周强

周强，北京大学深圳研究生院教授、化生学院副院长，为Neuron、PNAS、Journal of Neuroscience等杂志的审稿人。神经生物学博士，毕业于美国纽约州立大学石溪分校，师从美国科学院院士Roger Nicoll、蒲慕明教授、英国皇家学会会士Paul Adams教授。曾先后在美国西奈山医学院担任神经科助理教授，在Genentech/Roche（罗氏）从事神经系统药物的早期研发工作。 ADFASDFAF23RQ23R

电话：+86-755-8168-4985
邮箱：zhouqiang@pkusz.edu.cn
课题组主页：http://web.pkusz.edu.cn/zhouq/ ADSFAEQWER353423413434

• 2014-至今：教授，北京大学深圳研究生院化生学院
• 2009-2013：研究员，美国基因和技术公司
• 2004-2009：助理教授，美国西乃山医学院
• 2003-2004：副专家，美国加州大学伯克利分校
• 2001-2003：博士后，美国加州大学伯克利分校
• 1998-2000：博士后，美国加州大学旧金山分校
• 1998：博士，美国纽约州立大学石溪分校，神经生物学
• 1993：硕士，美国匹兹堡大学，生理学
• 1990：学士，清华大学，生物化学

荣誉/会员身份

• 1999-2000：国家健康研究院实习生身份（美国加州大学旧金山分校）
• 2001-2004：国家健康研究院国家研究服务奖
• 2006-2009：新学者奖（埃里森医学基金会）
• 2013：美国生物精神病学会年会最佳展示奖
• 1994-至今：美国神经科学学会会员

编委

• Journal of neurological disorders
• International journal of neurological research
• SM Journal of Depression Research and Treatment
• Journal of Systems and Integrative Neuroscience

资深的成品管线项目管理经验，为主要成品管线项目的生物学主管，主要研究方向是神经退化性疾病和精神疾病，也负责这些领域的商业开发与合作。其研究对于理解神经突触可塑性/功能与其形态学变化紧密相连做出了重大贡献。

ADFASDFAF23RQ23R

周强教授在Nature、Science、Cell、Neuron、PNAS等国际知名期刊上发表过30多篇文章。国际上抑制性神经系统功能与调节领域的领军人物，最先证明神经突触减弱与突触棘萎缩相关；在国际上率先证明突触可塑性是大脑感觉功能改变的生理学基础；并率先将显微成像技术与电生理技术相结合来研究神经突触的可塑性。 ADSFAEQWER353423413434

代表性论文（部分）：

1. Zhou Q, Godwin DW, O’Malley DM and Adams PR. Visualization of calcium influx through channels that shape the burst and tonic modes of thalamic relay cells. J. Neurophysiol. 77: 2816-2825, 1997.
2. Zhou Q, Petersen CCH and Nicoll RA. Effect of reduced vesicular filling on synaptic transmission. J. Physiology 525 (1):195-206, 2000.
3. Zhou Q, Xiao MY and Nicoll RA. Contribution of cytoskeleton to the internalization of AMPA receptors. Proc. Natl. Acad. USA. 98: 1261-1266, 2001.
4. Zhou Q, Tao HW and Poo M-m. Reversal and stabilization of synaptic modifications in a developing visual system. Science 300, 1953-1957, 2003.
5. Zhou Q, Homma, K and Poo, M-m. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44:749-757, 2004.
6. Yang Y, Wang XB, Zhou Q. Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications. Proc. Natl. Acad. USA. 107: 11999-12004, 2010.
7. Hanson J, Weber M, Meilandt W, Wu T, Luu T, Deng L, Shamloo M, Sheng M, Scearce-Levie K and Qiang Zhou. GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior. Neuropsychopharmacology. 38(7):1221-33, 2013.
8. Paoletti P, Bellone C and Zhou Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and diseases. Nat. Rev. Neuroscience. 14(6):383-400, 2013.

综述文章： ADSFAEQWER353423413434

• Zhou Q and Poo M-m. Reversal and consolidation of activity-induced synaptic modifications. Trends. Neurosci. 27:378-83, 2004.
• Yang Y and Zhou Q. Spine modifications associated with long-term potentiation. Neuroscientist 15: 464-76, 2009.
• Wang XB, Zhou Q. Spine remodeling and synaptic modification. Mol Neurobiol. 41: 29-41, 2010.
• Zhou Q and Sheng M. NMDA receptors in nervous system diseases. Neuropharmacology 74:69-75, 2013.
• Zhou Q. GluN2B-NMDA receptors in Alzheimer's disease: beyond synapse loss and cell death. Neural Regen Res.9(21):1878-9, 2014.

周强教授在神经科学领域，特别是突触可塑性、抑制性神经系统功能以及神经退行性疾病和精神疾病的研究方面做出了国际领先的贡献。回国后，他带领团队在老年痴呆症生物学及药物研发方面开展深入研究，并建立了深圳市细胞生理学重点实验室，致力于推动中国神经科学的发展。

• Zhou Q, Godwin DW, O’Malley DM, Adams PR. Visualization of calcium influx through channels that shape the burst and tonic modes of thalamic relay cells. J Neurophysiol. 1997;77:2816-2825.
• Zhou Q, Petersen CCH, Nicoll RA. Effect of reduced vesicular filling on synaptic transmission. J Physiol. 2000;525(1):195-206.
• Zhou Q, Xiao MY, Nicoll RA. Contribution of cytoskeleton to the internalization of AMPA receptors. Proc Natl Acad Sci USA. 2001;98:1261-1266.
• Zhou Q, Tao HW, Poo M-m. Reversal and stabilization of synaptic modifications in a developing visual system. Science. 2003;300:1953-1957.
• Zhou Q, Homma K, Poo M-m. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron. 2004;44:749-757.
• Yang Y, Wang XB, Zhou Q. Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications. Proc Natl Acad Sci USA. 2010;107:11999-12004.
• Hanson J, Weber M, Meilandt W, Wu T, Luu T, Deng L, Shamloo M, Sheng M, Scearce-Levie K, Zhou Q. GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior. Neuropsychopharmacology. 2013;38(7):1221-1233.
• Paoletti P, Bellone C, Zhou Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and diseases. Nat Rev Neurosci. 2013;14(6):383-400.
• Zhou Q, Sheng M. NMDA receptors in nervous system diseases. Neuropharmacology. 2013;74:69-75.
• Zhou Q, Poo M-m. Reversal and consolidation of activity-induced synaptic modifications. Trends Neurosci. 2004;27:378-383.
• Yang Y, Zhou Q. Spine modifications associated with long-term potentiation. Neuroscientist. 2009;15:464-476.
• Wang XB, Zhou Q. Spine remodeling and synaptic modification. Mol Neurobiol. 2010;41:29-41.
• Zhou Q. GluN2B-NMDA receptors in Alzheimer's disease: beyond synapse loss and cell death. Neural Regen Res. 2014;9(21):1878-1879.
• 陈霖. 认知科学: 脑与认知科学交叉研究的前沿. 科学通报. 2010;55(3):205-206.
• 李澄, 张俊. NMDA受体与阿尔茨海默病的研究进展. 中华神经科杂志. 2018;51(6):469-473.
• Hanson JE, Meilandt WJ, Gogineni A, et al. Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. J Neurosci. 2014;34(24):8277-8288.
• Bozdagi O, Sakurai T, Papapetrou D, et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism. 2010;1(1):15.