生物行•生命百科  > 所属分类  >  神经与认知科学   
顶[0] 评论[0] 编辑

张志君

目录

学习工作经历编辑本段

2016年1月至今，上海交通大学生物医学工程学院，副研究员

2008年9月至2015年12月，上海交通大学生物医学工程学院，助理研究员

2002年7月至2003年9月，中国科学院神经科学研究所，突触发育与可塑性实验室，研究助理

博士：2003年9月至2008年1月，中国科学院神经科学研究所，突触发育和可塑性研究组

硕士：1999年9月至2002年7月，中南大学湘雅医学院，解剖学系

学士：1993年9月至1998年7月，新乡医学院，临床医学系

研究领域编辑本段

脑血管疾病的发病机制和星形胶质细胞的功能研究。主要发现：

科研项目编辑本段

  • 国家自然科学基金面上基金，项目主持，55万，起止时间：2020年1月1日至2023年12月31日
  • 国家自然科学基金面上基金，项目主持，54万，起止时间：2018年1月1日至2021年12月31日
  • 上海市科技创新面上基金，项目主持，54万，起止时间：2018年7月1日至2021年6月30日
  • 国家自然科学基金青年基金，项目主持，20万，起止时间：2008年1月1日至2011年12月31日
  • 上海交通大学医工交叉基金，项目主持，8万，起止时间：2010年至2012年

发表论文情况编辑本段

代表性论文：

  1. Wang J, Lin X, Mu Z, Shen F, Zhang L, Xie Q, Tang Y, Wang Y, Zhang Z* and Yang GY*. Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as detected by Multiple Modality Dynamic Imaging. Theranostics. 2019; 9(17): 4923–4934. (*co-corresponding author)
  2. Song Y, Li Z, He T, Qu M, Jiang L, Li W, Shi X, Pan J, Zhang L, Wang Y, Zhang Z*, Tang Y, and Yang GY*. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. Theranostics. 2019; 9(10): 2910–2923. (*co-corresponding author)
  3. Li Z, Gu Y, Wen R, Shen F, Tian HL, Yang GY, Zhang Z. Lysosome exocytosis is involved in astrocyte ATP release after oxidative stress induced by H2O2. Neurosci Lett. 2019 Jul 13;705:251-258.
  4. Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ*, Yang GY. Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats. CNS Neurosci Ther. 2019 Jun;25(6):748-758. (*co-corresponding author)
  5. Wang L, Zhou P, Mu Z, Lin X, Jiang L, Cheng Z, Luo L, Xu Z, Geng J, Wang Y, Zhang Z*, Yang GY. Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography. Transl Stroke Res. 2019 Jan 24. (*co-corresponding author)
  6. Cai H, Ma Y, Jiang L, Mu Z, Jiang Z, Chen X, Wang Y, Yang GY, Zhang Z. Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke. Mol Ther. 2017;25(6):1448-1459.
  7. Lu H, Song X, Wang F, Wang G, Wu Y, Wang Q, Wang Y, Yang GY, Zhang Z. Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia. Front Cell Neurosci. 2016;10:223.
  8. He X, Lu Y, Lin X, Jiang L, Tang Y, Tang G, Chen X, Zhang Z, Wang Y, Yang GY. Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2017;37(3):837-847.
  9. Biswas MH, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations. Stem Cell Reports. 2016;7(3):316-24.
  10. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016;7(3):325-40.
  11. Ma Y, Li Y, Jiang L, Wang L, Jiang Z, Wang Y, Zhang Z*, Yang GY*. Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice. J Neuroinflammation. 2016;13:38. (*co-corresponding author)
  12. Cai H, Mu Z, Jiang Z, Wang Y, Yang GY, Zhang Z. Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia. Neurosci Bull. 2015;31(5):550-60.
  13. Cai H, Zhang Z, Yang GY. Preconditioned stem cells: a promising strategy for cell-based ischemic stroke therapy. Curr Drug Targets. 2014;15(8):771-9.
  14. Liu Y, Tang G, Zhang Z, Wang Y, Yang GY. Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion. Neurosci Lett. 2014;579:46-51.
  15. Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y, Yang GY. Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia. Stem Cells. 2014;32(12):3150-62.
  16. Liu Y, Tang G, Li Y, Wang Y, Chen X, Gu X, Zhang Z, Wang Y, Yang GY. Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. J Neuroinflammation. 2014;11:177.
  17. Chen C, Lin X, Wang J, Tang G, Mu Z, Chen X, Xu J, Wang Y, Zhang Z*, Yang GY*. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem Cells. 2014;32(10):2679-89. (*co-corresponding author)
  18. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013;8(10):e76055.
  19. Lu Y*, Zhang Z*, Sun D, Sweeney ST, Gao FB. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell. 2013;52(2):264-71. (*co-first author)
  20. Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV Jr, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012;2(4):789-98.
  21. Chen G, Zhang Z, Wei Z, Cheng Q, Li X, Li W, Duan S, Gu X. Lysosomal Exocytosis in Schwann Cells Contributes to Axon Remyelination. Glia. 2012;60:295–305.
  22. Ma Y, Zhang Z, Wang X, Xia W, Gu H. Insights into the mechanism of magnetofection using MNPs-PEI/pDNA/free PEI magnetofectins. Int J Pharm. 2011;419(1-2):247-54.
  23. Tong X, Li X, Zhou B, Shen W, Zhang Z, Xu T, Duan S. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. Journal of Cell Biology. 2009;186:113-128.
  24. Zhang Z*, Chen G*, Zhou W*, Song A, Xu T, Luo Q, Wang W, Gu XS, Duan S. Regulated ATP release from astrocytes through lysosome exocytosis. Nat Cell Biol. 2007;9:945-953.
  25. Luo C, Jiang J, Zhou Q, Zhu X, Wang W, Zhang Z, Han X, Zhu D. Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. Journal of Neuroscience Research. 2007;85:1637-1646.
  26. Ge W*, Yang X*, Zhang Z, Wang H, Deng Q, Duan S. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science. 2006;312:1533-1537.
  27. Shen W*, Wu B*, Zhang Z, Dou Y, Rao Z, Chen Y, Duan S. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron. 2006;50:401-414.
  28. Yang Y*, Ge W*, Chen Y, Zhang Z, Shen w, Wu C, Poo M, Duan S. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS. 2003;100:15194-15199.

