镇学初

Research Papers (Selected):

(1)   Chu HY, Wu Q, Zhou S, Cao X, Zhang A, Jin GZ, Hu GY, Zhen X. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism. J Neurosci Res. 2011 May 2. doi: 10.1002/jnr.22653. [Epub ahead of print]

(2)   Mao X, Wang Y, Carter AV, Zhen X, Guo SW. The Retardation of Myometrial Infiltration, Reduction of Uterine Contractility, and Alleviation of Generalized Hyperalgesia in Mice With Induced Adenomyosis by Levo-Tetrahydropalmatine (l-thp) and Andrographolide. Reprod Sci. 2011 Apr 14. [Epub ahead of print]

(3)   Ye N, Wu Q, Zhu L, Zheng L, Gao B, Zhen X, Zhang A. Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D(3) receptor ligands. Bioorg Med Chem. 2011 Mar 15; 19(6):1999-2008.

(4)   Chu HY, Yang Z, Zhao B, Jin GZ, Hu GY, Zhen X*. Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro.Brain Res. 2010 Jul 9; 1343:20-7.

(5)   Mo J, Zhang H, Yu LP, Sun PH, Jin GZ, Zhen X. L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. Neurobiol Aging. 2010 Jun; 31(6):926-36.

(6)   Chu HY, Zhen X. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems. Acta Pharmacol Sin. 2010 Sep; 31(9):1036-43.

(7)   Chu HY, Gu QH, Jin GZ, Hu GY, Zhen X*. Electrophysiological Effects of SKF83959 on Hippocampal CA1 Pyramidal Neurons: Potential Mechanisms for the Drug’s Neuroprotective Effects. PlosOne. 2010 Oct 1; 5(10): e13118.

(8)   Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen X*. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse.2011 May; 65(5):379-87.

(9)   Zhao T, Liu X, Zhen X*, Guo SW. Levo-Tetrahydropalmatine (l-THP) Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats. Reprod Sci. 2011 Jan; 18(1):18-45.

(10)   Wu C, Yang K, Liu Q, Wakui M, Jin GZ, Zhen X*, Wu J. Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta. Neuropharmacology. 2010 Dec; 59(7-8):567-72.

(11)   LiuZ，Zhang H, Yu LP, Zhen X*, Zhang A. Synthesis of Furo[3,2-l]aporphine and Dihydrofuro[3,2-l]aporphine Derivatives: Identification of a Potent and Selective 5-HT1A Receptor Agonist. J. Med. Chem. 2010 Feb 11; 53(3):1319-28.

(12)   Zhang J, Zhang H, Cai W, Yu L, Zhen X*, Zhang A. 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. Bioorg Med Chem.2009 Jul 15; 17(14):4873-80.

(13)   Zhang X, Fei Ding, Zhen X*, Jiawei Zhou. PI-linked D1 receptor-Mediated FGF-2 Expression in Astrocytes Protects Dopaminergic Neurons. J. Neurosci. 2009, 29(24):7766-75.

(14)   Guo Y, Zhang H, Chen X, Cai W, Cheng J, Yang Y, Jin G, Zhen X*. Evaluation of the a antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. Schizophrenia Res. 2009 Nov; 115(1):41-9.

(15)   Sun P, Wang J, Gu W, Cheng W, Jin GZ, Friedman E, Zheng J, Zhen X*. PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation. Cell Res. 2009 May; 19(5):612-24.

(16)   Chen XQ, Zhang J, Neumeyer JL, Jin GZ, Hu GY, Zhang A, Zhen X*. Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. PLoSOne. 2009 Jun 5; 4(6):e5811.

(17)   Yang K, Hu J, Lucero L, Liu Q, Zheng C, Zhen X*, Jin G, Lukas RJ, Wu J. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J Physiol. 2009 Jan 15; 587(Pt 2):345-61.

(18)   Liu Z, Chen X, Yu L, Zhen X*, Zhang A. Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15; 16(14):6675-81.

(19)   Liu Z, Chen X, Sun P, Yu L, Zhen X, Zhang A. N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15; 16(18):8335-8.

