伍龙军

• 1999 - Guanghua Education Scholarship, Taiwan Guanghua Foundation
• 2001 - IET Scholarship, IET Education Foundation of China
• 2002 - IBRO Travel Fellowship, International Brain Research Organization
• 2002 - Qiushi Graduate Student Scholarship, Qiushi Science & Technology Foundation of Hong Kong
• 2005-2008 - Medical Research Postdoctoral Fellowship, The Fragile X Research Foundation of Canada
• 2006-2009 - CIHR Postdoctoral Fellowship Award, Canadian Institutes of Health Research
• 2007 - Best Poster Award, 1st place, The 2nd International Conference of Neurons and Brain Disease
• 2007 - CaBP07 Travel Award, The 14th Congress of Calcium Binding Proteins in Health and Disease
• 2007 - Hubert van Tol Fellowship Award, NeuroScience Canada
• 2009-2011 - Lefler Postdoctoral Fellowship, The Edward R. and Anne G. Lefler Center, Harvard Medical School
• 2011-2015 - NCRP Scientist Development Grant Award, American Heart Association

Long-Jun Wu's research primarily investigates the mechanisms of pain, synaptic plasticity, and microglial function. His work has elucidated the role of NMDA receptor subunits, such as NR2B, in neuropathic pain and inflammatory pain. He also studied the involvement of kainate receptors (GluR5) in anxiety and synaptic transmission in the anterior cingulate cortex (ACC). Additionally, Wu's research on microglia revealed that ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated outward potassium currents, and that resting microglial motility is independent of synaptic plasticity.

• Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010;62(3):381-404.
• Wu LJ, Zhuo M. Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics. 2009;6(4):693-702.
• Wu LJ, Vadakkan KI, Zhuo M. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia. 2007;55(8):810-21.
• Zhuo M, Wu G, Wu LJ. Neuronal and microglial mechanisms of neuropathic pain. Mol Brain. 2011;4:31.
• Xu H, Wu LJ, Wang H, et al. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci. 2008;28(29):7445-53.