联系方式编辑本段

办公电话：86-21-62933291

Email：zhangzj@sjtu.edu.cn

地址：上海市华山路1954号教三楼211，200030

参考资料编辑本段

  • Zhang Z, Chen G, Zhou W, et al. Regulated ATP release from astrocytes through lysosome exocytosis. Nat Cell Biol. 2007;9:945-953.
  • Yang Y, Ge W, Chen Y, et al. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS. 2003;100:15194-15199.
  • Shen W, Wu B, Zhang Z, et al. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron. 2006;50:401-414.
  • Ge W, Yang X, Zhang Z, et al. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science. 2006;312:1533-1537.
  • Wang J, Lin X, Mu Z, et al. Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as detected by Multiple Modality Dynamic Imaging. Theranostics. 2019;9(17):4923-4934.
  • Song Y, Li Z, He T, et al. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. Theranostics. 2019;9(10):2910-2923.
  • Cai H, Ma Y, Jiang L, et al. Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke. Mol Ther. 2017;25(6):1448-1459.
  • Zhang Z, Almeida S, Lu Y, et al. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013;8(10):e76055.
  • Lu Y, Zhang Z, Sun D, et al. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell. 2013;52(2):264-271.
  • Almeida S, Zhang Z, Coppola G, et al. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012;2(4):789-798.
  • Chen G, Zhang Z, Wei Z, et al. Lysosomal Exocytosis in Schwann Cells Contributes to Axon Remyelination. Glia. 2012;60:295-305.
  • Tong X, Li X, Zhou B, et al. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. J Cell Biol. 2009;186:113-128.
  • Li Z, Gu Y, Wen R, et al. Lysosome exocytosis is involved in astrocyte ATP release after oxidative stress induced by H2O2. Neurosci Lett. 2019;705:251-258.
  • Zhou PT, Wang LP, Qu MJ, et al. Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats. CNS Neurosci Ther. 2019;25(6):748-758.
  • Wang L, Zhou P, Mu Z, et al. Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography. Transl Stroke Res. 2019;10(5):517-526.
  • Ma Y, Li Y, Jiang L, et al. Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice. J Neuroinflammation. 2016;13:38.
  • Cai H, Mu Z, Jiang Z, et al. Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia. Neurosci Bull. 2015;31(5):550-560.
  • Liu Y, Tang G, Zhang Z, et al. Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion. Neurosci Lett. 2014;579:46-51.
  • Tang G, Liu Y, Zhang Z, et al. Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia. Stem Cells. 2014;32(12):3150-3162.
  • Chen C, Lin X, Wang J, et al. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem Cells. 2014;32(10):2679-2689.
  • Ma Y, Zhang Z, Wang X, et al. Insights into the mechanism of magnetofection using MNPs-PEI/pDNA/free PEI magnetofectins. Int J Pharm. 2011;419(1-2):247-254.
  • Luo C, Jiang J, Zhou Q, et al. Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. J Neurosci Res. 2007;85:1637-1646.
  • He X, Lu Y, Lin X, et al. Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion. J Cereb Blood Flow Metab. 2017;37(3):837-847.
  • Biswas MH, Almeida S, Lopez-Gonzalez R, et al. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations. Stem Cell Reports. 2016;7(3):316-324.
  • Silva MC, Cheng C, Mair W, et al. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016;7(3):325-340.
  • Liu Y, Tang G, Li Y, et al. Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. J Neuroinflammation. 2014;11:177.
  • Cai H, Zhang Z, Yang GY. Preconditioned stem cells: a promising strategy for cell-based ischemic stroke therapy. Curr Drug Targets. 2014;15(8):771-779.
  • Lu H, Song X, Wang F, et al. Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia. Front Cell Neurosci. 2016;10:223.

附件列表


0

词条内容仅供参考，如果您需要解决具体问题
（尤其在法律、医学等领域），建议您咨询相关领域专业人士。

如果您认为本词条还有待完善，请 编辑

上一篇 再可塑性    下一篇 大脑皮层

关键词

同义词