贾怡昌

贾怡昌 博士， 清华大学医学院研究员

电子邮件：yichangjia@mail.tsinghua.edu.cn

神经功能研究是当今生命科学研究的重大问题之一，它对于我们理解脑高级认知功能，神经系统疾病发生发展，以及人工智能开发均具有重大意义。神经退行性疾病 是指大脑和脊髓神经细胞丧失的一大类疾病，全世界范围数以千万病人患病，但临床上却缺少可靠的治疗药物和方案。研究神经科学的基本问题，对于我们认识神经 行为发生及神经退行性疾病发病具有重要意义。本实验室感兴趣1）正常和病理条件下，特异的神经细胞的RNA代谢，以及RNA代谢紊乱所致神经退行性疾病的 发病机制；2）RNA结合蛋白的正常神经功能和其在神经退行性疾病致病过程中的作用；3）神经细胞内质网功能紊乱及其在神经退行性疾病中的作用。我们综合 运用神经生物学、分子细胞生物学、小鼠遗传学、高通量核酸测序和蛋白质组学等技术手段，在细胞和小鼠整体水平，研究以上问题。

1. Yichang Jia, John Mu, Susan Ackerman. (2012) Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration. Cell. 148, 296-308.

2. Jian Zhou, Wanlu Du, Kechun Zhou, Yilin Tai, Hanlan Yao, Yichang Jia, Yuqiang Ding, Yizheng Wang. (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nature Neuroscience. 11, 741-3.

3. YiqunYao, Xia Ding, Yichang Jia, Chuanxin Huang, Yizheng Wang, and Yunhui Xu. (2008) Anti-tumor effect of b-elemene in glioblastoma cells 3 depends on p38 MAPK activation. Cancer Lett. 264, 127-134.

4. Zenghua Wang, Bin Shen, Haolan Yao, Yichang Jia, Jing Ren, Youji Feng and Yizheng Wang. (2007) Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer. Oncogene. 26, 5107-5114.

5. Chuanxin Huang, Yichang Jia, Shenglian Yang, Biao Chen, Hongwei Sun, Feng Shen and Yizheng Wang. (2007) Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Exp. Cell Res. 313, 254-263.

6. Yichang Jia*, Jian Zhou*, Yilin Tai and Yizheng Wang. (2007) TRPC channels promote cerebellar granule neuron survival. Nature Neuroscience 10, 559-567. * These authors contributed equally to this work. (also see News and Views, Nature Neuroscience 10, 537-538)

7. Yan Li*, Yichang Jia*, Kai Cui*, Ning Li, Zai-Yu Zheng, Yi-Zheng Wang and Xiao-Bing Yuan. (2005) Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature. 434, 894-898. * These authors contributed equally to this work. (also see News and Views, Nature 434, 835-838)