田志刚
合肥市黄山路443号中国科学技术大学生命学院免疫所
Tel: 0551-3600845;
Fax: 0551-3600832;
E. mail: tzg@ustc.edu.cn
网页：http://ioi.ustc.edu.cn
田志刚 中国科技大学生命科学学院院长、教授、博士生导师、免疫学研究所所长。1982毕业于山西医科大学获医学学士学位，1985毕业于山东省医学科学院获免疫学硕士学位，1989毕业于白求恩医科大学获免疫学博士学位。国家"百千万人才工程"一、二层次专家（1996）、中国科学院“百人计划”获得者（2001）、国家杰出青年科学基金获得者（2001）、国家卫生部“突出贡献中青年专家”（2004）、国家教育部和国家基金委“天然免疫”创新研究群体学术带头人（2007）、国家自然科学二等奖首位完成人（2008）。曾任山东省医学科学院学术委员会副主任、基础医学研究所所长、山东肿瘤生物治疗研究中心主任、山东省肿瘤免疫与基因工程重点实验室主任。1993年开始多次赴美国国立卫生研究院癌症研究所进行合作研究。中华人民共和国国务院学位委员会学科评议组成员，国家自然科学基金生命科学部专家评审组专家，国家名词（免疫学）评审委员会专家，中国免疫学会副理事长，中国免疫学会肿瘤免疫与生物治疗分会会长，中国抗癌协会生物治疗专业委员会副主任委员。中国免疫学会英文会刊<Cellular & Molecular Immunology>执行主编，《中国免疫学杂志》副主编，《中国肿瘤生物治疗杂志》副主编。2000年以来通讯作者在PNAS (2篇)、Hepatology(6篇)、J Heptol (3篇)、J Immunol (6篇)等发表SCI论文100余篇; 中文论文200余篇。国际会议或机构作学术报告或主持20余次。毕业博士硕士生共53名。Tel: 0551-3600845;
Fax: 0551-3600832;
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| 田志刚 |
网页：http://ioi.ustc.edu.cn
主要研究兴趣：
1. NK细胞生物学研究;2．肝脏免疫学研究;
4．NK细胞为基础的新型生物治疗技术及产品研制。
主要在研课题:
主持国家自然科学基金重点项目、国家863课题、中国科学院知识创新工程重点项目，科技部973”项目（课题组组长） 、国家科技重大专项“重大传染病防治”项目等。
1. Jin Z, Sun R, Wei H, Gao Y, Chen Y, Tian Z. Natural killer T cells aggravate liver fibrosis of HBV transgenic mice via activating hepatic stellate cells. Hepatology 2010; accepted.
2. Jiang W, Sun R, Wei H, Zhou R, Tian Z. Toll-like receptor 9 activation aggravates Con A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol 2009; 182:3768-74
3. Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-Rea 1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. Hepatology 2009; 49:940-9
4.Wei HX, Chuang YH, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian ZX, Tian Z. CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J Immunol. 2008;181:7221- 9
5.Chen QF, Wei HM, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of CX3CL1 gene prevents mice from adenovirus vector-induced acute liver injury. Hepatology 2008; 47:648-58
6. Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology 2007; 46(3):706-15.
7.Zhou R, Wei H, Sun R, Tian ZG. NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice. Proc Natl Acad Sci USA. 2007; 104:7512-5.
8.Dong Z, Zhang J, Sun S, Wei H, Tian ZG. Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. Hepatology 2007; 45:1400-12.
9.Li B, Sun R, Wei H, Gao B, Tian ZG. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology 2006; 43:1211-9.
10.Jiang W, Sun R, Wei HM, Tian ZG. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc Natl Acad Sci USA 2005; 102: 17077-17082.
代表性论文:
1. Jin Z, Sun R, Wei H, Gao Y, Chen Y, Tian Z. Natural killer T cells aggravate liver fibrosis of HBV transgenic mice via activating hepatic stellate cells. Hepatology 2010; accepted.
2. Jiang W, Sun R, Wei H, Zhou R, Tian Z. Toll-like receptor 9 activation aggravates Con A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol 2009; 182:3768-74
3. Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-Rea 1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. Hepatology 2009; 49:940-9
4.Wei HX, Chuang YH, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian ZX, Tian Z. CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J Immunol. 2008;181:7221- 9
5.Chen QF, Wei HM, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of CX3CL1 gene prevents mice from adenovirus vector-induced acute liver injury. Hepatology 2008; 47:648-58
6. Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology 2007; 46(3):706-15.
7.Zhou R, Wei H, Sun R, Tian ZG. NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice. Proc Natl Acad Sci USA. 2007; 104:7512-5.
8.Dong Z, Zhang J, Sun S, Wei H, Tian ZG. Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. Hepatology 2007; 45:1400-12.
9.Li B, Sun R, Wei H, Gao B, Tian ZG. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology 2006; 43:1211-9.
10.Jiang W, Sun R, Wei HM, Tian ZG. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc Natl Acad Sci USA 2005; 102: 17077-17082.
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