李相尧

姓名：李相尧（Xiang-Yao LI）

性别：男

出生年月：1978年1月

地址：陕西省西安市雁翔路99号西安交通大学前沿科学技术研究院，B316室，邮编710054

电话：86-29-83395342

电子邮箱：Leexiangyao@gmail.com；lixiangy9@mail.xjtu.edu.cn

2002-2007：华东师范大学生命科学学院，神经生理学博士。

1996-2000：华东师范大学生命科学学院，生物科学学士。

2012/03-至今：西安交通大学前沿科学技术研究院，神经和疾病研究中心PI，教授，实验室副主任。

2007/12-2012/03：多伦多大学，生理学系，博士后（导师：卓敏）。

2006/5-2007/10：中国科学院神经科学研究所，突触发育与可塑性实验室，访问学生（导师：段树民）。

2002/9-2007/6：华东师范大学生命科学学院，脑科学研究中心，研究生（导师：孙心德）。

2000/7-2002/8：河南省南阳师范学院，生物系，助教。

1999/12-2000/6：中国科学院神经科学研究所，生物物理实验室，访问学生（导师：周专）。

1. 中枢神经系统的时间信息处理：中枢神经系统是人类最重要的部分之一。中枢神经系统的神经元处理来自周围神经系统的信息。神经冲动的时域特性携带关键信息，在正常和疾病条件下的脑功能中发挥作用。该课题组将综合运用多种方法研究信息编码的时间总和如何参与脑功能。

2. 慢性痛条件下中枢神经系统的能量代谢：人脑成像结果表明，慢性痛条件下疼痛相关脑区的能量代谢发生改变，但其细胞和分子机制尚不清楚。能量代谢被证明参与长期记忆的维持，提示能量代谢对于慢性痛的维持也很重要。因此，课题组计划结合多种方法研究慢性痛条件下能量代谢变化的机制。

