方浩

性别：男
出生年月：1974年5月
技术职称：副教授
工作单位：药物化学研究室

ADFASDFAF23RQ23R

1996年：毕业于中国药科大学药学院化学制药专业，获工学士。
2001年：毕业于中国药科大学药学院药物化学专业，获理学博士学位。 ADSFAEQWER353423413434
2001-2002年，美国密歇根大学药学院进行博士后研究工作。
2002-2004年，美国北卡州立大学化学系和佐治亚州立大学化学系进行博士后研究工作。
2004.12 -至今，山东大学药学院 ADFASDFAF23RQ23R

• 研究生课程：《药物信息学》
• 本科生课程：制药工程专业《化学制药工艺学》；临床药学（七年制）《药物化学原理》（双语）

• 计算机辅助药物设计实验（本科）
• 药物化学实验（本科）
• 药物分子设计实验（研究生）

1. 设计、合成针对肿瘤细胞表面特异性寡糖的水溶性荧光探针，国家自然科学基金(20602023)，2007-2009
2. 设计、合成针对肿瘤细胞表面特异性寡糖抗原的荧光分子探针，山东省优秀中青年科学家科研奖励基金(2006BS03021)，2006-2008
3. 基于固相树脂合成和高通量筛选的Bcl-2特异性调节剂的研究，国家自然科学基金海外青年学者合作研究基金（30728031）合作人，2008-2010

（1）特异性识别肿瘤细胞表面寡糖的有机硼酸类荧光探针 ADFASDFAF23RQ23R
（2）基于靶点结构的药物设计、合成及生物活性研究

ADFASDFAF23RQ23R

1. Liu FZ, Fang H, Zhu HW, Wang Q, Yang Y, Xu WF. Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors. Bioorg Med Chem. 2008, 16, 578-585.
2. Liu FZ, Fang H, Xu WF. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid. Chin. Chem. Lett. 2007,18, 393-396.
3. Fang, H; Li, M-Y; and Xia, L. Pharmacophore-guided design, synthesis and evaluation of quinazoline-arylpiperazines as new α1-adrenoceptor antagonists. Chin. Chem. Lett. 2007,18(1), 41-44.
4. Li, Q.; Fang, H.; Xu W. Novel 3-galloylamido-N’-substituted-2,6-piperidinedione-N- acetamide peptidomimetics as metalloproteinase inhibitors. Bioorg. Med. Chem.Lett. 2007, 17, 2935-2938.
5. Zhang, J.; Wang, Q.; Fang, H.; Xu, W. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorg Med Chem. 2007, 15, 2749-2758.
6. Zhang, L.; Zhang, J.; Fang, H.; Wang, Q.; Xu, W. Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors. Bioorg Med Chem, 2006, 14, 8286-8294.
7. Kaur, G.; Fang, H.; Gao, X.; Li, H.; Wang, B. Substituent effect on anthracene-based bisboronic acid glucose sensors. Tetrahedron,2006, 62, 2583-2589.
8. Fang, H.; Kaur, G.; Yan, J.; Wang, B. An Efficient Synthesis of Sterically Hindered Arylboronic Acids. Tetrahedron. Lett. 2005, 46, 1671-1674.
9. Yan, J; Fang, H.; Wang, B. Boronolectins and Fluorescent Boronolectins: An Examination of the Detailed Chemistry Issues Important for the Design. Med. Res. Rev, 2005, 25,490-520.
10. Li, M-Y.; Fang, H.; Xia, L. Pharmacophore-based Design, Synthesis, Biological Evaluation, and 3D-QSAR Studies of Aryl-piperazines as alpha1-Adrenoceptor Antagonists. Bioorg. Med. Chem.Lett. 2005, 15, 3216-3219.
11. Fang, H.; Li, M-Y; Xia, L. et al. Design and Synthesis of Novel Aryloxyalkyl-arylpiperazine Derivatives as alpha1A-Adrenoceptor Antagonists. Chinese. Chem. Lett. 2005, 16, 445-448.

• Liu FZ, Fang H, Zhu HW, Wang Q, Yang Y, Xu WF. Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors. Bioorg Med Chem. 2008, 16, 578-585.
• Liu FZ, Fang H, Xu WF. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid. Chin. Chem. Lett. 2007,18, 393-396.
• Fang, H; Li, M-Y; and Xia, L. Pharmacophore-guided design, synthesis and evaluation of quinazoline-arylpiperazines as new α1-adrenoceptor antagonists. Chin. Chem. Lett. 2007,18(1), 41-44.
• Li, Q.; Fang, H.; Xu W. Novel 3-galloylamido-N’-substituted-2,6-piperidinedione-N- acetamide peptidomimetics as metalloproteinase inhibitors. Bioorg. Med. Chem.Lett. 2007, 17, 2935-2938.
• Zhang, J.; Wang, Q.; Fang, H.; Xu, W. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorg Med Chem. 2007, 15, 2749-2758.
• Zhang, L.; Zhang, J.; Fang, H.; Wang, Q.; Xu, W. Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors. Bioorg Med Chem, 2006, 14, 8286-8294.
• Kaur, G.; Fang, H.; Gao, X.; Li, H.; Wang, B. Substituent effect on anthracene-based bisboronic acid glucose sensors. Tetrahedron,2006, 62, 2583-2589.
• Fang, H.; Kaur, G.; Yan, J.; Wang, B. An Efficient Synthesis of Sterically Hindered Arylboronic Acids. Tetrahedron. Lett. 2005, 46, 1671-1674.
• Yan, J; Fang, H.; Wang, B. Boronolectins and Fluorescent Boronolectins: An Examination of the Detailed Chemistry Issues Important for the Design. Med. Res. Rev, 2005, 25,490-520.
• Li, M-Y.; Fang, H.; Xia, L. Pharmacophore-based Design, Synthesis, Biological Evaluation, and 3D-QSAR Studies of Aryl-piperazines as alpha1-Adrenoceptor Antagonists. Bioorg. Med. Chem.Lett. 2005, 15, 3216-3219.
• Fang, H.; Li, M-Y; Xia, L. et al. Design and Synthesis of Novel Aryloxyalkyl-arylpiperazine Derivatives as alpha1A-Adrenoceptor Antagonists. Chinese. Chem. Lett. 2005, 16, 445-448.
• Wang, B.; Fang, H.; Yan, J. Boronic Acid-Based Fluorescent Sensors for Glucose. In: Geddes CD, Lakowicz JR, editors. Glucose Sensing. Topics in Fluorescence Spectroscopy, vol 11. Springer; 2006. p. 201-230.
• Xu, W.; Zhang, J.; Fang, H.; Wang, Q. Design and synthesis of pyrrolidine derivatives as neuraminidase inhibitors. In: Proceedings of the 5th International Conference on Pharmaceutical Sciences; 2007; Shanghai, China. p. 45-50.
• 刘方舟, 方浩, 徐文方. N-Boc-吡咯烷-2-甲酸衍生物的胺偶联方法研究. 中国化学快报. 2007;18(4):393-396.
• 李明阳, 方浩, 夏霖. 基于药效团的α1肾上腺素受体拮抗剂的合成、活性与3D-QSAR研究. 药学学报. 2005;40(8):739-744.