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孙文智

               孙文智   研究员

所在学院

首都医科大学

研究方向

情绪和情感的神经环路基础;生物医学工程

联系方式

sunwenzhi@cibr.ac.cn

 

 

 

个人简介

 

 

19996月,获得中国海洋大学海洋生物学专业学士学位
2004
8月,获得中国科学院神经科学研究所神经生物学专业博士学位
2004
8-200412月,在中国科学院神经科学研究所任助理研究员
2004
12-201010月,在加州大学伯克利分校从事博士后研究工作
2010
11-20125月,在杰克逊实验室(Jackson Laboratory)任副研究员科学家

2012
5-20169月,在霍华德休斯医学研究所(Howard Hughes Medical Institute)珍利亚研究园区(Janelia Research Campus)任研究专员

20169-2018年,加入上海科技大学,在iHuman研究所任PI Research Associate Professor),在生命科学与技术学院任助理教授、研究员

201812-2020年,北京脑科学与类脑研究中心 PI & 研究员
2020
-至今  首都医科大学

 

 

主要研究内容

 

 

我们对外界的感知有70%来自于视觉系统。视网膜捕获光子并抽提出其中的视觉信息,从而开始了一系列的神经系统对视觉信息的处理和加工过程,直至形成视觉意识来指导个体的行为。我们实验室利用光学脑功能成像、在体电生理结合遗传学工具,解析视觉通路,理解视觉系统对视觉信息的处理、加工和转换的神经机制,解释视觉系统是如何指导个体行为。具体我们将从这个三个方面展开研究:(1)从单个初级视皮层神经细胞在突出水平的信息输入入手来研究视觉信息在不同类型皮层神经细胞的整合,(2)解释上丘的神经环路,从环

路水平探索早期视觉环路逐级对视觉信息进行处理,抽提出关键的信息进而指导动物行为的神经机制,以期解释大脑从接受感觉输入到指导行为的运作机制,(3)探索新的光学脑功能成像技术,扩大其在脑研究中的应用范围。

 

 

代表性论文

 

 

1. 1. C Lu*, X Zhu*#, Y Feng*, W Ao, J Li, Z Gao, H Luo, M Chen, F Cai, S Zhan, H Li, W Sun#, J Hu# .Atypical antipsychotics antagonize GABAA receptors in the ventral tegmental area GABA neurons to relieve psychotic behaviors. .Molecular Psychiatry .2023.2.8.doi.org/10.1038/s41380-023-01982-8.SCI

2. 3. W Zhou*#, S Ke*, W Li, J Yuan, X Li, R Jin, X Jia, T Jiang, Z Dai, G He, Z Fang, L Shi, Q Zhang, H Gong, Q Luo, W Sun#, A Li#, P Li# .Mapping the Function of Whole‐Brain Projection at the Single Neuron Level.Advanced Science.2022.9(33).2202553.SCI

3. Samuel Lundt, Nannan Zhang, Jun-Liszt Li, Zhe Zhang, Li Zhang, Xiaowan Wang, Ruisi Bao, Feng Cai, Wenzhi Sun, Woo-Ping Ge, Shinghua Ding* .Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT .Journal of Cerebral Blood Flow & Metabolism .2021.11.0271678-21992625.SCI

4. Nanxiang Xiong#, Xiaofei Gao#, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-ping Ge*.Using arterial-venous analysis to characterize cancer metabolic consumption in patients .Nature Communications .2020.11 (1).1-9.SCI

5. Xu Zhang#, Bo Lei#, Yuan Yuan#, Li Zhang, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong*, Ji Hu*, Hai Qi*.Brain control of humoral immune responses amenable to behavioural modulation.Nature.2020.581.204–208.

6. Fang Wang, Juen Zhang, Yuan Yuan, Ming Chen, Zilong Gao, Shulu Zhan, Chengyu Fan, Wenzhi Sun*, Ji Hu* .Salience Processing by Glutamatergic Neurons in the Ventral Pallidum.Sci Bull .2020.65.389-401.SCI

7. Xiao Y, Luo H, Yang WZ, Zeng Y, Shen Y, Ni X, Shi Z, Zhong J, Liang Z, Fu X, Tu H, Sun W, Shen WL*, Hu J*, Yang J*.A brain signaling framework for stress-induced depression and ketamine treatment elucidated by phosphoproteomics.Frontiers in Cellular Neuroscience.2020.14.48.SCI

8. Xiaofei Gao, Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang, Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara GM Piccirillo, Ugur Eskiocak, Digant P Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, Wenzhi Sun, Robert M Bachoo, Woo-ping Ge*.Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles.Cell Reports .2020.30.2489-2500.SCI

9. Zhang S, Lv F, Yuan Y, Fan C, Li J, Sun W, Hu J*.Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.Frontiers in Neuroscience .2019.13.e565.

10. Zhou H, Zhang S, LV F, Sun W, Wang L, Fan C, Li J*, Hu J* .Citrate‐assisted efficient local delivery of naked oligonucleotide into live mouse brain cells .Cell proliferation .2019.52.e12622.

11. Liang Y, Sun W, Lu R, Chen M & Ji N*.A distinct population of L6 neurons in mouse V1 mediate cross-callosal communication.bioRxiv .2019.11.778019.

12. Yuan, Yuan#; Wu, Wei#; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi*; Hu, Ji*.Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.Curr Biol.2019.29(7).1243-1251.SCI

13. Su XY#, Chen M# Yuan Y, Li Y, Luo HQ, Sun W, Zhu MX, Liu MG*, Hu J*, Xu TL*.Central processing of itch in the midbrain reward center.Neuron .2019.102.858-872.

14. Zheng-dong Zhao#, Zongming Chen#, Xinkuan Xiang#, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li*, Wei L Shen*.Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.Nature Neuroscience.2019.22.921-932.

15. Lu R, W Sun, Liang Y, Kerlin A, Bierfeld J, Seelig J, Wilson V, Scholl B, Mohar B, Tanimoto M, Koyama M, Fitzpatrick D,Orger MB, Ji N*.Video-rate volumetric functional imaging of the brain at synaptic resolution.Nature Neuroscience.2017.20 .620-628.

16. Sun W, Tan Z, Mensh BD & Ji N*.Thalamus provides layer 4 of primary visual cortex with tuned inputs.Nature Neuroscience.2016.19.308-315.

                                  

 


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