陈宇星

陈宇星，女，1966年生，中国科技大学生命科学学院教授。

陈宇星

1980-1984年，哈尔滨理工大学应用物理专业，获学士学位。
1987-1991年，哈尔滨理工大学应用物理专业，获硕士学位。
1984-1999年，哈尔滨理工大学，任讲师、副教授。
1999-2003年，法国巴黎第十一大学及法国国家研究中心酶学与生化结构研究所，获博士学位。
2003-2004年，法国国家研究中心酶学与生化结构研究所，博士后。
2004-2008年，同济大学生命学院蛋白质研究所教授，博士生导师。

联系方式：电话：0551-3602492  E-mail：cyxing@ustc.edu.cn

生物大分子结构和功能的研究。对核苷酸代谢途径中的主要蛋白质及其复合物的结构和功能进行研究，主要针对在这一途径中的关键酶的结构和功能的研究，就人类的相关疾病的药物设计提供理论指导。另外我们还启动了膜蛋白结构和功能的研究，从ABC转运蛋白和P型ATP酶结构和功能的研究入手，试图建立一个膜蛋白的表达、纯化和结晶平台。

• 蛋白质机器及分子机制，973国家重点项目，子课题负责人；
• ABC转运蛋白和P型ATP酶结构和功能的研究——膜蛋白的结构与功能－表达、纯化，国家基金委海外合作项目，合作中方负责人；
• 胁迫条件下细胞内ATP平衡调控的结构生物学基础，国家基金委面上项目，项目负责人；
• NDP激酶与硫氧还蛋白结构和功能的关系，上海市浦江人才计划，项目负责人。

1. Du Y, Shi WW, He YX, Yang YH, Zhou CZ and Chen Y. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochemical Journal. 2011; DOI: 10.1042/BJ20102097
2. Du Y, He YX, Zhang ZY, Yang YH, Shi WW, Frolet C, Guilmi AM, Vernet T, Zhou CZ, Chen Y. Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae. Journal Structural Biology. 2011; 174:252-257.
3. Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC and Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci USA. 2010; 107(28) 12487-92.
4. Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports. 2009; 10(12):1320-1326
5. Bao R, Zhou CZ, Jiang C, Lin SX, Chi CW, Chen Y. The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. Journal of Biological Chemistry. 2009; 284(39):26676-84.
6. Bao R, Chen Y, Tang YJ, Janin J, Zhou CZ. Crystal structure of the yeast cytoplasmic thioredoxin Trx2. Proteins. 2007; 66(1): 246-249.
7. Chen Y, Solange Morera, Claudia Pasti, Angela Angusti, Nicola Solaroli, Michel Veron, Joel Janin, Stefano Manfredini & Dominique Deville-Bonne. Adenosine phosphonoacetic acid is slowly metabolized by NDP Kinase. Medicinal Chemistry. 2005; 1(6): 529-536.
8. Chen Y, Gallois-Montbrun S, Schneider B, Verron M, Morera S, Deville-Bonne D & Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. Journal Molecular Biology. 2003; 332: 915-926.

• Du Y, Shi WW, He YX, et al. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochemical Journal, 2011, DOI: 10.1042/BJ20102097.
• Du Y, He YX, Zhang ZY, et al. Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae. Journal of Structural Biology, 2011, 174: 252-257.
• Zhao MX, Jiang YL, He YX, et al. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proceedings of the National Academy of Sciences USA, 2010, 107(28): 12487-12492.
• Ma XX, Jiang YL, He YX, et al. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports, 2009, 10(12): 1320-1326.
• Bao R, Zhou CZ, Jiang C, et al. The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. Journal of Biological Chemistry, 2009, 284(39): 26676-26684.
• Bao R, Chen Y, Tang YJ, et al. Crystal structure of the yeast cytoplasmic thioredoxin Trx2. Proteins, 2007, 66(1): 246-249.
• Chen Y, Morera S, Pasti C, et al. Adenosine phosphonoacetic acid is slowly metabolized by NDP Kinase. Medicinal Chemistry, 2005, 1(6): 529-536.
• Chen Y, Gallois-Montbrun S, Schneider B, et al. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. Journal of Molecular Biology, 2003, 332: 915-926.
• Berman HM, Westbrook J, Feng Z, et al. The Protein Data Bank. Nucleic Acids Research, 2000, 28(1): 235-242.
• Laskowski RA. PDBsum: summaries and analyses of PDB structures. Nucleic Acids Research, 2001, 29(1): 221-222.
• 张旭, 陈宇星, 周丛照. 枯草芽孢杆菌ABC转运蛋白OpuC底物结合蛋白的结构与功能研究. 中国生物化学与分子生物学报, 2012, 28(3): 234-240.
• 李志强, 陈宇星, 周丛照. 肺炎链球菌粘蛋白结合域Spr1345的晶体结构研究. 生物化学与生物物理进展, 2011, 38(5): 432-438.