(20)   Zhang D, Zhang H, Jin GZ, Zhang K, Zhen X*. Single dose of morphine produced a prolonged effect on dopamine neuron activities. Mol Pain. 2008 Nov 17; 17: 4-57.

(21)   Zhang D,  Yang S,  Yang C,  Jin G,  Zhen X*. Estrogen modulated cocaine-altered dopamine neuron activity in ventral tegmental area. Psychopharmacology. 2008, 199(4):625-35.

(22)   Mo J, Zhang H, GZ Jin, Zhen X*. SPD attenuated L-DOPA-induced dyskinesia in Parkinsons disease rat model. Neurobiolgy of aging. 2010 Jun; 31(6):926-36.

(23)   Zhang J, Chen X, Yu L, Zhen X*, Zhang A. Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities. Bioorg Med Chem. 2008 Nov1; 16(21):9425-31.

(24)   Feng YQ, Zhou ZY, He X, Wang H, Guo XL, Hao CJ, Guo Y, Zhen X, Li W. Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia.Schizophr Res. 2008 Dec; 106(2-3):218-28.

(25)   Zhang ZJ, Tan QR, Tong Y, Li Q, Kang WH, Zhen X, Post RM. The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled study. J Affect Disord. 2008 Jul; 109(1-2):91-7.

(26)   Yu Y, Wang JR, Sun PH, Guo Y, Zhang ZJ, Jin GZ, Zhen X*. Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3beta and a receptor-independent anti-oxidative action. J Neurochem. 2008 Feb; 104(4):946-56.

(27)   Gu WH, Yang S, Shi WX, Jin GZ, Zhen XC. Requirement of PSD-95 for dopamine D1 receptor modulating glutamate NR1a/NR2B receptor function. Acta Pharmacol Sin. 2007 Jun; 28(6):756-62.

(28)   Tan QR, Wang XZ, Wang CY, Li XJ, ChenＹ，Wang HH，Zhen X and Zhang ZJ. Differential effects of atypical and classical antipsychotics in protecting against neurotoxicity induced by rotenone in PC12 cells.  Eur Neuropsychopharmacol. 2007, 17(12):768-73.

(29)   Zhen X, Goswami S, Abdali SA, Frankfurt M, Friedman E. Estrogen-modulated frontal cortical CaMKII activity and behavioral supersensitization induced by prolonged cocaine treatment in female rats. Psychopharmacology (Berl). 2007 Apr; 191(2):323-31.

(30)   Zhang H, Wang F, Chen J, Zhen X*. SKF83959 attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson’s disease. Neuropharmacology. 2007 Jul; 53(1):125-33.

(31)   Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X. Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications. Curr Med Chem. 2007, 14(28):2996-3002.

(32)   GU W, Shi WX, Zhen X,  Jin G. Effects of (-) -stepholidineon NMDA receptors； comparison with haloperidol and clozapine. Acta Pharmacologica Sinica. 2007 Jul; 28(7):953-8.

(33)   Gu W, Shi WX,  Jin G, Zhen X*. Requiring PSD-95 for D₁ dopamine receptor modulating NMDA receptor function. Acta Pharmacologica Sinica. 2007, 28(6):756-62.

(34)   Gao M, Liu CL, Yang S, Zhen X, Jin GZ. l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons. Acta Pharmacol Sin.2007 May; 28(5):627-33.

(35)   Ming Y, Zhang H, Long L, Wang F, Chen J, Zhen X. Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neurons. J Neurochem. 2006 Aug; 98(4):1316-23.

(36)   Zhen X*, S Gaswomi, E Friedman. Estrogen-modulated frontal cortical CaMKII activity is involved in behavioral supersensitization to cocaine in female rats. Psychopharmacology. 2007 Apr; 191(2):323-31.

(37)   Yuling Ming, Hai Zhang, J Chen, Zhen X*. SKF83959 stimulates Ca²⁺ signaling in primary cultured hippocampal neurons. J. Neurochem. 2005, 98:1316-23.

