张志君

职称：上海交通大学Med-X研究院 副研究员

张志君

学位：理学博士

上海市华山路1954号教三楼211,  200030
Room 211, Med-X Research Institute Shanghai Jiao Tong University
1954 Hua Shan Road, Shanghai 200030
China

办公室电话：86-21-62933291

Email：zhangzj@sjtu.edu.cn

2016/1 - 至今，    上海交通大学生物医学工程学院，副研究员

2008/9 - 2015/12，  上海交通大学生物医学工程学院，助理研究员

2002/7 - 2003/9，  中科院神经科学研究所，突触发育与可塑性实验室， 研究助理

博士 2003.9-2008.1    突触发育和可塑性研究组，中国科学院神经科学研究所

硕士1999.9-2002.7    解剖学系，中南大学湘雅医学院

学士 1993.9-1998.7    临床医学系，新乡医学院

脑血管疾病的发病机制和星形胶质细胞的功能研究
星形胶质细胞溶酶体能以钙离子依赖的方式进行释放，并含有高浓度的ATP，且呈现可调节性分泌（nature cell biology）。

发现星形胶质细胞来源的D型丝氨酸在突触可塑性中的关键作用（PNAS），沉默突触活化机制(Neuron)

 1. Wang J, Lin X, Mu Z, Shen F, Zhang L, Xie Q, Tang Y, Wang Y, Zhang Z* and Yang GY*. Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as detected by Multiple Modality Dynamic Imaging. Theranostics. 2019; 9(17): 4923–4934. doi: 10.7150/thno.32676.(*co-corresponding author)

2. Song Y, Li Z, He T, Qu M, Jiang L, Li W, Shi X, Pan J, Zhang L, Wang Y, Zhang Z*, Tang Y,  and Yang GY. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124.Theranostics. 2019; 9(10): 2910–2923.doi: 10.7150/thno.30879.(*co-corresponding author)

3. Li Z, Gu Y, Wen R, Shen F, Tian HL, Yang GY, Zhang Z. Lysosome exocytosis is involved in astrocyte ATP release after oxidative stress induced by H2O2. Neurosci Lett. 2019 Jul 13;705:251-258. doi: 10.1016/j.neulet.2019.03.046.

4. Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ*, Yang GY. Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats. CNS Neurosci Ther. 2019 Jun;25(6):748-758. doi: 10.1111/cns.13104. (*co-corresponding author)

5. Wang L, Zhou P, Mu Z, Lin X, Jiang L, Cheng Z, Luo L, Xu Z, Geng J, Wang Y, Zhang Z*, Yang GY. Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography. Transl Stroke Res. 2019 Jan 24. doi: 10.1007/s12975-019-0687-6.(*co-corresponding author)

6. Cai H, Ma Y, Jiang L, Mu Z, Jiang Z, Chen X, Wang Y, Yang GY, Zhang Z. Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke.  Mol Ther. 2017;25(6):1448-1459

7. Lu H, Song X, Wang F, Wang G, Wu Y, Wang Q, Wang Y, Yang GY, Zhang Z. Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia.Front Cell Neurosci. 2016;10:223.

8. He X, Lu Y, Lin X, Jiang L, Tang Y, Tang G, Chen X, Zhang Z, Wang Y, Yang GY. Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion. J Cereb Blood Flow Metab.  2017 ;37(3):837-847.

9. Biswas MH, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations. Stem Cell Reports. 2016;7(3):316-24.

10. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016;7(3):325-40.

5. Ma Y, Li Y, Jiang L, Wang L, Jiang Z, Wang Y, Zhang Z*, Yang GY*. Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice. J Neuroinflammation. 2016;13:38. (*co-corresponding author)

6. Cai H, Mu Z, Jiang Z, Wang Y, Yang GY, Zhang Z. Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia. Neurosci Bull. 2015;31(5):550-60.

7. Cai H, Zhang Z, Yang GY. Preconditioned stem cells: a promising strategy for cell-based ischemic stroke therapy. Curr Drug Targets. 2014;15(8):771-9.

8. Liu Y, Tang G, Zhang Z, Wang Y, Yang GY.Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion.Neurosci Lett. 2014;579:46-51. 

9. Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y, Yang GY.Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia.Stem Cells. 2014;32(12):3150-62.

10. Liu Y, Tang G, Li Y, Wang Y, Chen X, Gu X, Zhang Z, Wang Y, Yang GY.Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. J Neuroinflammation. 2014;11:177.

11. Chen C, Lin X, Wang J, Tang G, Mu Z, Chen X, Xu J, Wang Y, Zhang Z*, Yang  GY*. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem Cells. 2014;32(10):2679-89.  (*co-corresponding author)

12. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB.

  Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013 ;8(10):e76055.

13. Lu Y*, Zhang Z*, Sun D, Sweeney ST, Gao FB. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell. 2013;52(2):264-71. (*co-first author)

14. Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV Jr, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012;2(4):789-98.

15. Chen G, Zhang Z, Wei Z, Cheng Q, Li X, Li W, Duan S, Gu X. Lysosomal Exocytosis in Schwann Cells Contributes to Axon Remyelination. Glia 2012; 60:295–305

16. Yongjie Ma, Zhijun Zhang, Xiaoliang Wang, Weiliang Xia, Hongchen Gu. Insights into the mechanism of magnetofection using MNPs-PEI/pDNA/free PEI magnetofectins Int J Pharm. 2011;419(1-2):247-54

17. Tong X，Li X, Zhou B, Shen W, Zhang Z, Xu T, Duan S. Ca2+ signaling evoked by activation of Na+ channels and Na+ /Ca2+ exchangers is required for GABA-induced NG2 cell migration. Journal of Cell Biology 2009;186: 113-128

18. Zhang Z*, Chen G*, Zhou W*, Song A, Xu T, Luo Q, Wang W, Gu XS, Duan S. Regulated ATP release from astrocytes through lysosome exocytosis. Nat Cell Biol. 2007, 9:945-953

    19. Luo C, Jiang J, Zhou Q, Zhu X, Wang W, Zhang Z, Han X, Zhu D. Voluntary   exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. Journal of Neuroscience Research 2007;85:1637-1646 

   20. Ge W*., Yang X*., Zhang Z., Wang H., Deng Q., Duan S. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science, 2006;312, 1533-1537

   21. Shen W*., Wu B*., Zhang Z., Dou Y., Rao Z., Chen Y., Duan S. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron, 2006;50: 401-414 

   22. Yang Y*., Ge W*., Chen Y., Zhang Z., Shen w., Wu C., Poo M., and Duan S. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. PNAS, 2003;100: 15194 – 15199