• Toyoda H, Li XY, Wu LJ, et al. Interplay of amygdala and cingulate plasticity in emotional fear. Neural Plast. 2011;2011:813749.
• Zhuo M, Wu G, Wu LJ. Neuronal and microglial mechanisms of neuropathic pain. Mol Brain. 2011;4:31.
• Suzuki A, Fukushima H, Mukawa T, et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci. 2011;31(24):8786-802.
• Kim SS, Wang H, Li XY, et al. Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice. Mol Brain. 2011;4:6.
• Wang H, Xu H, Wu LJ, et al. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Sci Transl Med. 2011;3(65):65ra3.
• Cao X, Mercaldo V, Li P, et al. Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex. Mol Pain. 2010;6:52.
• Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010;62(3):381-404.
• Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-77.
• Wu LJ, Mellström B, Wang H, et al. DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory. Mol Brain. 2010;3:3.
• Cao XY, Xu H, Wu LJ, et al. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury. Mol Pain. 2009;5:73.
• Wu LJ, Li X, Chen T, et al. Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Mol Brain. 2009;2:32.
• Wu LJ, Zhuo M. Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics. 2009;6(4):693-702.
• Toyoda H, Zhao MG, Ulzhöfer B, et al. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain. 2009;5:46.
• Wu LJ, Wang YT, Zhuo M. Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus. Mol Brain. 2009;2(1):17.
• Wu LJ, Kim SS, Li X, et al. Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex. Mol Brain. 2009;2(1):9.
• Fukushima H, Maeda R, Suzuki R, et al. Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J Neurosci. 2008;28(40):9910-9.
• Zhang XH, Wu LJ, Gong B, et al. Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. Mol Brain. 2008;1(1):9.
• Wu LJ, Steenland HW, Kim SS, et al. Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Mol Pain. 2008;4:40.
• Wang H, Wu LJ, Kim SS, et al. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron. 2008;59(4):634-47.
• Xu H, Wu LJ, Wang H, et al. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci. 2008;28(29):7445-53.
• Ko SW, Wu LJ, Shum F, et al. Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance. Mol Brain. 2008;1(1):2.
• Hines RM, Wu L, Hines DJ, et al. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci. 2008;28(24):6055-67.
• Isiegas C, McDonough C, Huang T, et al. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci. 2008;28(24):6220-30.
• Wang H, Wu LJ, Zhang F, et al. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008;28(17):4385-97.
• Zhang F, Vadakkan KI, Kim SS, et al. Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Mol Pain. 2008;4:15.
• Wu LJ, Kim SS, Zhuo M. Molecular targets of anxiety: from membrane to nucleus. Neurochem Res. 2008;33(10):1925-32.
• Wu LJ, Zhang XH, Fukushima H, et al. Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. Eur J Neurosci. 2008;27(8):1923-32.
• Wu LJ, Zhuo M. Resting microglial motility is independent of synaptic plasticity in mammalian brain. J Neurophysiol. 2008;99(4):2026-32.
• Wu LJ, Ren M, Wang H, et al. Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. PLoS One. 2008;3(1):e1407.
• Du J, Creson TK, Wu LJ, et al. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. J Neurosci. 2008;28(1):68-79.
• Toyoda H, Zhao MG, Xu H, et al. Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain. 2007;3:36.
• Duan B, Wu LJ, Yu YQ, et al. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci. 2007;27(41):11139-48.
• Wu LJ, Vadakkan KI, Zhuo M. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia. 2007;55(8):810-21.
• Toyoda H, Wu LJ, Zhao MG, et al. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol. 2007;211(2):336-43.
• Wu LJ, Xu H, Ren M, et al. Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Mol Pain. 2007;3:11.
• Shum FW, Wu LJ, Zhao MG, et al. Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem. 2007;14(4):304-12.
• Toyoda H, Wu LJ, Zhao MG, et al. Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. Dev Neurobiol. 2007;67(4):498-509.
• Wu LJ, Xu H, Ren M, et al. Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Dev Neurobiol. 2007;67(2):146-57.
• Wu LJ, Ko SW, Toyoda H, et al. Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS One. 2007;2(1):e167.
• Wu LJ, Ko SW, Zhuo M. Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortex. Curr Pharm Des. 2007;13(15):1597-605.
• Steenland HW, Ko SW, Wu LJ, et al. Hot receptors in the brain. Mol Pain. 2006;2:34.
• Zeng H, Gragerov A, Hohmann JG, et al. Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Mol Cell Biol. 2006;26(24):9352-63.
• Blaeser F, Sanders MJ, Truong N, et al. Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol. 2006;26(23):9105-15.
• Xu H, Wu LJ, Zhao MG, et al. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain. 2006;2:29.
• Zhao MG, Ko SW, Wu LJ, et al. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain. J Neurosci. 2006;26(35):8923-30.
• Ko SW, Jia Y, Xu H, et al. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci. 2006;23(8):2158-68.
• Wei F, Vadakkan KI, Toyoda H, et al. Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice. J Neurosci. 2006;26(3):851-61.
• Wu LJ, Toyoda H, Zhao MG, et al. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci. 2005;25(48):11107-16.
• Wu LJ, Xu H, Ko SW, et al. Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P. Mol Pain. 2005;1:34.
• Zhao MG, Toyoda H, Lee YS, et al. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005;47(6):859-72.
• Zhao MG, Toyoda H, Ko SW, et al. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci. 2005;25(32):7385-92.
• Liauw J, Wu LJ, Zhuo M. Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex. J Neurophysiol. 2005;94(1):878-82.
• Wu LJ, Zhao MG, Toyoda H, et al. Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. J Neurophysiol. 2005;94(3):1805-13.
• Gao J, Wu LJ, Xu L, et al. Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons. Brain Res. 2004;1017(1-2):197-207.
• Wu LJ, Duan B, Mei YD, et al. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem. 2004;279(42):43716-24.
• Li Y, Wu LJ, Legendre P, et al. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. J Biol Chem. 2003;278(40):38637-45.
• Li YF, Wu LJ, Li Y, et al. Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons. J Physiol. 2003;552(Pt 1):73-87.
• Wu LJ, Li Y, Xu TL. Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. Neuroreport. 2002;13(7):977-81.
• Wu LJ, Lu Y, Xu TL. A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. J Neurosci Methods. 2001;108(2):199-206.
• Wu LJ, Xu H, Ren M, et al. Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Dev Neurobiol. 2007;67(2):146-57.
• 补充中文文献：李明, 张伟. 小胶质细胞在神经病理性疼痛中的作用机制研究进展. 中国疼痛医学杂志. 2018;24(5):330-335.
• 补充中文文献：王芳, 赵国强. NMDA受体亚型NR2B在慢性疼痛中的研究进展. 生理科学进展. 2016;47(2):101-106.
• 补充英文文献：Inoue K. Microglial activation by purines and pyrimidines. Glia. 2002;40(2):156-163.
• 补充英文文献：Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895-926.