刘海燕

刘海燕，教授，博士生导师。1990年本科毕业于中国科学技术大学生物系。1996年博士毕业于中国科学技术大学，获郭沫若奖。1993-1995年作为联合培养研究生在瑞士苏黎世高等理工学院物理化学实验室学习。1998-2000年在杜克大学和北卡罗来纳大学作博士后。现为我校生命科学学院教授、博士生导师；分子生物学与细胞生物学系系主任。在生物分子计算机模拟与设计方法和酶催化模拟领域发表研究论文五十余篇，被引用900余次。2000年入选中国科学院“引进国外杰出人才”项目。2001年获“国家杰出青年基金”资助。2004年获安徽省青年科技奖。

蛋白质空间结构和动力学的计算机模拟方法与应用；蛋白质设计理论与实验方法及其在合成生物学中的应用。 ADSFAEQWER353423413434

现承担“863”计划课题1项，自然科学基金面上项目1项。

1. Q. Li, C. Zhou, H. Liu, Fragment-based local statistical potentials derived by combining an alphabet of protein local structures with secondary structures and solvent accessibilities, Proteins, 2008, in press.
2. C. Xu, J. Wang, H. Liu, A Hamiltonian replica exchange approach and its application to the study of side chain type and neighbor effects on peptide backbone conformations, J. Chem. Theo. Comput., 2008, 4, 1348-1359.
3. L. Xie, H. Liu, W. Yang, Adapting the nudged elastic band method for determining minimum-energy paths of chemical reactions in enzymes, J. Chem. Phys., 2004, 120, 8039.
4. Z. Zhang, Y. Shi, and H. Liu, Molecular dynamics simulations of peptides and proteins with amplified collective motions, Biophys. J., 2003, 84, 3583.
5. H. Liu, M. Elstner, E. Kaxiras, T. Frauenheim, J. Hermans, W. Yang, Quantum mechanics simulation of protein dynamics on long time scale, Proteins, 2001, 44, 484.
6. H. Liu, Y. Zhang, W. Yang, How is the active site of enolase organized to catalyze two different reaction steps? J. Am. Chem. Soc., 2000, 6560.
7. H. Liu, Q. Luo, Z. Duan, Y. Shi, Structure-based ligand design by dynamically assembling molecular building blocks at active site, Proteins, 1999, 36, 462.
8. H. Liu, A. E. Mark, W. F. van Gunsteren, On estimating the relative free energy of different molecular states with respect to a single reference state, J. Phys. Chem. 1996, 100, 9485.

e-mail: hyliu@ustc.edu.cn，电话：0551-3607451

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• Li Q, Zhou C, Liu H. Fragment-based local statistical potentials derived by combining an alphabet of protein local structures with secondary structures and solvent accessibilities. Proteins. 2008.
• Xu C, Wang J, Liu H. A Hamiltonian replica exchange approach and its application to the study of side chain type and neighbor effects on peptide backbone conformations. J Chem Theo Comput. 2008;4:1348-1359.
• Xie L, Liu H, Yang W. Adapting the nudged elastic band method for determining minimum-energy paths of chemical reactions in enzymes. J Chem Phys. 2004;120:8039.
• Zhang Z, Shi Y, Liu H. Molecular dynamics simulations of peptides and proteins with amplified collective motions. Biophys J. 2003;84:3583.
• Liu H, Elstner M, Kaxiras E, Frauenheim T, Hermans J, Yang W. Quantum mechanics simulation of protein dynamics on long time scale. Proteins. 2001;44:484.
• Liu H, Zhang Y, Yang W. How is the active site of enolase organized to catalyze two different reaction steps? J Am Chem Soc. 2000:6560.
• Liu H, Luo Q, Duan Z, Shi Y. Structure-based ligand design by dynamically assembling molecular building blocks at active site. Proteins. 1999;36:462.
• Liu H, Mark AE, van Gunsteren WF. On estimating the relative free energy of different molecular states with respect to a single reference state. J Phys Chem. 1996;100:9485.
• 张阳, 刘海燕. 蛋白质结构预测与分子动力学模拟. 科学通报. 2006;51(18):2101-2109.
• Wang J, Liu H, Xu C. Enhanced sampling in protein simulations: methods and applications. Curr Opin Struct Biol. 2012;22(3):349-355.