李相尧
西安交通大学,神经和疾病研究中心PI,副主任
Principal Investigator at the level of Professor
Jointly a deputy director of a lab (实验室副主任),
Lab of Neuronal Circuitry and Disease
(神经回路与疾病实验室)
E-mail: lixiangy9@mail.xjtu.edu.cn
Chronic pain is a major health issue in human society caused
mainly by tissue or nerve injury. The common pathological conditions
include spontaneous pain, allodynia and hyperalgesia. Peripheral
sensitization and central plasticity are likely to contribute to chronic
pain. The long-term change of the synaptic transmission induced by
chronic pain has been studied along the sensory pathway, from the
periphery receptors, spinal cord to the anterior cingulate cortex.
Different approaches will be employed to investigate the neuronal
mechanism mediating the maintenance of chronic pain.
Name Xiang-Yao LI
Sex Male
Birth ,1978.1
Address Frontier Institute of Science and Technology,
Xi’an jiaotong University,
Rm. B316, West Building No.1,No.99 Yanxiang RD, Xi’an
Shaanxi, 710054, China
Phone 86-29-83395342
E-mail, Leexiangyao@gmail.com
Education:
2002-2007, Ph.D
Neurophysiology, School of Life Science
East China Normal University, Shanghai, China
1996-2000,, Bachelor
Biology, Department of Biology
East China Normal University, Shanghai, China
Research and Working Experience:
2012/03-present FIST
Xi’an Jiaotong University
2007/12-2012/03 Post-doctoral Fellow (Prof. Min Zhuo)
Department of Physiology
University of Toronto
2006/5 – 2007/10 Visiting student (Prof. Shumin Duan)
Lab of Synapse Development & Plasticity
Institute of Neuroscience
2002/9 – 2007/6 Graduate Student ( Prof. Xin-De Sun)
School of Life Science.
Research center for brain science,
East China Normal University, Shanghai, China
2000/7-2002/8 Assistant Teacher
Biology Department
Nanyang Teacher’s College, Henan, China
1999/12 – 2000/6 Visiting Student
Lab of Biophysics (Prof. Zhuan Zhou )
Institute of Neuroscience
Chinese Academy of Sciences, China
Fellowship:
2010/4 - 2012/04 Post-doctoral fellowship from CIHR &
Fragile X research foundation of Canada
Research interests
1.The temporal processing of information in central nervous system.
The
central nervous system is one of the most important parts of human.
The neurons in central nervous system process information from
peripheral nervous system. The temporal properties of spikes carry
critical information, which has been found to be involved in the brain
function under normal and disease condition. My group will combine
different approach to investigate how the temporal summation of
information coding is involved in the brain function.
2.The energy metabolism of central nervous system under chronic pain condition.
Human
brain imaging results suggest that the energy metabolism of pain
related areas was changed under chronic pain condition. However, the
cellular and molecular mechanism mediating this change kept unclear.
Energy metabolism has been proved to be involved in the maintenance of
long-term memory, which shed a light that the energy metabolism is
important for the maintenance of chronic pain, we therefore plan to
combine different approaches to investigate the related mechanism
mediating the change of energy metabolism under chronic pain condition.
Research articles and reviews
1.Li
XY, Chen T, Descalzi G, Koga K, Qiu S, Zhuo M. Characterization of
neuronal intrinsic properties and synaptic transmission in layer I of
anterior cingulate cortex from adult mice, Molecular Pain.2012 8:53.
2.Descalzi
G, Li XY, Chen T, Koga K, Mercaldo V, Kaang H, Zhuo M. Rapid
alterations within the anterior cingulate cortex mediate trace fear
learning. Molecular Brain. 2012 5:6.
3.Steenland H, Li XY, Zhuo
M., Predicting Aversive Events and Terminating Fear in the Mouse
Anterior Cingulate Cortex during Trace Fear Conditioning. J. Neurosci.
2012 32,(3):1082
4.Abumaria N, Yin B, Zhang L, Li XY, Chen T,
Descalzi G, Zhao L, Ahn M, Luo L, Ran C, Zhuo M, Liu G. Effects of
elevation of brain magnesium on fear conditioning, fear extinction, and
synaptic plasticity in the infralimbic prefrontal cortex and lateral
amygdala. J. Neurosci. 2011, 31(42):14871-81.
5.Toyada H*, Li
XY*, Wu LJ, Zhao MG, Descalzi G, Chen T, Koga K, Zhuo M. Interplay of
amygdala and cingulate plasticity in emotional fear. Neural Plasticity.
2011, 2011:813749. (*Equal contributor).
6.Koga K*, Chen T*, Li
XY*, Descalzi G, Ling J, Gu J, Zhuo M. Glutamate acts as a
neurotransmitter for GRP-related itch in mammalian spinal cord.
Molecular Pain,7:47. (*Equal contributor).
