何志刚

何志刚

姓名：何志刚
职业：上海交通大学基础医学院/医学科学研究院 教授 博士生导师
联系方式：zhigang.he@childrens.harvard.edu 重庆南路280号，200025，64154900

研究重点：防止在成人中枢神经系统轴突再生。集中在两个潜在的机制：在成人病灶部位的抑制活性，降低内在能力与神经元的成熟中枢神经系统有关。目前的研究，旨在确定细胞和分子机制的内在成熟的神经元的再生能力。

*为通讯作者, **为共同第一作者

1. Smith PD, Sun F., Park K., Cai B., Wang C., Kuwako K., Martinez-Carrasco I., Connolly L., He Z.. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron, 2009;64, 617-623.
2. Shen Y., Tenney A.P., Busch S.A., Horn K.P., Cuascut F.X., Liu K., He Z., Silver J. Flanagan J.G.. PTP{sigma} Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration. Science, 2009;326, 592-596.
3. Park K, Liu K, Hu Y, Smith P, Chen W., Cai B, Xu B, Connolly L., Kramvis I., Sahin M, He Z.. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science, 2008;322, 963-966.
4. Chivatakarn O, Kaneko S, He Z, Tessier-Lavigne M, Giger RJ.. The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. J Neurosci, 2007;27(27):7117-7124.
5. Kaneko S, Iwanami A, Nakamura M, Kishino A, Kikuchi K, Shibata S, Okano HJ, Ikegami T, Moriya A, Konishi O, Nakayama C, Kumagai K, Kimura T, Sato Y, Goshima Y, Taniguchi M, Ito M, He Z, Toyama Y, Okano H.. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nature Medicine, 2007;12, 1380-1389.
6. Kaneko S., Wang J., Kaneko M, Yiu G., Hurrell J., Chitnis T., Khoury S.J., He Z.. Protecting Axonal Degeneration by Increasing NAD Levels in Experimental Autoimmune Encephalomyelitis Models. J Neurosci, 2006;26(38):9794-9804.
7. Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z.. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science, 2005;310(5745):106-110.
8. Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z.. A local mechanism mediates NAD- dependent protection of axon degeneration. J Cell Biol, 2005;170(3):349-355.
9. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He Z.. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron, 2005;45, 345-351.
10. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z.. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature, 2002;417, 941-944.

• Smith PD, Sun F, Park K, et al. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron. 2009;64(5):617-623.
• Shen Y, Tenney AP, Busch SA, et al. PTPσ is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009;326(5952):592-596.
• Park K, Liu K, Hu Y, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008;322(5903):963-966.
• Koprivica V, Cho KS, Park JB, et al. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science. 2005;310(5745):106-110.
• Wang KC, Koprivica V, Kim JA, et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002;417(6892):941-944.
• 李锋, 王宇. 中枢神经再生研究进展. 中华神经医学杂志. 2018;17(3):225-230.
• 张伟, 陈涛. PTEN/mTOR信号通路与轴突再生. 神经科学通报. 2015;31(2):235-240.
• Chen C, Yu J, Zhang H, et al. The role of SOCS3 in central nervous system injury and repair. Front Cell Neurosci. 2017;11:143.
• Liu BP, Cafferty WB, Budel SO, et al. Extracellular regulators of axonal growth in the adult central nervous system. Philos Trans R Soc Lond B Biol Sci. 2006;361(1473):1593-1610.