刘永

刘永，男，1974年7月出生，博士，徐州医学院基础学院副教授、硕士生导师，兼任科研秘书。联系方式：电话0516-82920721，传真0516-85748486，E-mail yliu@xzmc.edu.cn，通信地址：徐州市淮海西路84号徐州医学院（221002）。

脑病细胞信号转导，特别是脑缺血再灌注损伤过程中神经元凋亡的信号通路调控。

• Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. FEBS Lett. 2008, 16;582(9):1298-1306.
• Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus. Neurosci. Lett. 2005, 379(1):55-58.
• PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci. Lett. 2007, 420(3):235-239.
• Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Brain 2006, 129(2):465-479.
• 钙离子介导NMDA受体与AMPA受体的相互抑制. 徐州医学院学报 2005, 5:379-382.

刘永及其团队揭示了脑缺血再灌注中GABA受体共激活通过解聚GluR6-PSD95-MLK3信号模块抑制JNK3凋亡通路，为开发神经保护药物提供了新靶点。此外，发现Pyk2抑制可减轻NMDA受体亚基2A的酪氨酸磷酸化，Src激酶抑制剂PP2能保护海马CA1锥体细胞，而含有TAT序列的GluR6-9c肽可有效透过血脑屏障发挥神经保护作用。钙离子在NMDA与AMPA受体间的相互抑制机制也为理解突触可塑性提供了重要线索。这些研究为脑卒中治疗策略的优化奠定了分子基础。

• Liu Y, et al. Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. FEBS Lett. 2008;582(9):1298-1306.
• Liu Y, et al. Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus. Neurosci Lett. 2005;379(1):55-58.
• Liu Y, et al. PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci Lett. 2007;420(3):235-239.
• Liu Y, et al. Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Brain. 2006;129(2):465-479.
• 刘永, 等. 钙离子介导NMDA受体与AMPA受体的相互抑制. 徐州医学院学报. 2005;25(5):379-382.
• Chen J, et al. Ischemic preconditioning attenuates mitochondrial dysfunction after global cerebral ischemia in rats. J Cereb Blood Flow Metab. 2003;23(9):1089-1099.
• Wang X, et al. The role of JNK3 in neuronal apoptosis after cerebral ischemia. Mol Neurobiol. 2004;29(1):1-12.
• Lee JM, et al. NMDA receptor subunits: diversity and role in excitotoxicity. Curr Opin Neurobiol. 2000;10(5):634-642.
• 张丹参, 等. 脑缺血再灌注损伤中GABA受体的保护作用. 中国药理学通报. 2010;26(3):281-285.