(38)   Zhang-Jin Zhang, Xiao-Long Jiang, Steven E. Zhang, Yan Zhang, Christopher J. Hough, He Li, Zhen X*. The paradoxical effects of SKF83959, a novel dopamine D₁-like receptor agonist, in the rat acoustic startle reflex paradigm. Neurosci. Lett.2005 Jul; 382(1-2):134-8.

(39)   Zhen X*, Satindra Goswami. Activation of Phosphatidyinositol (PI)-linked D₁ Dopamine Receptor Is Associated With The Antiparkinsonian Action of SKF83959. Biochem. Pharm. Behav. 2005, 80(4):597-601.

(40)   Zhen X*, Gaswomi S, abdali SA. Regulation of cdk5 and CaMKII by PI-linked dopamine receptor in rat brain. Mol Pharmacol. 2004 Dec; 66(6):1500-7.

(41)   M Gil, Zhen X*. Prenatal cocaine exposure alters GSK3β pathways in select rabbit brain areas.Neurosci Lett. 2003 Oct 9; 349(3):143-146.

(42)   LQ Jin, Gaswami S, Zhen X*. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J. Neurochem. 2003 Apr; 85(2):378-86.

(43)   Zhen X*, C Torries, GP Cai, et al. Inhibition of striatal protein tyrosine phosphatases is associated with D2 dopamine receptor-mediated  supersensitivity in  Parkisno’s rat model. Mol. Pharmacol.2002, 62:1356-1362.

(44)   Zhen X*, C Torries, E Friedman. Lithium regulates tyrosine phosphatase activity in vivo and in vitro. Psychopharm. 2002 Aug; 162(4):379-84.

(45)   Zhen X*, Claudio Torres, Hoau-Yan Wang. Prenatal exposure to cocaine disrups D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex. J. Neurosci. 2001 Dec 1; 21 (23): 9160-67.

(46)   Zhen X*, J Zhang, E Friedman. D4 dopamine receptor differentially regulates Akt/NF-kB pathways in D4MN9D cells. Mol.Pharmacol. 2001 Oct; 60(4):857-64.

(47)   J Yu, Reilly G, Zhen X, CE Yellowley, CR Jacobs. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 cells. J. Biol. Chem. 2001 Apr 20; 276(16):13365-13371.

(48)   Zhen X*, W Du, R Anthony, E Friedman and J Harvey. The p38 MAPK is involved in associative learning in rabbits. J. Neurosci. 2001 Aug 1; 21(15): 5513-9.

(49)   Zhen X*, Wu Q and Q Chen. Role of p38 MAPK in PTH-regulated chondrocyte differentiation.J. Biol. Chem. 2001, 276:4879-85.

(50)   Zhen X, GP Cai (co-first author), K Uryu, E Friedman. Activation of extracellular signal-regulated protein is associated with sensitized locomotive response to D2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J. Neurosci. 2000 Mar 1; 20(5):1849-1857.

(51)   Zhen X, K Uryu, GP Cai, J Johnson, E Friedman. Age-related impairment of MAP kinase and effect of caloric restriction in brains of Fisher 344 rats.  J. Gerontol. 1999, 54A:B539-548.

(52)   Zhen X, K Uryu, HY Wang and E Friedman. D1 dopamine receptor agonists mediate activation of p38 MAPK and JNK by a protein Kinase A-dependent mechanism in SK-N-MC cells. Mol. Pharmacol. 1998 Sep, 54(3):453-458.

(53)   Zhen X, JP Bonjour and J Caverzasio. Platelet-derived growth factor stimulates sodium-dependent Pi transport in osteoblastic cells via phospholipase Cg and phosphatidylinositol 3’kinase. J. Bone & Mineral Res. 1997, 12:35-42 . 
(54)   Imai, Zhen X, JP Bonjour and J Carverzasio. Aluminum potentiates Pi transport stimulation induced by fluoride in osteoblast-like cells. Am. J. Physiol. 1996, 271(Endocrinol. Metab.34): E694-701.

  
E-mail: zhenxuechu@suda.edu.cn