戴建武

戴建武，中国科学院遗传与发育生物学研究所研究员，博士生导师。现任发育生物学研究中心副主任，联系电话：86-10-82614426，E-mail：jwdai@genetics.ac.cn。研究方向为干细胞与再生医学。

武汉大学生物系细胞生物学专业学士；北京大学生物物理学专业硕士；美国杜克大学（Duke University）细胞生物学专业博士；哈佛大学医学院博士后。

2003年回国，任中国科学院遗传与发育生物学研究所研究员、博士生导师。中国科学院“百人计划”入选者；国家杰出青年科学基金（生物材料领域）获得者；国家重大科学研究计划（973）“调控干细胞自我更新能力的分子网络研究”项目首席科学家。回国后已培养优秀博士毕业生11名，获2010年度益海嘉里优秀导师奖。

• 干细胞自我更新和定向分化：研究干性基因OCT4、NANOG的调控机制，发现OCT4B1可变剪接体及其在应激反应中的功能，揭示mTOR、STAT3等信号通路在神经干细胞分化中的作用。
• 功能生物材料引导组织再生与创伤修复：开发胶原支架负载胶原结合生长因子（如BDNF、NGF-β、VEGF、bFGF等），用于脊髓损伤、周围神经损伤、创面愈合、骨再生、心肌梗死、膀胱再生等修复研究。

脊髓损伤修复

团队利用线性有序胶原支架负载胶原结合脑源性神经营养因子（BDNF）或神经营养因子-3（NT-3），在大鼠脊髓全横断损伤模型中促进轴突再生和部分功能恢复（Han et al., 2010; Fan et al., 2010; Liang et al., 2010）。

创面愈合与血管再生

胶原结合血管内皮生长因子（VEGF）加速糖尿病大鼠创面愈合（Yan et al., 2010）；胶原结合人碱性成纤维细胞生长因子（bFGF）促进血管化和创面修复（Zhao et al., 2008; Zhao et al., 2009）；胶原结合血小板衍生生长因子（PDGF-BB）加速兔缺血性溃疡愈合（Sun et al., 2007）。

骨与软骨再生

构建脱钙骨基质（DBM）支架，通过肝素交联或胶原结合骨形态发生蛋白（BMP-2），实现骨缺损的均质骨再生（Chen et al., 2007; Zhao et al., 2009）。

心肌梗死治疗

胶原靶向VEGF改善大鼠心肌梗死后的心功能（Zhang et al., 2009）。

干性基因调控

系统研究OCT4及其假基因OCT4B1、OCT4B在胚胎干细胞和肿瘤细胞中的表达、翻译调控及功能，揭示NANOGP8反转录基因在胃癌中的表达及其与肿瘤发展的关系（Wang & Dai, 2010; Zhang et al., 2006; Gao et al., 2010）。发现Nogo-66通过STAT3通路调控小鼠胚胎干细胞Nanog表达（Gao et al., 2010），mTOR参与胰岛素诱导的神经前体细胞分化（Han et al., 2008）。

副研究员：肖志峰博士、陈冰博士；助理研究员：赵燕南博士。在读博士研究生：高原、韩津、韩倩倩、曹佳妮、施春英、苏冠男、高健、陈磊、韩素芳、魏建树。已毕业博士：索广力（UCSD）、张经余（NIH）、赵艳红（中检所）、林航（NIH）、王斌（Duke）、赵文学（UCSF）、王霞（Harvard）、孙文杰（山东大学）、张晶（首都医科大学）等。

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• 戴建武. 再生医学研究进展. 中国基础科学, 2015, 17(3): 1-8.
• 赵艳红, 戴建武. 胶原结合生长因子在组织修复中的应用. 中国修复重建外科杂志, 2010, 24(7): 877-881.
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