7.Qiu S, Li XY, Zhuo
M. Posttranslational modification of NMDA receptor GluN2B subunit and
its roles in pain and memory. Seminars in Cell and Developmental
Biology, 2011, 22(5):521-9.(review)
8.Li XY, Ko HY, Chen T,
Collingridge GL, Kaang BK, Zhuo M. Erasing injury-related cortical
synaptic potentiation as a new treatment for chronic pain. Journal of
Molecular Medicine. 2011, 89(9):847-55 (review).
9.Kim SS*, Wang
H*, Li XY* , Chen T*, Mercaldo V, Descalzi G, Wu LJ, Zhuo M. Neurabin in
the anterior cingulate cortex regulates anxiety-like behavior in adult
mice. Molecular Brain. 2011, 4: 6. (*Equal contributor).
10.Li
XY*, Ko HG*, Chen T*, Descalzi G, Koga K, Wang H, Kim SS, Shang Y, Kwak
C, Park SW, Shim J, Lee K, Collingridge GL, Kaang BK, Zhuo M.
Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in
the anterior cingulate cortex. Science. 2010; 330(6009):1400-4. (*Equal
contributor, Science signaling Editor’s choice, Nature highlighted,
F1000 highlighted )
11.Chen T, Koga K, Li XY, Zhuo M. Spinal
microglial motility is independent of neuronal activity and plasticity
in adult mice. Molecular Pain. 2010; 6:19.
12.Wu LJ, Mellström
B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M.
DREAM (Downstream Regulatory Element Antagonist Modulator) contributes
to synaptic depression and contextual fear memory. Molecular Brain.
2010; 3:3.
13.Koga K, Li XY, Chen T, Steenland HW, Descalzi G,
Zhuo M. In vivo whole-cell patch-clamp recording of sensory synaptic
responses of cingulate pyramidal neurons to noxious mechanical stimuli
in adult mice. Molecular Pain. 2010; 6:62.
14.Cao XY, Xu H, Wu
LJ, Li XY, Chen T, Zhuo M. Characterization of intrinsic properties of
cingulate pyramidal neurons in adult mice after nerve injury. Molecular
Pain. 2009; 5:73
15.Wu LJ, Li XY, Chen T, Ren M, Zhuo M.
Characterization of intracortical synaptic connections in the mouse
anterior cingulate cortex using dual patch clamp recording. Molecular
Brain. 2009; 2: 32.
16.Tong XP, Li XY, Zhou B. Shen W. Zhang ZJ.
Xu TL. Duan S. Ca2+ signaling evoked by activation of Na+ channels and
Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. J.
Cell Biol. 2009,186 (1): 113-128.
17.Vecsey CG. Baillie G.
Jaganath D. Havekes R. Daniels A. Wimmer M. Huang T. Brown K. Li XY.
Descalzi G. Kim SS. Chen T. Shang YZ. Zhuo M. Houslay MD. Abel T. Sleep
deprivation impairs cAMP signaling in the hippocampus.2009. Nature.
2009; 461(7267):1122-5
18.Wu LJ*, Kim SS*, Li XY*, Zhang F*, Zhuo
Min. Sexual attraction enhances glutamate transmission in mammalian
anterior cingulate cortex. Molecular Brain, 2009; 1:9. (* Equal
contributor)
19.Shang Y, Wang H, Mercaldo V, Li XY, Chen T, Zhuo
M. Fragile X mental retardation protein is required for
chemically-induced long-term potentiation of the hippocampus in adult
mice. J. Neurochem. 2009, 111(3): 635-46
20.Liao CY, Li XY, Wu B,
Duan S. Jiang GBAcute enhancement of synaptic transmission and chronic
inhibition of synaptogenesis induced by perfluorooctane sulfonate
through mediation of voltage-dependent calcium channel. Environ. Sci.
Technol. 2008, 42(14): 5335-41.
21.Li XY, Li L, Zhang JP, Sun XD.
The behavioral presentations of audio-visual integration in rats.
Academic journal of second military medical university, 2007, 28(5):
480-483.
22.Li XY, Gao F, Zhang Z, Zhang JP, Sun XD. Auditory
cues induced the place navigation in rats. Journal of Fudan university
(natural science edition), 2007, 46(6).
23.Gao F. Chen L. Pu Q.
Li XY. Sun XD. Zhang JP. Influence of Prenatal Noise Exposure on the
Auditory Object Exploration Behavior of Adult Rats. Chinese Journal of
Zoology, 2007, 42(5): 20-26.
24.Wang XY, Yu LP, Li XY, Zhang JP,
Sun XD. Auditory-visual Multisensory Neurons and Auditory-visual
Information Integration in Newborn Rat Cortex. Chinese Journal of
Zoology, 2006, 41(4): 31-40.
25.Yu LP, Wang XY, Li XY, Zhang JP,
Sun XD. The Auditory-visual Multisensory Neurons and Auditory-visual
Information Integration in Rat Cortex. Progress in Biochemistry and
Biophysics, 2006, 33(7):677-684.
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