徐兴顺

徐兴顺，1996年7月毕业于徐州医学院临床医学系，毕业后留徐州医学院附属医院神经内科工作。2003年5月赴美留学，2007年12月获得东田纳西州大学生物医学（药理学）博士学位。2007年9月起在美国Emory大学接受博士后训练。2010年3月，加入苏州大学神经科学研究所。

脑缺血保护研究

多年以来，对神经科疾病特别是脑血管病一直有着浓厚的研究兴趣并取得了很多的科研成果。读博士期间，他研究了许多的神经多肽（如humanin）对小鼠脑缺血损伤的保护作用，并探讨了神经细胞的死亡机制，其中包括necroptosis — 一种新证实的程序性细胞死亡。

Ahi1蛋白功能研究

博士后训练期间，他研究了与Joubert综合症密切相关的蛋白Ahi1的功能，成功培育出条件性AHI1基因敲除小鼠，并发现Ahi1参与膜受体TrkB的循环再利用的代谢调节。其研究成果已发表在Stroke、Journal of Clinical Investigation、Brain Research、Journal of Neurochemistry等杂志上。

• 缺血再灌注损伤脑保护
• Ahi1蛋白功能研究

1. Xu X, Chua CC, Gao J, Hamdy RC, Chua BH (2006) Humanin is a novel neuroprotective agent against stroke. Stroke 37: 2613-2619.
2. Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, et al. (2007) Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 103: 2004-2014.
3. Xu X, Chua CC, Gao J, Chua KW, Wang H, et al. (2008) Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res 1227: 12-18.
4. Sheng G, Xu X, Lin YF, Wang CE, Rong J, et al. (2008) Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 118: 2785-2795.
5. Xu X, Chua CC, Zhang M, Geng D, Liu CF, et al. (2010) The role of PARP activation in glutamate-induced necroptosis in HT-22 cells. Brain Res.
6. Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. (2010) Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. PNAS.

• Xu X, Chua CC, Gao J, Hamdy RC, Chua BH. Humanin is a novel neuroprotective agent against stroke. Stroke. 2006;37:2613-2619.
• Xu X, Chua CC, Kong J, et al. Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem. 2007;103:2004-2014.
• Xu X, Chua CC, Gao J, et al. Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res. 2008;1227:12-18.
• Sheng G, Xu X, Lin YF, et al. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest. 2008;118:2785-2795.
• Xu X, Chua CC, Zhang M, et al. The role of PARP activation in glutamate-induced necroptosis in HT-22 cells. Brain Res. 2010.
• Xu X, Yang H, Lin YF, et al. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. PNAS. 2010.
• Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 2012;13:267-278.
• Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003;4:399-415.
• 夏一鸣, 李晓波, 张彦鹏等. Humanin对脑缺血再灌注损伤的保护作用及机制研究. 中华神经科杂志. 2019;52(5):374-380.
• 王任佳, 赵永波. Ahi1基因与神经系统疾病研究进展. 中国神经精神疾病杂志. 2016;42(7):432-436.