郑家麟

郑家麟（Jialin Zheng），医学博士，教授。现任同济大学医学与生命科学部主任，同时担任美国内布拉斯加大学医学中心（UNMC）药理学与实验神经科学教授及亚太发展项目主任。其医学学位于1987年获得自中国徐州医学院。 ADFASDFAF23RQ23R

郑家麟教授的神经毒理学实验室长期致力于揭示HIV-1相关痴呆（HAD）的发病机制，研究路线包括：神经发生、脑内单核吞噬细胞（MP）的活化、HIV病毒蛋白及其神经毒性效应，以及神经元、星形胶质细胞和MP释放的趋化因子及其对脑环境的直接后果。研究显示，神经发生在成年脑中扮演重要角色，并可通过神经元损伤、体育锻炼或应激而受到刺激。HIV感染和活化的MP可释放病毒蛋白和神经毒素（包括谷氨酸），损伤邻近神经元。受损神经元释放趋化因子，招募更多MP到损伤部位以修复损伤并促进神经发生，同时清除细胞碎片和病毒蛋白。然而，感染和活化的MP响应神经元信号后，会释放更多神经毒素，造成更多损伤，形成恶性循环。因此，整合神经科学、病毒学、免疫学、生物化学和受体药理学的研究，可全面探索HAD的神经病理机制。 ADFASDFAF23RQ23R

实验室的使命是最终开发出能够选择性抑制脑内神经毒素产生并增强神经元修复的药物。这些研究不仅有助于解答HAD的相关问题，也对阿尔茨海默病等其他神经系统疾病具有指导意义。 ADSFAEQWER353423413434

实验室综合运用免疫学、神经科学、病毒学、受体药理学、分子生物学和生物化学等技术，研究HIV-1相关障碍（HAD）的神经病理机制。

• Whitney, N., Eidem, T., Peng, H., Huang, Y., Zheng, J. (2009): Inflammation mediates varying effects in neurogenesis: Relevance to the pathogenesis of brain injury and neurodegenerative disorders. J. Neurochem. 108: 1343-1359 (PMC Journal -in process).
• Erdmann, N., Tian, C., Huang, Y., Zhao, J., Herek, S., Curthoys, N., and Zheng, J (2009). In vitro Glutaminase Regulation and Mechanisms of Glutamate Generation in HIV-1 Infected Macrophage. J. Neurochem. 109: 551-561 (PMCID: PMC2668921).
• Wu, Y., Peng, H., Cui, M., Whitney, N., Zheng, J. (2009). SDF-1 Increases Human Neural Progenitor Cell Proliferation Through PI3K/Akt/FOXO3a Signaling Pathway. J. Neurochem. 109: 1157-1167. (PMC Journal -in process).
• Huang, Y., Walstrom, A., Zhang, L., Cui, M., Ling, Y., Zhao, Y., and Zheng, J. (2009) Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLOS ONE 4: e5397. PMCID: PMC2672636.
• Tian, C., Murrin, C., Zheng, J. (2009). Mitochondrial fragmentation is involved in METH-induced cell death in rat hippocampal neural progenitor cells. PLOS ONE 4: e5546. PMCID: PMC2677674.
• Zheng, J., Huang, Y., Tang, K., Cui, M., Niemann, D., Lopez, A., Morgello, S. and Chen, S. (2008). HIV-1-Infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1b and TNF-a: Involvement of mitogen-activated protein kinase and protein kinase R. J. Neuroimmunol. 200: 100-110 (PMCID: PMC2596956).

• Whitney, N., Eidem, T., Peng, H., Huang, Y., Zheng, J. Inflammation mediates varying effects in neurogenesis: Relevance to the pathogenesis of brain injury and neurodegenerative disorders. J. Neurochem. 2009;108:1343-1359.
• Erdmann, N., Tian, C., Huang, Y., Zhao, J., Herek, S., Curthoys, N., Zheng, J. In vitro Glutaminase Regulation and Mechanisms of Glutamate Generation in HIV-1 Infected Macrophage. J. Neurochem. 2009;109:551-561.
• Wu, Y., Peng, H., Cui, M., Whitney, N., Zheng, J. SDF-1 Increases Human Neural Progenitor Cell Proliferation Through PI3K/Akt/FOXO3a Signaling Pathway. J. Neurochem. 2009;109:1157-1167.
• Huang, Y., Walstrom, A., Zhang, L., Cui, M., Ling, Y., Zhao, Y., Zheng, J. Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLOS ONE. 2009;4:e5397.
• Tian, C., Murrin, C., Zheng, J. Mitochondrial fragmentation is involved in METH-induced cell death in rat hippocampal neural progenitor cells. PLOS ONE. 2009;4:e5546.
• Zheng, J., Huang, Y., Tang, K., Cui, M., Niemann, D., Lopez, A., Morgello, S., Chen, S. HIV-1-Infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1b and TNF-a: Involvement of mitogen-activated protein kinase and protein kinase R. J. Neuroimmunol. 2008;200:100-110.
• 郑家麟, 彭洪, 崔明. HIV-1相关痴呆的神经病理机制研究进展. 中华神经科杂志. 2010;43(6):456-460.
• Kraft-Terry, S.D., Buch, S.K., Gendelman, H.E. The role of neuroinflammation in the pathogenesis of HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2009;4(4):410-421.
• Kaul, M., Garden, G.A., Lipton, S.A. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature. 2001;410(6831):988-994.
• Rao, V.R., Ruiz, A.P., Prasad, V.R. Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND). AIDS Res Ther. 2014;11:13.