管吉松

管吉松，博士，上海科技大学生命科学与技术学院研究员、博士生导师。

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2001年毕业于南京大学生物化学系获学士学位；2006年于中国科学院上海生命科学研究院神经科学研究所获博士学位；2006年至2010年在美国麻省理工学院（MIT）休斯医学研究所（HHMI）从事博士后研究；2011年至2017年任清华大学生命学院特聘研究员、博士生导师；2017年11月起任上海科技大学生命科学与技术学院副教授、研究员。

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实验室关注于研究哺乳动物大脑中的记忆存储、提取的相关编码规律和神经生物学机制。独立发展了大规模单神经元解析度的在体成像技术，寻找和追踪小鼠皮层内神经元群体在长期记忆形成于提取过程中的反应活动特征，探索脑对外界多模态环境的编码存储规律；利用多种手段，解析大脑中存储记忆的特异性神经环路以及表观遗传调控对记忆印迹细胞的作用，研究记忆的灵活性与稳定性调节机制；利用脑机接口等工程与医学手段，探索对脑损伤、脑疾病的修复治疗新方法。

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• Xinlu Ding, SanXiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie & Ji-Song Guan (2017) Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation. Nat Neurosci. 20(5):690-699. doi:10.1038/nn.4536
• Zhu T, Liang C, Li D, Tian M, Liu S, Gao G and Guan JS. (2016) Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep. 6: 26597.
• Guan JS, Jiang J, Xie H and Liu K-Y. (2016) How does the sparse memory Engram: Neurons encode the memory of a spatial-temporal event? Front. Neural Circuits. 10: 61. (Review)
• Guan JS, Xie H, Ding XL. (2015) The role of epigenetic regulation in learning and memory. Exp Neuro. 268: 30-36.
• Xie H, Liu Y, Zhu YZ, Ding XL, Yang YH and Guan JS. (2014) In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A. 111: 2788-2793.
• Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA and Tsai LH. (2011) Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLoS One. 6: e25735.
• Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I and Tsai LH. (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 483: 222-226.
• Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang XY, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R and Tsai LH. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 459: 55-60. (full research article)
• Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L and Zhang X (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell. 122: 619-631.

E-mail: guanjs@shanghaitech.edu.cn

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• Ding, X., Liu, S., Tian, M. et al. Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation. Nat Neurosci 20, 690–699 (2017).
• Zhu, T., Liang, C., Li, D. et al. Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep 6, 26597 (2016).
• Guan, J.S., Jiang, J., Xie, H. et al. How does the sparse memory Engram: Neurons encode the memory of a spatial-temporal event? Front. Neural Circuits 10, 61 (2016).
• Guan, J.S., Xie, H., Ding, X.L. The role of epigenetic regulation in learning and memory. Exp Neuro 268, 30-36 (2015).
• Xie, H., Liu, Y., Zhu, Y.Z. et al. In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A 111, 2788-2793 (2014).
• Guan, J.S., Su, S.C., Gao, J. et al. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLoS One 6, e25735 (2011).
• Gräff, J., Rei, D., Guan, J.S. et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483, 222-226 (2012).
• Guan, J.S., Haggarty, S.J., Giacometti, E. et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459, 55-60 (2009).
• Guan, J.S., Xu, Z.Z., Gao, H. et al. Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell 122, 619-631 (2005).
• Gräff, J., Tsai, L.H. Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci 14, 97-111 (2013).
• Kandel, E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030-1038 (2001).
• 韩中胜, 张旭. 记忆的神经基础. 生理科学进展 38, 293-298 (2007).
• 刘冰, 陈哲宇. 表观遗传调控与学习记忆. 生物化学与生物物理进展 39, 411-419 (2012).