNAS. 1994;91:9659-9663.
• Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of β-adrenergic signaling in heart failure? Circ Res. 2003;93:896-906.
• Xiang Y, Kobilka BK. Myocyte adrenoceptor signaling pathways. Science. 2003;300:1530-1532.
• 宁-李, 王-张, 刘-赵. G蛋白偶联受体在心血管疾病中的研究进展. 中国药理学通报. 2015;31(10):1345-1349.
• 陈-刘, 周-吴. β肾上腺素受体信号转导与心肌重塑. 生理科学进展. 2012;43(4):289-293.