徐晓明

姓名：徐晓明

职业：上海交通大学基础医学院/医学科学研究院 教授 博士生导师
联系方式: xu26@iupui.edu

主要从事脊髓发育、损伤和再生的研究。现有课题包括：

• 雪旺氏细胞和神经干细胞移植在脊髓修复中的作用
• 神经营养因子及基因治疗
• 脊髓二次损伤（如炎症和细胞程序性死亡）的机理和治疗
• 脊髓发生和再生时与轴突生长相关分子的表达

Nature Medicine, Journal of Cellular and Molecular Medicine等杂志评审专家；NIH基金评审专家；药理学报等编委

(为通讯作者,为共同第一作者)

1. Cao Q, He Q, Wang Y, Cheng X, Howard R, Zhang Y-P, DeVries W, Shields C, Magnuson D, Xu X-M, Kim D, Whittemore S. Transplantation of CNTF-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. J Neurosci. (Accepted 12/30/2009), 2010.
2. Zou J, Wang Y-X, Dou F-F, Lu H-Z, Ma Z, Lu P, Xu X-M. Glutamine synthetase downregulation reduces astrocyte protection against glutamate excitotoxicity to neurons. Neurochem Int (Accepted 1/4/2010) [NIHMSID 178580; PubMed 20064572], 2010.
3. Liu N-K, Xu X-M. Phospholipase A2 and its molecular mechanism after spinal cord injury. Mol Neurobiol (Accepted 1/6/2010), 2010.
4. Titsworth WL, Cheng X, Ke Y, Deng L, Burckardt KA, Pendleton C, Liu N-K, Shao H, Cao Q-L, Xu X-M. Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death. Glia, 2009;57(14):1521-1537.
5. Zhang L, Ma Z, Smith GM, Wen X, Pressman Y, Wood PM, Xu X-M. GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons. Glia, 2009;57(11):1178-91.
6. Ma Z, Cao Q, Zhang L, Hu J, Howard RM, Lu P, Whittemore SR, Xu X-M. Oligodendrocyte precursor cells differentially expressing Nogo-A but not MAG are more permissive to neurite outgrowth than mature oligodendrocytes. Exp Neurol, 2009;217:184-196.
7. Dou F, Huang L, Yu P, Zhu H, Wang X, Zou J, Lu P, Xu X-M. Temporospatial expression and cellular localization of oligodendrocyte myelin glycoprotein (OMgp) after traumatic spinal cord injury in adult rats. J Neurotrauma, 2009;26(12):2299-311.
8. Shi F, Zhu H, Yang S, Liu Y, Feng Y, Shi J, Xu D, Wu W, You S, Ma Z, Zou J, Lu P, Xu X-M. Glial response and myelin clearance in areas of Wallerian degeneration after spinal cord hemisection in the monkey Macaca Fascilularis. J Neurotrauma, 2009;26(11):2083-2096.
9. Liu N-K, Wang X, Lu Q-B, Xu X-M. Altered MicroRNA Expression following Traumatic Spinal Cord Injury. Exp Neurol, 2009;219:424-429.
10. Xu X-M, Onifer SM. Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury. Respir Physiol Neurobiol., 2009;169(2):171-82.
11. Gu W, Fu S, Wang Y, Li Y, Lu H, Xu XM, Lu P. Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway. BMC Neurosci, 2009;10:128-142.
12. Hu JG, Fu SL, Wang YX, Li Y, Jiang XY, Wang XF, Qiu M, Lu PH, Xu XM. PDGF-AA mediates oligodendrocyte lineage differentiation through activation of Erk signaling pathway. Neurosci, 2008;151:138-147.
13. Titsworth WL, Liu NK, Xu X-M. Role of secretory phospholipase A2 in CNS inflammation: Implications in traumatic spinal cord injury. CNS & Neurol Disorders-Drug Targets, 2008;7(3):254-269.
14. Liu Y, Wang X, Sherman R, Lu CC, Steward O, Xu XM, Zou Y. Repulsive Wnt signaling inhibits axon regeneration following central nervous system injury. J Neurosci, 2008;28:8376-8382.
15. Yu P, Huang L, Zou J, Yu Z, Wang Y, Wang X, Xu L, Liu X, Xu X-M, Lu P. Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery after spinal cord injury in rats. Neurobiology of Disease, 2008;32:535-542.
16. Wang X, Fu S, Wang Y, Yu P, Hu J, Gu W, Xu X-M, Lu P. Interleukin-1β mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway. (With Cover). Mol Cell Neurosci, 2007;36:343-354.
17. Liu N-K, Zhang YP, Han S, Pei J, Xu LY, Lu P-H, Shields CB, Xu X-M. Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. J Neuropath Exp Neurol, 2007;66:932-943.
18. Liu NK, Zhang YP, Titsworth WL, Jiang X, Han S, Lu PH, Shields CB, Xu X-M. A Novel Role of Phospholipase A2 in Mediating Spinal Cord Secondary Injury. Annal Neurol, 2006;59:606-619.
19. Cao Q, Xu X-M, DeVries WH, Enzmann GU, Ping PP, Tsoulfas P, Wood PM, Bunge MB, Whittemore SR. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci, 2005;25:6947-6957.
20. Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu X-M, He Z. Protein kinase C mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat. Neurosci., 2004;7:261-268.
21. Chau CH, Shum DKY, Li H, Pei J, Lui YY, Wirthlin L, Chan YS, Xu XM. Chondroitinase treatment enhances axonal regrowth through Schwann cell-seeded guidance channels after spinal cord injury. FASEB J., 2004;18:194-196.

• Cao Q, He Q, Wang Y, et al. Transplantation of CNTF-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. J Neurosci, 2010.
• Liu N-K, Xu X-M. Phospholipase A2 and its molecular mechanism after spinal cord injury. Mol Neurobiol, 2010.
• Titsworth WL, Cheng X, Ke Y, et al. Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death. Glia, 2009;57(14):1521-1537.
• Zhang L, Ma Z, Smith GM, et al. GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons. Glia, 2009;57(11):1178-91.
• 刘宁坤, 徐晓明. 脊髓损伤后磷脂酶A2的表达变化及其意义. 中国脊柱脊髓杂志, 2008;18(1):56-59.
• 徐晓明, 张艳萍. 雪旺细胞移植修复脊髓损伤的研究进展. 神经科学通报, 2007;23(3):145-150.
• Ding Y, Li H, Xu XM, et al. Fibroblast growth factor 21 promotes functional recovery after spinal cord injury by modulating autophagy. J Neurotrauma, 2020;37(24):2643-2655.
• Zhou Y, Wang Y, Xu XM, et al. Astrocyte-derived exosomes suppress microglial inflammation and promote functional recovery after spinal cord injury. Glia, 2022;70(7):1352-1368.