赵炜疆

赵炜疆，男，1975年11月出生，神经生物学专业博士，博士研究生导师。现任北京神经内科学会基础医学与转化医学专业委员会第三届委员。

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1999年获得牡丹江医科大学医学影像学专业学士学位，2003年和2007年分别获得首都医科大学神经生物学专业硕士和博士学位。2007-2009年在美国加州大学洛杉矶分校Cedars-Sinai医学中心从事博士后研究，师从原国际内分泌协会主席和国际垂体协会主席Shlomo Melmed教授。2009年11月入职汕头大学医学院神经科学中心，合作教授为德国科学院院士Melitta Schachner教授。2019年10月入职江南大学无锡医学院，承担临床医学专业本科学生的神经科学、基础医学英语及细胞生物学课程的教学工作。

主要从事噬菌体展示筛选人源L1抗体以及通过小分子化合物治疗脊髓损伤、阿尔茨海默病和神经系统衰老的实验治疗研究，其他工作包括神经调节蛋白（Neuregulin）在神经内分泌系统表达及功能研究以及神经肿瘤发病机制和下丘脑垂体调控。主持国家自然科学基金面上项目两项，江苏省双创计划项目一项，参与国家自然科学基金项目五项。

（暂无详细信息） ADSFAEQWER353423413434

（一）代表性项目

• 硫酸软骨素蛋白聚糖(CSPGs)结合肽联合激动型L1抗体治疗脊髓损伤实验研究（国家自然科学基金面上项目，70万，2015.01-2018.12）
• 激动型神经细胞粘附分子L1抗体治疗小鼠脊髓损伤实验研究（国家自然科学基金面上项目，55万，2012.01-2015.12）
• 基于关键靶蛋白筛选小分子化合物实验性治疗阿尔茨海默病（江苏省双创计划项目高校创新类，50万，2021.09-2024.08）

（二）代表性论文

1. Wang Y, Lv MN, Zhao WJ*. Research on Ferroptosis as a Therapeutic Target for the Treatment of Neurodegenerative Diseases. Ageing Research Reviews. 2023, 91:102035.
2. Zhang W, Dao JJ, Li Q, Liu C, Qiao CM, Cui C, Shen YQ, Zhao WJ*. Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs. Int J Biol Macromol. 2024, 275(Pt 1):133659.
3. Pan H, Xue WK, Zhao WJ*, Schachner M*. Expression and function of chondroitin 4-sulfate and chondroitin 6-sulfate in human glioma. FASEB J, 2021, 34(2):2853-2868.
4. Zhou SY, Li T, Zhang W, Wu J, Hong H, Quan W, Qiao XY, Cui C, Qiao CM, Zhao WJ*, Shen YQ*. The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease. Neural Regen Res. 2025, 20(8):2361-2372.
5. Zhao WJ#, Ou GY#, Lin WW. Integrative Analysis of Neuregulin Family Members-Related Tumor Microenvironment for Predicting the Prognosis in Gliomas. Frontiers in Immunology. 2021, 12: 682415.
6. Ou GY, Lin WW, Zhao WJ*. Construction of ceRNA networks composed of potential biomarkers in Alzheimer's disease. Journal of Alzheimer's Disease, 2021, 82, 169-183.
7. Liu C, Zhao Y, Zhao WJ*. Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression. J Neuroimmune Pharmacol. 2024, 19(1): 20.
8. Hu CL, Hu JK, Meng XH, Zhang HL, Shen HF, Huang PZ, Schachner M*, Zhao WJ*. L1CAM Beneficially Inhibits Histone Deacetylase 2 Expression under Conditions of Alzheimer's Disease. Current Alzheimer Research. 2020,17:382-392.
9. Lin WW*, Ou GY, Dai HF, Zhao WJ*. Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator. J Cell Biochem. 2024, 125(5): e30551.
10. Li Q, Ma ZB, Qin SH, Zhao WJ*. Virtual Screening-based Drug Development for the Treatment of Nervous System Diseases. Current Neuropharmacology. 2023,21(12): 2447-2464.

邮箱：weijiangzhao@jiangnan.edu.cn ADFASDFAF23RQ23R

• Wang Y, Lv MN, Zhao WJ. Research on Ferroptosis as a Therapeutic Target for the Treatment of Neurodegenerative Diseases. Ageing Research Reviews. 2023, 91:102035.
• Zhang W, Dao JJ, Li Q, et al. Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs. Int J Biol Macromol. 2024, 275(Pt 1):133659.
• Pan H, Xue WK, Zhao WJ, Schachner M. Expression and function of chondroitin 4-sulfate and chondroitin 6-sulfate in human glioma. FASEB J. 2021, 34(2):2853-2868.
• Zhou SY, Li T, Zhang W, et al. The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease. Neural Regen Res. 2025, 20(8):2361-2372.
• Zhao WJ, Ou GY, Lin WW. Integrative Analysis of Neuregulin Family Members-Related Tumor Microenvironment for Predicting the Prognosis in Gliomas. Frontiers in Immunology. 2021, 12:682415.
• Ou GY, Lin WW, Zhao WJ. Construction of ceRNA networks composed of potential biomarkers in Alzheimer's disease. Journal of Alzheimer's Disease. 2021, 82:169-183.
• Liu C, Zhao Y, Zhao WJ. Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression. J Neuroimmune Pharmacol. 2024, 19(1):20.
• Hu CL, Hu JK, Meng XH, et al. L1CAM Beneficially Inhibits Histone Deacetylase 2 Expression under Conditions of Alzheimer's Disease. Current Alzheimer Research. 2020, 17:382-392.
• Lin WW, Ou GY, Dai HF, Zhao WJ. Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator. J Cell Biochem. 2024, 125(5):e30551.
• Li Q, Ma ZB, Qin SH, Zhao WJ. Virtual Screening-based Drug Development for the Treatment of Nervous System Diseases. Current Neuropharmacology. 2023, 21(12):2447-2464.
• 赵炜疆. 硫酸软骨素蛋白聚糖结合肽联合激动型L1抗体治疗脊髓损伤实验研究. 国家自然科学基金面上项目, 2015-2018.
• 赵炜疆. 激动型神经细胞粘附分子L1抗体治疗小鼠脊髓损伤实验研究. 国家自然科学基金面上项目, 2012-2015.
• 赵炜疆. 基于关键靶蛋白筛选小分子化合物实验性治疗阿尔茨海默病. 江苏省双创计划项目, 2021-2024.
• Melmed S, et al. Pituitary Physiology and Pathophysiology. Endocrine Reviews. 2020.
• Schachner M, et al. Neural recognition molecules and synaptic plasticity. Current Opinion in Neurobiology. 2017.