• Li XY, Chen T, Descalzi G, Koga K, Qiu S, Zhuo M. Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice, Molecular Pain. 2012 8:53.
• Descalzi G, Li XY, Chen T, Koga K, Mercaldo V, Kaang H, Zhuo M. Rapid alterations within the anterior cingulate cortex mediate trace fear learning. Molecular Brain. 2012 5:6.
• Steenland H, Li XY, Zhuo M. Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning. J. Neurosci. 2012 32,(3):1082.
• Abumaria N, Yin B, Zhang L, Li XY, Chen T, Descalzi G, Zhao L, Ahn M, Luo L, Ran C, Zhuo M, Liu G. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J. Neurosci. 2011, 31(42):14871-81.
• Toyada H, Li XY, Wu LJ, Zhao MG, Descalzi G, Chen T, Koga K, Zhuo M. Interplay of amygdala and cingulate plasticity in emotional fear. Neural Plasticity. 2011, 2011:813749. (共同第一作者)
• Koga K, Chen T, Li XY, Descalzi G, Ling J, Gu J, Zhuo M. Glutamate acts as a neurotransmitter for GRP-related itch in mammalian spinal cord. Molecular Pain, 7:47. (共同第一作者)
• Qiu S, Li XY, Zhuo M. Posttranslational modification of NMDA receptor GluN2B subunit and its roles in pain and memory. Seminars in Cell and Developmental Biology, 2011, 22(5):521-9. (综述)
• Li XY, Ko HY, Chen T, Collingridge GL, Kaang BK, Zhuo M. Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain. Journal of Molecular Medicine. 2011, 89(9):847-55. (综述)
• Kim SS, Wang H, Li XY, Chen T, Mercaldo V, Descalzi G, Wu LJ, Zhuo M. Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice. Molecular Brain. 2011, 4: 6. (共同第一作者)
• Li XY, Ko HG, Chen T, Descalzi G, Koga K, Wang H, Kim SS, Shang Y, Kwak C, Park SW, Shim J, Lee K, Collingridge GL, Kaang BK, Zhuo M. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science. 2010; 330(6009):1400-4. (共同第一作者，被Science Signaling编辑推荐，Nature亮点报道，F1000亮点)
• Chen T, Koga K, Li XY, Zhuo M. Spinal microglial motility is independent of neuronal activity and plasticity in adult mice. Molecular Pain. 2010; 6:19.
• Wu LJ, Mellström B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M. DREAM contributes to synaptic depression and contextual fear memory. Molecular Brain. 2010; 3:3.
• Koga K, Li XY, Chen T, Steenland HW, Descalzi G, Zhuo M. In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice. Molecular Pain. 2010; 6:62.
• Cao XY, Xu H, Wu LJ, Li XY, Chen T, Zhuo M. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury. Molecular Pain. 2009; 5:73.
• Wu LJ, Li XY, Chen T, Ren M, Zhuo M. Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Molecular Brain. 2009; 2: 32.
• Tong XP, Li XY, Zhou B, Shen W, Zhang ZJ, Xu TL, Duan S. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. J. Cell Biol. 2009, 186(1):113-128.
• Vecsey CG, Baillie G, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown K, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, Abel T. Sleep deprivation impairs cAMP signaling in the hippocampus. Nature. 2009; 461(7267):1122-5.
• Wu LJ, Kim SS, Li XY, Zhang F, Zhuo M. Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex. Molecular Brain, 2009; 1:9. (共同第一作者)
• Shang Y, Wang H, Mercaldo V, Li XY, Chen T, Zhuo M. Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. J. Neurochem. 2009, 111(3):635-46.
• Liao CY, Li XY, Wu B, Duan S, Jiang GB. Acute enhancement of synaptic transmission and chronic inhibition of synaptogenesis induced by perfluorooctane sulfonate through mediation of voltage-dependent calcium channel. Environ. Sci. Technol. 2008, 42(14):5335-41.
• Li XY, Li L, Zhang JP, Sun XD. The behavioral presentations of audio-visual integration in rats. Academic journal of second military medical university, 2007, 28(5):480-483.
• Li XY, Gao F, Zhang Z, Zhang JP, Sun XD. Auditory cues induced the place navigation in rats. Journal of Fudan university (natural science edition), 2007, 46(6).
• Gao F, Chen L, Pu Q, Li XY, Sun XD, Zhang JP. Influence of Prenatal Noise Exposure on the Auditory Object Exploration Behavior of Adult Rats. Chinese Journal of Zoology, 2007, 42(5):20-26.
• Wang XY, Yu LP, Li XY, Zhang JP, Sun XD. Auditory-visual Multisensory Neurons and Auditory-visual Information Integration in Newborn Rat Cortex. Chinese Journal of Zoology, 2006, 41(4):31-40.
• Yu LP, Wang XY, Li XY, Zhang JP, Sun XD. The Auditory-visual Multisensory Neurons and Auditory-visual Information Integration in Rat Cortex. Progress in Biochemistry and Biophysics, 2006, 33(7):677-684.

2010/4-2012/04：加拿大卫生研究院（CIHR）及加拿大脆性X研究基金会博士后奖学金。

• Li XY, Ko HG, Chen T, et al. Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science. 2010;330(6009):1400-1404.
• Li XY, Chen T, Descalzi G, et al. Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice. Molecular Pain. 2012;8:53.
• Steenland H, Li XY, Zhuo M. Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning. J Neurosci. 2012;32(3):1082.
• Li XY, Ko HY, Chen T, et al. Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain. J Mol Med. 2011;89(9):847-855.
• 李相尧, 李丽, 张季平, 孙心德. 大鼠视听整合的行为学表现. 第二军医大学学报. 2007;28(5):480-483.
• 李相尧, 高飞, 张震, 张季平, 孙心德. 听觉线索诱导大鼠空间导航. 复旦学报(自然科学版). 2007;46(6).