丁梅

丁梅，研究员，博士生导师。1995年毕业于厦门大学获学士学位，2004年于美国加州大学圣克鲁斯分校（University of California, Santa Cruz）获得博士学位，2004至2008年在美国斯坦福大学（Stanford University）从事博士后研究。2008年加入中国科学院遗传与发育生物学研究所，担任研究员，入选中国科学院“百人计划”。

ADFASDFAF23RQ23R

人类感知、学习、记忆、思维、情绪均依赖于神经系统正确的信号传导，然而，神经系统信号传导究竟如何发生，是什么机制确保信息传导的连贯性和精确性，并不清楚。因此，实验室以秀丽隐杆线虫（Caenorhabditis elegans）为模式生物，从基础着手研究神经系统发育的分子机制。主要内容包括以下方面：

1. 神经细胞的定向分化

GABA和乙酰胆碱是两种重要的神经介质，分别由不同神经细胞产生、分泌。GABA抑制受体细胞活性，而乙酰胆碱是重要的神经激活介质。以这两种神经细胞体内定向分化为模型，综合利用遗传学、细胞生物学、生物信息学等方法，系统解析神经细胞功能分化的分子机制。 ADSFAEQWER353423413434

2. 神经细胞极性的形成

神经细胞既是信号传递的供体（突触前）也是信号传递的受体（突触后），突触前和突触后这两种功能区域是如何在细胞内分化构建以及不同区域的蛋白如何被定向转运或稳定，是研究重点之一。 ADSFAEQWER353423413434

3. 神经突触的动态平衡

神经突触是神经细胞功能的执行者。在正常发育以及后天学习过程中，神经突触能够特异形成也能特异消除，其调控机制尚不清楚。利用线虫体内动态观测优势，结合遗传、生化等手段，探索神经突触动态平衡建立的分子机制。

ADSFAEQWER353423413434

• Song S, Zhang B, Sun H, Li X, Xiang Y, Liu Z, Huang X, and Ding M. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8): e1001056.
• Ding M and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.
• Ding M, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One 3: e3346.
• Ding M, Chao D, Wang G, Shen K. (2007) Spatial Regulation of an E3 Ubiquitin Ligase Directs Selective Synapse Elimination. Science 317: 947-951.
• Ding M, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res 301: 84-90.
• Ding M, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130: 5791-5801.
• Chin-Sang ID, Moseley SL, Ding M, Harrington RJ, George SE, Chisholm AD. (2002) The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Development 129: 5499-5510.
• Chin-Sang ID, George SE, Ding M, Moseley SL, Lynch AS, Chisholm AD. (1999) The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Cell 99: 781-790.

• Song S, Zhang B, Sun H, et al. A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics, 2010, 6(8): e1001056.
• Ding M, Shen K. The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay, 2008, 30: 1075-1083.
• Ding M, Chao D, Wang G, et al. Spatial Regulation of an E3 Ubiquitin Ligase Directs Selective Synapse Elimination. Science, 2007, 317: 947-951.
• Ding M, King RS, Berry EC, et al. The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One, 2008, 3: e3346.
• Ding M, Woo WM, Chisholm AD. The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res, 2004, 301: 84-90.
• Ding M, Goncharov A, Jin Y, et al. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development, 2003, 130: 5791-5801.
• Chin-Sang ID, Moseley SL, Ding M, et al. The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Development, 2002, 129: 5499-5510.
• Chin-Sang ID, George SE, Ding M, et al. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans. Cell, 1999, 99: 781-790.
• Jin Y, Hoskins R, Horvitz HR. Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Nature, 1994, 372: 780-783.
• Miller KG, Emerson MD, Rand JB. Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans. Neuron, 1999, 24: 323-333.
• Shen K, Bargmann CI. The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans. Cell, 2003, 112: 619-630.
• 尉姗, 周红霞. 模式生物秀丽隐杆线虫在神经退行性疾病研究中的应用. 生命科学, 2018, 30(5): 548-555.