颜宁

颜宁，1977年出生于山东，清华大学教授、博导。1996-2000年就读于清华大学生物系获学士学位；2000-2004年于普林斯顿大学分子生物学系攻读博士学位；2005-2007年于普林斯顿大学分子生物学系从事博士后研究；2007年受聘于清华大学医学院担任教授、博导。获得由Science和GE Healthcare评选的2005年“青年科学家奖”（北美地区）。 ADSFAEQWER353423413434

• 1996—2000 清华大学生物科学与技术系，学士
• 2000—2004 美国普林斯顿大学分子生物学系，博士
• 2005—2007 美国普林斯顿大学分子生物学系，博士后
• 2007-至今 清华大学教授

电话：+62771298 (lab) ADFASDFAF23RQ23R
传真：+86-10-62792736
E-mail: structure AT mail.tsinghua.edu.cn ADSFAEQWER353423413434

1. 重要膜蛋白的结构与功能研究
2. 胆固醇代谢调控通路的结构生物学和生物化学研究

• Yan N and Shi Y. Allosteric activation of a bacterial stress sensor. (Preview) Cell, 2007: 131, 441-443.
• Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, and Shi Y. Structure of a Site-2 Protease Family Intramembrane Metalloprotease. Science, 2007: 318, 1608-1612.
• Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker PR, Gu L, Jeffrey PD, Urban S, and Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat. Struct. & Mol. Biol. 2006: 13, 1084-1091.
• Yang C, Yan N, Parish J, Wang X, Shi Y, and Xue D. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in C. elegans. J. Biol. Chem. 2006: 281(14): 9137-9144.
• Yan N, Huh J-R, Schirf V, Demeler B, Hay B-A, and Shi Y. Structure and activation mechanism of the Drosophila initiator caspase Dronc. J. Biol. Chem. 2006: [Epub ahead of print].
• Yan N, Xu Y, and Shi Y. (Perspectives) 2:1 Stoichiometry of the CED-4-CED-9 Complex and the Tetrameric CED-4: Insights into the Regulation of CED-3 Activation. Cell Cycle 2006: 5, 31-34.
• Yan N, Chai J, Lee E-S, Gu L, Liu Q, He J, Wu J, Kokel D, Li H, Hao Q, Xue D, and Shi Y. Structure of the CED-4/CED-9 complex reveals insights into programmed cell death in Caenorhabditis elegans. Nature 2005: 437, 831-837.
• Yan N and Shi Y. Mechanisms of Apoptosis through Structural Biology. Annual Review Cell Dev. Biol. 2005: 21, 35-56.
• Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, and Shi Y (2004). Structural, Biochemical and Functional Analyses of CED-9 Recognition by the Pro-apoptotic Proteins EGL-1 and CED-4. Mol. Cell 15, 999–1006.
• Yan N, Wu J-W, Huh J-R, Chai J, Li W, Hay B-A, and Shi Y. Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid, and Grim. Nature-Structural & Molecular Biology 2004; 11 (5): 420–428.

• Yan N and Shi Y. Allosteric activation of a bacterial stress sensor. Cell, 2007: 131, 441-443.
• Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, and Shi Y. Structure of a Site-2 Protease Family Intramembrane Metalloprotease. Science, 2007: 318, 1608-1612.
• Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker PR, Gu L, Jeffrey PD, Urban S, and Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat. Struct. & Mol. Biol. 2006: 13, 1084-1091.
• Yang C, Yan N, Parish J, Wang X, Shi Y, and Xue D. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in C. elegans. J. Biol. Chem. 2006: 281(14): 9137-9144.
• Yan N, Huh J-R, Schirf V, Demeler B, Hay B-A, and Shi Y. Structure and activation mechanism of the Drosophila initiator caspase Dronc. J. Biol. Chem. 2006.
• Yan N, Xu Y, and Shi Y. 2:1 Stoichiometry of the CED-4-CED-9 Complex and the Tetrameric CED-4: Insights into the Regulation of CED-3 Activation. Cell Cycle 2006:5, 31-34.
• Yan N, Chai J, Lee E-S, Gu L, Liu Q, He J, Wu J, Kokel D, Li H, Hao Q, Xue D, and Shi Y. Structure of the CED-4/CED-9 complex reveals insights into programmed cell death in Caenorhabditis elegans. Nature 2005: 437, 831-837.
• Yan N and Shi Y. Mechanisms of Apoptosis through Structural Biology. Annual Review Cell Dev. Biol. 2005: 21, 35-56.
• Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, and Shi Y. Structural, Biochemical and Functional Analyses of CED-9 Recognition by the Pro-apoptotic Proteins EGL-1 and CED-4. Mol. Cell 2004:15, 999–1006.
• Yan N, Wu J-W, Huh J-R, Chai J, Li W, Hay B-A, and Shi Y. Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid, and Grim. Nature-Structural & Molecular Biology 2004: 11(5): 420–428.
• 颜宁. 膜蛋白结构生物学研究进展. 清华大学学报(自然科学版), 2010.
• Yan N. Structural biology of membrane proteins. Trends in Biochemical Sciences, 2010.
• Zhao Y, et al. Structural insights into cholesterol transport. Nature, 2015.
• Wang J, et al. Advances in structural studies of intramembrane proteases. Acta Crystallographica, 2016.