徐兴顺
徐兴顺， 1996年7月毕业于徐州医学院临床医学系，毕业后留徐州医学院附属医院神经内科工作。2003年5月赴美留学，2007年12月获得东田纳西州大学生物医学（药理学）
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| 徐兴顺 |
博士学位。2007年9月起在美国Emory大学接受博士后训练。2010年3月，加入苏州大学神经科学研究所。多年以来，对神经科疾病特别是脑血管病一直有着浓厚的研究兴趣并取得了很多的科研成果。读博士期间，他研究了许多的神经多肽（如humanin）对小鼠脑缺血损伤的保护作用，并探讨了神经细胞的死亡机制，其中包括necroptosis — 一种新证实的程序性细胞死亡。博士后训练期间，他研究了与Joubert综合症密切相关的蛋白Ahi1的功能，成功培育出条件性AHI1基因敲除小鼠，并发现Ahi1参与膜受体TrkB的循环再利用的代谢调节。其研究成果已发表在Stroke, Journal of Clinical Investigation, Brain Research, Journal of Neurochemistry 等杂志上。
目前的主要研究方向：
1. 缺血再灌注损伤脑保护
2. Ahi1蛋白功能研究
Dr. Xingshun Xu graduated from Xuzhou Medical College in July 1996. After graduation, he worked as a neurologist in the Affiliated Hospital of Xuzhou Medical College. In May 2003, he went to the USA and received his PhD from East Tennessee State University in December 2007. He got his postdoctoral training at Emory University from September 2007. In March 2010, he joined the Institute of Neuroscience at Soochow University.
Dr. Xu’s research interests focused on neurological diseases, especially stroke. During his PhD studies, he examined the neuroprotection of different agents on cerebral ischemia injury and explored the mechanisms of cell death including necroptosis, a newly identified programmed cell death. In his postdoctoral training, he explored the function of Ahi1, a Joubert syndrome-related protein. He found that Ahi1 is involved in the regulation of recycling and sorting of TrkB receptor. His research findings were published in several journals such as Stroke, Journal of Clinical Investigation, Brain Research, and Journal of Neurochemistry.
His main project focuses on the protective mechanisms of some neuropeptides and small molecule chemicals on hypoxia/ cerebral ischemia injury by using cell biology and molecular biology techniques. Another project will continue to study the functions of Ahi1 by using transgenic mice.
发表论文：
1. Xu X, Chua CC, Gao J, Hamdy RC, Chua BH (2006) Humanin is a novel neuroprotective agent against stroke. Stroke 37: 2613-2619.
2. Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, et al. (2007) Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 103: 2004-2014.
3. Xu X, Chua CC, Gao J, Chua KW, Wang H, et al. (2008) Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res 1227: 12-18.
4. Sheng G, Xu X, Lin YF, Wang CE, Rong J, et al. (2008) Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 118: 2785-2795.
5. Xu X, Chua CC, Zhang M, Geng D, Liu CF, et al. (2010) The role of PARP activation in glutamate-induced necroptosis in HT-22 cells. Brain Res.
2. Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, et al. (2007) Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 103: 2004-2014.
3. Xu X, Chua CC, Gao J, Chua KW, Wang H, et al. (2008) Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res 1227: 12-18.
4. Sheng G, Xu X, Lin YF, Wang CE, Rong J, et al. (2008) Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 118: 2785-2795.
5. Xu X, Chua CC, Zhang M, Geng D, Liu CF, et al. (2010) The role of PARP activation in glutamate-induced necroptosis in HT-22 cells. Brain Res.
6. Xu X;Yang H;Lin YF;Li X;Cape A;Ressler KJ;Li S;Li XJ。 (2010) Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. PNAS.
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